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1. 发明授权

US07079714B2 Electro-optic devices having flattened frequency response with reduced drive voltage 有权
标题翻译：具有降低的驱动电压的具有平坦的频率响应的电光器件
公开(公告)号：US07079714B2
公开(公告)日：2006-07-18
申请号：US10631649
申请日：2003-07-31
申请人： Aref Chowdhury , Douglas M. Gill , Mark Lee
发明人： Aref Chowdhury , Douglas M. Gill , Mark Lee
IPC分类号： G02F1/035
CPC分类号： G02F1/2255 , G02F2201/12
摘要： The present invention is an improved electro-optical device comprising a substrate-supported layer of electro-optical material disposed between upper and lower electrodes. Conventional practice has been to make the electrodes thick to minimize electrical loss. Applicants, in contrast, have discovered that the performance of the device can be improved by making the electrodes thin—typically about 2 microns or less and preferably about 0.5 micron or less. While the thin electrodes take a relatively large loss penalty at low frequencies, at higher frequencies the thin electrodes provide a relatively low loss, thus producing a flattened frequency response as compared with thick electrode devices. The device can maintain a wide operating bandwidth at frequencies of interest for optical transmission while reducing the required drive voltage.
摘要翻译：本发明是一种改进的电光装置，其包括设置在上电极和下电极之间的电光材料的基片支撑层。传统的做法是使电极变厚以最小化电损耗。相比之下，申请人已经发现，可以通过使电极变薄 - 通常约2微米或更小，优选约0.5微米或更小来提高器件的性能。虽然薄电极在低频下具有相对较大的损耗损失，但是在较高频率下，薄电极提供相对较低的损耗，从而与厚电极器件相比产生平坦化的频率响应。该设备可以在减少所需的驱动电压的同时，在光学传输的频率下维持宽的工作带宽。

2. 发明授权

US06819808B2 Electro-optical modulators 有权
标题翻译：电光调制器
公开(公告)号：US06819808B2
公开(公告)日：2004-11-16
申请号：US10762976
申请日：2004-01-22
申请人： Christoph Georg Erben , Douglas M Gill , Howard Edan Katz , Mark Lee
发明人： Christoph Georg Erben , Douglas M Gill , Howard Edan Katz , Mark Lee
IPC分类号： G02F1035
CPC分类号： G02B6/1221 , G02B6/10 , G02B6/12004 , G02B6/26 , G02B2006/12038 , G02B2006/12061 , G02B2006/12069 , G02B2006/12097 , G02B2006/12176 , G02B2006/12197
摘要： A method includes transmitting a sequence of wavefronts of the optical carrier wave having a first wavelength to an optical waveguide and transmitting a control wave having a second wavelength to a control waveguide. The control wave electro-optically modulates velocities of the wavefronts in the optical waveguide. A dielectric cladding adjacent the optical waveguide has a refractive index at the second wavelength that is larger than the refractive index in the optical waveguide at the first wavelength.
摘要翻译：一种方法包括将具有第一波长的光载波的波前序列发射到光波导并将具有第二波长的控制波传输到控制波导。控制波电光调制光波导中波前的速度。邻近光波导的电介质包层具有比第一波长的光波导中的折射率大的第二波长处的折射率。

3. 发明授权

US06711308B2 Electro-optical modulators 有权
公开(公告)号：US06711308B2
公开(公告)日：2004-03-23
申请号：US10032798
申请日：2001-12-26
申请人： Christoph Georg Erben , Douglas M Gill , Howard Edan Katz , Mark Lee
发明人： Christoph Georg Erben , Douglas M Gill , Howard Edan Katz , Mark Lee
IPC分类号： G02F1035
CPC分类号： G02B6/1221 , G02B6/10 , G02B6/12004 , G02B6/26 , G02B2006/12038 , G02B2006/12061 , G02B2006/12069 , G02B2006/12097 , G02B2006/12176 , G02B2006/12197
摘要： An electro-optical modulator includes an optical waveguide for carrying an optical carrier wave and a control waveguide for carrying a control wave. The optical waveguide includes a cladding layer and a core. The two waveguides are collinear and overlap in an interaction region so that the refractive index of the optical waveguide responds to electric fields generated by the control wave in the interaction region. The refractive index of the cladding layer at the control wave's wavelength is higher than the refractive index of the core at the optical carrier wave's wavelength.

4. 发明申请

US20120028264A1 METHOD FOR USING GENE EXPRESSION TO DETERMINE PROGNOSIS OF PROSTATE CANCER 审中-公开
标题翻译：使用基因表达来确定前列腺癌预后的方法
公开(公告)号：US20120028264A1
公开(公告)日：2012-02-02
申请号：US13190391
申请日：2011-07-25
申请人： Steven Shak , Frederick L. Baehner , Tara Maddala , Mark Lee , Robert J. Pelham , Wayne Cowens , Diana Cherbavaz , Michael C. Kiefer , Michael Crager , Audrey Goddard , Joffre B. Baker
发明人： Steven Shak , Frederick L. Baehner , Tara Maddala , Mark Lee , Robert J. Pelham , Wayne Cowens , Diana Cherbavaz , Michael C. Kiefer , Michael Crager , Audrey Goddard , Joffre B. Baker
IPC分类号： C12Q1/68
摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.
摘要翻译：涉及从前列腺癌患者获得的生物样品中测量预后生物标志物或共表达生物标志物的表达水平的分子测定，以及测量的表达水平的分析以提供关于所述患者的可能预后的信息，以及可能性所述患者将具有前列腺癌的复发，或通过临床结果或TMPRSS2融合状态的可能性来分类肿瘤。

5. 发明申请

US20110081543A1 BIODEGRADABLE COMPOSITE BARRIER FILM 有权
标题翻译：生物可降解复合障碍膜
公开(公告)号：US20110081543A1
公开(公告)日：2011-04-07
申请号：US12894647
申请日：2010-09-30
申请人： Mark Lee , Keunsuk P. Chang , Nao Yokota
发明人： Mark Lee , Keunsuk P. Chang , Nao Yokota
IPC分类号： B32B7/02 , B32B27/28 , B32B27/36 , B32B15/09 , B32B27/06
CPC分类号： B65D65/466 , B32B27/08 , B32B27/18 , B32B27/28 , B32B27/32 , B32B27/36 , B32B2250/02 , B32B2250/03 , B32B2250/244 , B32B2255/10 , B32B2255/20 , B32B2255/205 , B32B2270/00 , B32B2307/31 , B32B2307/514 , B32B2307/702 , B32B2307/7163 , B32B2307/7246 , B32B2439/70 , Y10T428/12014 , Y10T428/1352 , Y10T428/1355 , Y10T428/1379 , Y10T428/273 , Y10T428/2813 , Y10T428/2817 , Y10T428/2826 , Y10T428/31678 , Y10T428/31681 , Y10T428/31786
摘要： The present invention is directed to a multilayer film having, as its main component, a hydroxy acid polymer with improved gas barrier and optional heat sealability. The oriented film of predominately hydroxy acid polymer having controlled shrink can be produced by melting and coextruding a hydroxy acid polymer with a much thinner layer of an amorphous aromatic copolyester to form a multilayer film that is quench cooled, then biaxially stretched at a process temperature above the glass transition and below the cold crystallization temperature of the hydroxy acid polymer. A heat-setting treatment with a controlled relaxation of the film above the hydroxy acid polymer glass transition temperature and below its melt temperature may be used to control shrinkage. The films thus obtained are vacuum metallized on the aromatic copolyester surface to produce environmentally friendly packaging from predominately renewable resources having improved gas barrier properties.
摘要翻译：本发明涉及一种具有改进的阻气性和任选的热封性的羟基酸聚合物作为其主要成分的多层膜。具有受控收缩的主要羟基酸聚合物的定向膜可以通过用非常薄的无定形芳族共聚酯层的熔融和共挤出羟基酸聚合物来形成多层膜，所述多层膜被淬火冷却，然后在上述过程温度下双轴拉伸玻璃化转变并低于羟基酸聚合物的冷结晶温度。可以使用在羟基酸聚合物玻璃化转变温度以上且低于其熔融温度下控制松弛膜的热定型处理来控制收缩。由此获得的薄膜在芳族共聚酯表面上真空金属化，以产生具有改进的气体阻隔性能的主要可再生资源的环境友好的包装。

6. 发明授权

US07803783B2 Use of WNT inhibitors to augment therapeutic index of chemotherapy 失效
标题翻译：使用WNT抑制剂来增加化疗的治疗指数
公开(公告)号：US07803783B2
公开(公告)日：2010-09-28
申请号：US11707386
申请日：2007-02-16
申请人： Mark Lee , Calvin Jay Kuo , Tannishtha Reya , Irving L. Weissman
发明人： Mark Lee , Calvin Jay Kuo , Tannishtha Reya , Irving L. Weissman
IPC分类号： A61K31/713
CPC分类号： A61K38/17 , C07K2319/30
摘要： Methods and compositions are provided for the protection of normal cells from cytoreductive therapy that target proliferating cells, by administering an inhibitor of Wnt signaling pathways. Wnt signaling is critically important for homeostasis of the epithelial lining of the adult intestine and other proliferating normal adult tissues.
摘要翻译：提供了通过施用Wnt信号通路抑制剂来保护正常细胞免受靶向增殖细胞的细胞减灭治疗的方法和组合物。 Wnt信号对成年肠和其他增殖正常成人组织的上皮内皮的稳态至关重要。

7. 发明申请

US20080012937A1 A/V display device capable of swapping digital/Analog A/V output modules 审中-公开
标题翻译：能够交换数字/模拟A / V输出模块的A / V显示设备
公开(公告)号：US20080012937A1
公开(公告)日：2008-01-17
申请号：US11485998
申请日：2006-07-14
申请人： Mark Lee , Jung-Chang Wu , Wei-Yu Wu
发明人： Mark Lee , Jung-Chang Wu , Wei-Yu Wu
IPC分类号： H04N7/18
CPC分类号： H04N5/64
摘要： An audio/video (A/V) display device capable of swapping digital/Analog A/V output modules mainly comprises a socket set up for inserting a digital/Analog A/V output module. By swapping different digital/Analog A/V output modules, said A/V display device can let users watch digital TV and DVD discs, browse photos stored in a memory card, organize data in said memory card, or play video games, etc.
摘要翻译：能够交换数字/模拟A / V输出模块的音频/视频（A / V）显示设备主要包括一个用于插入数字/模拟A / V输出模块的插座。通过交换不同的数字/模拟A / V输出模块，所述A / V显示设备可以让用户观看数字电视和DVD光盘，浏览存储在存储卡中的照片，组织所述存储卡中的数据或播放视频游戏等。

8. 发明授权

US07202589B2 Temperatures stable saw sensor with third-order elastic constants 有权
标题翻译：温度稳定的锯齿传感器具有三阶弹性常数
公开(公告)号：US07202589B2
公开(公告)日：2007-04-10
申请号：US10492724
申请日：2002-10-16
申请人： Victor Alexandrovich Kalinin , Mark Lee
发明人： Victor Alexandrovich Kalinin , Mark Lee
IPC分类号： H03H9/25
CPC分类号： H03H9/02834 , G01D5/485 , G01L1/165 , G01L3/106
摘要： A surface acoustic wave (SAW) sensor includes a transducer (240 provided on a substrate (23), wherein the transducer (24) is oriented on the substrate (23) so that the direction of acoustic wave propagation is such that the variation of sensor output with temperature, associated with the variation of the substrate third-elastic constants with temperature, substantially equal but opposite to the sum total of the variation of sensor output with temperature associated with the substrate linear temperature coefficient of expansion and with the variations with temperature of the substrate non-zero third order elastic constants, the substrate first-order elastic constants and the substrate density. The effect of temperature variation on sensor output is thereby minimized. This is achieved with a 35-degree arrangement or with reflective gratings inclined at an angle of 3.1 degrees to normal. Additionally, a robust package with a dish is given. Particular applications include the measurement of torque.
摘要翻译：表面声波（SAW）传感器包括换能器（240），其设置在基板（23）上，其中换能器（24）定向在基板（23）上，使得声波传播的方向使得传感器与温度的输出相关联的第三弹性常数与温度的变化相关，基本上等于但与传感器输出的变化与基板线性温度系数膨胀的温度的变化总和相反，衬底非零三阶弹性常数，衬底一级弹性常数和衬底密度，因此温度变化对传感器输出的影响最小化，这是通过35度布置或反射光栅倾斜于角度为3.1度至正常值，另外，还提供了带有盘的强力包装，具体应用包括测量扭矩。

9. 发明申请

US20070039390A1 Inspection system and associated method 有权
标题翻译：检验系统及相关方法
公开(公告)号：US20070039390A1
公开(公告)日：2007-02-22
申请号：US11205964
申请日：2005-08-17
申请人： Michael Duncan , Mark Lee , Fred Young
发明人： Michael Duncan , Mark Lee , Fred Young
IPC分类号： G01N29/04
CPC分类号： G01N29/226 , G01N29/265 , G01N2291/2694
摘要： A system and method for inspecting a structure are provided. The system includes at least one non-destructive inspection (“NDI”) sensor capable of acquiring data indicative of at least a portion of the structure, and at least one positional sensor for acquiring positional data of the NDI sensor. The system also includes a mechanism operable to trigger the NDI sensor and/or the positional sensor to acquire data such that data indicative of the structure and the positional data are acquired at approximately the same time. The system further includes a movable arm carrying the sensors and movably attached to a base. The system includes a data acquisition system capable of communicating with the sensors such that the data acquisition system generates information indicative of at least a portion of the structure based on the data acquired by the sensors.
摘要翻译：提供了一种用于检查结构的系统和方法。该系统包括能够获取表示该结构的至少一部分的数据的至少一个非破坏性检查（“NDI”）传感器，以及用于获取NDI传感器的位置数据的至少一个位置传感器。该系统还包括可操作以触发NDI传感器和/或位置传感器以获取数据的机构，使得在大约相同的时间获取指示结构和位置数据的数据。所述系统还包括携带所述传感器并可移动地附接到基座的可移动臂。该系统包括能够与传感器通信的数据采集系统，使得数据采集系统基于由传感器获取的数据生成指示结构的至少一部分的信息。

10. 发明授权

US07151337B2 Pressure monitor incorporating saw device 有权
标题翻译：压力监视器包括锯装置
公开(公告)号：US07151337B2
公开(公告)日：2006-12-19
申请号：US10508468
申请日：2003-03-17
申请人： Victor Alexandrovich Kalinin , Mark Lee , Raymond David Lohr , Arthur John Leigh
发明人： Victor Alexandrovich Kalinin , Mark Lee , Raymond David Lohr , Arthur John Leigh
IPC分类号： H03H9/00
CPC分类号： G01L19/0092 , G01L1/165 , G01L9/0025
摘要： A pressure monitor has a base and a lid secured to the base to define a substantially fluid tight chamber. At least part of the lid is flexible and forms a diaphragm which deflects responsive to changes in fluid pressure surrounding the monitor. A projection provided on the diaphragm transmits movement thereof to a distortable substrate located within the chamber. A first SAW device is mounted on the distortable substrate, and at least a second and third SAW device are mounted within the chamber. The second SAW device carried on a reference substrate section has its direction of propagation inclined at an angle to the direction of propagation of at least one of the first and third SAW devices. This way movement of the diaphragm induced by a change in pressure in the zone surrounding the monitor results in distortion of the distortable substrate, which is measurable by the SAW device mounted thereon, without distorting said reference substrate section.
摘要翻译：压力监视器具有固定到基座的底座和盖子，以限定基本上流体密封的腔室。盖的至少一部分是柔性的，并且形成响应于监视器周围的流体压力变化而偏转的隔膜。设置在隔膜上的突起将其运动传递到位于室内的可变形基板。第一SAW器件安装在可变形衬底上，并且至少第二和第三SAW器件安装在腔室内。携带在参考基板部分上的第二SAW器件具有与第一和第三SAW器件中的至少一个的传播方向成一角度的传播方向。以这种方式由围绕监视器的区域中的压力变化引起的隔膜的移动导致可变形的衬底的变形，其可由安装在其上的SAW器件测量，而不会使所述参考衬底部分变形。

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