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1. 发明授权

US07378413B2 2-amino-3-(alkyl)-pyrimidone derivatives 失效
标题翻译： 2-氨基-3-（烷基） - 嘧啶酮衍生物
公开(公告)号：US07378413B2
公开(公告)日：2008-05-27
申请号：US11035264
申请日：2005-01-13
申请人： Antonio Almario Carcia , Ryoichi Ando , Keiichi Arimoto , Fumiaki Uehara , Adrien Tak Li , Aya Shoda , Jonathan Reid Frost , Kazutoshi Watanabe
发明人： Antonio Almario Carcia , Ryoichi Ando , Keiichi Arimoto , Fumiaki Uehara , Adrien Tak Li , Aya Shoda , Jonathan Reid Frost , Kazutoshi Watanabe
IPC分类号： A61K31/505 , C07D401/04
CPC分类号： A61K31/505 , C07D401/04 , C07D401/14 , C07D409/14
摘要： A pyrimidone derivative represented by formula (I) or a salt thereof: Wherein: R1 represents a hydrogen atom or a C1-6 alkyl group which may be substituted by a C6,10 aryl group; R2 represents a C1-10 alkyl group which may be substituted, a C2-6 alkenyl group which may be substituted, a C3-6 alkynyl group which may be substituted, a C3-6 cycloalkyl group which may be substituted, or a C6-10 ARYL group which may be substituted; or R1 and R2 form together a C2-6 alkylene group which may be substituted; or R1 and R2 form together a chain of formula —(CH2)2—X—(CH2)2— or —(CH2)2—X—(CH2)3— where X represents a oxygen atom, a sulfur atom, or a nitrogen atom which may be substituted; R3 represents a 2, 3 or 4-pyridyl group optionally substituted by a C1-4 alkyl group, C1-4 alkoxy group or halogen atom; and R4 represents a C1-10 alkyl group optionally substituted by a hydroxyl group, amino, C1-6 monoalkylamino group, C2-12 dialkylamino group or C6,10 aryl group which may be substituted. And a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β such as Alzheimer's disease.
摘要翻译：由式（I）表示的嘧啶酮衍生物或其盐：其中R1表示氢原子或可以被C 6-10取代的C 1-6烷基， / SUB>芳基; R 2表示可以被取代的C 1-10烷基，可以被取代的C 2-6亚烷基，C 3-6亚烷基，可以被取代的亚炔基，可被取代的C 3-6亚烷基或可以被取代的C 6〜6-亚芳基; 或者R 1和R 2一起形成可以被取代的C 2-6亚烷基; 或者R 1和R 2一起形成式 - （CH 2 CH 2）2 - （CH 2）2 - 或 - （CH 2）2 -X-（CH 2）3 - - 其中X表示氧原子，硫原子或可被取代的氮原子; R 3表示任选被C 1-4烷基，C 1-4烷氧基或卤素原子取代的2,3或4-吡啶基; 并且R 4表示任选被羟基，氨基，C 1-6 - 单烷基氨基，C 2-12-12任意取代的C 1-10烷基。 >可以被取代的二烷基氨基或C 6,10 芳基。以及包含所述衍生物或其盐作为活性成分的药物，其用于由GSK3β如阿尔茨海默氏病的异常活性引起的神经变性疾病的预防和/或治疗性治疗。

2. 发明授权

US06844335B2 2-amino-3-(alkyl)-pyrimidone derivatives as GSK3.β.inhibitors 失效
标题翻译： 2-氨基-3-（烷基） - 嘧啶酮衍生物作为GSK3.beta.抑制剂
公开(公告)号：US06844335B2
公开(公告)日：2005-01-18
申请号：US10221598
申请日：2001-03-22
申请人： Antonio Almario Garcia , Ryoichi Ando , Keiichi Arimoto , Fumiaki Uehara , Adrien Tak Li , Aya Shoda , Jonathan Reid Frost , Kazutoshi Watanabe
发明人： Antonio Almario Garcia , Ryoichi Ando , Keiichi Arimoto , Fumiaki Uehara , Adrien Tak Li , Aya Shoda , Jonathan Reid Frost , Kazutoshi Watanabe
IPC分类号： A61K31/505 , A61K31/506 , A61P3/04 , A61P3/10 , A61P5/00 , A61P9/00 , A61P11/00 , A61P15/00 , A61P17/02 , A61P17/14 , A61P19/00 , A61P25/00 , A61P25/02 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , A61P27/02 , A61P27/06 , A61P31/12 , A61P35/00 , A61P35/02 , A61P43/00 , C07D401/04 , C07D401/14 , C07D409/14
CPC分类号： A61K31/505 , C07D401/04 , C07D401/14 , C07D409/14
摘要： A pyrimidone derivative represented by formula (I) or a salt thereof: Wherein: R1 represents a hydrogen atom or a C1-6 alkyl group which may be substituted by a C6,10 aryl group; R2 represents a C1-10 alkyl group which may be substituted, a C2-6 alkenyl group which may be substituted, a C3-6 alkynyl group which may be substituted, a C3-6 cycloalkyl group which may be substituted, or a C6-10 ARYL group which may be substituted; or R1 and R2 form together a C2-6 alkylene group which may be substituted; or R1 and R2 form together a chain of formula —(CH2)2—X—(CH2)2— or —(CH2)2—X—(CH2)3— where X represents a oxygen atom, a sulfur atom, or a nitrogen atom which may be substituted; R3 represents a 2, 3 or 4-pyridyl group optionally substituted by a C1-4 alkyl group, C1-4 alkoxy group or halogen atom; and R4 represents a C1-10 alkyl group optionally substituted by a hydroxyl group, amino, C1-6 monoalkylamino group, C2-12 dialkylamino group or C6,10 aryl group which may be substituted. And a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β such as Alzheimer's disease.
摘要翻译：由式（I）表示的嘧啶酮衍生物或其盐：其中：R1表示氢原子或可被C6,10芳基取代的C1-6烷基; R2表示可以被C 1-6烷基取代的C 1-10烷基，可被取代的C2-6烯基，可被取代的C3-6炔基，可被取代的C3-6环烷基或可被取代的C6-10ArYL基;或R1 并且R 2一起形成可被取代的C 2-6亚烷基;或者R 1和R 2一起形成式 - （CH 2）2 -X-（CH 2）2 - 或 - （CH 2）2 -X-（CH 2） 3-其中X表示氧原子，硫原子或可被取代的氮原子; R 3表示任选被C 1-4烷基，C 1-4烷氧基或卤素取代的2,3或4-吡啶基原子; R 4表示可以被羟基任选取代的C 1-10烷基，可以被取代的氨基，C 1-6单烷基氨基，C 2-12二烷基氨基或C 6〜10芳基。并且包含所述衍生物或其盐作为用于预防和/或治疗由GSK3β如阿尔茨海默病异常活动引起的神经变性疾病的活性成分。

3. 发明申请

US20050130998A1 2-amino-3-(alkyl)-pyrimidone derivatives 失效
标题翻译： 2-氨基-3-（烷基） - 嘧啶酮衍生物
公开(公告)号：US20050130998A1
公开(公告)日：2005-06-16
申请号：US11035264
申请日：2005-01-13
申请人： Antonio Almario Carcia , Ryoichi Ando , Keiichi Arimoto , Fumiaki Uehara , Adrien Li , Aya Shoda , Jonathan Frost , Kazutoshi Watanabe
发明人： Antonio Almario Carcia , Ryoichi Ando , Keiichi Arimoto , Fumiaki Uehara , Adrien Li , Aya Shoda , Jonathan Frost , Kazutoshi Watanabe
IPC分类号： A61K31/505 , A61K31/506 , A61P3/04 , A61P3/10 , A61P5/00 , A61P9/00 , A61P11/00 , A61P15/00 , A61P17/02 , A61P17/14 , A61P19/00 , A61P25/00 , A61P25/02 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , A61P27/02 , A61P27/06 , A61P31/12 , A61P35/00 , A61P35/02 , A61P43/00 , C07D401/04 , C07D401/14 , C07D409/14 , A61K31/513 , C07D43/02
CPC分类号： A61K31/505 , C07D401/04 , C07D401/14 , C07D409/14
摘要： A pyrimidone derivative represented by formula (I) or a salt thereof: Wherein: R1 represents a hydrogen atom or a C1-6 alkyl group which may be substituted by a C6,10 aryl group; R2 represents a C1-10 alkyl group which may be substituted, a C2-6 alkenyl group which may be substituted, a C3-6 alkynyl group which may be substituted, a C3-6 cycloalkyl group which may be substituted, or a C6-10 ARYL group which may be substituted; or R1 and R2 form together a C2-6 alkylene group which may be substituted; or R1 and R2 form together a chain of formula —(CH2)2—X—(CH2)2— or —(CH2)2—X—(CH2)3— where X represents a oxygen atom, a sulfur atom, or a nitrogen atom which may be substituted; R3 represents a 2, 3 or 4-pyridyl group optionally substituted by a C1-4 alkyl group, C1-4 alkoxy group or halogen atom; and R4 represents a C1-10 alkyl group optionally substituted by a hydroxyl group, amino, C1-6 monoalkylamino group, C2-12 dialkylamino group or C6,10 aryl group which may be substituted. And a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β such as Alzheimer's disease.
摘要翻译：由式（I）表示的嘧啶酮衍生物或其盐：其中R1表示氢原子或可以被C 6-10取代的C 1-6烷基， / SUB>芳基; R 2表示可以被取代的C 1-10烷基，可以被取代的C 2-6亚烷基，C 3-6亚烷基，可以被取代的亚炔基，可被取代的C 3-6亚烷基或可以被取代的C 6〜6-亚芳基; 或者R 1和R 2一起形成可以被取代的C 2-6亚烷基; 或者R 1和R 2一起形成式 - （CH 2 CH 2）2 - （CH 2）2 - 或 - （CH 2）2 -X-（CH 2）3 - - 其中X表示氧原子，硫原子或可被取代的氮原子; R 3表示任选被C 1-4烷基，C 1-4烷氧基或卤素原子取代的2,3或4-吡啶基; 并且R 4表示任选被羟基，氨基，C 1-6 - 单烷基氨基，C 2-12-12任意取代的C 1-10烷基。 >可以被取代的二烷基氨基或C 6,10 芳基。以及包含所述衍生物或其盐作为活性成分的药物，其用于由GSK3β如阿尔茨海默氏病的异常活性引起的神经变性疾病的预防和/或治疗性治疗。

4. 发明授权

US07256199B1 Pyrimidone derivatives 失效
标题翻译：嘧啶衍生物
公开(公告)号：US07256199B1
公开(公告)日：2007-08-14
申请号：US09787426
申请日：1999-09-24
申请人： Kazutoshi Watanabe , Ryoichi Ando , Ken-ichi Saito , Rie Kawamoto , Aya Shoda
发明人： Kazutoshi Watanabe , Ryoichi Ando , Ken-ichi Saito , Rie Kawamoto , Aya Shoda
IPC分类号： C07D401/04 , A61K31/506
CPC分类号： C07D401/04 , C07D401/14 , C07D409/14
摘要： A pyrimidone derivative represented by the formula (I) or a salts thereof: wherein R1 represents an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group and the like; R2 represents a hydrogen atom, hydroxyl group, an alkyl group, an alkenyl group and the like, R3 represents a pyridyl group, and a medicament comprising said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as Alzheimer disease.
摘要翻译：由式（I）表示的嘧啶酮衍生物或其盐：其中R 1表示烷基，烯基，炔基，环烷基，芳基等; R 2表示氢原子，羟基，烷基，烯基等，R 3表示吡啶基，并且包含所述衍生物或其盐作为活性成分，用于预防和/或治疗由tau蛋白激酶1多动症如阿尔茨海默病引起的疾病。

5. 发明授权

US06444849B1 Amide derivatives 失效
标题翻译：酰胺衍生物
公开(公告)号：US06444849B1
公开(公告)日：2002-09-03
申请号：US09469354
申请日：1999-12-22
申请人： Ryoichi Ando , Makoto Kawamura , Noriko Chiba , Kazutoshi Watanabe
发明人： Ryoichi Ando , Makoto Kawamura , Noriko Chiba , Kazutoshi Watanabe
IPC分类号： C07C23305
CPC分类号： C07D307/79 , C07C237/42 , C07C2601/08 , C07C2601/14 , C07D209/18 , C07D317/60 , C07D333/60
摘要： A compound represented by the following general formula (1); wherein X represents R1(R2)(R3)C— where R1 represents a C3-C8 cycloalkyl group, an optionally substituted C6-C14 aryl group, an optionally substituted heterocyclic residue, an optionally substituted C6-C14 aryloxy group, or an optionally substituted C7-C15 arylmethyl group; R2 and R3 independently represent hydrogen atom or a C1-C5 alkyl group, or R2 and R3 may combine to represent a C2-C7 alkylene group; or X represents R7—A— wherein R7 represents (i) a C1-C10 alkyl group which may optionally be substituted with an optionally substituted C6-C14 aryl group, an optionally substituted fluorenyl group or an optionally substituted heterocyclic group, (ii) an optionally substituted C6-C14 aryl group or (iii) an optionally substituted heterocyclic group, and A represents an oxygen atom or —N—R8 where R8 represents hydrogen atom or a C1-C5 alkyl group, Y represents an oxygen atom or a sulfur atom, R4 and R5 independently represent hydrogen atom or a C1-C5 alkyl group; and R6 represents hydrogen atom, a C1-C5 alkyl group which may optionally be substituted with a hydroxyl group, a hydroxyl group or a C1-C5 alkoxy group, provided that the compounds wherein R7 is a benzyl group, A and Y are an oxygen atom, R4 and R5 are hydrogen atom, and R6 is a propyl group are excluded, or a salt thereof, or a solvate thereof or a hydrate thereof.
摘要翻译：由以下通式（1）表示的化合物：其中X表示R 1（R 2）（R 3）C-，其中R 1表示C 3 -C 8环烷基，任选取代的C 6 -C 14芳基，任选取代的杂环残基，任选取代的C 6 -C 14芳氧基，或任选取代的C 7 -C 15芳基甲基; R2和R3独立地表示氢原子或C1-C5烷基，或R2和R3可以组合以表示C2-C7亚烷基; 或X表示R7-A，其中R7表示（i）可任选被任选取代的C 6 -C 14芳基取代的C 1 -C 10烷基，任选取代的芴基或任选取代的杂环基，（ii）任选地取代的C 6 -C 14芳基或（iii）任选取代的杂环基，A表示氧原子或-N-R 8，其中R 8表示氢原子或C 1 -C 5烷基，Y表示氧原子或硫原子， R4和R5独立地表示氢原子或C1-C5烷基; 并且R 6表示氢原子，可任选被羟基，羟基或C 1 -C 5烷氧基取代的C 1 -C 5烷基，条件是其中R 7为苄基，A和Y为氧的化合物为氧原子，R 4和R 5为氢原子，并且R 6为丙基，或其盐，或其溶剂合物或其水合物。

6. 发明授权

US07274071B2 Electrostatic damage protection device with protection transistor 有权
标题翻译：具有保护晶体管的静电损伤保护装置
公开(公告)号：US07274071B2
公开(公告)日：2007-09-25
申请号：US10979804
申请日：2004-11-03
申请人： Ryoichi Ando , Akira Uemoto , Toshio Kakiuchi
发明人： Ryoichi Ando , Akira Uemoto , Toshio Kakiuchi
IPC分类号： H01L23/62
CPC分类号： H01L27/0266
摘要： This invention provides an electrostatic damage protection device which can protects a device to be protected enough from an electrostatic damage and prevents damages of protection transistors themselves. A N-channel type first MOS transistor and a N-channel type second MOS transistor serving as protection transistors are connected in series between an output terminal and a ground potential. On the other hand, a P-channel type third MOS transistor and a P-channel type fourth MOS transistor serving as protection transistors are connected in series between a high power supply potential and the output terminal. These first, second, third, and fourth MOS transistors are formed of low withstand voltage MOS transistors.
摘要翻译：本发明提供了一种静电损伤保护装置，其能够保护装置受到足够的保护以免受到静电损坏，并且防止保护晶体管本身的损坏。用作保护晶体管的N沟道型第一MOS晶体管和N沟道型第二MOS晶体管串联连接在输出端和地电位之间。另一方面，用作保护晶体管的P沟道型第三MOS晶体管和P沟道型第四MOS晶体管串联连接在高电源电位和输出端之间。这些第一，第二，第三和第四MOS晶体管由低耐压MOS晶体管形成。

7. 发明授权

US4755257A Method of processing thin metal sheets by photoetching 失效
标题翻译：通过光刻处理薄金属片的方法
公开(公告)号：US4755257A
公开(公告)日：1988-07-05
申请号：US35050
申请日：1987-04-06
申请人： Toshio Yamamoto , Masaru Kawasaki , Takefumi Kandori , Ryoichi Ando
发明人： Toshio Yamamoto , Masaru Kawasaki , Takefumi Kandori , Ryoichi Ando
IPC分类号： C23F1/00 , C23F1/02 , H01J9/14 , H05K3/06 , H05K3/20 , B44C1/22
CPC分类号： H01J9/142 , C23F1/02 , H05K3/064 , H05K3/20 , H05K3/202
摘要： A photoetching method for processing a thin metal sheet to produce apertured shadow masks. The disclosed method utilizes a supporting layer for supporting a metal sheet. A photoresist layer is formed on the metal sheet for defining pattern images. An etching solution is supplied to metal sheet surfaces exposed through voids of the photoresist layer defining the pattern images to etch the metal surfaces. Then the photoresist layer is removed from the metal sheet, and the metal sheet is removed from the supporting sheet. The resulting metal sheet constitutes a shadow mask having a multiplicity of apertures. Productivity may be doubled by applying two metal sheets to opposite faces of the supporting sheet, respectively, and processing both metal sheets simultaneously.
摘要翻译：一种用于处理薄金属片以产生有孔荫罩的光刻方法。所公开的方法利用支撑层来支撑金属片。在金属片上形成用于限定图案图像的光致抗蚀剂层。将蚀刻溶液供给到通过限定图案图像的光致抗蚀剂层的空隙暴露的金属片表面，以蚀刻金属表面。然后从金属片上除去光致抗蚀剂层，并将金属片从支撑片上取出。得到的金属片构成具有多个孔的荫罩。通过将两个金属片分别施加到支撑片的相对面上，生产率可以加倍，同时处理两个金属片。

8. 发明授权

US5395958A Cyclopropene derivatives 失效
标题翻译：环丙烯衍生物
公开(公告)号：US5395958A
公开(公告)日：1995-03-07
申请号：US126646
申请日：1993-09-27
申请人： Ryoichi Ando , Yasuhiro Morinaka , Eiichi Nakamura
发明人： Ryoichi Ando , Yasuhiro Morinaka , Eiichi Nakamura
IPC分类号： C07D319/08 , C07F7/08 , C07C69/74 , C07C215/00 , C07C233/00 , C07D327/00
CPC分类号： C07D319/08 , C07F7/0814
摘要： The cyclopropene derivatives of the present invention are useful as the intermediates for producing cyclopropenone derivatives exhibiting strong inhibition activity of thiol protease such as calpain, papain, cathepsin B, cathepsin H, cathepsin L and the like.
摘要翻译：本发明的环丙烯衍生物可用作产生表现出硫蛋白酶如钙蛋白酶，木瓜蛋白酶，组织蛋白酶B，组织蛋白酶H，组织蛋白酶L等的强抑制活性的环丙烯酮衍生物的中间体。

9. 发明申请

US20050121725A1 Electrostatic damage protection device 有权
标题翻译：静电损坏保护装置
公开(公告)号：US20050121725A1
公开(公告)日：2005-06-09
申请号：US10979804
申请日：2004-11-03
申请人： Ryoichi Ando , Akira Uemoto , Toshio Kakiuchi
发明人： Ryoichi Ando , Akira Uemoto , Toshio Kakiuchi
IPC分类号： H01L27/04 , H01L21/822 , H01L21/8234 , H01L23/60 , H01L23/62 , H01L27/02 , H01L27/06 , H01L27/088 , H01L29/00 , H01L29/78
CPC分类号： H01L27/0266
摘要： This invention provides an electrostatic damage protection device which can protects a device to be protected enough from an electrostatic damage and prevents damages of protection transistors themselves. A N-channel type first MOS transistor and a N-channel type second MOS transistor serving as protection transistors are connected in series between an output terminal and a ground potential. On the other hand, a P-channel type third MOS transistor and a P-channel type fourth MOS transistor serving as protection transistors are connected in series between a high power supply potential and the output terminal. These first, second, third, and fourth MOS transistors are formed of low withstand voltage MOS transistors.
摘要翻译：本发明提供了一种静电损伤保护装置，其能够保护装置受到足够的保护以免受到静电损坏，并且防止保护晶体管本身的损坏。用作保护晶体管的N沟道型第一MOS晶体管和N沟道型第二MOS晶体管串联连接在输出端和地电位之间。另一方面，用作保护晶体管的P沟道型第三MOS晶体管和P沟道型第四MOS晶体管串联连接在高电源电位和输出端之间。这些第一，第二，第三和第四MOS晶体管由低耐压MOS晶体管形成。

10. 发明授权

US5422359A .alpha.-aminoketone derivatives 失效
标题翻译： α-氨基酮衍生物
公开(公告)号：US5422359A
公开(公告)日：1995-06-06
申请号：US171692
申请日：1993-12-22
申请人： Ryoichi Ando , Toshiro Sakaki , Yasuhiro Morinaka , Chizuko Takahashi , Yoshikuni Tamao
发明人： Ryoichi Ando , Toshiro Sakaki , Yasuhiro Morinaka , Chizuko Takahashi , Yoshikuni Tamao
IPC分类号： A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/443 , A61K31/4433 , A61P1/16 , A61P3/00 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P13/02 , A61P15/00 , A61P19/10 , A61P25/28 , A61P27/02 , A61P27/14 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D207/32 , C07D207/335 , C07D263/32 , C07D277/22 , C07D277/28 , C07D307/52 , C07D333/22 , C07D333/28 , C07D405/12 , C07D407/12 , C07D409/12 , C07D213/30 , C07D213/32
CPC分类号： C07D207/335 , C07D263/32 , C07D277/28 , C07D307/52 , C07D333/22 , C07D333/28 , C07D405/12 , C07D409/12
摘要： Alpha-aminoketone derivatives of the present invention strongly inhibit thiol protease such as papain, cathepsin B, cathepsin H, cathepsin L and calpain or the like and have excellent properties in absorbance on oral administration, tissue distribution and cell membrane permeability. The alpha-aminoketone derivatives can thus be used as therapeutic agents for treating muscular dystrophy, amyotrophy, cardiac infarction, stroke, Alzheimer's disease, disturbance of consciousness or dyskinesia caused upon brain trauma, multiple sclerosis, peripheral nervous neuropathy, cataract, inflammation, allergosis, fulminant hepatitis, osteoporosis, hypercalcemia, breast carcinoma, prostatic carcinoma or prostatomegaly. They may also be used as therapeutic agents for suppressing growth of cancer cells, preventing metastasis of cancer or suppressing aggregation of plaques.
摘要翻译：本发明的α-氨基酮衍生物强烈地抑制木瓜蛋白酶，组织蛋白酶B，组织蛋白酶H，组织蛋白酶L和钙蛋白酶等硫醇蛋白酶，并且在口服给药，组织分布和细胞膜通透性方面的吸光度具有优异的性质。因此，α-氨基酮衍生物因此可用作治疗肌营养不良症，肌萎缩症，心肌梗死，中风，阿尔茨海默病，意识障碍或脑外伤引起的运动障碍，多发性硬化，周围神经神经病变，白内障，炎症，过敏原，暴发性肝炎，骨质疏松症，高钙血症，乳腺癌，前列腺癌或前列腺肥大。它们也可以用作抑制癌细胞生长，预防癌转移或抑制斑块聚集的治疗剂。

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