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1. 发明授权

US07285532B2 Therapeutic method for treating bone formation diseases 有权
标题翻译：治疗骨形成疾病的治疗方法
公开(公告)号：US07285532B2
公开(公告)日：2007-10-23
申请号：US10735345
申请日：2003-12-12
申请人： Aris N. Economides , Neil Stahl , David M. Valenzuela , George D. Yancopoulos
发明人： Aris N. Economides , Neil Stahl , David M. Valenzuela , George D. Yancopoulos
IPC分类号： A61K38/16
CPC分类号： C07K16/22 , A61K38/00 , A61K39/00 , C07K14/475
摘要： Methods of treating and/or inhibiting a bone morphogenetic protein (BMP)-related disorder or condition by administering a BMP antagonist to a subject suffering from a BMP-related disorder or condition such that the BMP-related disorder or condition is treated. The method is carried out with a human noggin or a human noggin deletion mutant.
摘要翻译：通过向患有BMP相关病症或病症的受试者施用BMP拮抗剂以治疗和/或抑制骨形态发生蛋白（BMP）相关障碍或病症，使得与BMP相关的病症或病症得到治疗。该方法用人noggin或人noggin缺失突变体进行。

2. 发明授权

US5470952A CNTF and IL-6 antagonists 失效
标题翻译： CNTF和IL-6拮抗剂
公开(公告)号：US5470952A
公开(公告)日：1995-11-28
申请号：US140222
申请日：1993-10-20
申请人： Neil Stahl , Aris N. Economides , George D. Yancopoulos
发明人： Neil Stahl , Aris N. Economides , George D. Yancopoulos
IPC分类号： C12N15/09 , A61K38/00 , A61P3/02 , A61P19/10 , A61P35/02 , A61P43/00 , C07K7/06 , C07K14/475 , C07K14/52 , C07K14/54 , C07K14/715 , C12N15/19 , C12N15/24 , C12P21/02
CPC分类号： C07K14/715 , C07K14/475 , C07K14/5412 , A61K38/00
摘要： Heterodimer proteins comprising a soluble .alpha. specificity determining cytokine receptor component and the extracellular domain of a .beta. receptor component function as CNTF and IL-6 antagonsists.
摘要翻译：包含可溶性α特异性测定细胞因子受体组分的异二聚体蛋白质和β受体组分的胞外结构域作为CNTF和IL-6抗体分子起作用。

3. 发明授权

US07241739B2 Morphogenic protein 有权
标题翻译：形态发生蛋白
公开(公告)号：US07241739B2
公开(公告)日：2007-07-10
申请号：US10465474
申请日：2003-06-19
申请人： David M. Valenzuela , Eduardo A. Rojas , Aris N. Economides , Neil Stahl
发明人： David M. Valenzuela , Eduardo A. Rojas , Aris N. Economides , Neil Stahl
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： Human Cerberus proteins and related nucleic acids are provided. Included are proteins comprising a human cerberus domain having specific activity, particularly the ability to antagonize a bone morphogenic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.
摘要翻译：提供人Cerberus蛋白和相关核酸。包括包含具有比活性的人类cerberus结构域的蛋白质，特别是拮抗骨形态发生蛋白的能力。蛋白质可以用受试核酸从转化的宿主细胞重组产生。还提供了能够与所公开的基因，特异性结合剂和制备和使用本发明组合物的方法特异性杂交的分离的杂交探针和引物。

4. 发明授权

US06610510B1 Morphogenic proteins 有权
标题翻译：形态发生蛋白
公开(公告)号：US06610510B1
公开(公告)日：2003-08-26
申请号：US09423029
申请日：1999-11-16
申请人： David M. Valenzuela , Eduardo A. Rojas , Aris N. Economides , Neil Stahl
发明人： David M. Valenzuela , Eduardo A. Rojas , Aris N. Economides , Neil Stahl
IPC分类号： C12P2100
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： Human Cerberus proteins and related nucleic acids are provided. Included are proteins comprising a human cerberus domain having specific activity, particularly the ability to antagonize a bone morphogenic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.
摘要翻译：提供人Cerberus蛋白和相关核酸。包括包含具有比活性的人类cerberus结构域的蛋白质，特别是拮抗骨形态发生蛋白的能力。蛋白质可以用受试核酸从转化的宿主细胞重组产生。还提供了能够与所公开的基因，特异性结合剂和制备和使用本发明组合物的方法特异性杂交的分离的杂交探针和引物。

5. 发明授权

US06660499B1 DCR5, a BMP-binding protein, and applications thereof 有权
标题翻译： DCR5，BMP结合蛋白及其应用
公开(公告)号：US06660499B1
公开(公告)日：2003-12-09
申请号：US09762960
申请日：2001-02-14
申请人： Aris N. Economides , Neil Stahl
发明人： Aris N. Economides , Neil Stahl
IPC分类号： C12P2106
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/02
摘要： DCR5, a protein related to DAN (Differential-screening-selected gene Aberrative in Neuroblastoma) and related nucleic acids are provided. Included are natural DCR5 homologs from several species and proteins comprising a DCR5 domain having specific activity, particularly the ability to antagonize a bone morphogenetic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.
摘要翻译：提供了与DAN相关的蛋白质（神经母细胞瘤中的差异筛选选择基因Aberrative）和相关核酸的DCR5。包括来自几种物种的天然DCR5同源物和包含具有比活性的DCR5结构域的蛋白质，特别是拮抗骨形态发生蛋白的能力。蛋白质可以用受试核酸从转化的宿主细胞重组产生。还提供了能够与所公开的基因，特异性结合剂和制备和使用本发明组合物的方法特异性杂交的分离的杂交探针和引物。

6. 发明授权

US06846908B2 DCR-5 bone affecting ligand 有权
标题翻译： DCR-5骨影响配体
公开(公告)号：US06846908B2
公开(公告)日：2005-01-25
申请号：US10662756
申请日：2003-09-15
申请人： Aris N. Economides , Neil Stahl
发明人： Aris N. Economides , Neil Stahl
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61P19/08 , C07K14/47 , C07K14/475 , C07K16/18 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , G01N33/15 , G01N33/53 , G01N33/577 , C07K14/00 , C07K16/00 , C12P5/02 , C12P21/06 , C12P15/74
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/02
摘要： DCR5, a protein related to DAN (Differential-screening-selected gene Aberrative in Neuroblastoma) and related nucleic acids are provided. Included are natural DCR5 homologs from several species and proteins comprising a DCR5 domain having specific activity, particularly the ability to antagonize a bone morphogenetic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.
摘要翻译：提供了与DAN相关的蛋白质（神经母细胞瘤中的差异筛选选择基因Aberrative）和相关核酸的DCR5。包括来自几种物种的天然DCR5同源物和包含具有比活性的DCR5结构域的蛋白质，特别是拮抗骨形态发生蛋白的能力。蛋白质可以用受试核酸从转化的宿主细胞中重组产生。还提供了能够与所公开的基因，特异性结合剂和制备和使用本发明组合物的方法特异性杂交的分离的杂交探针和引物。

7. 发明授权

US07927583B2 Receptor based antagonists and methods of making and using 有权
标题翻译：基于受体的拮抗剂及其制备和使用方法
公开(公告)号：US07927583B2
公开(公告)日：2011-04-19
申请号：US12177185
申请日：2008-07-22
申请人： Neil Stahl , George D. Yancopoulos
发明人： Neil Stahl , George D. Yancopoulos
IPC分类号： A61K38/20 , A61K39/00 , A61K38/16
CPC分类号： C07H21/04 , A61K38/00 , C07K14/715 , C07K14/7155 , C07K16/244 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32
摘要： The present invention provides a fusion polypeptide capable of binding a cytokine to form a nonfunctional complex. It also provides a nucleic acid sequence encoding the fusion polypeptide and methods of making and uses for the fusion polypeptide.
摘要翻译：本发明提供能够结合细胞因子以形成非功能性复合物的融合多肽。它还提供编码融合多肽的核酸序列以及制备和用于融合多肽的方法。

8. 发明授权

US07531172B2 Methods of treating diseases with a VEGF antagonist 有权
标题翻译：用VEGF拮抗剂治疗疾病的方法
公开(公告)号：US07531172B2
公开(公告)日：2009-05-12
申请号：US11502736
申请日：2006-08-11
申请人： Neil Stahl , George D. Yancopoulos , Eric Furfine , Jesse M. Cedarbaum
发明人： Neil Stahl , George D. Yancopoulos , Eric Furfine , Jesse M. Cedarbaum
IPC分类号： A61K38/18 , C07K14/71 , C12N15/62
CPC分类号： A61K38/179
摘要： A method of reducing or preventing hypertension associated with administration of a vascular endothelial growth factor (VEGF) antagonist in a human subjects suffering from a disease or condition treatable with a VEGF antagonist in which is it desirable to reduce or prevent hypertension. The method is particularly useful for treatment of patients unresponsive to treatment with a VEGF inhibitor administered intravenously.
摘要翻译：在患有可用VEGF拮抗剂治疗的疾病或病症的人类受试者中降低或预防与血管内皮生长因子（VEGF）拮抗剂的给药相关的高血压的方法，其中希望减少或预防高血压。该方法对于治疗对用静脉内施用的VEGF抑制剂治疗无反应的患者特别有用。

9. 发明授权

US07435553B2 Isolating cells expressing secreted proteins 有权
标题翻译：分离表达分泌蛋白的细胞
公开(公告)号：US07435553B2
公开(公告)日：2008-10-14
申请号：US11434403
申请日：2006-05-15
申请人： James P Fandl , Neil Stahl , Gang Chen , George D. Yancopoulos
发明人： James P Fandl , Neil Stahl , Gang Chen , George D. Yancopoulos
IPC分类号： G01N33/53 , C12N15/09
CPC分类号： C40B30/04 , A01K2217/05 , A01K2267/01 , C07K14/315 , C07K14/52 , C07K16/2863 , C07K2317/77 , C07K2319/00 , C12N15/1051 , G01N33/56966 , G01N33/6845 , G01N2500/10
摘要： A method of detecting and isolating cells that produce any secreted protein of interest (POI), comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule.
摘要翻译：一种检测和分离产生任何分泌的感兴趣蛋白质（POI）的细胞的方法，包括：a）通过用核酸转染细胞系来构建瞬时或稳定表达结合POI的细胞表面捕获分子的细胞系编码这种细胞表面捕获分子; b）同时或随后用编码POI的第二核酸同时转染所述细胞，其中所述POI被分泌; c）通过使细胞与结合POI的检测分子接触来检测表面显示的POI; 和d）基于检测分子分离细胞。

10. 发明授权

US07083950B2 High affinity fusion proteins and therapeutic and diagnostic methods for use 有权
标题翻译：高亲和力融合蛋白和治疗和诊断方法使用
公开(公告)号：US07083950B2
公开(公告)日：2006-08-01
申请号：US10610452
申请日：2003-06-30
申请人： Neil Stahl , George D. Yancopoulos , Margaret Karow
发明人： Neil Stahl , George D. Yancopoulos , Margaret Karow
IPC分类号： C12P21/04 , C07H21/04
CPC分类号： C12N15/62 , C07K14/715 , C07K14/7155 , C07K16/244 , C07K16/248 , C07K16/468 , C07K2317/622 , C07K2317/92 , C07K2318/10 , C07K2318/20 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32
摘要： High affinity fusion proteins (“trapbodies”), capable of binding and inhibiting the activity of soluble, interacting proteins (“SIPs”) are described. The trapbodies are multimers, preferably dimers, of SIP-specific fusion polypeptides which comprise SIP binding domains derived from SIP targets and/or anti-SIP immunoglobulins, as well as multimerizing components.
摘要翻译：描述了能够结合和抑制可溶性相互作用蛋白（“SIP”）活性的高亲和力融合蛋白（“陷阱”）。所述捕获体是SIP特异性融合多肽的多聚体，优选二聚体，其包含衍生自SIP靶标和/或抗-Iss免疫球蛋白的SIP结合结构域，以及多聚化组分。

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