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1. 发明授权

US5476667A Method for drug formulation and a pharmaceutical composition 失效
标题翻译：药物制剂的方法和药物组合物
公开(公告)号：US5476667A
公开(公告)日：1995-12-19
申请号：US39175
申请日：1993-04-16
申请人： Arne Kristensen , Per Holm
发明人： Arne Kristensen , Per Holm
IPC分类号： A61K9/14 , A61K9/16 , A61K31/43 , A61K31/606 , A61K31/616 , A61K31/655 , A61K47/34
CPC分类号： A61K9/1641 , A61K9/1694
摘要： A melt granulating method for the production of pellets (spheres) which contain a therapeutically active substance of high-dosage type. The method is characterized by: (i) mechanically working a mixture which contains (a) the active substance in cohesive form and (b) a binder (melting point 40.degree. C.-100.degree. C.) while supplying sufficient energy for the binder to melt and to form spherical overwetted pellets; (ii) adding further cohesive substance, while maintaining the mechanical working; (iii) interrupting the mechanical working and supply of energy and cohesive substance when the desired mean particle size of dry pellets (spheres) has been achieved; and (iv) removing the smallest and largest particles and dividing the remaining pellets into dosage batches. A novel pharmaceutical composition containing a dosage of 300-500 mg of pellets is obtainable from this process.
摘要翻译： PCT No.PCT / SE91 / 00690 Sec。 371日期：1993年04月16日 102（e）日期1993年4月16日PCT 1991年10月15日PCT PCT。公开号WO92 / 06679 日期：1992年4月30日。一种用于生产含有高剂量治疗活性物质的丸粒（球）的熔体造粒方法。该方法的特征在于：（i）机械加工包含（a）活性物质以粘结形式和（b）粘合剂（熔点为40℃-100℃）的混合物，同时为粘合剂提供足够的能量熔化并形成球形过湿颗粒; （ii）在保持机械加工的同时加入更多的粘性物质; （iii）当达到所需的干颗粒（球体）平均颗粒尺寸时，中断机械加工和能量供应和粘性物质; 和（iv）除去最小和最大的颗粒，并将剩余的颗粒分成剂量批料。从该方法可获得含有300-500mg粒料剂量的新型药物组合物。

2. 发明授权

US08664239B2 Tacrolimus for improved treatment of transplant patients 有权
公开(公告)号：US08664239B2
公开(公告)日：2014-03-04
申请号：US13167420
申请日：2011-06-23
申请人： Robert D. Gordon , Per Holm , Anne-Marie Lademann , Tomas Norling
发明人： Robert D. Gordon , Per Holm , Anne-Marie Lademann , Tomas Norling
IPC分类号： A61K31/44 , A61K31/436
CPC分类号： A61K31/436 , A61K9/0053 , A61K9/1617 , A61K9/1641 , A61K9/1652 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2077 , A61K9/284 , A61K9/2846 , A61K9/4891 , A61K47/10 , Y10S514/885
摘要： An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

3. 发明授权

US08591946B2 Modified release compositions comprising tacrolimus 有权
公开(公告)号：US08591946B2
公开(公告)日：2013-11-26
申请号：US10569862
申请日：2004-08-30
申请人： Per Holm
发明人： Per Holm
IPC分类号： A61K9/14
CPC分类号： A61K9/0053 , A61K9/10 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2077 , A61K9/2095 , A61K9/2846 , A61K9/2893 , A61K31/00 , A61K31/436 , A61K31/439 , A61K31/4745 , Y10S514/885
摘要： A modified release composition comprising tacrolimus releases less than 20% w/w of the active ingredient within 0.5 hours when subjected to an in vitro dissolution test using USP Paddle method and using 0.1 N HCl as dissolution medium and has increased bioavailability by effectively reducing or even avoiding the effects of CYP3A4 metabolism. The modified composition may be coated with an enteric coating; and/or may comprise a solid dispersion or a solid solution of tacrolimus in a hydrophilic or water-miscible vehicle and one or more modifying release agents; and/or may comprise a solid dispersion or a solid solution of tacrolimus in an amphiphilic or hydrophobic vehicle and optionally one or more modifying release agents.

4. 发明申请

US20100323008A1 SOLID DOSAGE FORM COMPRISING A FIBRATE 有权
标题翻译：固体剂型包含纤维素
公开(公告)号：US20100323008A1
公开(公告)日：2010-12-23
申请号：US12642563
申请日：2009-12-18
申请人： Per Holm , Tomas Norling
发明人： Per Holm , Tomas Norling
IPC分类号： A61K9/32 , A61K31/216 , A61P3/00
CPC分类号： A61K9/20 , A61K9/2013 , A61K9/2018 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/22 , A61K31/40 , A61K45/06 , A61K2300/00
摘要： The invention provides stable, solid dosage forms and pharmaceutical compositions in particulate form comprising a fibrate, for example fenofibrate, dissolved in an non-aqueous vehicle in order to ensure improved bioavailability of the active ingredient upon oral administration relative to known fibrate formulations.
摘要翻译：本发明提供稳定的固体剂型和药物组合物，其包含溶解在非水载体中的贝特类，例如非诺贝特，以确保相对于已知的贝特类制剂口服给药时活性成分的生物利用度得到改善。

5. 发明授权

US07772273B2 Stabilized atorvastatin 失效
标题翻译：稳定阿托伐他汀
公开(公告)号：US07772273B2
公开(公告)日：2010-08-10
申请号：US11673270
申请日：2007-02-09
申请人： Per Holm
发明人： Per Holm
IPC分类号： A01N43/36
CPC分类号： A61K9/209 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/2077 , A61K9/2846 , A61K9/2866 , A61K31/138 , A61K31/40 , A61K31/401 , A61K2300/00
摘要： A stable pharmaceutical composition for oral administration comprising atorvastatin and an amount of a pharmaceutically acceptable organic alkalizing compound capable of establishing a microenvironment for atorvastatin having a pH of at least about 5, for example 2-amino-2-(hydroxymethyl)-1,3-propanediol (trometamol).
摘要翻译：一种用于口服给药的稳定药物组合物，其包含阿托伐他汀和一定量的药学上可接受的有机碱化化合物，其能够建立pH至少约为5的阿托伐他汀的微环境，例如2-氨基-2-（羟甲基） - 丙二醇（氨丁三醇）。

6. 发明申请

US20090186081A1 Disintegrating Loadable Tablets 审中-公开
标题翻译：崩解性可装载片剂
公开(公告)号：US20090186081A1
公开(公告)日：2009-07-23
申请号：US12087392
申请日：2007-01-05
申请人： Per Holm , Lillian Slot
发明人： Per Holm , Lillian Slot
IPC分类号： A61K9/20 , A61K47/02
CPC分类号： A61K9/2095 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054
摘要： A disintegrating loadable tablet product in compressed form comprising i) at least 60% w/w of a sorbent material having a specific surface area (BET surface area) of at least 50 m2/g as measured by gas adsorption or mixtures of such sorbent materials, and ii) a disintegrant or a mixture of disintegrants wherein the tablet in compressed form has a) a porosity of 45% v/v or more, b) a hardness of at least 20 Newton, and c) a loading capacity of at least 30% of a liquid. The tablet is suitable for the preparation of a tablet containing an active substance by e.g. immersing the tablet in a liquid containing the active substance. The invention thus provides a safe and reproducible new method of preparing pharmaceutical tablets.
摘要翻译：一种压缩形式的崩解性可装载片剂，其包含：i）通过气体吸附测定的至少60％w / w的具有至少50m 2 / g的比表面积（BET表面积）的吸附剂材料或这些吸附剂材料的混合物，和ii）崩解剂或崩解剂的混合物，其中压缩形式的片剂具有a）45％v / v以上的孔隙率，b）至少20牛顿的硬度，和c）至少负载能力 30％的液体。片剂适用于制备含有活性物质的片剂。将片剂浸入含有活性物质的液体中。因此，本发明提供了制备药物片剂的安全和可重现的新方法。

7. 发明申请

US20080070308A1 Portous Article For Delivering Chemical Substances 审中-公开
标题翻译：波多尔文章提供化学物质
公开(公告)号：US20080070308A1
公开(公告)日：2008-03-20
申请号：US11597786
申请日：2005-06-27
申请人： Thomas Ruhland , Per Holm
发明人： Thomas Ruhland , Per Holm
IPC分类号： G01N37/00
CPC分类号： B01J19/0046 , A61K9/2009 , A61K9/2095 , B01J2219/00351 , B01J2219/00454 , B01J2219/00459 , B01J2219/0054 , B01J2219/00599 , B01J2219/0072 , B01L3/0293 , B01L2200/16 , B01L2300/069 , C40B50/08 , C40B50/14 , C40B60/14 , C40B70/00 , Y02P20/582 , Y10T436/10
摘要： A reagent delivering article capable of retaining liquid reagents, a method of pre-paring said articles and the use of said articles for loading liquid reagents is provided. Furthermore a reagent delivering article loaded with at least one liquid reagent, a method of preparing same and the use of said loaded article in solution phase chemistry, where said loaded reagent is released from said article into the solution is provided.
摘要翻译：提供了能够保留液体试剂的试剂递送制品，预先制备所述制品的方法和所述制品用于装载液体试剂的用途。此外，提供了装载有至少一种液体试剂的试剂递送制品，其制备方法以及所述加载的试剂在溶液相化学中的用途，其中所述加载的试剂从所述制品释放到溶液中。

8. 发明申请

US20070105912A1 Pharmaceutical compositions comprising lercanidipine 审中-公开
标题翻译：包含氯卡地平的药物组合物
公开(公告)号：US20070105912A1
公开(公告)日：2007-05-10
申请号：US10581128
申请日：2004-12-01
申请人： Per Holm , Tomas Norling
发明人： Per Holm , Tomas Norling
IPC分类号： A61K31/455
CPC分类号： A61K31/44 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1652 , A61K9/2018 , A61K9/2031 , A61K9/2054 , A61K9/4858 , A61K31/4418
摘要： A controlled release pharmaceutical composition comprising lercanidipine dissolved or dispersed in a solid vehicle at ambient temperature, thus forming a solid dispersion, achieves delayed release of lercanidipine over an extended period of time, reduced food effect and increased bioavailability compared to commercially available lercanidipine containing products.
摘要翻译：一种控释药物组合物，其包含在环境温度下溶解或分散在固体载体中的氯卡地平，从而形成固体分散体，与市售的含有乐卡西地平的产品相比，在延长的时间段内实现延迟释放莱卡西平，降低的食物效应和增加的生物利用度。

9. 发明申请

US20050242209A1 Self-cleaning spray nozzle 有权
标题翻译：自清洁喷嘴
公开(公告)号：US20050242209A1
公开(公告)日：2005-11-03
申请号：US10519992
申请日：2003-12-22
申请人： Per Holm , Elo Nielsen
发明人： Per Holm , Elo Nielsen
IPC分类号： B05B7/04 , B05B7/06 , B05B7/12 , B05B15/02 , B05B1/32
CPC分类号： B05B7/1209 , B05B7/0475 , B05B7/066 , B05B15/55
摘要： A self-cleaning spray nozzle, and in particular a self-cleaning spray nozzle for use in an apparatus for the preparation of a particulate material by a controlled agglomeration method, for example a method for controlled growth of particle size. The apparatus is especially suitable for use in the preparation of pharmaceutical compositions containing a therapeutically and/or prophylactically active substance which has a relatively low aqueous solubility and/or which is subject to chemical decomposition.
摘要翻译：一种自清洁喷嘴，特别是用于通过受控的聚集方法制备颗粒材料的设备中的自清洁喷嘴，例如用于控制生长颗粒尺寸的方法。该装置特别适用于制备含有具有较低水溶性和/或经受化学分解的治疗和/或预防活性物质的药物组合物。

10. 发明申请

US20050165092A1 Crystalline base of citalopram 审中-公开
标题翻译：西酞普兰的结晶基
公开(公告)号：US20050165092A1
公开(公告)日：2005-07-28
申请号：US11090336
申请日：2005-03-24
申请人： Hans Petersen , Klaus Bogeso , Per Holm
发明人： Hans Petersen , Klaus Bogeso , Per Holm
IPC分类号： C07D307/87 , A61J3/10 , A61K9/20 , A61K31/00 , A61K31/34 , A61K31/343 , A61P25/00 , A61P25/24 , C07C209/86 , C07C253/14 , C07D20060101 , C07D307/84
CPC分类号： C07D307/87
摘要： The present invention relates to the crystalline base of the well known antidepressant drug citalopram, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, formulations of said base, a process for the preparation of purified salts of citalopram, such as the hydrobromide, using the base, the salts obtained by said process and formulations containing such salts.
摘要翻译：本发明涉及众所周知的抗抑郁药物西酞普兰，1- [3-（二甲基氨基）丙基] -1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃腈的结晶碱，所述碱的制剂，制备西酞普兰纯化盐的方法，例如使用碱的氢溴酸盐，通过所述方法获得的盐和含有这些盐的制剂。

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