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1. 发明授权

US09580426B2 Compounds that expand hematopoietic stem cells 有权
标题翻译：扩大造血干细胞的化合物
公开(公告)号：US09580426B2
公开(公告)日：2017-02-28
申请号：US13857939
申请日：2013-04-05
申请人： Anthony E. Boitano , Michael Cooke , Shifeng Pan , Peter G. Schultz , John Tellew , Yongqin Wan , Xing Wang
发明人： Anthony E. Boitano , Michael Cooke , Shifeng Pan , Peter G. Schultz , John Tellew , Yongqin Wan , Xing Wang
IPC分类号： C07D473/34 , A61K38/00 , C07D487/04 , C12N5/0789 , C07D473/16 , C07D495/04
CPC分类号： A61K35/28 , A61K9/0019 , A61K31/52 , A61K38/00 , A61K2035/124 , C07D473/16 , C07D473/34 , C07D487/04 , C07D495/04 , C12N5/0647 , C12N2501/38 , C12N2501/60
摘要： The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.
摘要翻译：本发明涉及用于扩增用于移植的CD34 +细胞数量的化合物和组合物。本发明还涉及包含扩大的造血干细胞（HSCs）的细胞群及其在自体或同种异体移植中用于治疗遗传性免疫缺陷和自身免疫性疾病和多种造血障碍的患者的细胞群，以重建造血细胞谱系和免疫系统防御。

2. 发明申请

US20100183564A1 COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS 有权
标题翻译：化学干扰细胞扩增的化合物
公开(公告)号：US20100183564A1
公开(公告)日：2010-07-22
申请号：US12608946
申请日：2009-10-29
申请人： Anthony E. Boitano , Michael Cooke , Shifeng Pan , Peter G. Schultz , John Tellew , Yongqin Wan , Xing Wang
发明人： Anthony E. Boitano , Michael Cooke , Shifeng Pan , Peter G. Schultz , John Tellew , Yongqin Wan , Xing Wang
IPC分类号： A61K35/28 , C07D473/34 , A61K31/52 , A61P35/02 , A61P35/00 , A61P7/06 , A61P37/00 , C12N5/0789 , C12N5/078
CPC分类号： A61K35/28 , A61K9/0019 , A61K31/52 , A61K38/00 , A61K2035/124 , C07D473/16 , C07D473/34 , C07D487/04 , C07D495/04 , C12N5/0647 , C12N2501/38 , C12N2501/60
摘要： The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.
摘要翻译：本发明涉及用于扩增用于移植的CD34 +细胞数量的化合物和组合物。本发明还涉及包含扩大的造血干细胞（HSCs）的细胞群及其在自体或同种异体移植中用于治疗遗传性免疫缺陷和自身免疫性疾病和多种造血障碍的患者的细胞群，以重建造血细胞谱系和免疫系统防御。

3. 发明授权

US08927281B2 Method for expanding hematopoietic stem cells 有权
标题翻译：扩大造血干细胞的方法
公开(公告)号：US08927281B2
公开(公告)日：2015-01-06
申请号：US12608946
申请日：2009-10-29
申请人： Anthony E. Boitano , Michael Cooke , Shifeng Pan , Peter G. Schultz , John Tellew , Yongqin Wan , Xing Wang
发明人： Anthony E. Boitano , Michael Cooke , Shifeng Pan , Peter G. Schultz , John Tellew , Yongqin Wan , Xing Wang
IPC分类号： C12N5/00 , C12N5/0789 , C07D487/04 , C07D473/34 , C07D473/16 , A61K38/00 , C07D495/04
CPC分类号： A61K35/28 , A61K9/0019 , A61K31/52 , A61K38/00 , A61K2035/124 , C07D473/16 , C07D473/34 , C07D487/04 , C07D495/04 , C12N5/0647 , C12N2501/38 , C12N2501/60
摘要： The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.
摘要翻译：本发明涉及用于扩增用于移植的CD34 +细胞数量的化合物和组合物。本发明还涉及包含扩大的造血干细胞（HSCs）的细胞群及其在自体或同种异体移植中用于治疗遗传性免疫缺陷和自身免疫性疾病和多种造血障碍的患者的细胞群，以重建造血细胞谱系和免疫系统防御。

4. 发明申请

US20110306625A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 有权
标题翻译：作为蛋白激酶抑制剂的化合物和组合物
公开(公告)号：US20110306625A1
公开(公告)日：2011-12-15
申请号：US12870130
申请日：2010-08-27
申请人： Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
发明人： Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
IPC分类号： A61K31/506 , A61P25/24 , A61P1/08 , C07D401/04 , A61P35/00
CPC分类号： C07D403/04 , A61K9/0053 , A61K31/4184 , A61K31/506 , A61K45/06 , C07D401/14 , C07D405/14 , A61K2300/00
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及B-Raf异常激活的疾病或病症。

5. 发明申请

US20130296318A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 有权
标题翻译：作为蛋白激酶抑制剂的化合物和组合物
公开(公告)号：US20130296318A1
公开(公告)日：2013-11-07
申请号：US13931111
申请日：2013-06-28
申请人： Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
发明人： Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
IPC分类号： C07D403/04 , C07D401/14 , C07D405/14 , A61K45/06 , A61K31/506
CPC分类号： C07D403/04 , A61K9/0053 , A61K31/4184 , A61K31/506 , A61K45/06 , C07D401/14 , C07D405/14 , A61K2300/00
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及B-Raf异常激活的疾病或病症。

6. 发明授权

US08501758B2 Compounds and compositions as protein kinase inhibitors 有权
标题翻译：化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：US08501758B2
公开(公告)日：2013-08-06
申请号：US12870130
申请日：2010-08-27
申请人： Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
发明人： Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
IPC分类号： A01N43/54
CPC分类号： C07D403/04 , A61K9/0053 , A61K31/4184 , A61K31/506 , A61K45/06 , C07D401/14 , C07D405/14 , A61K2300/00
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及B-Raf异常激活的疾病或病症。

7. 发明申请

US20140011825A1 Compounds and Compositions as Protein Kinase Inhibitors 有权
标题翻译：化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：US20140011825A1
公开(公告)日：2014-01-09
申请号：US14022540
申请日：2013-09-10
申请人： Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
发明人： Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
IPC分类号： C07D403/04 , A61K45/06 , A61K31/506
CPC分类号： C07D403/04 , A61K31/506 , A61K45/06
摘要： The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译：本发明提供式I或II的化合物：其中R1，R1b，R2，R3，R4，R5，R6和R7如本文所定义。式（I）或（II）的化合物及其药物组合物可用于治疗B-Raf相关疾病。

8. 发明申请

US20080064719A1 Crf Receptor Antagonists And Methods Relating Thereto 失效
标题翻译： Crf受体拮抗剂及其相关方法
公开(公告)号：US20080064719A1
公开(公告)日：2008-03-13
申请号：US11576954
申请日：2005-10-17
申请人： Marion Lanier , Manisha Moorjani , John Tellew , John Williams
发明人： Marion Lanier , Manisha Moorjani , John Tellew , John Williams
IPC分类号： A61K31/437 , A61P25/00 , A61P29/00 , A61P37/00 , A61P9/00 , C07D471/04
CPC分类号： C07D471/04
摘要： CRF receptor antagonists are disclosed which may have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in mammals, such as stroke. The CRF receptor antagonists of this invention have the following structure: and pharmaceutically acceptable salts, esters, solvates, stereoisomers and prodrugs thereof, wherein R1, R2, n, R5, Ar, and Het are as defined herein. Compositions containing a CRF receptor antagonists in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.
摘要翻译：公开了CRF受体拮抗剂，其可用于治疗各种疾病，包括治疗表现出哺乳动物如中风中CRF过度分泌的病症。本发明的CRF受体拮抗剂具有以下结构：及其药学上可接受的盐，酯，溶剂化物，立体异构体和前药，其中R 1，R 2，n，R Ar和Het如本文所定义。还公开了含有CRF受体拮抗剂与药学上可接受的载体组合的组合物，以及其用途的方法。

9. 发明申请

US20060270290A1 Lightweight personal rescue tube flotation device 审中-公开
标题翻译：轻量级救生管浮选装置
公开(公告)号：US20060270290A1
公开(公告)日：2006-11-30
申请号：US11137976
申请日：2005-05-25
申请人： John Tellew
发明人： John Tellew
IPC分类号： B63C9/08
CPC分类号： B63C9/18 , B63C9/155
摘要： A compact lightweight personal flotation device is described that permits a user to swim with little drag or encumbrance following deployment, said flotation device comprising a streamlined inflatable float, one or more inflation means such as an oral inflation tube or a compressed gas cartridge/inflator system, a tether to secure the float to the user's body or clothing, and an optionally detachable line attaching the two ends of the float to allow the float to be looped over the body of the user and used hands-free in the manner of a life ring.
摘要翻译：描述了一种紧凑的轻质私人浮选装置，其允许使用者在部署之后以较小的阻力或阻碍物游泳，所述浮选装置包括流线型的可充气浮子，一个或多个充气装置，例如口腔充气管或压缩气体盒/充气器系统，将浮子固定到使用者的身体或衣服上的系绳，以及连接浮子两端的可选择的可拆卸线，以使浮子环绕在使用者的身体上并以生命的方式使用免提环。

10. 发明授权

US08859548B2 Compounds and compositions as protein kinase inhibitors 有权
标题翻译：化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：US08859548B2
公开(公告)日：2014-10-14
申请号：US14022540
申请日：2013-09-10
申请人： Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
发明人： Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
IPC分类号： A61K31/50 , A61K45/06 , A61K31/506 , C07D403/04
CPC分类号： C07D403/04 , A61K31/506 , A61K45/06
摘要： The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译：本发明提供式I或II的化合物：其中R1，R1b，R2，R3，R4，R5，R6和R7如本文所定义。式（I）或（II）的化合物及其药物组合物可用于治疗B-Raf相关疾病。

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