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1. 发明申请

US20120218509A1 Silicone Hydrogel Contact Lenses 有权
标题翻译：硅胶水凝胶隐形眼镜
公开(公告)号：US20120218509A1
公开(公告)日：2012-08-30
申请号：US13404033
申请日：2012-02-24
申请人： Arthur Back , David Robert Morsley , Richard Rogers , Sarah Almond , Charlie Chen , Yuwen Liu , Charles A. Francis , Ye Hong
发明人： Arthur Back , David Robert Morsley , Richard Rogers , Sarah Almond , Charlie Chen , Yuwen Liu , Charles A. Francis , Ye Hong
IPC分类号： G02C7/04 , B65B63/00
CPC分类号： C08L83/04 , C08G77/20 , C08G77/46 , G02B1/043 , C08L101/14 , C08L83/12
摘要： Silicone hydrogel contact lenses are produced without using volatile organic solvents to extract materials from the polymerized contact lens bodies, and instead are washed with aqueous liquids. The silicone hydrogel contact lenses so produced have ophthalmically wettable lens surfaces such that less than five percent of a batch of twenty or more such silicone hydrogel contact lenses have visually identifiable non-wetting spots when the contact lenses are located on eyes of subjects.
摘要翻译：制造硅氧烷水凝胶隐形眼镜，而不使用挥发性有机溶剂从聚合的隐形眼镜体提取物质，而是用含水液体洗涤。如此制造的硅酮水凝胶隐形眼镜具有眼睛可润湿的透镜表面，使得当隐形眼镜位于受试者的眼睛上时，少于一批二十或更多个这种硅氧水凝胶隐形眼镜的百分之五具有视觉上可识别的非润湿斑点。

2. 发明授权

US08820928B2 Silicone hydrogel contact lenses 有权
标题翻译：硅胶水凝胶隐形眼镜
公开(公告)号：US08820928B2
公开(公告)日：2014-09-02
申请号：US13404033
申请日：2012-02-24
申请人： Arthur Back , David Robert Morsley , Richard Rogers , Sarah Almond , Charlie Chen , Yuwen Liu , Charles A. Francis , Ye Hong
发明人： Arthur Back , David Robert Morsley , Richard Rogers , Sarah Almond , Charlie Chen , Yuwen Liu , Charles A. Francis , Ye Hong
IPC分类号： G02C7/04 , C08L83/04 , G02B1/04 , C08G77/46 , C08G77/20
CPC分类号： C08L83/04 , C08G77/20 , C08G77/46 , G02B1/043 , C08L101/14 , C08L83/12
摘要： Silicone hydrogel contact lenses are produced without using volatile organic solvents to extract materials from the polymerized contact lens bodies, and instead are washed with aqueous liquids. The silicone hydrogel contact lenses so produced have ophthalmically wettable lens surfaces such that less than five percent of a batch of twenty or more such silicone hydrogel contact lenses have visually identifiable non-wetting spots when the contact lenses are located on eyes of subjects.
摘要翻译：制造硅氧烷水凝胶隐形眼镜，而不使用挥发性有机溶剂从聚合的隐形眼镜体提取物质，而是用含水液体洗涤。如此制造的硅酮水凝胶隐形眼镜具有眼睛可润湿的透镜表面，使得当隐形眼镜位于受试者的眼睛上时，少于一批二十或更多个这种硅氧水凝胶隐形眼镜的百分之五具有视觉上可识别的非润湿斑点。

3. 发明授权

US08513325B2 Silicone hydrogel contact lenses and related compositions and methods 有权
标题翻译：硅酮水凝胶隐形眼镜及相关组合物和方法
公开(公告)号：US08513325B2
公开(公告)日：2013-08-20
申请号：US13404027
申请日：2012-02-24
申请人： Yuwen Liu , Charlie Chen , Ye Hong , Charles A. Francis , Li Yao , Arthur Back
发明人： Yuwen Liu , Charlie Chen , Ye Hong , Charles A. Francis , Li Yao , Arthur Back
IPC分类号： G02B1/04 , C08F290/06 , C08F230/08 , C08F283/12 , G02C7/04
CPC分类号： G02B1/043 , B65B55/02 , C08L101/14 , C08L83/04 , C08L51/085
摘要： Silicone hydrogel contact lenses are produced without using volatile organic solvents to extract materials from the polymerized contact lens bodies, and instead are washed with aqueous liquids. The silicone hydrogel contact lenses so produced have ophthalmically wettable lens surfaces. The hydrated silicone hydrogel contact lenses have diameters that are at least 24% larger than the diameters of the silicone hydrogel contact lenses prior to hydration or washing.
摘要翻译：制造硅氧烷水凝胶隐形眼镜，而不使用挥发性有机溶剂从聚合的隐形眼镜体提取物质，而是用含水液体洗涤。如此生产的硅酮水凝胶隐形眼镜具有眼睛可润湿的透镜表面。水合硅酮水凝胶隐形眼镜的直径比水合或洗涤前的硅酮水凝胶隐形眼镜的直径大至少24％。

4. 发明授权

US08481662B2 Silicone hydrogel contact lenses having acceptable levels of energy loss 有权
标题翻译：硅酮水凝胶隐形眼镜具有可接受的能量损失水平
公开(公告)号：US08481662B2
公开(公告)日：2013-07-09
申请号：US13404040
申请日：2012-02-24
申请人： Ronghua Liu , Xinfeng Shi , Yuwen Liu , Charlie Chen , Ye Hong , Charles A. Francis , Li Yao , Arthur Back , Ying Zheng
发明人： Ronghua Liu , Xinfeng Shi , Yuwen Liu , Charlie Chen , Ye Hong , Charles A. Francis , Li Yao , Arthur Back , Ying Zheng
IPC分类号： C08F230/08 , C08F290/06 , G02B1/04
CPC分类号： G02C7/04 , G02B1/043 , C08L83/04 , C08L101/14
摘要： Silicone hydrogel contact lenses having ophthalmically acceptable levels of energy loss are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer which is a dual-end methacrylate end-capped polydimethylsiloxane having a number average molecular weight of at least 7,000 daltons. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.
摘要翻译：描述了具有眼睛上可接受的能量损失水平的硅酮水凝胶隐形眼镜。透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是碳原子数为1〜4的烷基，式（1）的各R 2独立地为氢原子或甲基。透镜还包括衍生自第二硅氧烷单体的单元，其是数均分子量至少为7,000道尔顿的双末端甲基丙烯酸酯封端的聚二甲基硅氧烷。还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

5. 发明申请

US20120220689A1 Silicone Hydrogel Contact Lenses 有权
标题翻译：硅胶水凝胶隐形眼镜
公开(公告)号：US20120220689A1
公开(公告)日：2012-08-30
申请号：US13404035
申请日：2012-02-24
申请人： Li Yao , Ye Hong , Yuwen Liu , Charlie Chen , Charles A. Francis , Arthur Back
发明人： Li Yao , Ye Hong , Yuwen Liu , Charlie Chen , Charles A. Francis , Arthur Back
IPC分类号： C08L43/04 , B65B55/02
CPC分类号： G02B1/043 , C08L83/12 , C08L101/14 , C08L33/10 , C08L33/08
摘要： Silicone hydrogel contact lenses that have good dimensional stability, are ophthalmically-acceptable, and can be manufactured without the use of alcohol solvents are formed from the reaction product of a polymerizable composition comprising at least one mono-functional acrylate-containing siloxane monomer having a molecular weight of less than 2,000; at least one bi-functional acrylate-containing siloxane monomer having a molecular weight of at least 3,000; and at least one hydrophilic vinyl-containing monomer, wherein the polymerizable composition has a molar ratio of total amount of mono-functional acrylate-containing siloxane monomer to total amount of bi-functional acrylate-containing siloxane monomer of at least 30:1, respectively.
摘要翻译：由可聚合组合物的反应产物形成具有良好的尺寸稳定性的眼科学可接受的硅酮水凝胶隐形眼镜，并且可以制造不含醇溶剂的可聚合组合物，该可聚合组合物包含至少一种含单分子丙烯酸酯的含有单官能丙烯酸酯的硅氧烷单体重量小于2000; 至少一种分子量至少为3,000的含二官能丙烯酸酯的硅氧烷单体; 和至少一种亲水性含乙烯基单体，其中所述可聚合组合物的含单体官能丙烯酸酯的硅氧烷单体的总量与含二官能丙烯酸酯的硅氧烷单体的总量的摩尔比分别为至少30:1 。

6. 发明申请

US20120216488A1 Silicone Hydrogel Contact Lenses And Related Compositions And Methods 有权
标题翻译：硅胶水凝胶隐形眼镜及相关成分及方法
公开(公告)号：US20120216488A1
公开(公告)日：2012-08-30
申请号：US13404027
申请日：2012-02-24
申请人： Yuwen Liu , Charlie Chen , Ye Hong , Charles A. Francis , Li Yao , Arthur Back
发明人： Yuwen Liu , Charlie Chen , Ye Hong , Charles A. Francis , Li Yao , Arthur Back
IPC分类号： B65B55/02 , G02C7/04
CPC分类号： G02B1/043 , B65B55/02 , C08L101/14 , C08L83/04 , C08L51/085
摘要： Silicone hydrogel contact lenses are produced without using volatile organic solvents to extract materials from the polymerized contact lens bodies, and instead are washed with aqueous liquids. The silicone hydrogel contact lenses so produced have ophthalmically wettable lens surfaces. The hydrated silicone hydrogel contact lenses have diameters that are at least 24% larger than the diameters of the silicone hydrogel contact lenses prior to hydration or washing.
摘要翻译：制造硅氧烷水凝胶隐形眼镜，而不使用挥发性有机溶剂从聚合的隐形眼镜体提取物质，而是用含水液体洗涤。如此生产的硅酮水凝胶隐形眼镜具有眼睛可润湿的透镜表面。水合硅酮水凝胶隐形眼镜的直径比水合或洗涤前的硅酮水凝胶隐形眼镜的直径大至少24％。

7. 发明授权

US08865789B2 Silicone hydrogel contact lenses 有权
标题翻译：硅胶水凝胶隐形眼镜
公开(公告)号：US08865789B2
公开(公告)日：2014-10-21
申请号：US13404035
申请日：2012-02-24
申请人： Li Yao , Ye Hong , Yuwen Liu , Charlie Chen , Charles A. Francis , Arthur Back
发明人： Li Yao , Ye Hong , Yuwen Liu , Charlie Chen , Charles A. Francis , Arthur Back
IPC分类号： C08L101/14 , B65B55/02 , G02C7/04 , C08G77/04 , G02B1/04
CPC分类号： G02B1/043 , C08L83/12 , C08L101/14 , C08L33/10 , C08L33/08
摘要： Silicone hydrogel contact lenses that have good dimensional stability, are ophthalmically-acceptable, and can be manufactured without the use of alcohol solvents are formed from the reaction product of a polymerizable composition comprising at least one mono-functional acrylate-containing siloxane monomer having a molecular weight of less than 2,000; at least one bi-functional acrylate-containing siloxane monomer having a molecular weight of at least 3,000; and at least one hydrophilic vinyl-containing monomer, wherein the polymerizable composition has a molar ratio of total amount of mono-functional acrylate-containing siloxane monomer to total amount of bi-functional acrylate-containing siloxane monomer of at least 30:1, respectively.
摘要翻译：由可聚合组合物的反应产物形成具有良好的尺寸稳定性的眼科学可接受的硅酮水凝胶隐形眼镜，并且可以制造不含醇溶剂的可聚合组合物，该可聚合组合物包含至少一种含单分子丙烯酸酯的含有单官能丙烯酸酯的硅氧烷单体重量小于2000; 至少一种分子量至少为3,000的含二官能丙烯酸酯的硅氧烷单体; 和至少一种亲水性含乙烯基单体，其中所述可聚合组合物的含单体官能丙烯酸酯的硅氧烷单体的总量与含二官能丙烯酸酯的硅氧烷单体的总量的摩尔比分别为至少30:1 。

8. 发明申请

US20140018465A1 High Water Content Silicone Hydrogel Contact Lenses 有权
标题翻译：高含水硅胶水凝胶隐形眼镜
公开(公告)号：US20140018465A1
公开(公告)日：2014-01-16
申请号：US13985109
申请日：2012-02-23
申请人： Yuwen Liu , Charlie Chen , Ye Hong , Charles A. Francis , Li Yao , Arthur Back
发明人： Yuwen Liu , Charlie Chen , Ye Hong , Charles A. Francis , Li Yao , Arthur Back
IPC分类号： G02B1/04
CPC分类号： G02B1/043 , C08F283/065 , C08L51/085 , C08L101/14
摘要： Silicone hydrogel contact lenses having a high water content are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer having a number average molecular weight of at least 7,000 daltons, and at least one vinyl-containing cross-linking agent. The lenses have average equilibrium water contents from about 30% wt/wt to about 70% wt/wt when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.
摘要翻译：描述了具有高水含量的硅氧烷水凝胶隐形眼镜。透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是碳原子数为1〜4的烷基，式（1）的各R 2独立地为氢原子或甲基。透镜还包括衍生自数均分子量为至少7,000道尔顿的第二硅氧烷单体的单元和至少一种含乙烯基交联剂。当完全水合时，透镜具有约30重量％至约70重量％的平均水含量。还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

9. 发明申请

US20120216489A1 Silicone Hydrogel Contact Lenses With High Freezable Water Content 审中-公开
标题翻译：硅胶水凝胶隐形眼镜具有高可冷冻含水量
公开(公告)号：US20120216489A1
公开(公告)日：2012-08-30
申请号：US13404041
申请日：2012-02-24
申请人： Paul Hungchaung Lee , Ronghua Liu , Xinfeng Shi , Yuwen Liu , Ye Hong , Charlie Chen , Li Yao , Arthur Back , Charles A. Francis
发明人： Paul Hungchaung Lee , Ronghua Liu , Xinfeng Shi , Yuwen Liu , Ye Hong , Charlie Chen , Li Yao , Arthur Back , Charles A. Francis
IPC分类号： B65B63/00 , C08L43/04
CPC分类号： B29D11/00038 , G02B1/043 , C08L101/14 , C08L83/04 , C08L33/10
摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including at least one siloxane monomer and at least one hydrophilic monomer are described. These silicone hydrogel contact lenses have, when fully hydrated, has an equilibrium freezable water content of at least 25% wt/wt as determined by differential scanning calorimetry (DSC). Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.
摘要翻译：描述了衍生自包含至少一种硅氧烷单体和至少一种亲水单体的可聚合组合物的硅氧烷水凝胶隐形眼镜。当通过差示扫描量热法（DSC）测定时，这些硅氧水凝胶隐形眼镜在完全水合时具有至少25％wt / wt的平衡可冷冻水含量。还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

10. 发明授权

US09360594B2 High water content silicone hydrogel contact lenses 有权
标题翻译：高含水硅胶水凝胶隐形眼镜
公开(公告)号：US09360594B2
公开(公告)日：2016-06-07
申请号：US13985109
申请日：2012-02-23
申请人： Yuwen Liu , Charlie Chen , Ye Hong , Charles A. Francis , Li Yao , Arthur Back
发明人： Yuwen Liu , Charlie Chen , Ye Hong , Charles A. Francis , Li Yao , Arthur Back
IPC分类号： C08L101/14 , G02B1/04 , G02C7/04 , C08G77/04 , C08L51/08 , C08F283/06
CPC分类号： G02B1/043 , C08F283/065 , C08L51/085 , C08L101/14
摘要： Silicone hydrogel contact lenses having a high water content are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer having a number average molecular weight of at least 7,000 daltons, and at least one vinyl-containing cross-linking agent. The lenses have average equilibrium water contents from about 30% wt/wt to about 70% wt/wt when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.
摘要翻译：描述了具有高水含量的硅氧烷水凝胶隐形眼镜。透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是碳原子数为1〜4的烷基，式（1）的各R 2独立地为氢原子或甲基。透镜还包括衍生自数均分子量为至少7,000道尔顿的第二硅氧烷单体的单元和至少一种含乙烯基交联剂。当完全水合时，透镜具有约30重量％至约70重量％的平均水含量。还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

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