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1. 发明授权

US5021431A Imidazolyl alkyl guanidine derivatives, processes for their preparation and pharmaceutical preparations containing these compounds 失效
标题翻译：咪唑基烷基胍衍生物，其制备方法和含有这些化合物的药物制剂
公开(公告)号：US5021431A
公开(公告)日：1991-06-04
申请号：US318467
申请日：1989-02-28
申请人： Armin Buschauer , Helmut Schickaneder , Walter Schunack , Sigurd Elz , Istvan Szelenyi , Gert Baumann , Kurt H. Ahrens
发明人： Armin Buschauer , Helmut Schickaneder , Walter Schunack , Sigurd Elz , Istvan Szelenyi , Gert Baumann , Kurt H. Ahrens
IPC分类号： C07D233/54 , C07D233/64 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
CPC分类号： C07D233/64 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
摘要： New imidazolylalkyl-guanidine derivatives are described, which by virtue of their agonistic action on histamine-H.sub.2 receptors and in part also due to their additional H.sub.1 -antagonistic receptor activity can be used in the treatment of cardiac diseases, certain forms of hypertension and diseases of arterial occlusion.These imidazolylalkyl-guanidine derivatives correspond to the general formula I: ##STR1##
摘要翻译：描述了新的咪唑基烷基胍衍生物，其由于其对组胺-H 2受体的激动作用，并且部分还由于其另外的H1拮抗受体活性而可用于治疗心脏疾病，某些形式的高血压和疾病动脉闭塞。这些咪唑烷基 - 胍衍生物对应于通式I：

2. 发明授权

US4912119A Imidazolylguanidine derivatives and compositions containing these compounds 失效
标题翻译：咪唑基胍衍生物和含有这些化合物的组合物
公开(公告)号：US4912119A
公开(公告)日：1990-03-27
申请号：US95892
申请日：1987-09-14
申请人： Armin Buschauer , Helmut Schickaneder , Peter Morsdorf , Walter Schunack , Gert Baumann , Kurt-Henning Ahrens
发明人： Armin Buschauer , Helmut Schickaneder , Peter Morsdorf , Walter Schunack , Gert Baumann , Kurt-Henning Ahrens
IPC分类号： A61K31/415 , A61K31/38 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61P7/02 , A61P9/00 , A61P9/12 , C07D233/54 , C07D233/64 , C07D401/12 , C07D409/12 , C07D409/14
CPC分类号： C07D233/64 , C07D401/12 , C07D409/14
摘要： New imidazolyl guanidine derivatives corresponding to the following general formula ##STR1## are described. These compounds may be used in cardiac diseases, certain forms of hypertension and in diseases of arterial occlusion on account of their agonistic action on histamine-H.sub.2 receptors and in part their additional H.sub.1 -antagonistic receptor activity.
摘要翻译：描述了对应于以下通式的新的咪唑基胍衍生物。这些化合物可能用于心脏疾病，某些形式的高血压和由于其对组胺-H 2受体的激动作用以及部分其额外的H1拮抗受体活性而在动脉闭塞的疾病中。

3. 发明授权

US08663147B2 Treatment of thromboangiitis obliterans by removal of autoantibodies 有权
标题翻译：通过去除自身抗体来治疗闭塞性血栓闭塞症
公开(公告)号：US08663147B2
公开(公告)日：2014-03-04
申请号：US12988267
申请日：2009-04-20
申请人： Gert Baumann
发明人： Gert Baumann
IPC分类号： A61M37/00
CPC分类号： A61K39/44 , C07K16/42
摘要： The invention relates to the use of a specific ligand for antibodies, preferably autoantibodies in the manufacture of a column for the treatment of thromboangiitis obliterans. The invention pertains furthermore to the apharesis column with at least one anti-IgG antibody for the treatment of thromboangiitis obliterans.
摘要翻译：本发明涉及特异性配体在制备用于治疗闭塞血栓闭塞性血管炎的柱中的抗体，优选自身抗体的用途。本发明还涉及具有至少一种用于治疗闭塞血栓闭塞性血栓闭塞症的抗IgG抗体的apharesis柱。

4. 发明申请

US20110105980A1 TREATMENT OF THROMBOANGIITIS OBLITERANS BY REMOVAL OF AUTOANTIBODIES 有权
标题翻译：通过移除自身免疫治疗血栓形成障碍物
公开(公告)号：US20110105980A1
公开(公告)日：2011-05-05
申请号：US12988267
申请日：2009-04-20
申请人： Gert Baumann
发明人： Gert Baumann
IPC分类号： A61M1/36 , B23P17/04 , B01D15/08
CPC分类号： A61K39/44 , C07K16/42
摘要： The invention relates to the use of a specific ligand for antibodies, preferably autoantibodies in the manufacture of a column for the treatment of thromboangiitis obliterans. The invention pertains furthermore to the apharesis column with at least one anti-IgG antibody for the treatment of thromboangiitis obliterans.
摘要翻译：本发明涉及特异性配体在制备用于治疗闭塞血栓闭塞性血管炎的柱中的抗体，优选自身抗体的用途。本发明还涉及具有至少一种用于治疗闭塞血栓闭塞性血栓闭塞症的抗IgG抗体的apharesis柱。

5. 发明授权

US07022322B2 treatment of cardiomyopathy by removal of autoantibodies 失效
标题翻译：通过去除自身抗体治疗心肌病
公开(公告)号：US07022322B2
公开(公告)日：2006-04-04
申请号：US10299940
申请日：2002-11-19
申请人： Robert Koll , Jutta Müller-Derlich , Stephan Felix , Petra Reinke , Stefan Brehme , Gert Baumann , Reiner Spaethe
发明人： Robert Koll , Jutta Müller-Derlich , Stephan Felix , Petra Reinke , Stefan Brehme , Gert Baumann , Reiner Spaethe
IPC分类号： A61K39/395
CPC分类号： C07K1/22 , A61K35/16 , B01D15/3809 , C07K16/2869 , Y10S424/81
摘要： Immunoapheresis treatment for cardiomyopathy comprises passing the patient's plasma over a column having coupled thereto a specific ligand for human immunoglobulin, thereby removing a significant portion of the immunoglobulin from the patient's plasma, and then reinfusing the plasma to the patient. The invention is the use of a specific ligand for human immunoglobulin in the manufacture of a column having the ligand coupled thereto, the column being useful for immunoapheresis treatment of a patient with cardiomyopathy. The specific ligand binds, and thereby removes, human autoantibodies which are harmful to cardiac tissue such as antibodies against β1-adrenergic receptors, ADP-ATP carriers, α and β myosin heavy chains, and adenine nucleotide translocators. Immunoapheresis treatment using the column results in improvement of hemodynamic parameters such as mean arterial pressure, mean pulmonary pressure, pumonary capillary wedge pressure, right atrial pressure, cardiac output, cariac index, stroke volume index, and systemic vascular resistance.
摘要翻译：用于心肌病的免疫分离治疗包括将患者的血浆通过与其连接的用于人免疫球蛋白的特异性配体的柱，从而从患者血浆中除去大部分免疫球蛋白，然后将血浆重新输入患者体内。本发明是用于人免疫球蛋白的特异性配体用于制备具有偶联配体的柱，该柱可用于对患有心肌病的患者的免疫分离治疗。特异性配体结合并从而除去对心脏组织有害的人自身抗体，例如针对β1 - 肾上腺素能受体，ADP-ATP载体，α和β肌球蛋白重链的抗体和腺嘌呤核苷酸转运蛋白。使用柱的免疫分析法治疗可改善血流动力学参数，如平均动脉压，平均肺压，血管毛细血管楔压，右心房压，心输出量，Cariac指数，卒中体积指数和全身血管阻力。

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