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1. 发明授权

US08888741B2 Balloon catheter and method for manufacturing same 有权
标题翻译：球囊导管及其制造方法
公开(公告)号：US08888741B2
公开(公告)日：2014-11-18
申请号：US12533528
申请日：2009-07-31
申请人： Arthur Brunner , Adrian Blaser , Matthias Wesselmann , Patrice Bachmann
发明人： Arthur Brunner , Adrian Blaser , Matthias Wesselmann , Patrice Bachmann
IPC分类号： A61M25/10
CPC分类号： A61M25/1006 , A61M25/1029 , A61M25/1034 , A61M25/1038 , A61M2025/1004
摘要： A balloon catheter comprises an outer shaft having a distal end, an inner shaft situated therein to form an annular fluid line and projecting beyond the distal end of the outer shaft, and a balloon which is dilatable under the influence of a fluid introduced through the fluid line under pressure. At its proximal end the balloon is attached in a fluid-tight manner to the distal end region of the outer shaft at a first attachment zone, and at its distal end is attached in a fluid-tight manner to the distal end region of the inner shaft at a second attachment zone. Between the attachment zones, in the undilated state the balloon is placed in longitudinal folds along its length. The balloon, at least at its distal end, has an untapered design with a thin wall thickness (d) which is essentially unchanged over the length of the balloon, and the longitudinal folds extend into the attachment zone at that location.
摘要翻译：气囊导管包括具有远端的外轴，位于其中的内轴以形成环形流体管线并突出超过外轴的远端，以及气球，其在通过流体引入的流体的影响下可膨胀在压力下。在其近端处，气囊在第一附接区域以不透水的方式附接到外轴的远端区域，并且其远端以流体密封的方式附接到内部的远端区域轴在第二附接区域。在连接区域之间，在未膨胀状态下，气囊沿其长度被放置成纵向折叠。至少在其远端处，球囊具有无壁纸设计，其壁厚（d）在气囊的长度上基本不变，并且纵向折叠延伸到该位置处的附接区域。

2. 发明申请

US20100030144A1 BALLOON CATHETER AND METHOD FOR MANUFACTURING SAME 有权
标题翻译：气泡导管及其制造方法
公开(公告)号：US20100030144A1
公开(公告)日：2010-02-04
申请号：US12533528
申请日：2009-07-31
申请人： Arthur Brunner , Adrian Blaser , Matthias Wesselmann , Patrice Bachmann
发明人： Arthur Brunner , Adrian Blaser , Matthias Wesselmann , Patrice Bachmann
IPC分类号： A61M25/10 , B29C65/02
CPC分类号： A61M25/1006 , A61M25/1029 , A61M25/1034 , A61M25/1038 , A61M2025/1004
摘要： A balloon catheter comprises an outer shaft having a distal end, an inner shaft situated therein to form an annular fluid line and projecting beyond the distal end of the outer shaft, and a balloon which is dilatable under the influence of a fluid introduced through the fluid line under pressure. At its proximal end the balloon is attached in a fluid-tight manner to the distal end region of the outer shaft at a first attachment zone, and at its distal end is attached in a fluid-tight manner to the distal end region of the inner shaft at a second attachment zone. Between the attachment zones, in the undilated state the balloon is placed in longitudinal folds along its length. The balloon, at least at its distal end, has an untapered design with a thin wall thickness (d) which is essentially unchanged over the length of the balloon, and the longitudinal folds extend into the attachment zone at that location.
摘要翻译：气囊导管包括具有远端的外轴，位于其中的内轴以形成环形流体管线并突出超过外轴的远端，以及气球，其在通过流体引入的流体的影响下可膨胀在压力下。在其近端处，气囊在第一附接区域以不透水的方式附接到外轴的远端区域，并且其远端以流体密封的方式附接到内部的远端区域轴在第二附接区域。在连接区域之间，在未膨胀状态下，气囊沿其长度被放置成纵向折叠。至少在其远端处，球囊具有无壁纸设计，其壁厚（d）在气囊的长度上基本不变，并且纵向折叠延伸到该位置处的附接区域。

3. 发明授权

US08430844B2 Balloon catheter 有权
标题翻译：气球导管
公开(公告)号：US08430844B2
公开(公告)日：2013-04-30
申请号：US13023921
申请日：2011-02-09
申请人： Matthias Wesselmann , Hans Lang , Susanne Pfenninger-Ganz , Adrian Blaser , Christoph Hannes Hoser , Horst Josef Fischer , Bodo Quint
发明人： Matthias Wesselmann , Hans Lang , Susanne Pfenninger-Ganz , Adrian Blaser , Christoph Hannes Hoser , Horst Josef Fischer , Bodo Quint
IPC分类号： A61M29/00
CPC分类号： A61M25/1011 , A61M25/1034 , A61M25/104 , A61M2025/1013 , A61M2025/1084
摘要： A balloon catheter, including an outer shaft with a distal end and a fluid line, an inner part located distal anterior to its distal end, as well as a balloon that can be inflated under the influence of a fluid that has been pressurized by the fluid line, that is fastened fluid-tight onto the distal end section of the outer shaft with a first fastening zone at its proximal end, and fluid-tight onto inner part with a second fastening zone at its distal end, whereby the balloon, on at least one of its two ends is designed without cone and with essentially unvarying thin wall thickness, the balloon is provided on at least one of its two ends with respectively one twist anterior to its fastening zone, and a second balloon is placed above the first balloon and is also provided with a twist on at least one of its two ends anterior to the fastening zone, that is directed in the opposite direction of the twist of the first balloon end that is positioned underneath.
摘要翻译：包括具有远端和流体管线的外轴的气囊导管，位于其远端前方远端的内部部分，以及可在被流体加压的流体的影响下膨胀的气囊线，其被紧密地紧固到外轴的远端部分上，在其近端具有第一紧固区域，并且在其远端处具有第二紧固区域的流体密封到内部部分，由此气囊其两端中的至少一端被设计成没有锥体并且具有基本上不变的薄壁厚度，所述气囊在其两端中的至少一个上设置有分别在其紧固区之前的一个扭曲，并且第二气球被放置在第一气球的上方并且还在其紧固区域之前的两个端部中的至少一个上具有扭转，该扭转部分沿着位于下方的第一气囊端部的扭转的相反方向。

4. 发明申请

US20110202001A1 BALLOON CATHETER 有权
标题翻译：气球导管
公开(公告)号：US20110202001A1
公开(公告)日：2011-08-18
申请号：US13023921
申请日：2011-02-09
申请人： Matthias Wesselmann , Hans Lang , Susanne Pfenninger-Ganz , Adrian Blaser , Christoph Hannes Hoser , Horst Josef Fischer , Bodo Quint
发明人： Matthias Wesselmann , Hans Lang , Susanne Pfenninger-Ganz , Adrian Blaser , Christoph Hannes Hoser , Horst Josef Fischer , Bodo Quint
IPC分类号： A61M25/10
CPC分类号： A61M25/1011 , A61M25/1034 , A61M25/104 , A61M2025/1013 , A61M2025/1084
摘要： A balloon catheter, including an outer shaft with a distal end and a fluid line, an inner part located distal anterior to its distal end, as well as a balloon that can be inflated under the influence of a fluid that has been pressurized by the fluid line, that is fastened fluid-tight onto the distal end section of the outer shaft with a first fastening zone at its proximal end, and fluid-tight onto inner part with a second fastening zone at its distal end, whereby the balloon, on at least one of its two ends is designed without cone and with essentially unvarying thin wall thickness, the balloon is provided on at least one of its two ends with respectively one twist anterior to its fastening zone, and a second balloon is placed above the first balloon and is also provided with a twist on at least one of its two ends anterior to the fastening zone, that is directed in the opposite direction of the twist of the first balloon end that is positioned underneath.
摘要翻译：包括具有远端和流体管线的外轴的气囊导管，位于其远端前方远端的内部部分，以及可在被流体加压的流体的影响下膨胀的气囊线，其被紧密地紧固到外轴的远端部分上，在其近端具有第一紧固区域，并且在其远端处具有第二紧固区域的流体密封到内部部分，由此气囊其两端中的至少一端被设计成没有锥体并且具有基本上不变的薄壁厚度，所述气囊在其两端中的至少一个上设置有分别在其紧固区之前的一个扭曲，并且第二气球被放置在第一气球的上方并且还在其紧固区域之前的两个端部中的至少一个上具有扭转，该扭转部分沿着位于下方的第一气囊端部的扭转的相反方向。

5. 发明授权

US09198913B2 Nitroimidazooxazines and their uses in anti-tubercular therapy 有权
标题翻译：硝基咪唑并恶嗪及其在抗结核治疗中的应用
公开(公告)号：US09198913B2
公开(公告)日：2015-12-01
申请号：US12847452
申请日：2010-07-30
申请人： William Alexander Denny , Andrew Mark Thompson , Adrian Blaser , Zhenkun Ma , Brian Desmond Palmer , Hamish Scott Sutherland , Iveta Kmentova
发明人： William Alexander Denny , Andrew Mark Thompson , Adrian Blaser , Zhenkun Ma , Brian Desmond Palmer , Hamish Scott Sutherland , Iveta Kmentova
IPC分类号： A61K31/5365 , C07D498/04
CPC分类号： A61K31/5365 , C07D498/04
摘要： The present invention relates to novel nitroimidazooxazines, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.
摘要翻译：本发明涉及新型的硝基咪唑并恶嗪，其制备方法及其用作治疗结核分枝杆菌和其他微生物感染的药物，单独或与其它抗感染治疗组合。

6. 发明申请

US20110028466A1 NITROIMIDAZOOXAZINE AND NITROIMIDAZOOXAZOLE ANALOGUES AND THEIR USES 有权
标题翻译： NITROIMIDAZOOXAZINE和NITROIMIDAZOOXAZOLE ANALOGUES及其用途
公开(公告)号：US20110028466A1
公开(公告)日：2011-02-03
申请号：US12847459
申请日：2010-07-30
申请人： Andrew Mark Thompson , William Alexander Denny , Adrian Blaser , Zhenkun Ma
发明人： Andrew Mark Thompson , William Alexander Denny , Adrian Blaser , Zhenkun Ma
IPC分类号： A61K31/5365 , A61K31/4965 , A61K31/506 , A61K31/4439 , A61K31/424 , C07D498/04 , A61P31/04
CPC分类号： C07D498/04
摘要： The current invention pertains to nitroimidazooxazine and nitroimidazooxazole analogues, their methods of preparation, and uses of the compounds as treatment for Mycobacterium tuberculosis, for use as anti-tubercular drugs, for use as anti-protozoal agents with unexpectedly high potency against Trypanosoma cruzi or Leishmania donovani, and for the treatment of other microbial infections.
摘要翻译：本发明涉及硝基咪唑并恶嗪和硝基咪唑并恶唑类似物，其制备方法，以及该化合物作为结核分枝杆菌治疗的用途，用作抗结核药物，用作对克氏锥虫或利什曼原虫具有意想不到的高效力的抗原生动物 donovani和治疗其他微生物感染。

7. 发明申请

US20090281088A1 BICYCLIC NITROIMIDAZOLE-SUBSTITUTED PHENYL OXAZOLIDINONES 有权
标题翻译：双环硝基咪唑取代苯基氧杂环己烷
公开(公告)号：US20090281088A1
公开(公告)日：2009-11-12
申请号：US12411220
申请日：2009-03-25
申请人： Charles Z. Ding , Genliang Lu , Keith Combrink , Dianjun D. Chen , Minsoo Song , Jiancheng Wang , Zhenkun Ma , Brian Desmond Palmer , Adrian Blaser , Andrew M. Thompson , Iveta Kmentova , Hamish Scott Sutherland , William Alexander Denny
发明人： Charles Z. Ding , Genliang Lu , Keith Combrink , Dianjun D. Chen , Minsoo Song , Jiancheng Wang , Zhenkun Ma , Brian Desmond Palmer , Adrian Blaser , Andrew M. Thompson , Iveta Kmentova , Hamish Scott Sutherland , William Alexander Denny
IPC分类号： A61K31/5365 , C07D498/04 , A61K31/551 , A61K31/496 , A61K31/4439 , A61K31/506 , A61P31/04
CPC分类号： C07D498/04
摘要： The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.
摘要翻译：本发明提供了一系列双环硝基咪唑取代的苯基恶唑烷酮，其中双环硝基咪唑药效团与苯基恶唑烷酮共价键合，其药物组合物，以及组合物用于预防和治疗细菌感染的方法。双环硝基咪唑取代的苯基恶唑烷酮对于野生型和抗性病原体菌株具有惊人的抗菌活性，因此可用于预防，控制和治疗由这些病原体引起的许多人和兽医细菌感染如结核分枝杆菌。

8. 发明申请

US20090186886A1 Tricyclic 1,2,4-Triazine Oxides and Compositions for Therapeutic Use in Cancer Treatments 有权
标题翻译：用于治疗癌症治疗的三环1,2,4-三嗪氧化物和组合物
公开(公告)号：US20090186886A1
公开(公告)日：2009-07-23
申请号：US11887368
申请日：2006-03-31
申请人： Michael Patrick Hay , Adrian Blaser , William Alexander Denny , Kevin Owen Hicks , Ho Huat Lee , Karin Pchalek , Frederik Bastiaan Pruijn , Bronwyn Gae Siim , William Robert Wilson , Shangjin Yang
发明人： Michael Patrick Hay , Adrian Blaser , William Alexander Denny , Kevin Owen Hicks , Ho Huat Lee , Karin Pchalek , Frederik Bastiaan Pruijn , Bronwyn Gae Siim , William Robert Wilson , Shangjin Yang
IPC分类号： A61K31/5377 , C07D253/10 , A61K31/53 , C07D413/06 , C07D491/048 , A61P35/00
CPC分类号： C07D253/10 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D491/056
摘要： The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula I and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.
摘要翻译：本发明涉及式I的新型三环1,2,4-三嗪-1-氧化物和新型三环1,2,4-三嗪-1,4-二氧化物及其相关类似物及其制备方法及其用途低氧选择性药物和用于癌症治疗的放射增敏剂，单独或与辐射和/或其它抗癌药物组合。

9. 发明授权

US08293734B2 Nitroimidazooxazine and nitroimidazooxazole analogues and their uses 有权
标题翻译：硝基咪唑并恶嗪类及其用途
公开(公告)号：US08293734B2
公开(公告)日：2012-10-23
申请号：US12847459
申请日：2010-07-30
申请人： Andrew Mark Thompson , William Alexander Denny , Adrian Blaser , Zhenkun Ma
发明人： Andrew Mark Thompson , William Alexander Denny , Adrian Blaser , Zhenkun Ma
IPC分类号： C07D498/04 , A61K31/5365
CPC分类号： C07D498/04
摘要： The current invention pertains to nitroimidazooxazine and nitroimidazooxazole analogues, their methods of preparation, and uses of the compounds as treatment for Mycobacterium tuberculosis, for use as anti-tubercular drugs, for use as anti-protozoal agents with unexpectedly high potency against Trypanosoma cruzi or Leishmania donovani, and for the treatment of other microbial infections.
摘要翻译：本发明涉及硝基咪唑并恶嗪和硝基咪唑并恶唑类似物，其制备方法，以及该化合物作为结核分枝杆菌治疗的用途，用作抗结核药物，用作对克氏锥虫或利什曼原虫具有意想不到的高效力的抗原生动物 donovani和治疗其他微生物感染。

10. 发明申请

US20120028973A1 NITROIMIDAZOOXAZINES AND THEIR USES IN ANTI-TUBERCULAR THERAPY 有权
标题翻译：硝基咪唑及其在抗血小板治疗中的应用
公开(公告)号：US20120028973A1
公开(公告)日：2012-02-02
申请号：US12847452
申请日：2010-07-30
申请人： William Alexander Denny , Andrew Mark Thompson , Adrian Blaser , Brian Desmond Palmer , Zhenkun Ma , Hamish Scott Sutherland , Iveta Kmentova
发明人： William Alexander Denny , Andrew Mark Thompson , Adrian Blaser , Brian Desmond Palmer , Zhenkun Ma , Hamish Scott Sutherland , Iveta Kmentova
IPC分类号： A61K31/5365 , A61P31/06 , C07D498/04
CPC分类号： A61K31/5365 , C07D498/04
摘要： The present invention relates to novel nitroimidazooxazines, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.
摘要翻译：本发明涉及新型的硝基咪唑并恶嗪，其制备方法及其用作治疗结核分枝杆菌和其他微生物感染的药物，单独或与其它抗感染治疗组合。

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