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1. 发明授权

US5314463A Bipolar nerve electrode 失效
标题翻译：双极神经电极
公开(公告)号：US5314463A
公开(公告)日：1994-05-24
申请号：US47211
申请日：1993-04-14
申请人： Antoine N. J. M. Camps , Pierre A. Grandjean , Gary M. Johnson , Philip H. J. Lee , Nicolaas M. H. Lokhoff , Willem J. Van Driel
发明人： Antoine N. J. M. Camps , Pierre A. Grandjean , Gary M. Johnson , Philip H. J. Lee , Nicolaas M. H. Lokhoff , Willem J. Van Driel
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/0551 , A61N1/0595 , A61N1/0558
摘要： One aspect of this invention relates to a temporary heart wire, and external connector therefore, and the combination of the two, wherein the distal end of the heart wire includes a temporary affixation coil (8) and distal pacing (2) and sensing (1) electrodes connected by means of a coaxial helicoidally wound cable (3) to a proximal electrode (7) and a breakaway needle (6) which also serves as a proximal electrode. The lead is adapted to be inserted into a disposable connector having a snap aperture element (19) for receiving the breakaway needle, and about which the needle is broken, as well as electrical contacts (17, 18) for contacting the proximal electrodes and adapted to be connected to a temporary external pacemaker. According to another aspect of this invention, there is provided a permanent bipolar nerve electrode which includes two electrodes (52), (54) adapted to be positioned along the nerve trunk (58). The bipolar nerve electrode further includes an affixation coil (56) and a thin insulation layer or flap (57), this latter being adapted to be sutured to the surface of the patient's muscle to thereby preclude or limit stimulating electrical energy to be transmitted to adjacent muscles, this allowing for a more focused concentration of electrical energy to the nerve trunk (58) to be stimulated.
摘要翻译：本发明的一个方面涉及临时心脏线，以及外部连接器，以及两者的组合，其中心脏线的远端包括临时固定线圈（8）和远端起搏器（2）和感测（1））电极通过同轴螺旋缠绕电缆（3）连接到近端电极（7）和分离针（6），其也用作近端电极。引线适于插入具有用于接收分离针并且针被破坏的卡合孔元件（19）的一次性连接器以及用于接触近端电极的电触头（17,18），并且适于连接到临时外部起搏器。根据本发明的另一方面，提供了一种永久性双极神经电极，其包括适于沿神经干（58）定位的两个电极（52），（54）。双极神经电极还包括固定线圈（56）和薄绝缘层或薄片（57），后者适于被缝合到患者肌肉的表面，从而排除或限制刺激性的电能传递到相邻的肌肉，这允许更加集中的电能集中到神经干（58）被刺激。

2. 发明授权

US5241957A Bipolar temporary pacing lead and connector and permanent bipolar nerve wire 失效
标题翻译：双极板太阳能电线和连接器和永久双极线
公开(公告)号：US5241957A
公开(公告)日：1993-09-07
申请号：US795942
申请日：1991-11-18
申请人： Antoine N. J. M. Camps , Pierre A. Grandjean , Gary M. Johnson , Philip H. J. Lee , Nicolaas M. H. Lokhoff , Willem J. Van Driel
发明人： Antoine N. J. M. Camps , Pierre A. Grandjean , Gary M. Johnson , Philip H. J. Lee , Nicolaas M. H. Lokhoff , Willem J. Van Driel
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0595 , A61N1/0558
摘要： A temporary heart wire, and external connector therefore, and the combination of the two, wherein the distal end of the heart wire includes a temporary affixation coil (8) and distal pacing (2) and sensing (1) electrodes connected by means of a coaxial helicoidally wound cable (3) to a proximal electrode (7) and a breakaway needle (6) which also serves as a proximal electrode. The lead is adapted to be inserted into a disposable connector having a snap aperture element (19) for receiving the breakaway needle, and about which the needle is broken, as well as electrical contacts (17, 18) for contacting the proximal electrodes and adapted to be connected to a temporary external pacemaker. In an alternate embodiment, there is provided a permanent bipolar nerve electrode which includes two electrodes (52), (54) adapted to be positioned along the nerve trunk (58). The bipolar nerve electrode further includes an affixation coil (56) and a thin insulation layer or flap (57), this latter being adapted to be sutured to the surface of the patient's muscle to thereby preclude or limit stimulating electrical energy to be transmitted to adjacent muscles, this allowing for a more focused concentration of electrical energy to the nerve trunk (58) to be stimulated.
摘要翻译：因此，临时心脏线和外部连接器以及两者的组合，其中心脏线的远端包括临时固定线圈（8）和远端起搏器（2），并且感测（1）电极通过同轴螺旋缠绕电缆（3）连接到近端电极（7）和分离针（6），其也用作近端电极。引线适于插入具有用于接收分离针并且针被破坏的卡合孔元件（19）的一次性连接器以及用于接触近端电极的电触头（17,18），并且适于连接到临时外部起搏器。在替代实施例中，提供了一种永久性双极神经电极，其包括适于沿着神经干（58）定位的两个电极（52），（54）。双极神经电极还包括固定线圈（56）和薄绝缘层或薄片（57），后者适于被缝合到患者肌肉的表面，从而排除或限制刺激性的电能传递到相邻的肌肉，这允许更加集中的电能集中到神经干（58）被刺激。

3. 发明授权

US5031621A Nerve electrode with biological substrate 失效
标题翻译：神经电极与生物底物
公开(公告)号：US5031621A
公开(公告)日：1991-07-16
申请号：US446865
申请日：1989-12-06
申请人： Pierre A. Grandjean , Philip H. J. Lee
发明人： Pierre A. Grandjean , Philip H. J. Lee
IPC分类号： A61B5/0408 , A61B5/0478 , A61B5/0492 , A61N1/04 , A61N1/05
CPC分类号： A61B5/0408 , A61N1/0551
摘要： An electrode and method of making same characterized by a biological material used as a substrate. The electrode is used primarily as a stimulation electrode, but could also be used to monitor electrical activity of neural tissues. The biological substrate is a chronically implantable material of treaterd human or animal tissue. The use of this material tends to prevent undue fibrosis and necrosis of the nerve tissue. An inner layer of a non-biologic dielectric may be used to increase to resistivity of the structure. Similarly an inner layer of shielding material may also be used.
摘要翻译：一种电极及其制造方法，其特征在于用作基底的生物材料。电极主要用作刺激电极，但也可用于监测神经组织的电活动。生物底物是经处理的人或动物组织的长期可植入材料。使用这种材料倾向于防止神经组织不适当的纤维化和坏死。可以使用非生物电介质的内层来增加结构的电阻率。类似地，也可以使用屏蔽材料的内层。

4. 发明授权

US08095219B2 Stimulation of the stomach in response to sensed parameters to treat obesity 有权
标题翻译：响应于感测参数来刺激胃以治疗肥胖
公开(公告)号：US08095219B2
公开(公告)日：2012-01-10
申请号：US12359138
申请日：2009-01-23
申请人： Philip H. J. Lee , Todd K. Whitehurst , Carla M. Woods
发明人： Philip H. J. Lee , Todd K. Whitehurst , Carla M. Woods
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61N1/05
摘要： A neurostimulation kit and a method of treating a patient are provided. The kit comprises a stimulation backing that includes a flat, electrically insulative, body having a pair of opposing first and second planar surfaces, and an electrode affixed to the first surface of the insulative body. The stimulation backing is implanted within a patient and affixed therein to place the electrode into contact with a tissue surface. The kit comprises a neurostimulator including a housing and stimulation circuitry contained within the housing. The neurostimulator is implanted within the patient by affixing the housing to the second surface of the insulative body, such that the stimulation circuitry is electrically coupled to the electrode.
摘要翻译：提供神经刺激试剂盒和治疗患者的方法。该套件包括刺激衬垫，其包括具有一对相对的第一和第二平坦表面的平坦的电绝缘体，以及固定到绝缘体的第一表面的电极。将刺激背衬植入患者体内并固定在其中以使电极与组织表面接触。该套件包括神经刺激器，其包括容纳在壳体内的壳体和刺激电路。神经刺激器通过将外壳固定到绝缘体的第二表面而植入患者体内，使得刺激电路电耦合到电极。

5. 发明授权

US5273518A Cardiac assist apparatus 失效
标题翻译：心脏辅助装置
公开(公告)号：US5273518A
公开(公告)日：1993-12-28
申请号：US829182
申请日：1992-01-31
申请人： Philip H. J. Lee , Michael A. Colson
发明人： Philip H. J. Lee , Michael A. Colson
IPC分类号： A61H31/00 , A61M1/10 , A61M1/12 , F04B43/06 , A61N1/362
CPC分类号： F04B43/06 , A61M1/1003 , A61M1/1068 , A61M1/122 , A61M1/106 , A61M1/107
摘要： Regulators for improved cardiac assist systems of the type including skeletal muscle powered fluid pressure means, a cardiac cup and/or an aortic balloon pump. The regulators convert the positive pressures generated by contracting muscle into both positive and negative pressures useful in the systems.
摘要翻译：用于改善类型的心脏辅助系统的调节器，包括骨骼肌动力流体压力装置，心脏杯和/或主动脉球囊泵。监管机构将收缩肌肉产生的积极压力转化为系统中有用的正压和负压。

6. 发明授权

US5086787A Steroid eluting intramuscular lead 失效
标题翻译：类固醇洗脱肌内铅
公开(公告)号：US5086787A
公开(公告)日：1992-02-11
申请号：US662526
申请日：1991-02-28
申请人： Pierre-Andre Grandjean , Ivan Bourgeois , Philip H. J. Lee
发明人： Pierre-Andre Grandjean , Ivan Bourgeois , Philip H. J. Lee
IPC分类号： A61B17/06 , A61M1/10 , A61M1/12 , A61N1/05 , A61N1/36 , A61N1/362
CPC分类号： A61B17/06166 , A61M1/1003 , A61M1/122 , A61N1/05 , A61N1/0587 , A61N1/36042 , A61M1/1037 , A61M1/1068 , A61M1/107
摘要： An intramuscular lead for electrically stimulating muscle tissue particularly configured for a cardiac assist system powered by surgically modified skeletal muscle tissue. Electrical stimulation is supplied via the intramuscular lead to cause contraction of the skeletal muscle in synchrony with the natural or artificially paced heart rate and timed to obtain the desired hemodynamic effect. The improved lead has an electrode which is embedded in the skeletal muscle. The stimulation threshold of the skeletal muscle is held relatively low by the action of a glucocorticosteroid imbedded within the strand of suture material. A spacer coil of biocompatible material is coiled around the strand of suture material, such that the turns of both coils are substantially interleaved. The spacer coil is saturated with a specific agent such as steroid or antibiotic. The compression movement of the muscle tissue and the electrode coil against the spacer coil will cause the drug to be dispensed therefrom.
摘要翻译：用于电刺激肌肉组织的肌内引线，特别配置用于由外科手术修改的骨骼肌组织供电的心脏辅助系统。电刺激通过肌肉内引起，以与天然或人为的心跳速度同步地引起骨骼肌的收缩并定时获得所需的血液动力学效应。改进的铅具有嵌入在骨骼肌中的电极。骨骼肌的刺激阈值通过嵌入在缝线材料股线内的糖皮质激素的作用而保持相对较低。生物相容性材料的间隔线圈卷绕在缝线材料股线周围，使得两个线圈的匝基本交错。间隔线圈用特定的试剂例如类固醇或抗生素饱和。肌肉组织和电极线圈相对于间隔线圈的压缩运动将导致药物被分配。

7. 发明授权

US5009229A Steroid eluting intramuscular lead 失效
标题翻译：类固醇洗脱肌内铅
公开(公告)号：US5009229A
公开(公告)日：1991-04-23
申请号：US446594
申请日：1989-12-06
申请人： Pierre-Andre Grandjean , Philip H. J. Lee
发明人： Pierre-Andre Grandjean , Philip H. J. Lee
IPC分类号： A61N1/04 , A61B17/06 , A61M1/10 , A61M1/12 , A61N1/05 , A61N1/36
CPC分类号： A61N1/0587 , A61B17/06166 , A61M1/1003 , A61M1/122
摘要： An improved lead for electrically stimulating muscle tissue particularly configured for a cardiac assist system powered by surgically modified skeletal muscle tissue. The skeletal muscle is either wrapped about the heart itself, or about an auxiliary pumping chamber attached to the aorta. Electrical stimulation is supplied via the improved lead to cause contraction of the skeletal muscle in synchronism with the natural or artificially paced heart rate and timed to obtain the desired hemodynamic effect. The improved lead has an electrode which is embedded in the skeletal muscle. The stimulation threshold of the skeletal muscle is held relatively low by the action of a glucocorticosteroid imbedded within the suture material. By placing the drug material in this position, it acts as an anti-inflammatory along the entire path of the suture material and treats the specific area of the electrode contact from within the muscle itself. The specific area of electrode contact may also be treated from the electrode side by placing a similar drug within the electrode.
摘要翻译：用于电刺激肌肉组织的改进的引线，特别构造成用于由外科手术修改的骨骼肌组织供电的心脏辅助系统。骨骼肌或者围绕心脏本身缠绕，或围绕连接到主动脉的辅助抽吸室。电刺激通过改进的导线供给以引起骨骼肌与天然或人为的起搏心率同步的收缩并且定时以获得所需的血液动力学效应。改进的铅具有嵌入在骨骼肌中的电极。通过嵌入在缝合材料中的糖皮质激素的作用，骨骼肌的刺激阈值保持相对较低。通过将药物材料置于该位置，其沿着缝线材料的整个路径起抗炎作用，并且在肌肉本身内处理电极接触的特定面积。电极接触的比面积也可以通过在电极内放置类似的药物从电极侧进行处理。

8. 发明授权

US07483746B2 Stimulation of the stomach in response to sensed parameters to treat obesity 有权
标题翻译：响应于感测参数来刺激胃以治疗肥胖
公开(公告)号：US07483746B2
公开(公告)日：2009-01-27
申请号：US11295783
申请日：2005-12-06
申请人： Philip H. J. Lee , Todd K. Whitehurst , Carla M. Woods
发明人： Philip H. J. Lee , Todd K. Whitehurst , Carla M. Woods
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61N1/05
摘要： Systems for treating an obese patient include one or more sensors configured to sense one or more physical parameters of the patient and one or more implanted stimulators configured to apply a stimulus to the stomach in response to the sensed parameters. Methods of treating an obese patient include sensing one or more physical parameters of the patient and applying a stimulus to the stomach with one or more implanted stimulators in response to the sensed parameters.
摘要翻译：用于治疗肥胖患者的系统包括被配置为感测患者的一个或多个物理参数的一个或多个传感器和被配置为响应于所感测的参数向胃施加刺激的一个或多个植入的刺激器。治疗肥胖患者的方法包括感测患者的一个或多个物理参数，并响应于所感测的参数，用一个或多个注入的刺激器向胃施加刺激。

9. 发明授权

US5318501A Linear motion, muscle-actuated cardiac assist device 失效
标题翻译：线性运动，肌肉驱动的心脏辅助装置
公开(公告)号：US5318501A
公开(公告)日：1994-06-07
申请号：US950868
申请日：1992-09-24
申请人： Philip H. J. Lee , Michael Colson , Kendra Gealow
发明人： Philip H. J. Lee , Michael Colson , Kendra Gealow
IPC分类号： A61M1/10 , A61M1/12
CPC分类号： A61M1/10 , A61M1/1003 , A61M1/106
摘要： A linear motion, muscle-actuated cardiac assist device novelly uses a powering muscle whose contractions and relaxations are made in a substantially linear fashion, as opposed to the curvilinear muscle motions associated with prior art muscle-actuated cardiac assist devices. As a result, collateral circulation of the powering muscle need not be cut, theoretically leading to prevention of ischemia in the powering muscle. Other benefits include: greater energy efficiency of the powering muscle; greater available choice of powering muscles (i.e., not limited to the latissimus dorsi as the powering muscle); and reduced profile height of the cardiac assist device to reduce protrusion from the implanted area of the body.
摘要翻译：线性运动，肌肉驱动的心脏辅助装置新颖地使用与其与现有技术的肌肉驱动的心脏辅助装置相关的曲线肌运动相反地以基本线性的方式制造收缩和松弛的动力肌。结果，动力肌的侧支循环不需要切断，理论上导致预防动力肌肉缺血。其他好处包括：提高肌力的能量效率; 更大的可用选择的动力肌肉（即，不限于作为动力肌的背阔肌）; 并且减小心脏辅助装置的轮廓高度以减少从身体的植入区域的突出。

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