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1. 发明授权

US5169842A Oligophosphates with an antiviral action 失效
标题翻译：具有抗病毒作用的寡糖
公开(公告)号：US5169842A
公开(公告)日：1992-12-08
申请号：US697870
申请日：1991-05-09
申请人： Antonius Lobberding , Axel C. Heitmann , Burkhard Mielke , Udo Stropp , Axel Kretschmer , Helga Rubsamen-Waigmann , Lothar Biesert , Haryadi Suhartono
发明人： Antonius Lobberding , Axel C. Heitmann , Burkhard Mielke , Udo Stropp , Axel Kretschmer , Helga Rubsamen-Waigmann , Lothar Biesert , Haryadi Suhartono
IPC分类号： A61K31/66 , A61K31/665 , A61K31/675 , A61K47/48 , A61P31/12 , C07F9/09 , C07F9/165 , C07F9/6558 , C08G79/02
CPC分类号： C08G79/02
摘要： Novel oligophosphates with an antiviral action of the formula ##STR1## in which n is 3-50,B and E are, independently of one another, O, S or NH,A is O, NR or S,D is O, S or NR.sub.2, in which independently each R is H, alkyl, aralkyl or aryl,andX is --(CH.sub.2).sub.m --, ##STR2##
摘要翻译：具有式（1）的抗病毒作用的新型寡磷酸酯，其中n为3-50，B和E彼此独立地为O，S或NH，A为O，NR或S，D为O ，S或NR 2，其中独立地各R是H，烷基，芳烷基或芳基，X是 - （CH 2）m - ，

2. 发明授权

US5583035A HIV antisense expression vectors 失效
标题翻译： HIV反义表达载体
公开(公告)号：US5583035A
公开(公告)日：1996-12-10
申请号：US338355
申请日：1994-11-14
申请人： Axel Kretschmer , Horst-Peter Antonicek , Jorg Baumgarten , Antonius Loebberding , Burkhard Mielke , Wolfgang Springer , Udo Stropp , Mark-Michael Struck , Lothar Biesert , Helga Rubsamen-Waigmann , Hary Suhartono , Thomas-Peter Hausner
发明人： Axel Kretschmer , Horst-Peter Antonicek , Jorg Baumgarten , Antonius Loebberding , Burkhard Mielke , Wolfgang Springer , Udo Stropp , Mark-Michael Struck , Lothar Biesert , Helga Rubsamen-Waigmann , Hary Suhartono , Thomas-Peter Hausner
IPC分类号： C12N15/113 , C12H5/22 , C12H15/85
CPC分类号： C12N15/1132 , C12N2310/111 , C12N2799/021
摘要： The present invention relates to the targeted blocking of the genetic information of the viral messenger ribonucleic acid (mRNA) for virus replication (e.g. of HIV) in transfected, haematopoietic cells with particularly suitable expression systems, which express a complementary "antisense RNA".
摘要翻译：本发明涉及具有表达互补的“反义RNA”的特别合适的表达系统的转染的造血细胞中用于病毒复制的病毒信使核糖核酸（mRNA）的遗传信息的靶向阻断。

3. 发明授权

US5849893A Nucleic acid-binding oligomers possessing C-branching for therapy and diagnostics 失效
标题翻译：具有C支化的核酸结合寡聚体用于治疗和诊断
公开(公告)号：US5849893A
公开(公告)日：1998-12-15
申请号：US719048
申请日：1996-09-24
申请人： Antonius Lobberding , Burkhard Mielke , Christoph Schwemler , Eckhard Schwenner , Udo Stropp , Wolfgang Springer , Axel Kretschmer , Thorsten Potter
发明人： Antonius Lobberding , Burkhard Mielke , Christoph Schwemler , Eckhard Schwenner , Udo Stropp , Wolfgang Springer , Axel Kretschmer , Thorsten Potter
IPC分类号： C12N15/09 , A61K31/40 , A61K31/495 , A61K31/505 , A61K38/00 , A61K38/10 , A61P31/12 , C07C271/22 , C07C309/66 , C07D207/16 , C07D239/46 , C07D239/47 , C07D239/54 , C07D403/04 , C07D403/12 , C07D473/18 , C07D473/30 , C07D473/34 , C07K5/00 , C07K5/062 , C07K5/078 , C07K5/097 , C07K5/117 , C07K7/06 , C07K7/08 , C07K14/00 , C07H21/04
CPC分类号： C07D239/47 , C07C309/66 , C07D239/54 , C07D403/04 , C07K14/003 , C07K7/06 , C07K7/08 , A61K38/00
摘要： The invention relates to nucleic acid-binding oligomers possessing C-branching of the general formula (I) ##STR1## and to the corresponding monomers, whose radicals have the meaning given in the description, and to their use as medicaments or diagnostic aids.
摘要翻译：本发明涉及具有通式（I）C支化的核酸结合低聚物（I）和相应的单体，其基团具有说明书中给出的含义，以及它们作为药物或诊断用途艾滋病。

4. 发明授权

US5623049A Nucleic acid-binding oligomers possessing N-branching for therapy and diagnostics 失效
标题翻译：具有N-支化用于治疗和诊断的核酸结合寡聚体
公开(公告)号：US5623049A
公开(公告)日：1997-04-22
申请号：US300884
申请日：1994-09-06
申请人： Antonius L obberding , Burkhard Mielke , Christoph Schwemler , Eckhard Schwenner , Udo Stropp , Wolfgang Springer , Axel Kretschmer , Thorsten P otter
发明人： Antonius L obberding , Burkhard Mielke , Christoph Schwemler , Eckhard Schwenner , Udo Stropp , Wolfgang Springer , Axel Kretschmer , Thorsten P otter
IPC分类号： C07D239/47 , A61K31/195 , A61K31/40 , A61K31/401 , A61K38/00 , A61K38/10 , A61P31/12 , C07D239/54 , C07D403/06 , C07D403/12 , C07D473/18 , C07D473/30 , C07D473/34 , C07K5/00 , C07K5/06 , C07K5/062 , C07K7/06 , C07K14/00 , C07K19/00 , C07K7/00 , C07D239/00 , C07H5/04 , C07H21/04
CPC分类号： C07D239/54 , C07D403/06 , C07D473/18 , C07D473/30 , C07D473/34 , C07K14/003 , C07K5/06026 , A61K38/00
摘要： The invention relates to nucleic acid-binding oligomers possessing N-branching of the general formula (I), ##STR1## and their monomers, where the individual radicals have the meaning given in the description, and to their use as medicaments or as aids in diagnostics.
摘要翻译：本发明涉及具有通式（I）的N-支化的核酸结合寡聚体及其单体，其中各个基团具有说明书中给出的含义，以及它们作为药物或作为诊断的辅助工具。

5. 发明授权

US5955571A Nucleic acid-binding oligomers for therapy and diagnosis 失效
标题翻译：用于治疗和诊断的核酸结合寡聚体
公开(公告)号：US5955571A
公开(公告)日：1999-09-21
申请号：US509913
申请日：1995-08-01
申请人： Christoph Schwemler , Thorsten Potter , Burkhard Mielke , Eckhard Schwenner , Axel Kretschmer , Udo Stropp , Winfried Kosch , Hansjorg Durr
发明人： Christoph Schwemler , Thorsten Potter , Burkhard Mielke , Eckhard Schwenner , Axel Kretschmer , Udo Stropp , Winfried Kosch , Hansjorg Durr
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P31/12 , C07K5/02 , C07K14/00 , C12Q1/68 , C07K5/00
CPC分类号： C07K14/003 , A61K38/00
摘要： The present invention relates to compounds of the general formula (I), ##STR1## in which the radicals have the meaning given in the description, to processes for their preparation and to their use as medicaments.
摘要翻译：本发明涉及通式（I）的化合物，其中基团具有说明书中给出的含义，其制备方法及其作为药物的用途。

6. 发明申请

US20110166838A1 ALGORITHMS FOR OUTCOME PREDICTION IN PATIENTS WITH NODE-POSITIVE CHEMOTHERAPY-TREATED BREAST CANCER 审中-公开
标题翻译：患有结直肠癌治疗乳腺癌的患者的预后预测方法
公开(公告)号：US20110166838A1
公开(公告)日：2011-07-07
申请号：US12999522
申请日：2009-06-16
申请人： Mathias Gehrmann , Ralf Kronenwett , Udo Stropp , Christian Von Törne , Karsten Weber
发明人： Mathias Gehrmann , Ralf Kronenwett , Udo Stropp , Christian Von Törne , Karsten Weber
IPC分类号： G06F7/60
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G16B20/00 , G16B25/00 , G16B40/00
摘要： The invention relates to methods for predicting an outcome of cancer in a patient suffering from cancer, said patient having been previously diagnosed as node positive and treated with cytotoxic chemotherapy, said method comprising determining in a biological sample from said patient an expression level of a plurality of genes selected from the group consisting of ACTG1, CAl2, CALM2, CCND1, CHPT1, CLEC2B, CTSB, CXCL13, DCN, DHRS2, EIF4B, ERBB2, ESR1, FBXO28, GABRP, GAPDH, H2AFZ, IGFBP3, IGHG1, IGKC, KCTD3, KIAA0101, KRT17, MLPH, MMP1, NAT1, NEK2, NR2F2, OAZ1, PCNA, PDLIM5, PGR, PPIA, PRC1, RACGAP1, RPL37A, SOX4, TOP2A, UBE2C and VEGF; ABCB1, ABCG2, ADAM15, AKR1C1, AKR1C3, AKT1, BANF1, BCL2, BIRC5, BRMS1, CASP10, CCNE2, CENPJ, CHPT1, EGFR, CTTN, ERBB3, ERBB4, FBLN1, FIP1L1, FLT1, FLT4, FNTA, GATA3, GSTP1, Herstatin, IGF1R, IGHM, KDR, KIT, CKRT5, SLC39A6, MAPK3, MAPT, MKI67, MMP7, MTA1, FRAP1, MUC1, MYC, NCOA3, NFIB, OLFM1, TP53, PCNA, PI3K, PPERLD1, RAB31, RAD54B, RAF1, SCUBE2, STAU, TINF2, TMSL8, VGLL1, TRA@, TUBA1, TUBB, TUBB2A.
摘要翻译：本发明涉及用于预测患有癌症的患者的癌症结果的方法，所述患者先前被诊断为淋巴结阳性并用细胞毒性化疗治疗，所述方法包括在来自所述患者的生物样品中确定多个表达水平选自ACTG1，CA2，CALM2，CCND1，CHPT1，CLEC2B，CTSB，CXCL13，DCN，DHRS2，EIF4B，ERBB2，ESR1，FBXO28，GABRP，GAPDH，H2AFZ，IGFBP3，IGHG1，IGKC，KCTD3， KIAA0101，KRT17，MLPH，MMP1，NAT1，NEK2，NR2F2，OAZ1，PCNA，PDLIM5，PGR，PPIA，PRC1，RACGAP1，RPL37A，SOX4，TOP2A，UBE2C和VEGF; ABCB1，ABCG2，ADAM15，AKR1C1，AKR1C3，AKT1，BANF1，BCL2，BIRC5，BRMS1，CASP10，CCNE2，CENPJ，CHPT1，EGFR，CTTN，ERBB3，ERBB4，FBLN1，FIP1L1，FLT1，FLT4，FNTA，GATA3，GSTP1， Herbatin，IGF1R，IGHM，KDR，KIT，CKRT5，SLC39A6，MAPK3，MAPT，MKI67，MMP7，MTA1，FRAP1，MUC1，MYC，NCOA3，NFIB，OLFM1，TP53，PCNA，PI3K，PPERLD1，RAB31，RAD54B，RAF1， SCUBE2，STAU，TINF2，TMSL8，VGLL1，TRA @，TUBA1，TUBB，TUBB2A。

7. 发明申请

US20110172928A1 MOLECULAR MARKERS FOR CANCER PROGNOSIS 审中-公开
标题翻译：癌症预防分子标记
公开(公告)号：US20110172928A1
公开(公告)日：2011-07-14
申请号：US12999406
申请日：2009-06-16
申请人： Mathias Gehrmann , Udo Stropp , Karsten Weber , Christian Von Törne , Marcus Schmidt
发明人： Mathias Gehrmann , Udo Stropp , Karsten Weber , Christian Von Törne , Marcus Schmidt
IPC分类号： G06F19/00
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G16B20/00 , G16B25/00 , G16B40/00
摘要： The present invention relates to methods for prediction of an outcome of neoplastic disease or cancer. More specifically, the present invention relates to a method for the prediction of breast cancer by determining in a biological sample from said patient an expression level of a plurality of genes selected from the group consisting of ACTG1, CA12, CALM2, CCND1, CHPT1, CLEC2B, CTSB, CXCL13, DCN, DHRS2, EIF4B, ERBB2, ESR1, FBXO28, GABRP, GAPDH, H2AFZ, IGFBP3, IGHG1, IGKC, KCTD3, KIAA0101, KRT17, MLPH, MMP1, NAT1, NEK2, NR2F2, OAZ1, PCNA, PDLIM5, PGR, PPIA, PRC1, RACGAP1, RPL37A, SOX4, TOP2A, UBE2C and VEGF.
摘要翻译：本发明涉及用于预测肿瘤性疾病或癌症的结果的方法。更具体地，本发明涉及通过在来自所述患者的生物样品中测定多种选自ACTG1，CA12，CALM2，CCND1，CHPT1，CLEC2B的多种基因的表达水平来预测乳腺癌的方法，CTSB，CXCL13，DCN，DHRS2，EIF4B，ERBB2，ESR1，FBXO28，GABRP，GAPDH，H2AFZ，IGFBP3，IGHG1，IGKC，KCTD3，KIAA0101，KRT17，MLPH，MMP1，NAT1，NEK2，NR2F2，OAZ1，PCNA，PDLIM5 ，PGR，PPIA，PRC1，RACGAP1，RPL37A，SOX4，TOP2A，UBE2C和VEGF。

8. 发明申请

US20110166845A1 METHOD FOR THE QUALITY ASSESSMENT OF NUCLEIC ACID AMPLIFICATION REACTIONS 审中-公开
标题翻译：核酸扩增反应质量评估方法
公开(公告)号：US20110166845A1
公开(公告)日：2011-07-07
申请号：US13061797
申请日：2009-07-16
申请人： Christian Von Törne , Mareike Assink , Udo Stropp
发明人： Christian Von Törne , Mareike Assink , Udo Stropp
IPC分类号： G06G7/58
CPC分类号： C12Q1/6851 , G16B40/00 , C12Q2537/165
摘要： The invention relates to a method for the quality assessment of nucleic acid amplification reactions which is based on a mathematical approach for the quality assessment of complete nucleic acid amplification reactions and comprises the following steps: a) Carrying out an amplification reaction for at least one nucleic acid target molecule, b)Collecting time-related data reflecting the course of the amplification reaction, c) Fitting these time-related data with a growth model equation comprising at least one parameter, d) Obtaining, from said fitting process, at least one value for the at least one parameter.
摘要翻译：本发明涉及一种核酸扩增反应质量评估方法，该方法基于完整核酸扩增反应的质量评估的数学方法，包括以下步骤：a）对至少一个核酸进行扩增反应酸性靶分子，b）收集反映扩增反应过程的时间相关数据，c）使用包含至少一个参数的生长模型方程拟合这些时间相关数据，d）从所述拟合过程获得至少一个至少一个参数的值。

9. 发明申请

US20090197246A1 Haplotypes and polymorphisms linked to human thiopurine s-methyltransferase deficiencies 审中-公开
标题翻译：单倍型和与人类硫嘌呤S-甲基转移酶缺陷相关的多态性
公开(公告)号：US20090197246A1
公开(公告)日：2009-08-06
申请号：US10585474
申请日：2005-01-07
申请人： Udo Stropp
发明人： Udo Stropp
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12N9/1007 , C12Q1/6886 , C12Q2600/106 , C12Q2600/16 , C12Q2600/172
摘要： Haplotypes and polymorphisms of thiopurine S-methyltransferase (TPMT) are described that are linked to TPMT deficiencies which can cause potentially fatal toxicity when patients are treated with thiopurines like mercaptopurine, azathioprine, or thioguanine. The mutant alleles as well as PCR fragments, kits and methods for assaying the TPMT genotype of individual patients are disclosed. Furthermore, algorithms are disclosed that combine the genotypes of a set of single nucleotide polymorphisms to haplotypes that give a distinct information about the TPMT phenotype.
摘要翻译：描述了硫代嘌呤S-甲基转移酶（TPMT）的单倍型和多态性，其与TPMT缺陷相关，当患者用硫嘌呤如巯基嘌呤，硫唑嘌呤或硫鸟嘌呤治疗时，可引起潜在的致命毒性。公开了突变等位基因以及用于测定个体患者的TPMT基因型的PCR片段，试剂盒和方法。此外，公开了将一组单核苷酸多态性的基因型与单倍型组合的算法，其给出了关于TPMT表型的不同信息。

10. 发明申请

US20070128597A1 Single nucleotide polymorphisms sensitively predicting adverse drug reactions (adr) and drug efficacy 审中-公开
标题翻译：单核苷酸多态性敏感地预测不良药物反应（adr）和药物功效
公开(公告)号：US20070128597A1
公开(公告)日：2007-06-07
申请号：US10525278
申请日：2003-08-18
申请人： Stephan Schwers , Harald Kallabis , Udo Stropp
发明人： Stephan Schwers , Harald Kallabis , Udo Stropp
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , G01N33/6893 , G01N2800/32 , G01N2800/52
摘要： Single Nucleotide Polymorphisms sensitively predicting Advserse Drug Reactions (ADR) and Drug Efficacy Abs tract. The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad metabolizer of statins. The invention provides further diagnostic methods and kits including antibodies determining whether a human subject is at risk for a cardiovascular disease. Still further the invention provides polymorphic sequences and other genes. The present invention further relates to isolated polynucleotides encoding a phenotype associated (PA) gene polypeptide useful in methods to identify therapeutic agents and useful for preparation of a medicament to treat cardiovascular disease or influence drug response, the polynucleotide is selected from the group comprising: SEQ ID 1-168 with allelic variation as indicated in the sequences section contained in a functional surrounding like full length cDNA for PA gene polypeptide and with or without the PA gene promoter sequence.
摘要翻译：单核苷酸多态性灵敏预测Advancese药物反应（ADR）和药物功效性Abs。本发明提供了包括寡核苷酸和/或多核苷酸或衍生物的诊断方法和试剂盒，包括确定人类受试者在他汀类药物治疗后是否有获得不良药物反应风险的抗体，还是人类受试者是高反应者还是低反应者他汀类药物或代谢物。本发明提供了进一步的诊断方法和试剂盒，包括确定人受试者是否处于心血管疾病风险的抗体。本发明还提供了多态序列和其他基因。本发明还涉及编码可用于鉴定治疗剂并用于制备治疗心血管疾病或影响药物应答的药物的方法中的表型相关（PA）基因多肽的分离的多核苷酸，所述多核苷酸选自SEQ ID NO： ID 1-168，其具有如包含在功能性周围的序列部分中所示的等位基因变异，如PA基因多肽的全长cDNA并具有或不具有PA基因启动子序列。

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