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1. 发明申请

US20120143119A1 Delivery of Serotonin Receptor Antagonists By Microinjection Systems 审中-公开
标题翻译：通过显微注射系统递送血清素受体拮抗剂
公开(公告)号：US20120143119A1
公开(公告)日：2012-06-07
申请号：US13294895
申请日：2011-11-11
申请人： Anthony P. Deasey , Patrick Frankham , Wolfgang Renz , Thomas Lang
发明人： Anthony P. Deasey , Patrick Frankham , Wolfgang Renz , Thomas Lang
IPC分类号： A61M5/32 , A61N1/30 , A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , A61N1/30 , A61N1/325
摘要： In an aspect of the invention, serotonin receptor antagonist formulations are provided for subcutaneous, transdermal or intradermal delivery to a subject. In an embodiment, serotonin receptor antagonist formulations include ondansetron or ondansetron-containing formulations. In another embodiment, serotonin receptor antagonist formulations include palonosetron or palonosetron-containing formulations. In another aspect of the invention, microinjection devices are provided for delivering a serotonin receptor antagonist formulation to a subject.
摘要翻译：在本发明的一个方面，提供5-羟色胺受体拮抗剂制剂用于对受试者的皮下，透皮或皮内递送。在一个实施方案中，5-羟色胺受体拮抗剂制剂包括昂丹司琼或昂丹司琼的制剂。在另一个实施方案中，5-羟色胺受体拮抗剂制剂包括帕洛诺司琼或含有帕洛诺司琼的制剂。在本发明的另一方面，提供显微注射装置用于将5-羟色胺受体拮抗剂制剂递送至受试者。

2. 发明申请

US20120089118A1 DELIVERY OF BISPHOSPHONATES BY MICROINJECTION SYSTEMS 审中-公开
标题翻译：通过微观系统递送双膦酸盐
公开(公告)号：US20120089118A1
公开(公告)日：2012-04-12
申请号：US13269491
申请日：2011-10-07
申请人： Anthony P. Deasey , Patrick Frankham , Wolfgang Renz , Thomas Lang
发明人： Anthony P. Deasey , Patrick Frankham , Wolfgang Renz , Thomas Lang
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： A system for the administration of a bisphosphonate to a subject comprises a bisphosphonate formulation and a microinjection device. In an embodiment, the bisphosphonate formulation includes ibandronate sodium. In some cases, the bisphosphonate formulation includes an excipient. The bisphosphonate formulation may be delivered to the subject subcutaneously, transdermally or intradermally.
摘要翻译：用于向受试者施用双膦酸盐的系统包括双膦酸盐制剂和显微注射装置。在一个实施方案中，双膦酸盐制剂包含伊班膦酸钠。在一些情况下，双膦酸盐制剂包括赋形剂。双膦酸盐制剂可以皮下，经皮或皮内递送至受试者。

3. 发明授权

US08555864B2 Internal combustion engine with an exhaust-gas recirculation and method for operating an internal combustion engine 有权
公开(公告)号：US08555864B2
公开(公告)日：2013-10-15
申请号：US13300905
申请日：2011-11-21
申请人： Hans-Georg Nitzke , Jörg Larink , Jens Jeschke , Thomas Lang , Jürgen Wendt , Achim Freitag , Jörn Müller , Axel Groenendijk , Lothar Nee , Uwe Scher , Werner Aberle , Dieter Mannigel
发明人： Hans-Georg Nitzke , Jörg Larink , Jens Jeschke , Thomas Lang , Jürgen Wendt , Achim Freitag , Jörn Müller , Axel Groenendijk , Lothar Nee , Uwe Scher , Werner Aberle , Dieter Mannigel
IPC分类号： F02B47/08 , F02M25/07 , F02B33/44
CPC分类号： F02D9/04 , F02D41/0072 , F02D41/1446 , F02D2041/0067 , F02M26/05 , F02M26/06 , F02M26/10 , F02M26/15 , F02M26/24 , F02M26/38 , F02M26/47 , Y02T10/14 , Y02T10/47
摘要： An internal combustion engine has a high-pressure exhaust-gas recirculation line and a low-pressure exhaust-gas recirculation line with a low-pressure exhaust-gas recirculation valve. The low-pressure exhaust-gas recirculation line branches off from the exhaust-gas system downstream of a turbine of an exhaust-gas turbocharger and opens into a fresh-air system upstream of a compressor of the exhaust-gas turbocharger. An exhaust-gas flap is disposed in the exhaust-gas system downstream from where the low-pressure exhaust-gas recirculation line branches off from the exhaust-gas system. At least one pressure sensor is disposed in the low-pressure exhaust-gas recirculation line and configured such that the at least one pressure sensor determines a pressure difference in the low-pressure exhaust-gas recirculation line between a point upstream of the low-pressure exhaust-gas recirculation valve and a point downstream of the low-pressure exhaust-gas recirculation valve. A method for operating an internal combustion engine is also provided.

4. 发明申请

US20110207361A1 TERMINAL FOR CONNECTING LEAD ENDS 失效
标题翻译：终端用于连接导线端
公开(公告)号：US20110207361A1
公开(公告)日：2011-08-25
申请号：US13126224
申请日：2009-09-07
申请人： Michael Heckert , Thomas Lang
发明人： Michael Heckert , Thomas Lang
IPC分类号： H01R13/627
CPC分类号： H01R4/4836
摘要： An electrical connector for connecting the bare end of an insulated conductor with an electrical contact, including a connector housing containing a chamber in which are mounted a bus bar connected with the contact, and a clamping spring normally biased toward the bus bar. A retaining device maintains the spring in a retained open condition spaced from said bus bar, thereby to permit the conductor bare end to be introduced into the chamber toward a clamping position adjacent the bus bar. An operating member is displaced in a controlled manner to release the spring from its retained condition, whereby the spring biases the conductor toward electrical engagement with the bus bar. To remove the conductor, the operating member is operated again to displace the spring toward its open condition.
摘要翻译：一种用于将绝缘导体的裸露端与电触点相连接的电连接器，包括一个连接器壳体，该连接器壳体包含一个与接触件连接的汇流条安装在其中的腔室，以及一个通常偏向母线的夹紧弹簧。保持装置将弹簧保持在与所述汇流条间隔开的保持打开状态，从而允许导体裸露端朝向靠近母线的夹紧位置被引入腔室。操作构件以受控的方式移动以将弹簧从其保持状态释放，由此弹簧将导体偏压到与汇流条电气接合。为了去除导体，再次操作操作构件以将弹簧移向其打开状态。

5. 发明申请

US20100212471A1 CUTTING TOOL FOR CUTTING LABELS 审中-公开
标题翻译：切割工具切割标签
公开(公告)号：US20100212471A1
公开(公告)日：2010-08-26
申请号：US12709121
申请日：2010-02-19
申请人： Thomas Lang
发明人： Thomas Lang
IPC分类号： B26D7/26
CPC分类号： B26D1/405 , B26D7/2614 , B26D2007/2685 , Y10T83/9461 , Y10T83/9464
摘要： The invention relates to a cutting tool (1), in particular for cutting labels, comprising a housing (2) which is arranged such as to be able to rotate about an axis of rotation (X), and a cutting element (4) which is arranged on this housing (2), wherein this cutting element (4) has a cutting edge (6) which extends essentially in a direction parallel to the axis of rotation (X), and wherein this cutting element (4) is detachably arranged in a recess (14) of the housing (2) formed by a plurality of walls (2a, 2b, 2c) of the housing (2), with a loading body (12) arranged in the recess (8) which loads the cutting element (4) in a working mode in a loading direction (P) in order to hold the cutting element on the housing, and with a springing element (20) which exerts a force on the loading body (12) in the loading direction (P) in the working mode of the cutting tool, and wherein a movement of the loading body (12) in the loading direction (P) is guided by a guide surface (F) and this guide surface runs in a plane (E) which is defined by a longitudinal direction (L) of the cutting element (4) and the loading direction (P). According to the invention, the guide surface (F) is the only guide surface (F) running in the plane (E) which guides the movement of the loading body (12) in the loading direction (P).
摘要翻译：本发明涉及一种切割工具（1），特别是用于切割标签的切割工具（1），该切割工具包括一个能绕旋转轴线（X）旋转的壳体（2）和一个切割元件（4）布置在该壳体（2）上，其中该切割元件（4）具有基本上沿平行于旋转轴线（X）的方向延伸的切割刃（6），并且其中该切割元件（4）可拆卸地布置在由壳体（2）的多个壁（2a，2b，2c）形成的壳体（2）的凹部（14）中，具有设置在凹部（8）中的装载主体（12）元件（4）在加载方向（P）的工作模式中，以便将切割元件保持在壳体上，以及弹簧元件（20），该弹簧元件在加载方向上对加载体（12）施加力 P），并且其中装载主体（12）在装载方向（P）上的移动由引导表面（F）引导，并且该gui 表面在由切割元件（4）的纵向方向（L）和加载方向（P）限定的平面（E）中延伸。根据本发明，引导表面（F）是在平面（E）中延伸的唯一引导表面（F），该平面（E）引导装载体（12）沿装载方向（P）的移动。

6. 发明申请

US20060086176A1 Method for diagnosing an engine control unit and corresponding engine control unit 有权
标题翻译：用于诊断发动机控制单元和相应的发动机控制单元的方法
公开(公告)号：US20060086176A1
公开(公告)日：2006-04-27
申请号：US11243782
申请日：2005-10-05
申请人： Jan Piewek , Jens Jeschke , Andreas Wagner , Thomas Lang
发明人： Jan Piewek , Jens Jeschke , Andreas Wagner , Thomas Lang
IPC分类号： G01L23/22 , G01M15/00
CPC分类号： F02D35/023 , F02D41/222 , Y02T10/40
摘要： A method for diagnosing an engine control unit (4) conducts an analysis as to whether the signal values from the cylinder pressure sensors (3) are faulty based on at least one characteristic value which is derived from an evaluation of signal values from the cylinder pressure sensors (3) of the cylinders (2) in a combustion engine (5). In addition to this is described the engine control unit (4) designed to execute the method. Also hereby disclosed is a method which, based on symmetrical aspects, determines a crankshaft angle (phipCylMaxTDC) for a cylinder pressure maximum during push mode operation of the combustion engine (5).
摘要翻译：用于诊断发动机控制单元（4）的方法基于从来自气缸压力的信号值的评估导出的至少一个特性值来进行来自气缸压力传感器（3）的信号值是否有故障的分析内燃机（5）中气缸（2）的传感器（3）。除此之外，还描述了设计用于执行该方法的发动机控制单元（4）。此外，还公开了一种基于对称方面的方法，其确定在内燃机（5）的推压模式操作期间的气缸最大压力的曲轴角度（phipCylMaxTDC）。

7. 发明申请

US20050132053A1 Message analysis device and message for displaying messages 有权
标题翻译：消息分析设备和消息显示消息
公开(公告)号：US20050132053A1
公开(公告)日：2005-06-16
申请号：US10504032
申请日：2003-01-30
申请人： Michael Roth , Andreas Michl , Thomas Lang , Stephan Sandhaeger
发明人： Michael Roth , Andreas Michl , Thomas Lang , Stephan Sandhaeger
IPC分类号： H04L12/24 , G06F15/16
CPC分类号： H04L41/22 , H04L41/0631
摘要： A message analysis device is described including a storage device, display device, and a selection device. The storage device can be used to store messages in a file in chronological order, and the a display device can be used to display at least one first and one second window. One part of the messages, which are chronologically stored in the file, can be displayed in the first window. The selection device can be used to select at least one message to be displayed in the second window, corresponding to a parent and/or child generation of a specific message. Accordingly, information can be evaluated from a message header to determine and represent those parent-generation messages that causally triggered a specific message and/or those child-generation messages that are causally determined by the specific message.
摘要翻译：描述了包括存储设备，显示设备和选择设备的消息分析设备。存储装置可用于以时间顺序将消息存储在文件中，并且显示装置可用于显示至少一个第一和第二窗口。消息的一部分，按时间顺序存储在文件中，可以显示在第一个窗口中。选择装置可以用于选择要在第二窗口中显示的至少一个消息，对应于特定消息的父和/或子代。因此，可以从消息头来评估信息，以确定和表示因特定触发特定消息的父生代消息和/或由特定消息因果确定的那些子代生成消息。

8. 发明申请

US20050037772A1 Method and system for determining displacement time of a mobile user terminal equipment 有权
标题翻译：确定移动用户终端设备的移动时间的方法和系统
公开(公告)号：US20050037772A1
公开(公告)日：2005-02-17
申请号：US10492322
申请日：2002-10-04
申请人： Michael Alger , Thomas Lang
发明人： Michael Alger , Thomas Lang
IPC分类号： G01S19/48 , G07C5/04 , G08G1/01 , H04W64/00 , H04B7/185
CPC分类号： G07C5/04 , G01S19/42 , G08G1/0104 , H04W64/006
摘要： A method as well as a system are described for determining the travel time of at least one mobile user end device between a starting point (A) and an end point (E) that is spatially separated from it. To this end, specific pieces of information of at least one mobile user end device located at the starting point (A) and at the end point (E) are determined and each linked to a time marker. The specific pieces of information of the mobile user end devices are compared with one another electronically in at least one central processing unit. When the specific pieces of information of a mobile user end device are in agreement at the starting point (A) as well as at the end point (E), the time difference between the time markers is formed electronically in the central processing unit and the travel times are determined therefrom. The method can be carried out advantageously by the use of a cellular mobile wireless system (10), wherein the starting point (A) and the end point (E) are each formed by corresponding cells (12, 13) of the mobile wireless system (10). The determination of the travel time results from the data of the mobile wireless system (10).
摘要翻译：描述了一种方法以及系统，用于确定至少一个移动用户终端设备在与其空间分离的起始点（A）和终点（E）之间的行进时间。为此，确定位于起始点（A）和终点（E）处的至少一个移动用户终端设备的特定信息段，并且每个链接到时间标记。在至少一个中央处理单元中电子地将移动用户终端设备的特定信息彼此进行比较。当移动用户终端设备的特定信息在起始点（A）和终点（E）处于一致时，时间标记之间的时间差在电子地形成在中央处理单元中，并且行程时间由此确定。该方法可以有利地通过使用蜂窝移动无线系统（10）进行，其中起始点（A）和终点（E）各自由移动无线系统的相应小区（12,13）形成（10）。旅行时间的确定是由移动无线系统（10）的数据产生的。

9. 发明授权

US08091535B2 Internal combustion engine with an exhaust-gas recirculation and method for operating an internal combustion engine 有权
公开(公告)号：US08091535B2
公开(公告)日：2012-01-10
申请号：US12466708
申请日：2009-05-15
申请人： Hans-Georg Nitzke , Jörg Larink , Jens Jeschke , Thomas Lang , Jürgen Wendt , Achim Freitag , Jörn Müller , Axel Groenendijk , Lothar Nee , Uwe Scher , Werner Aberle , Dieter Mannigel
发明人： Hans-Georg Nitzke , Jörg Larink , Jens Jeschke , Thomas Lang , Jürgen Wendt , Achim Freitag , Jörn Müller , Axel Groenendijk , Lothar Nee , Uwe Scher , Werner Aberle , Dieter Mannigel
IPC分类号： F02B47/08 , F02B33/44 , F02M25/07
CPC分类号： F02D9/04 , F02D41/0072 , F02D41/1446 , F02D2041/0067 , F02M26/05 , F02M26/06 , F02M26/10 , F02M26/15 , F02M26/24 , F02M26/38 , F02M26/47 , Y02T10/14 , Y02T10/47
摘要： An internal combustion engine has a high-pressure exhaust-gas recirculation line and a low-pressure exhaust-gas recirculation line with a low-pressure exhaust-gas recirculation valve. The low-pressure exhaust-gas recirculation line branches off from the exhaust-gas system downstream of a turbine of an exhaust-gas turbocharger and opens into a fresh-air system upstream of a compressor of the exhaust-gas turbocharger. An exhaust-gas flap is disposed in the exhaust-gas system downstream from where the low-pressure exhaust-gas recirculation line branches off from the exhaust-gas system. At least one pressure sensor is disposed in the low-pressure exhaust-gas recirculation line and configured such that the at least one pressure sensor determines a pressure difference in the low-pressure exhaust-gas recirculation line between a point upstream of the low-pressure exhaust-gas recirculation valve and a point downstream of the low-pressure exhaust-gas recirculation valve. A method for operating an internal combustion engine is also provided.

10. 发明申请

US20090311696A1 POLYMORPHISMS IN THE HUMAN CYP2B6 GENE AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS 审中-公开
标题翻译：人CYP2B6基因多态性及其在诊断和治疗应用中的应用
公开(公告)号：US20090311696A1
公开(公告)日：2009-12-17
申请号：US12404772
申请日：2009-03-16
申请人： Ulrich Zanger , Thomas Lang
发明人： Ulrich Zanger , Thomas Lang
IPC分类号： C12Q1/68 , C07H21/00 , C12N15/63 , G01N33/68
CPC分类号： C12N9/0038 , A01K2217/05 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/573
摘要： Described are general means and methods of diagnosing and treating the phenotypic spectrum as well as the overlapping clinical characteristics with several forms of inherited abnormal expression and/or function of the CYP2B6 genes. In particular, polynucleotides of molecular variant CYP2B6 genes which, for example, are associated with insufficient metabolization and/or sensitively of drugs, and vectors comprising such polynucleotides are provided. Furthermore, host cells comprising such polynucleotides or vectors and their use for the production of variant CYP2B6 proteins are described. In addition, variant CYP2B6 proteins and antibodies specifically recognizing such proteins as well as transgenic non-human animals comprising the above-described polynucleotide or vectors are provided. Described are also methods for identifying and obtaining inhibitors for therapy of disorders related to the malfunction of the CYP2B6 gene as well as methods of diagnosing the status of such disorders. Pharmaceutical and diagnostic compositions useful for diagnosing and treating various diseases with drugs that are substrates, inhibitors or modulators of the CYP2B6 gene product are described as well.
摘要翻译：描述了诊断和治疗表型谱的一般手段和方法以及CYP2B6基因的几种形式的遗传异常表达和/或功能的重叠临床特征。特别地，提供了例如与代谢不足和/或敏感性相关的分子变体CYP2B6基因的多核苷酸以及包含这种多核苷酸的载体。此外，描述了包含这种多核苷酸或载体的宿主细胞及其用于产生变体CYP2B6蛋白的用途。此外，提供变体CYP2B6蛋白质和特异性识别这些蛋白质的抗体以及包含上述多核苷酸或载体的转基因非人动物。还描述了用于鉴定和获得用于治疗与CYP2B6基因功能紊乱相关的疾病的抑制剂的方法以及诊断此类疾病状态的方法。也描述了可用于诊断和治疗各种疾病的药物和诊断组合物，其中药物是CYP2B6基因产物的底物，抑制剂或调节剂。

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