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1. 发明申请

US20110008215A1 Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure 有权
标题翻译：具有多运行能力的放射合成模块化系统，降低辐射风险
公开(公告)号：US20110008215A1
公开(公告)日：2011-01-13
申请号：US12803862
申请日：2010-07-08
申请人： Arkadij M. Elizarov , Carroll Edward Ball , Jianzhong Zhang , Hartmuth C. Kolb , Reza Miraghaie , Todd Graves , Artem Lebedev
发明人： Arkadij M. Elizarov , Carroll Edward Ball , Jianzhong Zhang , Hartmuth C. Kolb , Reza Miraghaie , Todd Graves , Artem Lebedev
IPC分类号： G21C1/00
CPC分类号： B01J19/0093 , B01J2219/0081 , B01J2219/00826 , B01J2219/0086 , B01J2219/00871 , B01J2219/00936
摘要： Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.
摘要翻译：宏观和微流体装置及相关技术以及使用这种装置的化学过程。更具体地，这些装置可以用于以有效，紧凑和安全的操作者方式全面自动化合成用于成像的放射性化合物，例如通过正电子发射断层摄影（PET）。特别地，本发明的实施例涉及一种用于多步合成放射性药物的自动化，多运行微流控仪器，例如PET探针，其包括含有辐射递送部件的远程屏蔽微型电池。

2. 发明授权

US08273300B2 Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure 有权
标题翻译：具有多运行能力的放射合成模块化系统，降低辐射风险
公开(公告)号：US08273300B2
公开(公告)日：2012-09-25
申请号：US12803862
申请日：2010-07-08
申请人： Arkadij M. Elizarov , Carroll Edward Ball , Jianzhong Zhang , Hartmuth C. Kolb , Reza Miraghaie , Todd Graves , Artem Lebedev
发明人： Arkadij M. Elizarov , Carroll Edward Ball , Jianzhong Zhang , Hartmuth C. Kolb , Reza Miraghaie , Todd Graves , Artem Lebedev
IPC分类号： G21C1/00 , B01J19/00 , B01J8/00
CPC分类号： B01J19/0093 , B01J2219/0081 , B01J2219/00826 , B01J2219/0086 , B01J2219/00871 , B01J2219/00936
摘要： Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.
摘要翻译：宏观和微流体装置及相关技术以及使用这种装置的化学过程。更具体地，这些装置可以用于以有效，紧凑和安全的操作者方式全面自动化合成用于成像的放射性化合物，例如通过正电子发射断层摄影（PET）。特别地，本发明的实施例涉及一种用于多步合成放射性药物的自动化多运行微流体仪器，例如PET探针，其包括含有辐射递送部件的远程屏蔽微型电池。

3. 发明申请

US20100307602A1 System and Method for Processing High Purity Materials 有权
标题翻译：高纯度材料加工系统及方法
公开(公告)号：US20100307602A1
公开(公告)日：2010-12-09
申请号：US12857828
申请日：2010-08-17
申请人： DAVID KANDIYELI , Todd Graves , Rhey Yang
发明人： DAVID KANDIYELI , Todd Graves , Rhey Yang
IPC分类号： B67D7/72
CPC分类号： B24B57/00 , Y10T137/0391 , Y10T137/2931
摘要： Systems and methods for processing high purity materials are disclosed. A unit operation processes a material stream, an operational parameter of the unit operation is monitored, and a standby unit is charged with pressurized gas to achieve system pressure. The material stream is diverted to the standby unit in response to the operational parameter of the unit operation registering a threshold value. Flow exiting the standby unit is first vented via an outlet, and then directed toward a point of use after the pressurized gas has been purged. The unit operation may then be serviced and subsequently brought back online. A second unit operation may process a second material stream simultaneously, and the second material stream may be periodically diverted to the standby unit in like manner, thus reducing line pressure variation. The disclosed method may be performed manually or implemented automatically through use of a controller.
摘要翻译：公开了用于处理高纯度材料的系统和方法。单元操作处理材料流，监测单元操作的操作参数，并且备用单元用加压气体充电以实现系统压力。响应于注册阈值的单元操作的操作参数，物料流被转移到备用单元。离开待机单元的流量首先通过出口排出，然后在加压气体被清除之后指向使用点。然后可以对单元操作进行维护并随后恢复在线。第二单元操作可以同时处理第二材料流，并且第二材料流可以以类似的方式周期地转移到备用单元，从而减少管线压力变化。所公开的方法可以手动执行或通过使用控制器自动实现。

4. 发明申请

US20080012157A1 SYSTEM AND METHOD FOR DELIVERING CHEMICALS 有权
标题翻译：用于输送化学品的系统和方法
公开(公告)号：US20080012157A1
公开(公告)日：2008-01-17
申请号：US11778809
申请日：2007-07-17
申请人： David Kandiyeli , Todd Graves , Rhey Yang
发明人： David Kandiyeli , Todd Graves , Rhey Yang
IPC分类号： B67D5/08
CPC分类号： B24B57/02 , B24B37/04 , Y10T137/0318 , Y10T137/85954
摘要： Systems and method for delivering materials to a tool are disclosed. A material delivery system utilizes two or more sources of the material to be delivered to the tool. One or more of the sources of the tool may be a batch mixer. The material delivery system also includes at least two material delivery recirculation lines providing material to at tool. The material delivery system may be manually or automatically controlled to switch supply of the material from one source to another, and/or to switch from one material delivery recirculation line to another.
摘要翻译：公开了将材料递送到工具的系统和方法。材料输送系统利用两种或更多种材料来传递给工具。工具的一个或多个来源可以是分批混合器。材料输送系统还包括至少两个材料输送再循环管线，用于向工具提供材料。材料输送系统可以手动或自动地控制，以切换材料从一个源到另一个的供应，和/或从一个材料输送再循环管线切换到另一个。

5. 发明授权

US08402998B2 System and method for delivering chemicals 有权
标题翻译：用于输送化学品的系统和方法
公开(公告)号：US08402998B2
公开(公告)日：2013-03-26
申请号：US13349039
申请日：2012-01-12
申请人： David Kandiyeli , Todd Graves , Rhey Yang
发明人： David Kandiyeli , Todd Graves , Rhey Yang
IPC分类号： B05B9/03 , B05B15/00 , B05D1/02
CPC分类号： B24B57/02 , B24B37/04 , Y10T137/0318 , Y10T137/85954
摘要： Systems and method for delivering materials to a tool are disclosed. A material delivery system utilizes two or more sources of the material to be delivered to the tool. One or more of the sources of the tool may be a batch mixer. The material delivery system also includes at least two material delivery recirculation lines providing material to at tool. The material delivery system may be manually or automatically controlled to switch supply of the material from one source to another, and/or to switch from one material delivery recirculation line to another.
摘要翻译：公开了将材料递送到工具的系统和方法。材料输送系统利用两种或更多种材料来传递给工具。工具的一个或多个来源可以是分批混合器。材料输送系统还包括至少两个材料输送再循环管线，用于向工具提供材料。材料输送系统可以手动或自动地控制，以切换材料从一个源到另一个的供应，和/或从一个材料输送再循环管线切换到另一个。

6. 发明授权

US08308845B2 System and method for processing high purity materials 有权
标题翻译：用于加工高纯度材料的系统和方法
公开(公告)号：US08308845B2
公开(公告)日：2012-11-13
申请号：US12857828
申请日：2010-08-17
申请人： David Kandiyeli , Todd Graves , Rhey Yang
发明人： David Kandiyeli , Todd Graves , Rhey Yang
IPC分类号： B01D50/00
CPC分类号： B24B57/00 , Y10T137/0391 , Y10T137/2931
摘要： Systems and methods for processing high purity materials are disclosed. A unit operation processes a material stream, an operational parameter of the unit operation is monitored, and a standby unit is charged with pressurized gas to achieve system pressure. The material stream is diverted to the standby unit in response to the operational parameter of the unit operation registering a threshold value. Flow exiting the standby unit is first vented via an outlet, and then directed toward a point of use after the pressurized gas has been purged. The unit operation may then be serviced and subsequently brought back online. A second unit operation may process a second material stream simultaneously, and the second material stream may be periodically diverted to the standby unit in like manner, thus reducing line pressure variation. The disclosed method may be performed manually or implemented automatically through use of a controller.
摘要翻译：公开了用于处理高纯度材料的系统和方法。单元操作处理材料流，监测单元操作的操作参数，并且备用单元用加压气体充电以实现系统压力。响应于注册阈值的单元操作的操作参数，物料流被转移到备用单元。离开待机单元的流量首先通过出口排出，然后在加压气体被清除之后指向使用点。然后可以对单元操作进行维护并随后恢复在线。第二单元操作可以同时处理第二材料流，并且第二材料流可以以类似的方式周期地转移到备用单元，从而减少管线压力变化。所公开的方法可以手动执行或通过使用控制器自动实现。

7. 发明申请

US20120111413A1 System and Method for Delivering Chemicals 有权
标题翻译：化学品运输系统和方法
公开(公告)号：US20120111413A1
公开(公告)日：2012-05-10
申请号：US13349039
申请日：2012-01-12
申请人： David Kandiyeli , Todd Graves , Rhey Yang
发明人： David Kandiyeli , Todd Graves , Rhey Yang
IPC分类号： B05D1/00 , B05D1/36
CPC分类号： B24B57/02 , B24B37/04 , Y10T137/0318 , Y10T137/85954
摘要： Systems and method for delivering materials to a tool are disclosed. A material delivery system utilizes two or more sources of the material to be delivered to the tool. One or more of the sources of the tool may be a batch mixer. The material delivery system also includes at least two material delivery recirculation lines providing material to at tool. The material delivery system may be manually or automatically controlled to switch supply of the material from one source to another, and/or to switch from one material delivery recirculation line to another.
摘要翻译：公开了将材料递送到工具的系统和方法。材料输送系统利用两种或更多种材料来传递给工具。工具的一个或多个来源可以是分批混合器。材料输送系统还包括至少两个材料输送再循环管线，用于向工具提供材料。材料输送系统可以手动或自动地控制，以切换材料从一个源到另一个的供应，和/或从一个材料输送再循环管线切换到另一个。

8. 发明授权

US07066191B2 Installation for making available highly pure fine chemicals 失效
标题翻译：安装提供高纯度精细化学品
公开(公告)号：US07066191B2
公开(公告)日：2006-06-27
申请号：US10413509
申请日：2003-04-14
申请人： Todd Graves , Martin Vondran , Martin Benzinger
发明人： Todd Graves , Martin Vondran , Martin Benzinger
IPC分类号： B08B7/00
CPC分类号： B01J4/02 , B01J19/0006 , B01J2219/00011 , B01J2219/00022 , B01J2219/00164 , B01J2219/00171 , B01J2219/00177 , Y10T137/0402 , Y10T137/7043 , Y10T137/7062
摘要： A system and method for providing process chemicals. The system includes a housing comprising a functional component positioned in a first compartment, a control module positioned in a second compartment and at least one connecting line positioned in a third compartment. At least one compartment is positioned in a defined location in the housing. Modules may be removable received in their respective compartments.
摘要翻译：一种提供过程化学品的系统和方法。该系统包括壳体，其包括定位在第一隔室中的功能部件，位于第二隔室中的控制模块和位于第三隔室中的至少一个连接线。至少一个隔间被定位在壳体中的限定位置。模块可以在其各自的隔间中被移除。

9. 发明授权

US08113236B2 System and method for delivering chemicals 有权
标题翻译：用于输送化学品的系统和方法
公开(公告)号：US08113236B2
公开(公告)日：2012-02-14
申请号：US11778809
申请日：2007-07-17
申请人： David Kandiyeli , Todd Graves , Rhey Yang
发明人： David Kandiyeli , Todd Graves , Rhey Yang
IPC分类号： B05D1/00
CPC分类号： B24B57/02 , B24B37/04 , Y10T137/0318 , Y10T137/85954
摘要： Systems and method for delivering materials to a tool are disclosed. A material delivery system utilizes two or more sources of the material to be delivered to the tool. One or more of the sources of the tool may be a batch mixer. The material delivery system also includes at least two material delivery recirculation lines providing material to at tool. The material delivery system may be manually or automatically controlled to switch supply of the material from one source to another, and/or to switch from one material delivery recirculation line to another.
摘要翻译：公开了将材料递送到工具的系统和方法。材料输送系统利用两种或更多种材料来传递给工具。工具的一个或多个来源可以是分批混合器。材料输送系统还包括至少两个材料输送再循环管线，用于向工具提供材料。材料输送系统可以手动或自动地控制，以切换材料从一个源到另一个的供应，和/或从一个材料输送再循环管线切换到另一个。

10. 发明授权

US07799115B2 System and method for processing high purity materials 有权
标题翻译：用于加工高纯度材料的系统和方法
公开(公告)号：US07799115B2
公开(公告)日：2010-09-21
申请号：US11778806
申请日：2007-07-17
申请人： David Kandiyeli , Todd Graves , Rhey Yang
发明人： David Kandiyeli , Todd Graves , Rhey Yang
IPC分类号： B01D46/46
CPC分类号： B24B57/00 , Y10T137/0391 , Y10T137/2931
摘要： Systems and methods for processing high purity materials are disclosed. A unit operation processes a material stream, an operational parameter of the unit operation is monitored, and a standby unit is charged with pressurized gas to achieve system pressure. The material stream is diverted to the standby unit in response to the operational parameter of the unit operation registering a threshold value. Flow exiting the standby unit is first vented via an outlet, and then directed toward a point of use after the pressurized gas has been purged. The unit operation may then be serviced and subsequently brought back online. A second unit operation may process a second material stream simultaneously, and the second material stream may be periodically diverted to the standby unit in like manner, thus reducing line pressure variation. The disclosed method may be performed manually or implemented automatically through use of a controller.
摘要翻译：公开了用于处理高纯度材料的系统和方法。单元操作处理材料流，监测单元操作的操作参数，并且备用单元用加压气体充电以实现系统压力。响应于注册阈值的单元操作的操作参数，物料流被转移到备用单元。离开待机单元的流量首先通过出口排出，然后在加压气体被清除之后指向使用点。然后可以对单元操作进行维护并随后恢复在线。第二单元操作可以同时处理第二材料流，并且第二材料流可以以类似的方式周期地转移到备用单元，从而减少管线压力变化。所公开的方法可以手动执行或通过使用控制器自动实现。

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