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1. 发明授权

US08843196B2 Subcutaneous cardiac sensing and stimulation system 有权
标题翻译：皮下心脏感知和刺激系统
公开(公告)号：US08843196B2
公开(公告)日：2014-09-23
申请号：US13237221
申请日：2011-09-20
申请人： Apurv Kamath , Paul Haefner , Darrell O. Wagner , Marina Brockway
发明人： Apurv Kamath , Paul Haefner , Darrell O. Wagner , Marina Brockway
IPC分类号： A61N1/05 , A61N1/39 , A61N1/365 , A61B17/00 , A61B19/00 , A61B17/34 , A61N1/37 , A61B17/32 , A61B17/3203 , A61B18/00
CPC分类号： A61N1/3956 , A61B17/320068 , A61B17/3203 , A61B17/3415 , A61B17/3417 , A61B90/30 , A61B2017/00243 , A61B2017/00247 , A61B2017/320044 , A61B2017/320084 , A61B2018/00392 , A61B2090/3945 , A61B2090/3979 , A61B2217/005 , A61B2217/007 , A61N1/05 , A61N1/056 , A61N1/0568 , A61N1/0587 , A61N1/36542 , A61N1/36585 , A61N1/37 , A61N1/3925 , A61N1/3962 , A61N1/3987
摘要： Cardiac systems and methods using ECG and blood information for arrhythmia detection and discrimination. Detection circuitry is configured to produce an ECG. An implantable blood sensor configured to produce a blood sensor signal is coupled to a processor. The processor is coupled to the detection and energy delivery circuitry, and used to evaluate and treat cardiac rhythms using both the cardiac electrophysiologic and blood sensor signals. The blood sensor is configured for subcutaneous non-intrathoracic placement and provided in or on the housing, on a lead coupled to the housing, and/or separate to the housing and coupled to the processor via hardwire or wireless link. The blood sensor may be configured for optical sensing, using a blood oxygen saturation sensor or pulse oximeter. A cardiac rhythm may be evaluated using the electrocardiogram signal and the blood sensor signal, and tachyarrhythmias may be treated after confirmation using the blood sense signal.
摘要翻译：心脏系统和方法使用ECG和血液信息进行心律失常检测和辨别。检测电路被配置为产生ECG。构造成产生血液传感器信号的可植入血液传感器耦合到处理器。处理器耦合到检测和能量输送电路，并且用于使用心脏电生理学和血液传感器信号来评价和治疗心律。血液传感器被配置用于皮下非胸内放置并且设置在壳体中或外壳上，在耦合到壳体的引线上和/或分离到壳体并经由硬线或无线链路耦合到处理器。血液传感器可以被配置为使用血氧饱和度传感器或脉搏血氧计进行光学感测。可以使用心电图信号和血液传感器信号评估心律，并且可以在使用血液感测信号确认之后治疗快速性心律失常。

2. 发明授权

US07142912B2 Method and apparatus for assessing and treating atrial fibrillation risk 有权
标题翻译：评估和治疗房颤风险的方法和装置
公开(公告)号：US07142912B2
公开(公告)日：2006-11-28
申请号：US10194435
申请日：2002-07-12
申请人： Darrell O. Wagner , Robert J. Sweeney , Adam W. Cates , Apurv Kamath , Eric G. Lovett
发明人： Darrell O. Wagner , Robert J. Sweeney , Adam W. Cates , Apurv Kamath , Eric G. Lovett
IPC分类号： A61N1/08
CPC分类号： A61N1/3622 , A61N1/395 , A61N1/3962
摘要： A method and apparatus for assessing the risk of atrial fibrillation in a patient by calculating the relative frequency of short and long intervals between successive heart beats during sinus rhythm is presented. An imbalance of short over long sinus intervals has been found to indicate a higher risk of atrial fibrillation. An implantable cardiac device may be configured to automatically deliver interventional therapy to restore sinus interval balance when such an imbalance is detected.
摘要翻译：提出了一种通过计算窦性心律连续心脏跳动之间的短间隔和长间隔的相对频率来评估患者心房颤动风险的方法和装置。发现短窦间隔短暂的不平衡表明心房颤动的风险更高。可植入的心脏装置可以被配置为当检测到这种不平衡时，自动地进行介入治疗以恢复窦间隔平衡。

3. 发明申请

US20110077701A1 METHOD AND APPARATUS FOR TISSUE PROTECTION AGAINST ISCHEMIA USING REMOTE CONDITIONING 有权
标题翻译：使用远程调节对组织织物组织防护的方法和装置
公开(公告)号：US20110077701A1
公开(公告)日：2011-03-31
申请号：US12963224
申请日：2010-12-08
申请人： Haris J. Sih , Tamara Colette Baynham , Darrell O. Wagner
发明人： Haris J. Sih , Tamara Colette Baynham , Darrell O. Wagner
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/3627
摘要： A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.
摘要翻译：刺激系统提供刺激以保护身体的缺血区域免于由局部缺血引起的组织损伤。刺激被递送到远离缺血区域的一个或多个刺激部位，以产生保护缺血区域免受缺血引起的组织损伤的生理作用。在一个实施例中，刺激系统将心脏保护刺激递送到远离心脏的一个或多个刺激部位，以保护心脏免于与心脏缺血事件相关的损伤。在另一个实施例中，刺激系统将远程调节刺激递送到心脏中或心脏上的一个或多个刺激部位，以保护非心脏区域免于与非心脏缺血事件相关的损伤。

4. 发明授权

US5251624A Pulse generator for use in an implantable atrial defibrillator 失效
标题翻译：用于可植入心房除颤器的脉冲发生器
公开(公告)号：US5251624A
公开(公告)日：1993-10-12
申请号：US902998
申请日：1992-06-22
申请人： Joseph M. Bocek , Kenneth R. Infinger , Darrell O. Wagner
发明人： Joseph M. Bocek , Kenneth R. Infinger , Darrell O. Wagner
IPC分类号： A61N1/39 , A61N1/36
CPC分类号： A61N1/3956 , A61N1/3906 , A61N1/3912 , A61N1/395
摘要： A pulse generator for use in implantable atrial defibrillator provides cardiovertinq electrical energy to the atria of a heart through at least one lead having a pair of electrodes associated with the atria of the heart. The pulse generator includes a depletable, low voltage, power source such as a battery. A charging circuit coupled to the battery includes a flyback transformer for converting the battery voltage to low duty cycle pulsating high voltage electrical energy to store the high voltage electrical energy in a storage capacitor coupled to the charging circuit. A crosspoint switch selectively couples the storage capacitor to the electrodes for applying a portion of the stored electrical energy to the atria of the heart for cardioverting the atria of the heart.

5. 发明授权

US4892101A Method and apparatus for offsetting baseline portion of oximeter signal 失效
标题翻译：用于抵消血氧计信号基线部分的方法和装置
公开(公告)号：US4892101A
公开(公告)日：1990-01-09
申请号：US315330
申请日：1989-02-24
申请人： Peter W. Cheung , Karl F. Gauglitz , Lee R. Mason , Stephen J. Prosser , Robert E. Smith , Darrell O. Wagner , Scott W. Hunsaker
发明人： Peter W. Cheung , Karl F. Gauglitz , Lee R. Mason , Stephen J. Prosser , Robert E. Smith , Darrell O. Wagner , Scott W. Hunsaker
IPC分类号： A61B5/00
CPC分类号： A61B5/14551
摘要： A feedback control system is disclosed for use in processing signals employed in pulse transmittance oximetry. The signals are produced in response to light transmitted through, for example, a finger at two different wavelengths. Each signal includes a slowly varying baseline component representing the relatively fixed attenuation of light produced by bone, tissue, skin, and hair. The signals also include pulsatile components representing the attenuation produced by the changing blood volume and oxygen saturation within the finger. The signals are processed by the feedback control system before being converted by an analog-to-digital (A/D) converter (72) for subsequent analysis by a microcomputer (16). The feedback control system includes a controllable offset subtractor (66), a programmable gain amplifier (68), controllable drivers (44) for the light sources (40, 42), and the microcomputer (16). The microcomputer (16) receives signals from the offset subtractor (66), gain amplifier (68), drivers (44) and A/D converter (72) to produce signals that control the function of the subtractor (66) and drivers (44) in the following manner. Normally, the drivers ( 44) are maintained within a predetermined current range. In the event the microcomputer (16) senses an output from the converter (72) that is not within a predetermined range, the drive signal is adjusted to produce an acceptable signal. The magnitude of the offset removed by the subtractor (66), as controlled by the microcomputer (16), is maintained at a constant level when the converter (72) output is within a first predetermined range and is a predetermined function of the converter (72) output when that output falls within a second predetermined range.
摘要翻译：公开了一种反馈控制系统，用于处理脉冲透射比率测定中使用的信号。信号是响应于透过例如两个不同波长的手指的光产生的。每个信号包括缓慢变化的基线分量，其表示由骨，组织，皮肤和头发产生的光的相对固定的衰减。信号还包括表示由手指内的血液体积变化和氧饱和度产生的衰减的脉动成分。这些信号由模拟数字（A / D）转换器（72）转换之前由反馈控制系统处理，用于微计算机（16）的后续分析。反馈控制系统包括可控偏移减法器（66），可编程增益放大器（68），用于光源（40,42）的可控驱动器（44）和微计算机（16）。微型计算机（16）从偏移减法器（66），增益放大器（68），驱动器（44）和A / D转换器（72）接收信号，以产生控制减法器（66）和驱动器（44）的功能的信号）。通常，驱动器（44）保持在预定的电流范围内。在微计算机（16）感测到转换器（72）的输出不在预定范围内的情况下，调节驱动信号以产生可接受的信号。当转换器（72）输出在第一预定范围内并且是转换器的预定功能时，被微计算机（16）控制的减法器（66）去除的偏移量的幅度保持在恒定水平 72）当该输出处于第二预定范围内时输出。

6. 发明授权

US09031792B2 Method of using a lead to regulate protein expression 有权
标题翻译：使用铅调节蛋白质表达的方法
公开(公告)号：US09031792B2
公开(公告)日：2015-05-12
申请号：US11277552
申请日：2006-03-27
申请人： Darrell O. Wagner , Haris J. Sih , Jihong Qu , Jeffrey Ross , Steven D. Girouard , Ronald W. Heil, Jr.
发明人： Darrell O. Wagner , Haris J. Sih , Jihong Qu , Jeffrey Ross , Steven D. Girouard , Ronald W. Heil, Jr.
IPC分类号： G01N33/48 , A61K48/00 , A61N1/05
CPC分类号： A61K48/0008 , A61K48/0083 , A61N1/05
摘要： A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.
摘要翻译：提供了一种系统和装置，其包括通过发射一种或多种刺激来控制存在于或释放的装置中的一种或多种表达盒的表达的基因调控系统。表达盒包括可调节的转录控制元件，其响应于与感兴趣的开放阅读框架相关联的发射刺激。该系统可选地包括用于感测指示需要的参数的传感器，用于接收外部命令的遥测模块或用于调节开放阅读框的基因表达的可编程设备。

7. 发明授权

US5674253A Cardioversion system with cardioverting energy attenuator 失效
标题翻译：心律转复系统与心律转换能量衰减器
公开(公告)号：US5674253A
公开(公告)日：1997-10-07
申请号：US708218
申请日：1996-09-06
申请人： John M. Adams , Clifton A. Alferness , Darrell O. Wagner
发明人： John M. Adams , Clifton A. Alferness , Darrell O. Wagner
IPC分类号： A61N1/39
CPC分类号： A61N1/3931
摘要： A defibrillation system for providing post-cardiac surgery atrial cardioversion includes a lead system having defibrillation electrodes for electrical contact with the heart beneath the skin of a patient and a non-implantable external defibrillator for providing defibrillation electrical energy. An interface unit is coupled between the external defibrillator and the lead system and includes an attenuator circuit for attenuating the defibrillation electrical energy provided by the external defibrillator.
摘要翻译：用于提供心脏外手术心房复律的除颤系统包括具有用于与患者皮肤下的心脏电接触的除颤电极的引导系统和用于提供除颤电能的非植入式外部除颤器。接口单元耦合在外部除颤器和引导系统之间，并且包括用于衰减由外部除颤器提供的除颤电能的衰减器电路。

8. 发明授权

US08874207B2 Method and apparatus for tissue protection against ischemia using remote conditioning 有权
标题翻译：使用远程调理的组织保护针对缺血的方法和装置
公开(公告)号：US08874207B2
公开(公告)日：2014-10-28
申请号：US12963224
申请日：2010-12-08
申请人： Haris J. Sih , Tamara Colette Baynham , Darrell O. Wagner
发明人： Haris J. Sih , Tamara Colette Baynham , Darrell O. Wagner
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61N1/3627
摘要： A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.
摘要翻译：刺激系统提供刺激以保护身体的缺血区域免于由局部缺血引起的组织损伤。刺激被递送到远离缺血区域的一个或多个刺激部位，以产生保护缺血区域免受缺血引起的组织损伤的生理作用。在一个实施例中，刺激系统将心脏保护刺激递送到远离心脏的一个或多个刺激部位，以保护心脏免于与心脏缺血事件相关的损伤。在另一个实施例中，刺激系统将远程调节刺激递送到心脏中或心脏上的一个或多个刺激部位，以保护非心脏区域免于与非心脏缺血事件相关的损伤。

9. 发明申请

US20110137385A1 METHOD AND APPARATUS FOR RELIEVING ANGINA SYMPTOMS USING LIGHT 审中-公开
标题翻译：使用光来消除神经症状的方法和装置
公开(公告)号：US20110137385A1
公开(公告)日：2011-06-09
申请号：US13024975
申请日：2011-02-10
申请人： Tamara Colette Baynham , Darrell O. Wagner , Haris J. Sih
发明人： Tamara Colette Baynham , Darrell O. Wagner , Haris J. Sih
IPC分类号： A61N5/06
CPC分类号： A61F2/82 , A61F2/915 , A61F2002/91575 , A61F2230/0054 , A61F2250/0002 , A61N1/3787 , A61N5/0601 , A61N2005/0602 , A61N2005/0652 , A61N2005/0653
摘要： An implantable medical device includes a light emitting circuit incorporated into an intravascular stent. The light emitting circuit emits a light to an ischemic region. The light has characteristics suitable for reliving the angina symptoms associated with ischemia.
摘要翻译：可植入医疗装置包括并入血管内支架中的发光电路。发光电路将光发射到缺血区域。该光具有适合于重现与缺血相关的心绞痛症状的特征。

10. 发明授权

US07885710B2 Method and apparatus for tissue protection against ischemia using remote conditioning 有权
标题翻译：使用远程调理的组织保护针对缺血的方法和装置
公开(公告)号：US07885710B2
公开(公告)日：2011-02-08
申请号：US11318263
申请日：2005-12-23
申请人： Haris J. Sih , Tamara Colette Baynham , Darrell O. Wagner
发明人： Haris J. Sih , Tamara Colette Baynham , Darrell O. Wagner
IPC分类号： A61N1/372
CPC分类号： A61N1/3627
摘要： A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.
摘要翻译：刺激系统提供刺激以保护身体的缺血区域免于由局部缺血引起的组织损伤。刺激被递送到远离缺血区域的一个或多个刺激部位，以产生保护缺血区域免受缺血引起的组织损伤的生理作用。在一个实施例中，刺激系统将心脏保护刺激递送到远离心脏的一个或多个刺激部位，以保护心脏免于与心脏缺血事件相关的损伤。在另一个实施例中，刺激系统将远程调节刺激递送到心脏中或心脏上的一个或多个刺激部位，以保护非心脏区域免于与非心脏缺血事件相关的损伤。

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