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1. 发明申请

US20130034884A1 MICROORGANISMS FOR PRODUCING 1,4-BUTANEDIOL AND METHODS RELATED THERETO 审中-公开
标题翻译：用于生产1,4-丁二醇的微生物及其相关方法
公开(公告)号：US20130034884A1
公开(公告)日：2013-02-07
申请号：US13530053
申请日：2012-06-21
申请人： Anthony P. BURGARD , Robin E. Osterhout , Jun Sun , Priti Pharkya
发明人： Anthony P. BURGARD , Robin E. Osterhout , Jun Sun , Priti Pharkya
IPC分类号： C12N1/21 , C12N9/02 , C12P17/04 , C12N1/19 , C12P7/18 , C12P7/42
CPC分类号： C12N15/52 , C12N9/0008 , C12P7/16 , C12P7/18 , C12P7/42 , C12Y102/99006 , Y02E50/10
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
摘要翻译：本发明提供了包含1,4-丁二醇（BDO），4-羟基丁酰辅酶A，4-羟基丁醛或腐胺途径的非天然存在的微生物，其包含至少一种编码BDO，4-羟基丁酰辅酶A，表达量足以产生BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的β-羟基丁酸或腐胺途径酶，并进一步优化BDO的表达。本发明另外提供了使用这些微生物生产BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的方法。

2. 发明申请

US20130011891A1 MICROORGANISMS FOR PRODUCING BUTADIENE AND METHODS RELATED THERETO 有权
标题翻译：用于生产二苯乙烯的微生物及其相关方法
公开(公告)号：US20130011891A1
公开(公告)日：2013-01-10
申请号：US13527440
申请日：2012-06-19
申请人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
IPC分类号： C12P5/02 , C12N1/15 , C12N1/19 , C12P7/04 , C12N1/21
CPC分类号： C12P7/04 , C12N15/52 , C12N15/70 , C12P5/026 , C12P7/16
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene or crotyl alcohol pathway. The invention additionally provides methods of using such organisms to produce butadiene or crotyl alcohol.
摘要翻译：本发明提供具有丁二烯或巴豆醇途径的非天然存在的微生物。本发明另外提供了使用这种生物体来生产丁二烯或巴豆醇的方法。

3. 发明授权

US08048661B2 Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes 有权
标题翻译：包含编码还原型TCA途径酶的外源核酸的微生物生物
公开(公告)号：US08048661B2
公开(公告)日：2011-11-01
申请号：US13011796
申请日：2011-01-21
申请人： Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
发明人： Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
IPC分类号： C12N9/00 , C12N1/20
CPC分类号： C12P7/00 , C12N9/0006 , C12N9/001 , C12N9/0095 , C12N9/1029 , C12N9/1217 , C12N9/88 , C12N9/93 , C12P7/04 , C12P7/18 , C12P7/42 , C12P19/42
摘要： A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. A method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen includes culturing this organism for a sufficient period of time to produce a product.
摘要翻译：非天然存在的微生物体包括具有还原性TCA或Wood-Ljungdahl途径的微生物生物体，其中至少一种编码这些途径酶的外源核酸以足够的量表达以增强通过乙酰辅酶A的碳通量。通过乙酰辅酶A增强碳通量的方法包括在条件和足够的时间段内培养这些非天然存在的微生物，以产生具有乙酰辅酶A作为结构单元的产物。另一种非天然存在的微生物生物体包括至少一种编码以足够量表达的酶的外源核酸，以增强在一氧化碳或氢气存在下还原当量的可用性，从而通过碳水化合物 - 碳原料。在一氧化碳或氢气存在下增强还原当量的可用性的方法包括在足够的时间内培养该生物体以产生产物。

4. 发明授权

US08580543B2 Microorganisms and methods for the biosynthesis of butadiene 有权
标题翻译：用于生物合成丁二烯的微生物和方法
公开(公告)号：US08580543B2
公开(公告)日：2013-11-12
申请号：US13101046
申请日：2011-05-04
申请人： Mark J. Burk , Anthony P. Burgard , Jun Sun , Robin E. Osterhout , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Jun Sun , Robin E. Osterhout , Priti Pharkya
IPC分类号： C12P5/02 , C12N1/20 , C12N1/00
CPC分类号： C12P5/026 , C07C11/16 , C08F136/06 , C12N15/52
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.
摘要翻译：本发明提供具有丁二烯途径的非天然存在的微生物。本发明另外提供了使用这些生物体来生产丁二烯的方法。

5. 发明申请

US20120225466A1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF BUTADIENE 有权
标题翻译：二苯乙烯生物合成的微生物和方法
公开(公告)号：US20120225466A1
公开(公告)日：2012-09-06
申请号：US13365132
申请日：2012-02-02
申请人： Mark J. Burk , Anthony P. Burgard , Jun Sun , Robin E. Osterhout , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Jun Sun , Robin E. Osterhout , Priti Pharkya
IPC分类号： C12P5/02 , C12N1/19 , C12N1/15 , C12N1/21
CPC分类号： C12P5/02 , C07C1/24 , C07C2521/04 , C07C2521/12 , C07C2521/16 , C07C2523/10 , C07C2523/28 , C07C2523/31 , C07C2523/745 , C07C2527/167 , C07C2527/173 , C12N15/52 , C12P5/026 , C12P7/04 , Y02E50/343 , C07C11/167
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.
摘要翻译：本发明提供具有丁二烯途径的非天然存在的微生物。本发明另外提供了使用这些生物体来生产丁二烯的方法。

6. 发明申请

US20110201089A1 METHODS FOR INCREASING PRODUCT YIELDS 有权
标题翻译：增加产品线的方法
公开(公告)号：US20110201089A1
公开(公告)日：2011-08-18
申请号：US13011796
申请日：2011-01-21
申请人： Anthony P. BURGARD , Robin E. Osterhout , Jun Sun , Priti Pharkya
发明人： Anthony P. BURGARD , Robin E. Osterhout , Jun Sun , Priti Pharkya
IPC分类号： C12N1/00
CPC分类号： C12P7/00 , C12N9/0006 , C12N9/001 , C12N9/0095 , C12N9/1029 , C12N9/1217 , C12N9/88 , C12N9/93 , C12P7/04 , C12P7/18 , C12P7/42 , C12P19/42
摘要： A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. A method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen includes culturing this organism for a sufficient period of time to produce a product.
摘要翻译：非天然存在的微生物体包括具有还原性TCA或Wood-Ljungdahl途径的微生物生物体，其中至少一种编码这些途径酶的外源核酸以足够的量表达以增强通过乙酰辅酶A的碳通量。通过乙酰辅酶A增强碳通量的方法包括在条件和足够的时间段内培养这些非天然存在的微生物，以产生具有乙酰辅酶A作为结构单元的产物。另一种非天然存在的微生物生物体包括至少一种编码以足够量表达的酶的外源核酸，以增强在一氧化碳或氢气存在下还原当量的可用性，从而通过碳水化合物 - 碳原料。在一氧化碳或氢气存在下增强还原当量的可用性的方法包括在足够的时间内培养该生物体以产生产物。

7. 发明授权

US09321701B2 Microorganisms and methods for the biosynthesis of butadiene 有权
公开(公告)号：US09321701B2
公开(公告)日：2016-04-26
申请号：US13365132
申请日：2012-02-02
申请人： Mark J. Burk , Anthony P. Burgard , Jun Sun , Robin E. Osterhout , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Jun Sun , Robin E. Osterhout , Priti Pharkya
IPC分类号： C12P5/02 , C12N1/20 , C12N1/00 , C07H21/04 , C07C1/24 , C12P7/04
CPC分类号： C12P5/02 , C07C1/24 , C07C2521/04 , C07C2521/12 , C07C2521/16 , C07C2523/10 , C07C2523/28 , C07C2523/31 , C07C2523/745 , C07C2527/167 , C07C2527/173 , C12N15/52 , C12P5/026 , C12P7/04 , Y02E50/343 , C07C11/167
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.

8. 发明授权

US09169486B2 Microorganisms for producing butadiene and methods related thereto 有权
标题翻译：用于生产丁二烯的微生物及其相关方法
公开(公告)号：US09169486B2
公开(公告)日：2015-10-27
申请号：US13527440
申请日：2012-06-19
申请人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
IPC分类号： C12N1/20 , C12P5/02 , C12N15/52 , C12P7/04 , C12P7/16
CPC分类号： C12P7/04 , C12N15/52 , C12N15/70 , C12P5/026 , C12P7/16
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene or crotyl alcohol pathway. The invention additionally provides methods of using such organisms to produce butadiene or crotyl alcohol.
摘要翻译：本发明提供具有丁二烯或巴豆醇途径的非天然存在的微生物。本发明另外提供了使用这种生物体来生产丁二烯或巴豆醇的方法。

9. 发明授权

US09133487B2 Microorganisms for producing methacrylic acid and methacrylate esters and methods related thereto 有权
标题翻译：用于生产甲基丙烯酸和甲基丙烯酸酯的微生物及其相关方法
公开(公告)号：US09133487B2
公开(公告)日：2015-09-15
申请号：US13436811
申请日：2012-03-30
申请人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
IPC分类号： C12N1/12 , C12N1/20 , C12P7/40 , C12P19/32 , C12P7/42 , C12P7/62
CPC分类号： C12P7/40 , C12P7/42 , C12P7/62 , C12P19/32
摘要： The invention provides a non-naturally occurring microbial organism having a methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a methacrylic acid pathway. The invention additionally provides a method for producing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate. The method can include culturing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a methacrylic acid pathway enzyme in a sufficient amount to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate, under conditions and for a sufficient period of time to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate.
摘要翻译：本发明提供具有甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯途径的非天然存在的微生物生物。微生物生物体含有编码甲基丙烯酸途径中的酶的至少一种外源核酸。本发明另外提供了生产甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯的方法。该方法可以包括培养产生甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯的微生物，其中微生物生物体表达至少一种编码甲基丙烯酸途径酶的外源核酸，其量足以产生甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯在条件下和足够的时间以产生甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯。

10. 发明申请

US20110212507A1 METHODS FOR INCREASING PRODUCT YIELDS 有权
标题翻译：增加产品线的方法
公开(公告)号：US20110212507A1
公开(公告)日：2011-09-01
申请号：US13011818
申请日：2011-01-21
申请人： Anthony P. BURGARD , Robin E. Osterhout , Jun Sun , Priti Pharkya
发明人： Anthony P. BURGARD , Robin E. Osterhout , Jun Sun , Priti Pharkya
IPC分类号： C12N1/00
CPC分类号： C12P7/42 , C12N9/0008 , C12N9/0095 , C12P7/04 , C12P7/16 , C12P7/18 , C12P7/52 , Y02E50/10
摘要： A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. A method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen includesculturing this organism for a sufficient period of time to produce a product.
摘要翻译：非天然存在的微生物体包括具有还原性TCA或Wood-Ljungdahl途径的微生物生物体，其中至少一种编码这些途径酶的外源核酸以足够的量表达以增强通过乙酰辅酶A的碳通量。通过乙酰辅酶A增强碳通量的方法包括在条件和足够的时间段内培养这些非天然存在的微生物，以产生具有乙酰辅酶A作为结构单元的产物。另一种非天然存在的微生物生物体包括至少一种编码以足够量表达的酶的外源核酸，以增强在一氧化碳或氢气存在下还原当量的可用性，从而通过碳水化合物 - 碳原料。在一氧化碳或氢气存在下增强还原当量的可用性的方法包括在足够的时间内培养该生物体以产生产物。

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