专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06291466B1 Cholinergic agents in the treatment of presbyopia 失效
标题翻译：胆碱能药物治疗老花眼
公开(公告)号：US06291466B1
公开(公告)日：2001-09-18
申请号：US09126064
申请日：1998-07-30
申请人： Arlene Gwon , Elizabeth WoldeMussie
发明人： Arlene Gwon , Elizabeth WoldeMussie
IPC分类号： A67K31505
CPC分类号： A61K31/695 , A61K31/00 , A61K31/221 , A61K31/27 , A61K31/341 , A61K31/4178 , A61K31/4453 , A61K31/452 , A61K31/551 , A61K31/5513 , Y10S514/912
摘要： A method for increasing or decreasing parasympathetic/cholinergic/ciliary tonic contraction in order to restore the resting portion of the eye and allow normal positive and negative accommodation includes administering to a presbyopic subject an effective amount of a muscarinic agent.
摘要翻译：用于增加或减少副交感神经/胆碱能/睫状肌紧张收缩以恢复眼睛的静息部分并允许正常的阳性和阴性适应的方法包括向老花科对象施用有效量的毒蕈碱药。

2. 发明授权

US06410544B1 Cholinergic agents in the treatment of presbyopia 有权
标题翻译：胆碱能药物治疗老花眼
公开(公告)号：US06410544B1
公开(公告)日：2002-06-25
申请号：US09842299
申请日：2001-04-25
申请人： Arlene Gwon , Elizabeth WoldeMussie
发明人： Arlene Gwon , Elizabeth WoldeMussie
IPC分类号： A61K31505
CPC分类号： A61K31/695 , A61K31/00 , A61K31/221 , A61K31/27 , A61K31/341 , A61K31/4178 , A61K31/4453 , A61K31/452 , A61K31/551 , A61K31/5513 , Y10S514/912
摘要： A method for increasing or decreasing parasympathetic/cholinergic/ciliary tonic contraction in order to restore the resting portion of the eye and allow normal positive and negative accommodation includes administering to a myopic or hyperopic presbyope.
摘要翻译：用于增加或减少副交感神经/胆碱能/睫状肌紧张收缩以恢复眼睛的静息部分并允许正常的阳性和阴性适应的方法包括给予近视或远视的远视。

3. 发明授权

US5559151A Method for reducing intraocular pressure in the mammalian eye by administration of chloride channel blockers 失效
标题翻译：通过施用氯化物通道阻断剂降低哺乳动物眼睛眼内压的方法
公开(公告)号：US5559151A
公开(公告)日：1996-09-24
申请号：US346660
申请日：1994-11-30
申请人： Joseph S. Adorante , Elizabeth WoldeMussie , Guadalupe Ruiz
发明人： Joseph S. Adorante , Elizabeth WoldeMussie , Guadalupe Ruiz
IPC分类号： A61K45/00 , A61K31/00 , A61K31/137 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/24 , A61K31/245 , A61K31/26 , A61P27/02 , A61P27/06
CPC分类号： A61K31/00 , A61K31/137 , A61K31/192 , A61K31/196 , A61K31/26 , Y10S514/912 , Y10S514/913
摘要： Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains, as the active ingredient, one or more compounds having chloride channel blocking activity. Examples of chloride channel blockers utilized in the pharmaceutical composition and method of treatment are: ##STR1## wherein R is hydrogen or a pharmaceutically-acceptable cation, e.g. an alkali or alkaline earth metal, or a quaternary amine; or R represents a ester-forming moiety, e.g. a lower alkyl radical, having up to six carbon atoms, that may be derived from a lower alkanol.
摘要翻译：公开了用于治疗哺乳动物眼中的青光眼和/或高眼压症的药物组合物和方法，其通过向哺乳动物眼睛施用本发明的药物组合物，其含有一种或多种具有氯通道阻断活性的化合物作为活性成分。在药物组合物和治疗方法中使用的氯化物通道阻断剂的实例是：其中R是氢或药学上可接受的阳离子，例如，碱金属或碱土金属或季胺; 或R表示酯形成部分，例如。具有至多6个碳原子的低级烷基，其可以衍生自低级链烷醇。

4. 发明授权

US08541426B2 Pharmaceutical compositions and methods of treating dry eye disorders 有权
标题翻译：治疗干眼症的药物组合物和方法
公开(公告)号：US08541426B2
公开(公告)日：2013-09-24
申请号：US12668604
申请日：2008-07-04
申请人： Channing R. Beals , Elizabeth WoldeMussie , Hovhannes John Gukasyan , Jingwen Ma
发明人： Channing R. Beals , Elizabeth WoldeMussie , Hovhannes John Gukasyan , Jingwen Ma
IPC分类号： A61K31/519
CPC分类号： A61K31/519 , A61K9/0048
摘要： Inhibitors of Janus kinase-3 (“Jak3”) are useful for treating dry eye disorders and other disorders requiring the wetting of the eye. Jak3 inhibitors useful for treating eye disorders include the compound 3-{(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo [2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile.
摘要翻译： Janus激酶-3（“Jak3”）的抑制剂可用于治疗干眼病和其它需要润湿眼睛的疾病。用于治疗眼睛疾病的Jak3抑制剂包括化合物3 - {（3R，4R）-4-甲基-3- [甲基 - （7H-吡咯并[2,3-d]嘧啶-4-基） - 氨基] - 哌啶 -1-基} -3-氧代 - 丙腈。

5. 发明授权

US5521210A Ophthalmic use of muscarinic agonists having increased duration of activity 失效
标题翻译：具有增加活动持续时间的毒蕈碱激动剂的眼科用途
公开(公告)号：US5521210A
公开(公告)日：1996-05-28
申请号：US48829
申请日：1993-04-13
申请人： Elizabeth WoldeMussie , Roger F. Steinert , Guadalupe Ruiz
发明人： Elizabeth WoldeMussie , Roger F. Steinert , Guadalupe Ruiz
IPC分类号： A61K31/40
CPC分类号： A61K31/40 , Y10S514/912 , Y10S514/913
摘要： A method for inducing prolonged pseudoaccommodation includes the instillation of an ophthalmic formulation into an eye for contracting the iris sphincter muscle, but not the ciliary muscle, in order to cause sphincter muscle contraction for a period of greater than about one hour per installation. The method further provides for the stabilization of an implanted intraocular lens immediately after surgery and for reducing glare following radial keratotomy.
摘要翻译：用于诱导长时间假性调节的方法包括将眼用制剂滴入眼睛以将虹膜括约肌肌肉而不是睫状肌收缩，以便每次安装大于约1小时引起括约肌收缩。该方法进一步提供了在手术后立即稳定植入的眼内晶状体，并且用于减小径向角膜切开术后的眩光。

6. 发明授权

US5866605A Method for providing a neuroprotective effect to the mammalian eye by administration of chloride channel blockers 失效
标题翻译：通过施用氯化物通道阻断剂向哺乳动物眼睛提供神经保护作用的方法
公开(公告)号：US5866605A
公开(公告)日：1999-02-02
申请号：US998912
申请日：1997-12-29
申请人： Joseph S. Adorante , Elizabeth WoldeMussie , Guadalupe Ruiz
发明人： Joseph S. Adorante , Elizabeth WoldeMussie , Guadalupe Ruiz
IPC分类号： A61K45/00 , A61K31/00 , A61K31/137 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/24 , A61K31/245 , A61K31/26 , A61P27/02 , A61P27/06
CPC分类号： A61K31/00 , A61K31/137 , A61K31/192 , A61K31/196 , A61K31/26 , Y10S514/912 , Y10S514/913
摘要： Pharmaceutical compositions and a method are disclosed for providing neuroprotective effect to the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains, as the active ingredient, one or more compounds having chloride channel blocking activity. Examples of chloride channel blockers utilized in the pharmaceutical composition and method of treatment are: ##STR1## wherein R is hydrogen or a pharmaceutically-acceptable cation, e.g. an alkali or alkaline earth metal, or a quaternary amine; or R represents a ester-forming moiety, e.g. a lower alkyl radical, having up to six carbon 20 atoms, that may be derived from a lower alkanol.
摘要翻译：公开了药物组合物和方法，通过向哺乳动物眼睛施用含有作为活性成分的一种或多种具有氯化物通道阻断活性的化合物的本发明的药物组合物，向哺乳动物眼睛提供神经保护作用。在药物组合物和治疗方法中使用的氯化物通道阻断剂的实例是：其中R是氢或药学上可接受的阳离子，例如，碱金属或碱土金属或季胺; 或R表示酯形成部分，例如。具有至多6个碳原子的低级烷基，其可以衍生自低级链烷醇。

7. 发明授权

US5716952A Method for reducing intraocular pressure in the mammalian eye by administration of muscarinic antagonists 失效
公开(公告)号：US5716952A
公开(公告)日：1998-02-10
申请号：US853374
申请日：1992-03-18
申请人： Elizabeth WoldeMussie , Guadalupe Ruiz
发明人： Elizabeth WoldeMussie , Guadalupe Ruiz
IPC分类号： A61K45/00 , A61K31/135 , A61K31/445 , A61K31/55 , A61P27/02 , A61K31/34
CPC分类号： A61K31/55 , A61K31/135 , A61K31/445 , Y10S514/913
摘要： Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains as the active ingredient one or more muscarinic antagonist compounds. Examples of muscarinic antagonists utilized in the pharmaceutical composition and method of treatment are: 10H-thieno(3,4-b)(1,5)benzodiazepin-10-one 4,9-dihydro-3-methyl-4-((4-methyl-1-piperazinyl)acetyl) (telenzepine); 5,11-dihydro-11�4'-methyl-1'-piperazinyl)-acetyl!-6H-pyrido�2,3-b!�1,4!benzodiazepin-6-one (pirenzepine); racemic 11-��2-(Diethylamino)methyl!-1-piperidinyl!-acetyl!-5,11-dihydro-6H-pyrido�2,3-b!�1,4!benzodiazepin-6-one (AF-DX 116); dextrorotatory 11-��2-(Diethylamino)methyl!-1-piperidinyl!-acetyl!-5,11-dihydro-6H-pyrido�2,3-b!�1,4! benzodiazepin-6-one (AF-DX 250); an ophthalmically acceptable salt of 4-diphenylacetoxy-1,1-dimethyl piperidine (4-DAMP); .alpha.-cyclohexyl, -.alpha.-phenyl-1-piperidinepropanol (trihexyphenidyl); cyclohexanemethanol, .alpha.-phenyl, .alpha.-�3-(1-piperidinyl)-1-propynyl (hexbutinol); 6H-pyrido�2,3-b!�1,4!benzodiazepin-6-one, 11-��4-�4-(diethylamino)butyl!-1-piperidinyl!acetyl!-5,11-dihydro (AQ-RA 741); 11-H-pyrido�2,3-b!�1,4!benzodiazepine-11-carboxamide, N-�2-�2-�(dipropylamino)methyl!-1-piperidinyl!ethyl!-5-, 6-dihydro-6-oxo, monomethanesulfonate (AF-DX 384); 1,8-octanediamine, N,N'-bis�6-��2-methoxyphenyl)methyl!amino!hexyl!-tetrahydrochloride (methoctramine) and naphto�2,3-c!furan-1(3H)-one, 4-2-(1,6-dimethyl-2-piperidinyl)ethenyl!decahydro-3-methyl-, �3S-�3 .alpha., 3a .alpha., 4 .beta.�1E,2(2R*,6S*)!,4a .beta., 8a .alpha., 9a .alpha.!!(himbacine).

8. 发明申请

US20070212395A1 Ocular therapy using sirtuin-activating agents 审中-公开
标题翻译：使用sirtuin激活剂的眼部治疗
公开(公告)号：US20070212395A1
公开(公告)日：2007-09-13
申请号：US11371117
申请日：2006-03-08
申请人： John Donello , Rong Yang , Elizabeth WoldeMussie , Fabien Schweighoffer
发明人： John Donello , Rong Yang , Elizabeth WoldeMussie , Fabien Schweighoffer
IPC分类号： A61K31/7048 , A61K31/353 , A61F2/02 , A61K31/05
CPC分类号： A61K9/0051 , A61K9/1647 , A61K31/05
摘要： Ophthalmically therapeutic compositions, such as polymeric drug delivery systems, include a therapeutic component that includes a sirtuin-activating agent, such as resveratrol, which, upon delivery to the posterior segment of a mammalian eye, treats ocular conditions. Methods of making and using the present compositions are also described.
摘要翻译：眼科治疗组合物，例如聚合物药物递送系统，包括治疗组分，其包括沉默调节蛋白激活剂，例如白藜芦醇，其在递送至哺乳动物眼睛的后部段时治疗眼部病症。还描述了制备和使用本发明组合物的方法。

9. 发明授权

US5891911A Method for reducing intraocular pressure in the mammalian eye by administration of calcium chelators 失效
标题翻译：通过施用钙螯合剂降低哺乳动物眼睛眼内压的方法
公开(公告)号：US5891911A
公开(公告)日：1999-04-06
申请号：US260648
申请日：1995-07-28
申请人： Joseph S. Adorante , Elizabeth WoldeMussie , Guadalupe Ruiz
发明人： Joseph S. Adorante , Elizabeth WoldeMussie , Guadalupe Ruiz
IPC分类号： A61K31/00 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/23 , A61K47/48
CPC分类号： A61K47/4813 , A61K31/00 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/23 , Y10S514/912
摘要： Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains as the active ingredient one or more compounds having calcium chelating activity. Examples of calcium chelating agents utilized in the pharmaceutical composition and method of treatment are: ##STR1## and lower alkyl and alkoxyalkyl esters thereof.
摘要翻译：公开了药物组合物和方法，用于通过向哺乳动物眼睛施用含有作为活性成分的一种或多种具有钙螯合活性的化合物的本发明的药物组合物来治疗哺乳动物眼中的青光眼和/或高眼压症。用于药物组合物和治疗方法的钙螯合剂的实例是：其低级烷基和烷氧基烷基酯。

10. 发明授权

US5573758A Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers 失效
公开(公告)号：US5573758A
公开(公告)日：1996-11-12
申请号：US431170
申请日：1995-04-28
申请人： Joseph S. Adorante , Elizabeth WoldeMussie , Guadalupe Ruiz
发明人： Joseph S. Adorante , Elizabeth WoldeMussie , Guadalupe Ruiz
IPC分类号： A61K45/00 , A61K31/00 , A61K31/407 , A61K31/475 , A61K31/49 , A61K35/64 , A61K38/17 , A61P27/02 , A61K31/74
CPC分类号： A61K9/0048 , A61K31/00 , A61K31/407 , A61K31/49 , A61K38/1767 , Y10S514/912 , Y10S514/913 , Y10S514/914
摘要： Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains, as the active ingredient, one or more compounds having potassium channel blocking activity. Examples of potassium channel blockers utilized in the pharmaceutical composition and method of treatment are quinine, tremogenic indole alkaloids, such as Penitrem A and paspalicine, and insect toxins such as charybdotoxin and iberiotoxin.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式