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1. 发明申请

US20130297224A1 Method for evaluating a set of measurement data from an oral glucose tolerance test 审中-公开
标题翻译：用于评估来自口服葡萄糖耐量试验的一组测量数据的方法
公开(公告)号：US20130297224A1
公开(公告)日：2013-11-07
申请号：US13935151
申请日：2013-07-03
申请人： Arnulf Staib , Ortrud Quarder , Gerhard Werner
发明人： Arnulf Staib , Ortrud Quarder , Gerhard Werner
IPC分类号： G06F19/00
CPC分类号： G16C99/00 , G01N2800/00 , G09B23/28
摘要： A method is provided for evaluating a set of measurement data from an oral glucose tolerance test. The method may include calculating a similarity measure that quantifies the similarity between a time profile of the series of measured data of the glucose concentration and a corresponding glucose reference profile. The method may include calculating a further similarity measure that quantifies the similarity between the profile of the series of measured values of the further analyte concentration and the corresponding analyte sample profile, wherein the data set is represented by a point in a vector space that comprises coordinate axes that are formed by the similarity measures, whereby the coordinates of said point contain the calculated values of the similarity measures. The method also may include evaluating the position of the point with respect to reference points, which each represent a defined state of health, in order to calculate a parameter that specifies the state of the glucose metabolism of the patient.
摘要翻译：提供了一种用于从口服葡萄糖耐量试验中评估一组测量数据的方法。该方法可以包括计算相似性度量，其量化葡萄糖浓度的一系列测量数据的时间分布与相应的葡萄糖参考分布之间的相似性。该方法可以包括计算另外的相似性度量，其量化所述另外的分析物浓度的一系列测量值的轮廓与相应的分析物样品分布之间的相似性，其中所述数据集由向量空间中包含坐标通过相似性测量形成的轴，由此所述点的坐标包含相似性度量的计算值。该方法还可以包括评估点相对于参考点的位置，每个参考点表示一个确定的健康状态，以便计算指定患者的葡萄糖代谢状态的参数。

2. 发明申请

US20110196216A1 ELECTRODE SYSTEM FOR MEASURING AN ANALYTE CONCENTRATION UNDER IN-VIVO CONDITIONS 有权
标题翻译：用于测量体内条件下分析物浓度的电极系统
公开(公告)号：US20110196216A1
公开(公告)日：2011-08-11
申请号：US13042773
申请日：2011-03-08
申请人： Ortrud Quarder , Arnulf Staib , Reinhold Mischler , Ewald Rieger , Ralph Gillen , Ulrike Kamecke
发明人： Ortrud Quarder , Arnulf Staib , Reinhold Mischler , Ewald Rieger , Ralph Gillen , Ulrike Kamecke
IPC分类号： A61B5/1473 , G01N27/30 , G01N33/50
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/7207 , C12Q1/001 , C12Q1/006
摘要： An electrode system for measuring the concentration of an analyte under in-vivo conditions comprises a counter-electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.
摘要翻译：用于在体内条件下测量分析物浓度的电极系统包括具有电导体的对电极，具有电导体的工作电极，在该电导体上布置有用于催化转化分析物的固定化酶分子的酶层，以及扩散屏障，其将分析物从电极系统周围的体液扩散到酶分子。酶层是多个场的形式，其布置在工作电极的导体上彼此间隔一定距离。

3. 发明授权

US09394563B2 Electrode system for measuring an analyte concentration under in-vivo conditions 有权
标题翻译：用于在体内条件下测量分析物浓度的电极系统
公开(公告)号：US09394563B2
公开(公告)日：2016-07-19
申请号：US13042773
申请日：2011-03-08
申请人： Ortrud Quarder , Arnulf Staib , Reinhold Mischler , Ewald Rieger , Ralph Gillen , Ulrike Kamecke
发明人： Ortrud Quarder , Arnulf Staib , Reinhold Mischler , Ewald Rieger , Ralph Gillen , Ulrike Kamecke
IPC分类号： A61B5/05 , A61B5/04 , C12Q1/00 , A61B5/145 , A61B5/1486 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/7207 , C12Q1/001 , C12Q1/006
摘要： An electrode system for measuring the concentration of an analyte under in-vivo conditions comprises a counter-electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.
摘要翻译：用于在体内条件下测量分析物浓度的电极系统包括具有电导体的对电极，具有电导体的工作电极，在该电导体上布置有用于催化转化分析物的固定化酶分子的酶层，以及扩散屏障，其将分析物从电极系统周围的体液扩散到酶分子。酶层是多个场的形式，其布置在工作电极的导体上彼此间隔一定距离。

4. 发明授权

US08942778B2 Analyte monitoring sensor system for monitoring a constituent in body tissue 有权
标题翻译：用于监测身体组织中成分的分析物监测传感器系统
公开(公告)号：US08942778B2
公开(公告)日：2015-01-27
申请号：US13110335
申请日：2011-05-18
申请人： Gregor Ocvirk , Helmut Rinne , Arnulf Staib
发明人： Gregor Ocvirk , Helmut Rinne , Arnulf Staib
IPC分类号： A61B5/05 , A61B5/1486 , A61B5/145
CPC分类号： A61B5/14865 , A61B5/14532
摘要： The invention generally relates to a sensor system. In particular to a sensor for glucose monitoring. The invention also also relates to an arrangement and a method for monitoring a constituent and in particular glucose in body tissue using a sensor system.
摘要翻译：本发明一般涉及传感器系统。具体涉及用于葡萄糖监测的传感器。本发明还涉及一种使用传感器系统监测身体组织中的成分，特别是葡萄糖的装置和方法。

5. 发明授权

US08131474B2 Method and system for investigating glucose metabolism 有权
标题翻译：调查葡萄糖代谢的方法和系统
公开(公告)号：US08131474B2
公开(公告)日：2012-03-06
申请号：US11276816
申请日：2006-03-15
申请人： Arnulf Staib , Johannes Pill , Reinhard Kotulla , Reiner Hegger
发明人： Arnulf Staib , Johannes Pill , Reinhard Kotulla , Reiner Hegger
IPC分类号： G01N33/48
CPC分类号： G01N33/66 , A61B5/14532 , G06F19/00 , Y10T436/104998 , Y10T436/144444
摘要： The invention relates to a method for investigating the glucose metabolism of a human being for disease-relevant and/or disease-related particularities. The glucose concentration g(t1) to g(tn) of a body fluid is measured at time points t1 to tn that are distributed over a period of at least six hours. The data points are then determined in phase space coordinates from the glucose concentration measuring values g(t1) to g(tn). The data points are then processed to highlight disease-relevant and/or disease-related particularities of the glucose metabolism of the investigated human being. The processing of the data points can be implemented by plotting them in a phase space representation or by determining from the data points a disturbance parameter that is correlated to the severity of a disturbance of glucose metabolism.
摘要翻译：本发明涉及一种用于调查人的葡萄糖代谢的方法，用于疾病相关和/或疾病相关的特异性。在至少6小时内分配的时间点t1至tn测量体液的葡萄糖浓度g（t1）至g（tn）。然后从相对于葡萄糖浓度测量值g（t1）到g（tn）的相位空间坐标确定数据点。然后处理数据点以突出所研究的人的葡萄糖代谢的疾病相关和/或疾病相关的特征。可以通过将它们绘制在相位空间表示中或通过从数据点确定与葡萄糖代谢紊乱的严重性相关的干扰参数来实现数据点的处理。

6. 发明申请

US20060287591A1 SENSOR SYSTEM AS WELL AS AN ARRANGEMENT AND METHOD FOR MONITORING A CONSTITUENT AND IN PARTICULAR GLUCOSE IN BODY TISSUE 有权
标题翻译：传感器系统作为布置和方法，用于监测身体组织和特定葡萄糖在身体组织
公开(公告)号：US20060287591A1
公开(公告)日：2006-12-21
申请号：US11425020
申请日：2006-06-19
申请人： Gregor Ocvirk , Helmut Rinne , Arnulf Staib
发明人： Gregor Ocvirk , Helmut Rinne , Arnulf Staib
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532
摘要： The invention generally relates to a sensor system. In particular to a sensor for glucose monitoring The invention also also relates to an arrangement and a method for monitoring a constituents and in particular glucose in body tissue using a sensor system.
摘要翻译：本发明一般涉及传感器系统。具体涉及用于葡萄糖监测的传感器本发明还涉及一种使用传感器系统来监测组分，特别是体内组织中的葡萄糖的装置和方法。

7. 发明申请

US20080262333A1 Analytical Method and Investigation System 有权
标题翻译：分析方法和调查系统
公开(公告)号：US20080262333A1
公开(公告)日：2008-10-23
申请号：US12130091
申请日：2008-05-30
申请人： Arnulf Staib , Hans-Martin Kloetzer , Matthias Essenpreis
发明人： Arnulf Staib , Hans-Martin Kloetzer , Matthias Essenpreis
IPC分类号： A61B5/145
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/743 , A61B2560/0223 , G06F19/00 , G06F19/3456
摘要： Metabolism diseases are evaluated by using a sensor to measure concentration of a medically significant analyte in a human or animal body fluid. The measurement data are correlated with the concentration of a medically significant analyte in body fluid over a time period of at least eight hours. An analytical facility analyzes time intervals within the time period to determine a stability parameter that characterizes the analyte concentration dynamics of change. The analytical facility further analyzes the stability parameters to determine disease-related particularities of metabolism.
摘要翻译：通过使用传感器来测量人体或动物体液中医学上重要的分析物的浓度来评估代谢疾病。在至少8小时的时间内，测量数据与体液中医学上重要的分析物的浓度相关。分析设备分析时间段内的时间间隔，以确定表征变化的分析物浓度动力学的稳定性参数。分析设备进一步分析稳定性参数，以确定与疾病相关的新陈代谢特征。

8. 发明授权

US07389133B1 Method and device for continuous monitoring of the concentration of an analyte 有权
标题翻译：用于连续监测分析物浓度的方法和装置
公开(公告)号：US07389133B1
公开(公告)日：2008-06-17
申请号：US11870606
申请日：2007-10-11
申请人： Reinhard Kotulla , Arnulf Staib , Ralph Gillen
发明人： Reinhard Kotulla , Arnulf Staib , Ralph Gillen
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14503 , A61B5/14532 , A61B5/7207 , A61B5/7239 , A61B2560/0223
摘要： The disclosure generally relates to continuous monitoring of an analyte by determining its change over time in the living body of a human or animal. A measurement variable value correlating with the desired concentration of the analyte are measured as the measurement signal (zt) and the change over time of the concentration is determined from the measurement signal as the useful signal (yt) using a calibration. A filter algorithm is used to reduce errors of the useful signal, which result from noise contained in the measurement signal. The filter algorithm includes an operation in which the influence of an actual measurement value on the useful signal is weighted using a weighting factor (V).
摘要翻译：本公开通常涉及通过确定其在人或动物的生物体中随时间的变化来连续监测分析物。测量与分析物的期望浓度相关的测量变量值作为测量信号（z> t），并且从测量信号确定浓度随时间的变化作为有用信号（y < SUB> t ）。使用滤波器算法来减少由测量信号中包含的噪声导致的有用信号的误差。滤波器算法包括使用加权因子（V）对实际测量值对有用信号的影响进行加权的操作。

9. 发明申请

US20080139902A1 METHOD AND DEVICE FOR CONTINUOUS MONITORING OF THE CONCENTRATION OF AN ANALYTE 有权
标题翻译：用于连续监测分析仪浓度的方法和装置
公开(公告)号：US20080139902A1
公开(公告)日：2008-06-12
申请号：US11870606
申请日：2007-10-11
申请人： Reinhard Kotulla , Arnulf Staib , Ralph Gillen
发明人： Reinhard Kotulla , Arnulf Staib , Ralph Gillen
IPC分类号： A61B5/145
CPC分类号： A61B5/14503 , A61B5/14532 , A61B5/7207 , A61B5/7239 , A61B2560/0223
摘要： The disclosure generally relates to continuous monitoring of an analyte by determining its change over time in the living body of a human or animal. A measurement, variable value correlating with the desired concentration of the analyte are measured as the measurement signal (zt) and the change over time of the concentration is determined from the measurement signal as the useful signal (yt) using a calibration. A filter algorithm is used to reduce errors of thee useful signal, which result from noise contained in the measurement signal. The filter algorithm includes an operation in which the influence of an actual measurement value on the useful signal is weighted using a weighting factor (V).
摘要翻译：本公开通常涉及通过确定其在人或动物的生物体中随时间的变化来连续监测分析物。测量与分析物的期望浓度相关的可变值作为测量信号（z ），并且从测量信号确定浓度随时间的变化作为有用信号（y 使用校准。滤波器算法用于减少由测量信号中包含的噪声导致的有用信号的误差。滤波器算法包括使用加权因子（V）对实际测量值对有用信号的影响进行加权的操作。

10. 发明申请

US20060052679A1 Method and device for continuous monitoring of the concentration of an analyte 审中-公开
标题翻译：用于连续监测分析物浓度的方法和装置
公开(公告)号：US20060052679A1
公开(公告)日：2006-03-09
申请号：US11266637
申请日：2005-11-03
申请人： Reinhard Kotulla , Arnulf Staib , Ralph Gillen
发明人： Reinhard Kotulla , Arnulf Staib , Ralph Gillen
IPC分类号： A61B5/00
CPC分类号： A61B5/14503 , A61B5/14532 , A61B5/7207 , A61B5/7239 , A61B2560/0223
摘要： The present invention generally relates to a method for continuous monitoring of the concentration of an analyte by determining its change over time in the living body of a human or animal. A measurement variable value correlating with the desired concentration of the analyte are measured as the measurement signal (zt) and the change over time of the concentration is determined from the measurement signal as the useful signal (yt) using a calibration. A filter algorithm is used to reduce errors of the useful signal, which result from noise contained in the measurement signal. The filter algorithm includes an operation in which the influence of an actual measurement value on the useful signal is weighted using a weighting factor (V).
摘要翻译：本发明一般涉及通过确定其在人或动物的活体中随时间的变化来连续监测分析物的浓度的方法。测量与分析物的期望浓度相关的测量变量值作为测量信号（z> t），并且从测量信号确定浓度随时间的变化作为有用信号（y < SUB> t ）。使用滤波器算法来减少由测量信号中包含的噪声导致的有用信号的误差。滤波器算法包括使用加权因子（V）对实际测量值对有用信号的影响进行加权的操作。

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