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    • 6. 发明申请
    • ANTIMICROBIAL MICROEMULSION MOUTHWASH COMPOSITION
    • 抗微生物微乳液组合物
    • US20130280180A1
    • 2013-10-24
    • US13990475
    • 2011-11-15
    • Deeleep Kumar RoutMaya Treesa SajiRitesh Kumar Sinha
    • Deeleep Kumar RoutMaya Treesa SajiRitesh Kumar Sinha
    • A61K8/04A61Q11/00
    • A61K8/04A61K8/068A61K8/19A61K8/27A61K8/34A61K8/347A61K8/463A61K8/466A61K2800/412A61Q11/00A61Q17/005
    • The invention relates to a transparent/translucent liquid antimicrobial mouthwash composition that is substantially free of low molecular weight alcohol. It is a problem to include antimicrobial actives of natural origin (essential oils) which are generally substantially water insoluble materials in an aqueous composition that is transparent or translucent. One way of including such oils in water while ensuring transparency is to formulate them in a microemulsion composition. However microemulsion compositions generally require high amounts of surfactants and solvents especially low molecular weight alcohol. It is thus a challenge to formulate a mouthwash composition that is on the one hand effective in killing microbes while on the other hand has a transparent/translucent appearance while being substantially free of low molecular weight alcohol. The present inventors have solved this problem and have come up with a microemulsion mouthwash composition which meets all of the above objectives while being especially effective in killing S. mutans, a bacteria responsible for diseases in oral cavity.
    • 本发明涉及一种基本上不含低分子量醇的透明/半透明液体抗微生物漱口剂组合物。 包括天然来源的抗微生物活性物质(精油)是一个问题,其通常在透明或半透明的水性组合物中基本上是水不溶性材料。 将这种油包含在水中同时确保透明度的一种方法是将它们制成微乳液组合物。 然而,微乳液组合物通常需要大量的表面活性剂和溶剂,特别是低分子量醇。 因此,配制漱口水组合物是一个挑战,一方面杀死微生物是有效的,另一方面具有透明/半透明的外观,同时基本上不含低分子量醇。 本发明人已经解决了这个问题,并提出了一种满足上述目的的微乳液漱口剂组合物,同时特别有效地杀死了造成口腔疾病的变形链球菌。