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1. 发明申请

US20100267609A1 COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF 审中-公开
标题翻译：抑制β-分泌酶活性的化合物及其使用方法
公开(公告)号：US20100267609A1
公开(公告)日：2010-10-21
申请号：US12481339
申请日：2009-06-09
申请人： Arun K. GHOSH , Jordan J. N. Tang , Geoffrey Bilcer , Wanpin Chang , Lin Hong , Gerald E. Koelsch , Jeffrey A. Loy , Robert T. Turner, III , Thippeswamy Devasumadram
发明人： Arun K. GHOSH , Jordan J. N. Tang , Geoffrey Bilcer , Wanpin Chang , Lin Hong , Gerald E. Koelsch , Jeffrey A. Loy , Robert T. Turner, III , Thippeswamy Devasumadram
IPC分类号： A61K38/07 , C07K5/10 , A61K38/16 , A61P25/28
CPC分类号： C07D207/16 , A61K38/00 , C07D213/30 , C07D213/40 , C07D215/14 , C07D215/36 , C07D215/54 , C07D231/12 , C07D233/56 , C07D249/08 , C07D307/14 , C07D307/16 , C07D307/20 , C07D307/93 , C07D493/04 , C07K5/0207 , C07K14/8142 , C07K2299/00 , C12N9/6478 , C12Q1/37 , G01N33/6896
摘要： Compounds inhibit memapsin 2 β-secretase activity and selectively inhibit memapsin 2 β-secretase activity relative to memapsin 1 β-secretase activity. The compounds are employed in methods to inhibit memapsin 2 β-secretase activity, in the treatment of Alzheimer's disease, in the inhibition of hydrolysis of a β-secretase site of a β-amyloid precursor protein and to decrease β-amyloid protein in in vitro samples and in mammals. Proteins of memapsin 2 associated with compounds of the invention are crystallized.
摘要翻译：化合物抑制Memapsin 2和bgr - 分泌酶活性，并相对于memapsin 1和bgr-分泌酶活性选择性抑制memapsin 2和bgr-分泌酶活性。这些化合物用于抑制膜蛋白2和分泌酶活性的方法，用于治疗阿尔茨海默病，抑制β-淀粉样蛋白前体蛋白的分泌酶位点的水解并降低β-淀粉样蛋白蛋白质在体外样品和哺乳动物中。与本发明化合物相关的胶原蛋白2的蛋白质结晶。

2. 发明授权

US4310187A Door securing mechanism 失效
标题翻译：门固定机构
公开(公告)号：US4310187A
公开(公告)日：1982-01-12
申请号：US94343
申请日：1979-11-14
申请人： Jeffrey A. Loy , Albert H. Goetsch , John W. Lahman
发明人： Jeffrey A. Loy , Albert H. Goetsch , John W. Lahman
IPC分类号： E05C9/06 , E05C9/16
CPC分类号： E05C9/06 , E05C9/16 , Y10T292/0862 , Y10T292/0915 , Y10T292/237
摘要： A mechanism for securing a door to a door frame includes a plurality of generally C-shaped clamps rotatably secured about the door's periphery, each of the clamps including a rear radial clamp leg engageable with the rear of the door frame, a forward radial clamp leg overlying the front surface of the door, and a connecting base extending between the radial legs, with inner cam surfaces on each radial leg and an outer cam surface on the forward radial leg. A plurality of wedges are slidably secured to the door front surface for radial movement between extended and retracted positions wherein the wedge respectively engages or does not engage the inner cam surface on an associated forward clamp leg to effect latching or unlatching of each clamp about the door and frame. Each wedge includes a cam block carried by an arm overlying an associated clamp and spaced radially outwardly of the wedge cam surface to engage said outer cam surface of the associated forward clamp leg to move the rear clamp leg from the door frame as the wedge is moved to its retracted position.
摘要翻译：用于将门固定到门框的机构包括可围绕门的周边可旋转地固定的多个大致C形的夹具，每个夹具包括可与门框的后部接合的后部径向夹具腿，前部径向夹具腿覆盖门的前表面，以及在径向腿之间延伸的连接基部，每个径向腿上的内凸轮表面和前向径向腿上的外凸轮表面。多个楔形件可滑动地固定到门前表面上用于在延伸位置和缩回位置之间的径向运动，其中楔形件分别接合或不接合相关联的前夹具腿上的内凸轮表面，以实现每个夹具围绕门的闭锁或解锁和框架。每个楔块包括一个凸轮块，该凸轮块由一个臂组成，覆盖相关联的夹具并与楔形凸轮表面径向向外间隔开，以与所述相关联的前夹具腿的所述外凸轮表面啮合，以使楔形件移动时将后夹具腿从门框移动到其缩回位置。

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