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1. 发明申请

US20070071326A1 System and method for vascular border detection 有权
标题翻译：血管边界检测系统和方法
公开(公告)号：US20070071326A1
公开(公告)日：2007-03-29
申请号：US11449569
申请日：2006-06-08
申请人： Jon Klingensmith , Anuja Nair , Barry Kuban , D. Vince
发明人： Jon Klingensmith , Anuja Nair , Barry Kuban , D. Vince
IPC分类号： G06K9/48 , G06K9/00
CPC分类号： A61B8/12 , A61B5/02007 , A61B8/0858
摘要： A system and method is provided for using the frequency spectrum of a radio frequency (RF) signal backscattered from vascular tissue to identify at least one border (e.g., tissue interface, etc.) on a vascular image. Embodiments of the present invention operate in accordance with a data gathering device (e.g., an intra-vascular ultrasound (IVUS) device, etc.) electrically connected to a computing device and a transducer via a catheter. The transducer is used to gather radio frequency (RF) data backscattered from vascular tissue. The RF data is then provided to (or acquired by) the computing device via the data-gathering device. In one embodiment of the present invention, the computing device includes (i) at least one data storage device (e.g., database, memory, etc.) for storing a plurality of tissue types and parameters related thereto and (ii) at least one application (e.g., a characterization application, a gradient-border application, a frequency-border application and/or an active-contour application). The characterization application is used to convert (or transform) the RF data into the frequency domain and to identify a plurality of parameters associated therewith. The identified parameters are then compared to the parameters stored in the data storage device to identify the corresponding tissue type. This information (e.g., tissue type, corresponding RF data, etc.) is then used, either alone or together with other border-related information (e.g., gradient information, other-border information, etc.), to determine at least one border on a vascular image.
摘要翻译：提供了一种用于使用从血管组织反向散射的射频（RF）信号的频谱来识别血管图像上的至少一个边界（例如，组织界面等）的系统和方法。本发明的实施例根据通过导管电连接到计算设备和换能器的数据采集装置（例如，血管内超声（IVUS）装置等）进行操作。传感器用于收集从血管组织反向散射的射频（RF）数据。然后，RF数据经由数据收集装置提供给计算装置（或者由其获取）。在本发明的一个实施例中，计算设备包括：（i）至少一个数据存储设备（例如，数据库，存储器等），用于存储与之相关的多个组织类型和参数，以及（ii）至少一个应用（例如，表征应用，梯度边界应用，频率边界应用和/或主动轮廓应用）。表征应用用于将RF数据转换（或变换）到频域中并且识别与其相关联的多个参数。然后将识别的参数与存储在数据存储设备中的参数进行比较，以识别相应的组织类型。然后，单独或与其他边界相关信息（例如，梯度信息，其他边界信息等）一起使用该信息（例如，组织类型，对应的RF数据等）以确定至少一个边界在血管图像上。

2. 发明申请

US20050196026A1 System and method for vascular border detection 有权
标题翻译：血管边界检测系统和方法
公开(公告)号：US20050196026A1
公开(公告)日：2005-09-08
申请号：US10837352
申请日：2004-04-29
申请人： Jon Klingensmith , Anuja Nair , Barry Kuban , D. Vince
发明人： Jon Klingensmith , Anuja Nair , Barry Kuban , D. Vince
IPC分类号： A61B8/08 , A61B8/12 , G06K9/00
CPC分类号： A61B8/12 , A61B5/02007 , A61B8/0858
摘要： A system and method is provided for using the frequency spectrum of a radio frequency (RF) signal backscattered from vascular tissue to identify at least one border (e.g., tissue interface, etc.) on a vascular image. Embodiments of the present invention operate in accordance with a data gathering device (e.g., an intra-vascular ultrasound (IVUS) device, etc.) electrically connected to a computing device and a transducer via a catheter. The transducer is used to gather radio frequency (RF) data backscattered from vascular tissue. The RF data is then provided to (or acquired by) the computing device via the data-gathering device. In one embodiment of the present invention, the computing device includes (i) at least one data storage device (e.g., database, memory, etc.) for storing a plurality of tissue types and parameters related thereto and (ii) at least one application (e.g., a characterization application, a gradient-border application, a frequency-border application and/or an active-contour application). The characterization application is used to convert (or transform) the RF data into the frequency domain and to identify a plurality of parameters associated therewith. The identified parameters are then compared to the parameters stored in the data storage device to identify the corresponding tissue type. This information (e.g., tissue type, corresponding RF data, etc.) is then used, either alone or together with other border-related information (e.g., gradient information, other-border information, etc.), to determine at least one border on a vascular image.
摘要翻译：提供了一种用于使用从血管组织反向散射的射频（RF）信号的频谱来识别血管图像上的至少一个边界（例如，组织界面等）的系统和方法。本发明的实施例根据通过导管电连接到计算设备和换能器的数据采集装置（例如，血管内超声（IVUS）装置等）进行操作。传感器用于收集从血管组织反向散射的射频（RF）数据。然后，RF数据经由数据收集装置提供给计算装置（或者由其获取）。在本发明的一个实施例中，计算设备包括（i）至少一个数据存储设备（例如，数据库，存储器等），用于存储与之相关的多个组织类型和参数，以及（ii）至少一个应用（例如，表征应用，梯度边界应用，频率边界应用和/或主动轮廓应用）。特征应用用于将RF数据转换（或变换）到频域中并且识别与其相关联的多个参数。然后将识别的参数与存储在数据存储设备中的参数进行比较，以识别相应的组织类型。然后，单独或与其他边界相关信息（例如，梯度信息，其他边界信息等）一起使用该信息（例如，组织类型，对应的RF数据等）以确定至少一个边界在血管图像上。

3. 发明申请

US20070201736A1 System and method for vascular border detection 审中-公开
标题翻译：血管边界检测系统和方法
公开(公告)号：US20070201736A1
公开(公告)日：2007-08-30
申请号：US11786599
申请日：2007-04-12
申请人： Jon Klingensmith , Anuja Nair , Barry Kuban , D. Vince
发明人： Jon Klingensmith , Anuja Nair , Barry Kuban , D. Vince
IPC分类号： G06K9/00
CPC分类号： A61B8/12 , A61B5/02007 , A61B8/0858
摘要： The present invention uses a radio frequency (RF) signal backscattered from vascular tissue to identify a border on a vascular image. Embodiments of the invention operate in accordance with a data gathering device connected to a computing device and a transducer via a catheter. The transducer is used to gather RF data backscattered from vascular tissue. The RF data is provided to the computing device via the data-gathering device. In one embodiment of the present invention, the computing device includes (i) a data storage device for storing tissue types and related parameters and (ii) an application. The application is used to convert the RF data into the frequency domain and to identify associated parameters. The parameters are compared to the parameters stored in the data storage device to identify the corresponding tissue type. This information is used, possibly with other border-related information, to determine a border on a vascular image.
摘要翻译：本发明使用从血管组织反向散射的射频（RF）信号来识别血管图像上的边界。本发明的实施例根据经由导管连接到计算设备和换能器的数据采集设备进行操作。传感器用于收集从血管组织反向散射的RF数据。 RF数据经由数据收集装置提供给计算装置。在本发明的一个实施例中，计算设备包括（i）用于存储组织类型和相关参数的数据存储设备，以及（ii）应用。该应用程序用于将RF数据转换为频域并识别相关参数。将参数与存储在数据存储设备中的参数进行比较，以识别相应的组织类型。该信息可能与其他与边界有关的信息用于确定血管图像上的边界。

4. 发明申请

US20050154315A1 System and method for determining a transfer function 有权
标题翻译：用于确定传递函数的系统和方法
公开(公告)号：US20050154315A1
公开(公告)日：2005-07-14
申请号：US10758477
申请日：2004-01-14
申请人： Anuja Nair , D. Vince , Jon Klingensmith , Barry Kuban
发明人： Anuja Nair , D. Vince , Jon Klingensmith , Barry Kuban
IPC分类号： A61B8/12 , A61B8/06
CPC分类号： A61B5/02007 , A61B5/726 , A61B8/12
摘要： A system and method is provided for using ultrasound data backscattered from vascular tissue to estimate the transfer function of a catheter (including components attached thereto—e.g., IVUS console, transducer, etc.). Specifically, in accordance with a first embodiment of the present invention, a computing device is electrically connected to a catheter and used to acquire RF backscattered data from a vascular structure (e.g., a blood vessel, etc.). The backscattered ultrasound data is then used, together with an algorithm, to estimate the transfer function. The transfer function can then be used (at least in a preferred embodiment) to calculate response data for the vascular tissue (i.e., the tissue component of the backscattered ultrasound data). In a second embodiment of the present invention, an IVUS console is electrically connected to a catheter and a computing device and is used to acquire RF backscattered data from a vascular structure. The backscattered data is then transmitted to the computing device, where it is used to estimate the catheter's transfer function and to calculate response data for the vascular tissue. The response data and histology data are then used to characterize at least a portion of the vascular tissue (e.g., identify tissue type, etc.).
摘要翻译：提供了一种系统和方法，用于使用从血管组织反向散射的超声数据来估计导管（包括与其连接的部件，例如，IVUS控制台，换能器等）的传递功能。具体地，根据本发明的第一实施例，计算设备电连接到导管并用于从血管结构（例如，血管等）获取RF背散射数据。然后将后向散射的超声数据与算法一起用于估计传递函数。然后可以使用传递函数（至少在一个优选实施例中）来计算血管组织的反应数据（即背散射超声数据的组织分量）。在本发明的第二实施例中，IVUS控制台电连接到导管和计算设备，并用于从血管结构获取RF背散射数据。然后将背散射数据传输到计算设备，其中其用于估计导管的传递函数并计算血管组织的反应数据。然后使用响应数据和组织学数据来表征血管组织的至少一部分（例如，识别组织类型等）。

5. 发明申请

US20070100239A1 System and method for characterizing vascular tissue 有权
标题翻译：用于表征血管组织的系统和方法
公开(公告)号：US20070100239A1
公开(公告)日：2007-05-03
申请号：US11580342
申请日：2006-10-14
申请人： Anuja Nair , Barry Kuban , D. Vince , Jon Klingensmith
发明人： Anuja Nair , Barry Kuban , D. Vince , Jon Klingensmith
IPC分类号： A61B8/00
CPC分类号： A61B8/0891 , A61B5/02007 , A61B5/7203 , A61B5/726 , A61B8/0833 , A61B8/12 , A61B8/4461 , A61B8/4488 , A61B8/461 , A61B8/467 , A61B8/52 , A61B8/5238 , G01S7/5205 , G01S7/52087 , G01S15/8977 , G06F19/00
摘要： A system and method is provided for using ultrasound data backscattered from vascular tissue to estimate the transfer function of a catheter and/or substantially synchronizing the acquisition of blood-vessel data to an identifiable portion of heartbeat data. Specifically, in accordance with a first embodiment of the present invention, a computing device is electrically connected to a catheter and used to acquire RF backscattered data from a vascular structure (e.g., a blood vessel, etc.). The backscattered ultrasound data is then used, together with an algorithm, to estimate at least one transfer function. The transfer function(s) can then be used (at least in a preferred embodiment) to calculate response data for the vascular tissue (i.e., the tissue component of the backscattered ultrasound data). In a second embodiment of the present invention, an IVUS console is electrically connected to a catheter and a computing device and is used to acquire RF backscattered data from a vascular structure. The backscattered data is then transmitted to the computing device, where it is used to estimate the catheter's transfer function and to calculate response data for the vascular tissue. The response data and histology data are then used to characterize at least a portion of the vascular tissue (e.g., identify tissue type, etc.). In a third embodiment of the present invention, a data-gathering device (e.g., an IVUS device, etc.) is electrically connected to a heart-monitoring device (e.g., an EKG device, etc.), which is used to gather heartbeat data from a patient. In accordance with this embodiment of the present invention, the backscattered data is acquired during a cyclical portion of the heartbeat data so that the blood vessel can be analyzed or imaged as if it were standing still, or not expanding and relaxing.
摘要翻译：提供了一种用于使用从血管组织反向散射的超声数据来估计导管的传递功能和/或使血管数据的获取基本上同步到心跳数据的可识别部分的系统和方法。具体地，根据本发明的第一实施例，计算设备电连接到导管并用于从血管结构（例如，血管等）获取RF背散射数据。然后将后向散射超声数据与算法一起用于估计至少一个传递函数。然后可以使用传递函数（至少在一个优选实施例中）来计算血管组织的反应数据（即反向散射超声数据的组织分量）。在本发明的第二实施例中，IVUS控制台电连接到导管和计算设备，并用于从血管结构获取RF背散射数据。然后将背散射数据传输到计算设备，其中其用于估计导管的传递函数并计算血管组织的反应数据。然后使用响应数据和组织学数据来表征血管组织的至少一部分（例如，识别组织类型等）。在本发明的第三实施例中，数据收集装置（例如，IVUS装置等）电连接到用于收集心跳的心脏监测装置（例如，EKG装置等）来自病人的资料根据本发明的该实施例，在心跳数据的循环部分期间获取背散射数据，使得血管可以被分析或成像，就好像静止不动，或者不扩张和放松。

6. 发明申请

US20060253033A1 System and method of characterizing vascular tissue 有权
标题翻译：表征血管组织的系统和方法
公开(公告)号：US20060253033A1
公开(公告)日：2006-11-09
申请号：US11445591
申请日：2006-06-01
申请人： Anuja Nair , D. Vince , Jon Klingensmith , Barry Kuban
发明人： Anuja Nair , D. Vince , Jon Klingensmith , Barry Kuban
IPC分类号： A61B8/14
CPC分类号： A61B8/12 , A61B5/02007 , A61B5/7257 , A61B5/726 , A61B8/0833 , G06T7/0012 , G06T2207/30101
摘要： A system and method is provided for using backscattered data and known parameters to characterize vascular tissue. Specifically, in one embodiment of the present invention, an ultrasonic device is used to acquire RF backscattered data (i.e., IVUS data) from a blood vessel. The IVUS data is then transmitted to a computing device and used to create an IVUS image. The blood vessel is then cross-sectioned and used to identify its tissue type and to create a corresponding image (i.e., histology image). A region of interest (ROI), preferably corresponding to the identified tissue type, is then identified on the histology image. The computing device, or more particularly, a characterization application operating thereon, is then adapted to identify a corresponding region on the IVUS image. To accurately match the ROI, however, it may be necessary to warp or morph the histology image to substantially fit the contour of the IVUS image. After the corresponding region is identified, the IVUS data that corresponds to this region is identified. Signal processing is then performed and at least one parameter is identified. The identified parameter and the tissue type (e.g., characterization data) is stored in a database. In another embodiment of the present invention, the characterization application is adapted to receive IVUS data, determine parameters related thereto (either directly or indirectly), and use the parameters stored in the database to identify a tissue type or a characterization thereof.
摘要翻译：提供了一种使用背散射数据和已知参数来表征血管组织的系统和方法。具体地，在本发明的一个实施例中，使用超声波装置从血管获取RF背散射数据（即，IVUS数据）。然后将IVUS数据传输到计算设备并用于创建IVUS图像。然后将血管切片并用于识别其组织类型并产生相应的图像（即，组织学图像）。然后在组织学图像上识别优选对应于所识别的组织类型的感兴趣区域（ROI）。然后，计算设备，或更具体地，在其上操作的表征应用程序适用于识别IVUS图像上的对应区域。然而，为了精确地匹配ROI，可能需要使组织学图像变形或变形以基本上适合IVUS图像的轮廓。识别对应区域后，识别与该区域对应的IVUS数据。然后执行信号处理，并且识别至少一个参数。所识别的参数和组织类型（例如表征数据）被存储在数据库中。在本发明的另一个实施例中，表征应用适于接收IVUS数据，确定与其相关的参数（直接或间接），并且使用存储在数据库中的参数来识别组织类型或其表征。

7. 发明申请

US20060241487A1 System and method of characterizing vascular tissue 有权
公开(公告)号：US20060241487A1
公开(公告)日：2006-10-26
申请号：US11445782
申请日：2006-06-01
申请人： Anuja Nair , D. Vince , Jon Klingonamith , Barry Kuban
发明人： Anuja Nair , D. Vince , Jon Klingonamith , Barry Kuban
IPC分类号： A61B8/14
CPC分类号： A61B8/12 , A61B5/02007 , A61B5/7257 , A61B5/726 , A61B8/0833 , G06T7/0012 , G06T2207/30101
摘要： A system and method is provided for using backscattered data and known parameters to characterize vascular tissue. Specifically, in one embodiment of the present invention, an ultrasonic device is used to acquire RF backscattered data (i.e., IVUS data) from a blood vessel. The IVUS data is then transmitted to a computing device and used to create an IVUS image. The blood vessel is then cross-sectioned and used to identify its tissue type and to create a corresponding image (i.e., histology image). A region of interest (ROI), preferably corresponding to the identified tissue type, is then identified on the histology image. The computing device, or more particularly, a characterization application operating thereon, is then adapted to identify a corresponding region on the IVUS image. To accurately match the ROI, however, it may be necessary to warp or morph the histology image to substantially fit the contour of the IVUS image. After the corresponding region is identified, the IVUS data that corresponds to this region is identified. Signal processing is then performed and at least one parameter is identified. The identified parameter and the tissue type (e.g., characterization data) is stored in a database. In another embodiment of the present invention, the characterization application is adapted to receive IVUS data, determine parameters related thereto (either directly or indirectly), and use the parameters stored in the database to identify a tissue type or a characterization thereof.

8. 发明申请

US20140172087A1 METHOD FOR PHYSIOLOGIC CONTROL OF A CONTINUOUS FLOW TOTAL ARTIFICIAL HEART 有权
标题翻译：连续流量人造心脏生理控制方法
公开(公告)号：US20140172087A1
公开(公告)日：2014-06-19
申请号：US14187615
申请日：2014-02-24
申请人： David Horvath , Alex Massiello , Leonard A. R. Golding , Barry Kuban
发明人： David Horvath , Alex Massiello , Leonard A. R. Golding , Barry Kuban
IPC分类号： A61M1/10 , F04D15/00
CPC分类号： A61M1/1001 , A61M1/1005 , A61M1/101 , A61M1/1031 , A61M1/1086 , A61M1/12 , A61M2205/3334 , F04D15/0066
摘要： A method is provided of controlling a pump including a electrical motor coupled to a rotor which carries first and second impellers at opposite ends thereof. The method includes: (a) driving the rotor using the motor, so as to circulate fluid from the first impeller through a first fluid circuit, the second impeller, a second fluid circuit, and back to the first impeller; (b) determining a resistance of the first fluid circuit, based on a first motor parameter which is a function of electrical power delivered to the motor; (c) determining a flow rate through the first fluid circuit based on a second motor parameter which is a function of electrical power delivered to the motor; and (d) varying at least one operational parameter of the pump so as to maintain a predetermined relationship between the flow rate and the resistance of the first fluid circuit.
摘要翻译：提供了一种控制泵的方法，该泵包括耦合到转子的电动机，该转子在其相对端承载第一和第二叶轮。该方法包括：（a）使用电动机驱动转子，以使来自第一叶轮的流体通过第一流体回路，第二叶轮，第二流体回路循环到第一叶轮; （b）基于作为传送到电动机的电功率的函数的第一电动机参数来确定第一流体回路的电阻; （c）基于作为传送到所述电动机的电功率的函数的第二电动机参数来确定通过所述第一流体回路的流量; 以及（d）改变所述泵的至少一个操作参数，以便保持所述第一流体回路的流量和所述阻力之间的预定关系。

9. 发明授权

US08657874B2 Method for physiologic control of a continuous flow total artificial heart 有权
标题翻译：连续流总人造心脏生理控制方法
公开(公告)号：US08657874B2
公开(公告)日：2014-02-25
申请号：US12349658
申请日：2009-01-07
申请人： David Horvath , Alex Massiello , Leonard A. R. Golding , Barry Kuban
发明人： David Horvath , Alex Massiello , Leonard A. R. Golding , Barry Kuban
IPC分类号： A61M1/10
CPC分类号： A61M1/1001 , A61M1/1005 , A61M1/101 , A61M1/1031 , A61M1/1086 , A61M1/12 , A61M2205/3334 , F04D15/0066
摘要： A method is provided of controlling a pump including a electrical motor coupled to a rotor which carries first and second impellers at opposite ends thereof. The method includes: (a) driving the rotor using the motor, so as to circulate fluid from the first impeller through a first fluid circuit, the second impeller, a second fluid circuit, and back to the first impeller; (b) determining a resistance of the first fluid circuit, based on a first motor parameter; (c) determining a flow rate through the first fluid circuit based on a second motor parameter; and (d) varying at least one operational parameter of the pump so as to maintain a predetermined relationship between the flow rate and the resistance of the first fluid circuit.
摘要翻译：提供了一种控制泵的方法，该泵包括耦合到转子的电动机，该转子在其相对端承载第一和第二叶轮。该方法包括：（a）使用电动机驱动转子，以使来自第一叶轮的流体通过第一流体回路，第二叶轮，第二流体回路循环到第一叶轮; （b）基于第一电动机参数确定第一流体回路的电阻; （c）基于第二电动机参数确定通过第一流体回路的流量; 以及（d）改变所述泵的至少一个操作参数，以便保持所述第一流体回路的流量和所述阻力之间的预定关系。

10. 发明授权

US09821098B2 Method for physiologic control of a continuous flow total artificial heart 有权
公开(公告)号：US09821098B2
公开(公告)日：2017-11-21
申请号：US14187615
申请日：2014-02-24
申请人： David Horvath , Alex Massiello , Leonard A. R. Golding , Barry Kuban
发明人： David Horvath , Alex Massiello , Leonard A. R. Golding , Barry Kuban
IPC分类号： A61M1/10 , F04D15/00 , A61M1/12
CPC分类号： A61M1/1001 , A61M1/1005 , A61M1/101 , A61M1/1031 , A61M1/1086 , A61M1/12 , A61M2205/3334 , F04D15/0066
摘要： A method is provided of controlling a pump including a electrical motor coupled to a rotor which carries first and second impellers at opposite ends thereof. The method includes: (a) driving the rotor using the motor, so as to circulate fluid from the first impeller through a first fluid circuit, the second impeller, a second fluid circuit, and back to the first impeller; (b) determining a resistance of the first fluid circuit, based on a first motor parameter which is a function of electrical power delivered to the motor; (c) determining a flow rate through the first fluid circuit based on a second motor parameter which is a function of electrical power delivered to the motor; and (d) varying at least one operational parameter of the pump so as to maintain a predetermined relationship between the flow rate and the resistance of the first fluid circuit.

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