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1. 发明申请

US20110312934A1 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF 审中-公开
标题翻译： 2-氨基-6-环丙氨基-3-（吡啶-4-基）咪唑并[1,2-B] - 吡啶衍生物，其制备方法及其治疗应用
公开(公告)号：US20110312934A1
公开(公告)日：2011-12-22
申请号：US13058665
申请日：2009-08-12
申请人： Antonio Almario Garcia , Philippe Burnier , Sylvain Cote-Des Combes , Jean-François Gibert , Christophe Pacaud , Frédéric Puech , Yulin Chiang , Larry Davis , Zhongli Gao , Qiuxia Zhao
发明人： Antonio Almario Garcia , Philippe Burnier , Sylvain Cote-Des Combes , Jean-François Gibert , Christophe Pacaud , Frédéric Puech , Yulin Chiang , Larry Davis , Zhongli Gao , Qiuxia Zhao
IPC分类号： A61K31/551 , C07D498/10 , C07D471/08 , A61P25/30 , A61K31/5386 , A61P35/00 , A61P25/00 , C07D487/04 , A61K31/5025
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention relates to 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives of the general formula (I) where: R2 is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, C1-4-alkyloxy-C-M-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl>C3-7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-4-fluoroalkyl group; R3 is a hydrogen atom or a substituent selected from halogen atoms and the C1-3 alkyl, —NR4R5, hydroxyl or C1-4 alkyloxy groups; A is a C1-7-alkylene group optionally substituted by one or two Ra groups; B is a C1-7-alkylene group optionally substituted by one or two Rb groups; L is either a nitrogen atom optionally substituted by an Rc or Rd group or a carbon atom substituted by an Re1 group and an Rd group or by two Re2 groups; Rd is a group selected from a hydrogen atom or a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkylthio-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C1-6-fluoroalkyl, hydroxy-C1-6-alkyl group; Rf is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl, C3-7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-allyl, C1-6-fluoroalkyl or benzyl group. The invention also relates to a method for preparing same and to the therapeutic application thereof.
摘要翻译：本发明涉及通式（I）的2-烷基-6-环氨基-3-（吡啶-4-基）咪唑并[1,2-b]哒嗪衍生物，其中：R2是C1-6烷基，C3 7-环烷基，C 3-7 - 环烷基-C 1-4 - 烷基，C 1-4 - 烷氧基-C1-烷基，C 3-7 - 环烷氧基-C 1-4 - 烷基，C 3-7 - 环烷基-C 1-4 - 烷氧基 C 1-4烷基，羟基-C 1-6 - 烷基，C 1-4 - 氟代烷基; R3是氢原子或选自卤素原子和C1-3烷基，-NR4R5，羟基或C1-4烷氧基的取代基; A是任选被一个或两个R a基团取代的C 1-7 - 亚烷基; B是任选被一个或两个Rb基团取代的C 1-7 - 亚烷基; L是任选被Rc或Rd基团取代的氮原子或被Re 1基团和Rd基团取代的碳原子或两个Re 2基团; Rd是选自氢原子或C 1-6 - 烷基，C 3-7 - 环烷基，C 3-7 - 环烷基-C 1-6 - 烷基，C 1-6 - 烷硫基-C 1-6 - 烷基，C 1-6 - 烷氧基-C 1-6 - 烷基，C 1-6 - 氟代烷基，羟基-C 1-6 - 烷基; R f是C 1-6 - 烷基，C 3-7 - 环烷基，C 3-7 - 环烷基-C 1-6 - 烷基，C 1-6 - 烷氧基-C 1-6 - 烷基，C 3-7 - 环烷氧基-C 1-4 - 烷基 C 3-7 - 环烷基-C 1-4 - 烷氧基-C 1-4 - 烷基，羟基-C 1-6 - 烯丙基，C 1-6 - 氟烷基或苄基。本发明还涉及其制备方法及其治疗应用。

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