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1. 发明申请

US20090011946A1 Use of Sequence Specific Polymers in Chemical Detection 审中-公开
标题翻译：在化学检测中使用序列比聚合物
公开(公告)号：US20090011946A1
公开(公告)日：2009-01-08
申请号：US11793576
申请日：2005-12-20
申请人： Arun Majumdar , Mark O. Trulson
发明人： Arun Majumdar , Mark O. Trulson
IPC分类号： C40B30/04 , B01J19/00 , G01N21/64 , G01N27/00 , C40B40/14 , C08G73/00 , G01N33/566
CPC分类号： G01N33/54373 , G01N33/542
摘要： A method for chemical detection is provided. In one aspect, the method comprises exposing a sample to a sequence specific polymer under conditions such that an analyte in the sample binds to the polymer. Binding of the analyte to the sequence specific polymer results in a change in a property of the sequence specific polymer that is transduced to a response transduction medium, which generates a detectable response. Another aspect provides a detection device comprising the sequence specific polymer and response transduction medium.
摘要翻译：提供了一种用于化学检测的方法。在一个方面，该方法包括在样品中的分析物与聚合物结合的条件下将样品暴露于序列特异性聚合物。分析物与序列特异性聚合物的结合导致转导到响应转导介质的序列特异性聚合物的性质的变化，其产生可检测的反应。另一方面提供一种包含序列特异性聚合物和响应转导介质的检测装置。

2. 发明申请

US20120171778A1 FUNCTIONALIZATION OF NANOFLUIDIC CHANNELS 有权
标题翻译：纳米通道的功能化
公开(公告)号：US20120171778A1
公开(公告)日：2012-07-05
申请号：US11969010
申请日：2008-01-03
申请人： Peidong Yang , Rohit Karnik , Kenneth Castelino , Rong Fan , Arun Majumdar
发明人： Peidong Yang , Rohit Karnik , Kenneth Castelino , Rong Fan , Arun Majumdar
IPC分类号： G01N27/00 , B82Y15/00
CPC分类号： G01N33/54373
摘要： A functionalized nanofluidic channel and method for functionalization that provides control over the ionic environment and geometry of the nanofluidic channel with the immobilization of biomolecules on the inner surface of the channel and use of high ionic concentration solutions. In one embodiment, the surface charge of the nanochannel is controlled with the immobilization of a protein such as streptavidin in the nanochannel. In another embodiment, the biomolecules are receptors and changes in nanochannel conductance indicates ligand binding events. The functionalized nanofluidic channel can be easily adapted for use with microchannel arrays.
摘要翻译：功能化纳米流体通道和功能化方法，其通过在通道的内表面上固定生物分子并使用高离子浓度溶液来提供对纳米流体通道的离子环境和几何形状的控制。在一个实施方案中，通过在纳米通道中固定蛋白质例如链霉亲和素来控制纳米通道的表面电荷。在另一个实施方案中，生物分子是受体，并且纳米通道电导的变化表示配体结合事件。功能化纳米流体通道可以容易地适用于微通道阵列。

3. 发明授权

US08093628B2 Fluidic nanotubes and devices 有权
标题翻译：流体纳米管和器件
公开(公告)号：US08093628B2
公开(公告)日：2012-01-10
申请号：US12027428
申请日：2008-02-07
申请人： Peidong Yang , Rongrui He , Joshua Goldberger , Rong Fan , Yiying Wu , Deyu Li , Arun Majumdar
发明人： Peidong Yang , Rongrui He , Joshua Goldberger , Rong Fan , Yiying Wu , Deyu Li , Arun Majumdar
IPC分类号： G01N27/28
CPC分类号： C30B25/02 , B01L3/502761 , B01L2200/0631 , B01L2200/0663 , B01L2300/12 , B01L2300/161 , B82Y10/00 , B82Y30/00 , C30B29/602 , C30B29/605 , C30B33/00 , G01N27/00 , H01L21/0242 , H01L21/02472 , H01L21/02516 , H01L21/02521 , H01L21/0254 , H01L21/0262 , H01L21/02639 , H01L21/02664 , H01L29/0676 , H01L29/068
摘要： Fluidic nanotube devices are described in which a hydrophilic, non-carbon nanotube, has its ends fluidly coupled to reservoirs. Source and drain contacts are connected to opposing ends of the nanotube, or within each reservoir near the opening of the nanotube. The passage of molecular species can be sensed by measuring current flow (source-drain, ionic, or combination). The tube interior can be functionalized by joining binding molecules so that different molecular species can be sensed by detecting current changes. The nanotube may be a semiconductor, wherein a tubular transistor is formed. A gate electrode can be attached between source and drain to control current flow and ionic flow. By way of example an electrophoretic array embodiment is described, integrating MEMs switches. A variety of applications are described, such as: nanopores, nanocapillary devices, nanoelectrophoretic, DNA sequence detectors, immunosensors, thermoelectric devices, photonic devices, nanoscale fluidic bioseparators, imaging devices, and so forth.
摘要翻译：描述了流体性纳米管器件，其中亲水性，非碳纳米管的端部流体耦合到储存器。源极和漏极触点连接到纳米管的相对端，或者在靠近纳米管开口的每个储存器内。可以通过测量电流（源 - 漏，离子或组合）来感测分子种类的通过。管内部可以通过结合结合分子来官能化，使得可以通过检测电流变化来感测不同的分子种类。纳米管可以是半导体，其中形成管状晶体管。栅极电极可以连接在源极和漏极之间，以控制电流和离子流。作为示例，描述了集成MEMs开关的电泳阵列实施例。描述了各种应用，例如：纳米孔，纳米毛细管装置，纳米电泳，DNA序列检测器，免疫传感器，热电装置，光子器件，纳米流体生物分离器，成像装置等。

4. 发明授权

US07834264B2 Methods of fabricating nanostructures and nanowires and devices fabricated therefrom 有权
标题翻译：制造纳米结构和纳米线的方法和由其制造的器件
公开(公告)号：US07834264B2
公开(公告)日：2010-11-16
申请号：US11645236
申请日：2006-12-22
申请人： Arun Majumdar , Ali Shakouri , Timothy D. Sands , Peidong Yang , Samuel S. Mao , Richard E. Russo , Henning Feick , Eicke R. Weber , Hannes Kind , Michael Huang , Haoquan Yan , Yiying Wu , Rong Fan
发明人： Arun Majumdar , Ali Shakouri , Timothy D. Sands , Peidong Yang , Samuel S. Mao , Richard E. Russo , Henning Feick , Eicke R. Weber , Hannes Kind , Michael Huang , Haoquan Yan , Yiying Wu , Rong Fan
IPC分类号： H01L35/00 , H01L35/02 , H01L35/12
CPC分类号： H01L29/0665 , B82Y10/00 , B82Y20/00 , G02B6/107 , H01L21/0237 , H01L21/02381 , H01L21/0245 , H01L21/02521 , H01L21/02532 , H01L21/02554 , H01L21/02603 , H01L21/02645 , H01L21/02653 , H01L24/45 , H01L29/0673 , H01L29/0676 , H01L29/068 , H01L29/12 , H01L29/125 , H01L31/0352 , H01L33/06 , H01L33/18 , H01L33/24 , H01L35/00 , H01L41/094 , H01L41/18 , H01L41/183 , H01L2224/45565 , H01L2224/45599 , H01L2924/00014 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/0101 , H01L2924/01013 , H01L2924/01014 , H01L2924/01015 , H01L2924/01018 , H01L2924/01019 , H01L2924/01022 , H01L2924/01023 , H01L2924/01024 , H01L2924/01025 , H01L2924/01027 , H01L2924/01028 , H01L2924/0103 , H01L2924/01031 , H01L2924/01032 , H01L2924/01039 , H01L2924/01047 , H01L2924/01051 , H01L2924/01052 , H01L2924/01058 , H01L2924/0106 , H01L2924/01061 , H01L2924/01068 , H01L2924/01074 , H01L2924/01075 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01083 , H01L2924/01084 , H01L2924/04953 , H01L2924/10253 , H01L2924/10329 , H01L2924/12036 , H01L2924/12041 , H01L2924/12042 , H01L2924/1305 , H01L2924/1306 , H01L2924/13062 , H01L2924/13091 , H01L2924/14 , H01L2924/19042 , H01L2924/19043 , H01L2924/30107 , H01S5/341 , H01S5/3412 , Y10S977/762 , Y10S977/763 , Y10S977/764 , Y10S977/765 , Y10S977/951 , Y10T428/24994 , Y10T428/249949 , Y10T428/29 , Y10T428/2913 , Y10T428/2916 , Y10T428/292 , Y10T428/2933 , Y10T428/2958 , Y10T428/2973 , Y10T428/298 , H01L2924/00011 , H01L2924/00 , H01L2224/48
摘要： One-dimensional nanostructures having uniform diameters of less than approximately 200 nm. These inventive nanostructures, which we refer to as “nanowires”, include single-crystalline homostructures as well as heterostructures of at least two single-crystalline materials having different chemical compositions. Because single-crystalline materials are used to form the heterostructure, the resultant heterostructure will be single-crystalline as well. The nanowire heterostructures are generally based on a semiconducting wire wherein the doping and composition are controlled in either the longitudinal or radial directions, or in both directions, to yield a wire that comprises different materials. Examples of resulting nanowire heterostructures include a longitudinal heterostructure nanowire (LOHN) and a coaxial heterostructure nanowire (COHN).
摘要翻译：具有小于约200nm的均匀直径的一维纳米结构。这些本发明的纳米结构，我们称之为“纳米线”，包括具有不同化学成分的至少两种单晶材料的单晶均匀结构以及异质结构。由于使用单晶材料来形成异质结构，所以得到的异质结构也将是单晶的。纳米线异质结构通常基于半导体线，其中掺杂和组成在纵向或径向方向上或在两个方向上被控制，以产生包括不同材料的导线。所得纳米线异质结构的实例包括纵向异质结构纳米线（LOHN）和同轴异质结构纳米线（COHN）。

5. 发明授权

US5831181A Automated tool for precision machining and imaging 失效
标题翻译：用于精密加工和成像的自动化工具
公开(公告)号：US5831181A
公开(公告)日：1998-11-03
申请号：US536419
申请日：1995-09-29
申请人： Arun Majumdar , Mohammed Dahleh , James Samir Ismail
发明人： Arun Majumdar , Mohammed Dahleh , James Samir Ismail
IPC分类号： B26D3/08 , G01B7/34 , G01Q60/00 , G03F7/00 , H01L21/304
CPC分类号： G01Q10/06 , B82Y10/00 , B82Y35/00 , B82Y40/00 , G01Q60/38 , G03F7/0002 , G01Q80/00 , Y10S83/919 , Y10S977/856
摘要： A modified Atomic Force Microscope (AFM), which can machine and image the surface of a sample with nanometer precision in all three orthogonal directions by varying the depth-of-cut of the sample. A multi-repetitive sensor system is provided as is a radially halved quartered electrode to substantially maintain parallelism or substantial parallelism.
摘要翻译：改进的原子力显微镜（AFM），可以通过改变样品的切割深度，在所有三个正交方向上以纳米精度对样品的表面进行加工和成像。提供了一种多重重复传感器系统，其是径向减半的四极电极，以基本上保持平行度或基本平行度。

6. 发明申请

US20050255448A1 System for amplifying optical detection of cantilever deflection 审中-公开
标题翻译：用于放大悬臂偏转光学检测系统
公开(公告)号：US20050255448A1
公开(公告)日：2005-11-17
申请号：US10883964
申请日：2004-07-06
申请人： Arun Majumdar , Srinath Satyanarayana
发明人： Arun Majumdar , Srinath Satyanarayana
IPC分类号： C12M1/34 , C12Q1/00 , G01N27/00
CPC分类号： G01N29/036 , B82Y35/00 , G01N2291/0256
摘要： A sensor system configured to amplify cantilever deflection, having: a reflective membrane connected to a cantilever, wherein the reflective membrane rotates more than the cantilever when the cantilever deflects. A sensor system, including: a cantilever having a first end and a second end, the first end being held at a first fixed location and the second end being free to move; and a reflective membrane having a first end and a second end, the first end being held at a second fixed location and the second end being attached to the cantilever.
摘要翻译：配置成放大悬臂偏转的传感器系统，其具有连接到悬臂的反射膜，其中当悬臂偏转时，反射膜比悬臂旋转更多。一种传感器系统，包括：具有第一端和第二端的悬臂，所述第一端保持在第一固定位置，所述第二端自由移动; 以及具有第一端和第二端的反射膜，所述第一端保持在第二固定位置，所述第二端附接到所述悬臂。

7. 发明授权

US09881999B2 Methods of fabricating nanostructures and nanowires and devices fabricated therefrom 有权
公开(公告)号：US09881999B2
公开(公告)日：2018-01-30
申请号：US12488310
申请日：2009-06-19
申请人： Arun Majumdar , Ali Shakouri , Timothy D. Sands , Peidong Yang , Samuel S. Mao , Richard E. Russo , Henning Feick , Eicke R. Weber , Hannes Kind , Michael Huang , Haoquan Yan , Yiying Wu , Rong Fan
发明人： Arun Majumdar , Ali Shakouri , Timothy D. Sands , Peidong Yang , Samuel S. Mao , Richard E. Russo , Henning Feick , Eicke R. Weber , Hannes Kind , Michael Huang , Haoquan Yan , Yiying Wu , Rong Fan
IPC分类号： B32B5/02 , B32B9/00 , H01L29/06 , B82Y10/00 , B82Y20/00 , G02B6/10 , H01L21/02 , H01L23/00 , H01L29/12 , H01L31/0352 , H01L33/06 , H01L33/24 , H01L35/00 , H01L41/18 , H01L41/09 , H01L33/18 , H01S5/34
CPC分类号： H01L29/0665 , B82Y10/00 , B82Y20/00 , G02B6/107 , H01L21/0237 , H01L21/02381 , H01L21/0245 , H01L21/02521 , H01L21/02532 , H01L21/02554 , H01L21/02603 , H01L21/02645 , H01L21/02653 , H01L24/45 , H01L29/0673 , H01L29/0676 , H01L29/068 , H01L29/12 , H01L29/125 , H01L31/0352 , H01L33/06 , H01L33/18 , H01L33/24 , H01L35/00 , H01L41/094 , H01L41/18 , H01L41/183 , H01L2224/45565 , H01L2224/45599 , H01L2924/00014 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/0101 , H01L2924/01013 , H01L2924/01014 , H01L2924/01015 , H01L2924/01018 , H01L2924/01019 , H01L2924/01022 , H01L2924/01023 , H01L2924/01024 , H01L2924/01025 , H01L2924/01027 , H01L2924/01028 , H01L2924/0103 , H01L2924/01031 , H01L2924/01032 , H01L2924/01039 , H01L2924/01047 , H01L2924/01051 , H01L2924/01052 , H01L2924/01058 , H01L2924/0106 , H01L2924/01061 , H01L2924/01068 , H01L2924/01074 , H01L2924/01075 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01083 , H01L2924/01084 , H01L2924/04953 , H01L2924/10253 , H01L2924/10329 , H01L2924/12036 , H01L2924/12041 , H01L2924/12042 , H01L2924/1305 , H01L2924/1306 , H01L2924/13062 , H01L2924/13091 , H01L2924/14 , H01L2924/19042 , H01L2924/19043 , H01L2924/30107 , H01S5/341 , H01S5/3412 , Y10S977/762 , Y10S977/763 , Y10S977/764 , Y10S977/765 , Y10S977/951 , Y10T428/24994 , Y10T428/249949 , Y10T428/29 , Y10T428/2913 , Y10T428/2916 , Y10T428/292 , Y10T428/2933 , Y10T428/2958 , Y10T428/2973 , Y10T428/298 , H01L2924/00011 , H01L2924/00 , H01L2224/48
摘要： One-dimensional nanostructures having uniform diameters of less than approximately 200 nm. These inventive nanostructures, which we refer to as “nanowires”, include single-crystalline homostructures as well as heterostructures of at least two single-crystalline materials having different chemical compositions. Because single-crystalline materials are used to form the heterostructure, the resultant heterostructure will be single-crystalline as well. The nanowire heterostructures are generally based on a semiconducting wire wherein the doping and composition are controlled in either the longitudinal or radial directions, or in both directions, to yield a wire that comprises different materials. Examples of resulting nanowire heterostructures include a longitudinal heterostructure nanowire (LOHN) and a coaxial heterostructure nanowire (COHN).

8. 发明授权

US09158847B1 Cognitive memory encoding networks for fast semantic indexing storage and retrieval 有权
标题翻译：认知记忆编码网络，用于快速语义索引存储和检索
公开(公告)号：US09158847B1
公开(公告)日：2015-10-13
申请号：US13553662
申请日：2012-07-19
申请人： Arun Majumdar
发明人： Arun Majumdar
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30864 , G06F17/30312 , G06F17/30958 , G06N3/02
摘要： The invention provides a fast approximate as well as exact hierarchical network storage and retrieval system and method for encoding and indexing graphs or networks into a data structure called the Cognitive Signature for property based, analog based or structure or sub-structure based search. The system and method produce a Cognitive Memory from a multiplicity of stored Cognitive Signatures and are ideally suited to store and index all or parts of massive data sets, linguistic graphs, protein graphs, chemical graphs, graphs of biochemical pathways, image or picture graphs as well as dynamical graphs such as traffic graphs or flows and motion picture sequences of graphs. The system and method have the advantage that properties of the Cognitive Signature of the graph can be used in correlations to the properties of the underlying data making the system ideal for semantic indexing of massive scale graph data sets.
摘要翻译：本发明提供了一种快速近似以及精确的分层网络存储和检索系统和方法，用于将图形或网络编码和索引到称为认知签名的数据结构中，用于基于属性，基于模拟或基于结构或子结构的搜索。系统和方法从多种存储的认知签名中产生认知记忆，并且非常适合存储和索引大量数据集，语言图，蛋白质图，化学图，生物化学通路图，图像或图像图的全部或部分以及诸如流量图或流的动态图和图的运动图像序列。该系统和方法的优点在于，图形的认知签名的属性可以用于与底层数据的属性相关联，使系统成为大规模图形数据集的语义索引的理想选择。

9. 发明申请

US20100233029A1 COMPENSATED MEMBRANE CAPACITIVE BIO-CHEMICAL SENSOR 审中-公开
标题翻译：补偿膜电容式生物化学传感器
公开(公告)号：US20100233029A1
公开(公告)日：2010-09-16
申请号：US12440990
申请日：2007-09-12
申请人： Arun Majumdar , Si-Hyung Lim
发明人： Arun Majumdar , Si-Hyung Lim
IPC分类号： G01N30/00 , C23F1/00
CPC分类号： G01N33/553
摘要： A sensor having a membrane, which is adapted to deflect in response to a change in surface stress. The membrane has a first and a second surface, which includes a first coating layer on the first surface of the membrane, and a second coating layer on the second surface of the membrane. The first coating layer is adapted to couple one or more probe molecules with the membrane.
摘要翻译：具有膜的传感器，其适于响应于表面应力的变化而偏转。膜具有第一和第二表面，其包括在膜的第一表面上的第一涂层和在膜的第二表面上的第二涂层。第一涂层适于将一个或多个探针分子与膜耦合。

10. 发明申请

US20100003516A1 METHODS OF FABRICATING NANOSTRUCTURES AND NANOWIRES AND DEVICES FABRICATED THEREFROM 有权
标题翻译：制造纳米结构的方法和纳米结构及其制备的器件
公开(公告)号：US20100003516A1
公开(公告)日：2010-01-07
申请号：US12488310
申请日：2009-06-19
申请人： Arun Majumdar , Ali Shakouri , Timothy D. Sands , Peidong Yang , Samuel S. Mao , Richard E. Russo , Henning Feick , Eicke R. Weber , Hannes Kind , Michael Huang , Haoquan Yan , Yiying Wu , Rong Fan
发明人： Arun Majumdar , Ali Shakouri , Timothy D. Sands , Peidong Yang , Samuel S. Mao , Richard E. Russo , Henning Feick , Eicke R. Weber , Hannes Kind , Michael Huang , Haoquan Yan , Yiying Wu , Rong Fan
IPC分类号： B32B5/02 , B32B9/00 , B32B15/00
CPC分类号： H01L29/0665 , B82Y10/00 , B82Y20/00 , G02B6/107 , H01L21/0237 , H01L21/02381 , H01L21/0245 , H01L21/02521 , H01L21/02532 , H01L21/02554 , H01L21/02603 , H01L21/02645 , H01L21/02653 , H01L24/45 , H01L29/0673 , H01L29/0676 , H01L29/068 , H01L29/12 , H01L29/125 , H01L31/0352 , H01L33/06 , H01L33/18 , H01L33/24 , H01L35/00 , H01L41/094 , H01L41/18 , H01L41/183 , H01L2224/45565 , H01L2224/45599 , H01L2924/00014 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/0101 , H01L2924/01013 , H01L2924/01014 , H01L2924/01015 , H01L2924/01018 , H01L2924/01019 , H01L2924/01022 , H01L2924/01023 , H01L2924/01024 , H01L2924/01025 , H01L2924/01027 , H01L2924/01028 , H01L2924/0103 , H01L2924/01031 , H01L2924/01032 , H01L2924/01039 , H01L2924/01047 , H01L2924/01051 , H01L2924/01052 , H01L2924/01058 , H01L2924/0106 , H01L2924/01061 , H01L2924/01068 , H01L2924/01074 , H01L2924/01075 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01083 , H01L2924/01084 , H01L2924/04953 , H01L2924/10253 , H01L2924/10329 , H01L2924/12036 , H01L2924/12041 , H01L2924/12042 , H01L2924/1305 , H01L2924/1306 , H01L2924/13062 , H01L2924/13091 , H01L2924/14 , H01L2924/19042 , H01L2924/19043 , H01L2924/30107 , H01S5/341 , H01S5/3412 , Y10S977/762 , Y10S977/763 , Y10S977/764 , Y10S977/765 , Y10S977/951 , Y10T428/24994 , Y10T428/249949 , Y10T428/29 , Y10T428/2913 , Y10T428/2916 , Y10T428/292 , Y10T428/2933 , Y10T428/2958 , Y10T428/2973 , Y10T428/298 , H01L2924/00011 , H01L2924/00 , H01L2224/48
摘要： One-dimensional nanostructures having uniform diameters of less than approximately 200 nm. These inventive nanostructures, which we refer to as “nanowires”, include single-crystalline homostructures as well as heterostructures of at least two single-crystalline materials having different chemical compositions. Because single-crystalline materials are used to form the heterostructure, the resultant heterostructure will be single-crystalline as well. The nanowire heterostructures are generally based on a semiconducting wire wherein the doping and composition are controlled in either the longitudinal or radial directions, or in both directions, to yield a wire that comprises different materials. Examples of resulting nanowire heterostructures include a longitudinal heterostructure nanowire (LOHN) and a coaxial heterostructure nanowire (COHN).
摘要翻译：具有小于约200nm的均匀直径的一维纳米结构。这些本发明的纳米结构，我们称之为“纳米线”，包括具有不同化学成分的至少两种单晶材料的单晶均匀结构以及异质结构。由于使用单晶材料来形成异质结构，所以得到的异质结构也将是单晶的。纳米线异质结构通常基于半导体线，其中掺杂和组成在纵向或径向方向上或在两个方向上被控制，以产生包括不同材料的导线。所得纳米线异质结构的实例包括纵向异质结构纳米线（LOHN）和同轴异质结构纳米线（COHN）。

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