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1. 发明授权

US6119701A Methods, agents and devices for removing nucleophilic toxins from tobacco and tobacco smoke 失效
标题翻译：用于从烟草和烟草烟雾中去除亲核毒素的方法，试剂和装置
公开(公告)号：US6119701A
公开(公告)日：2000-09-19
申请号：US23569
申请日：1998-02-13
申请人： Anthony Cerami , Carla Cerami , Peter Ulrich
发明人： Anthony Cerami , Carla Cerami , Peter Ulrich
IPC分类号： A24D3/10 , A24D3/14 , A24B15/00 , A24B15/10
CPC分类号： A24D3/14 , A24D3/10
摘要： This invention provides methods, devices and agents for the removal of nucleophilic toxins present in tobacco and tobacco smoke, without the removal of nicotine. The filter element of a tobacco smoking device or an air filtration device used in conjunction with a tobacco smoking device may comprise chemical moieties reactive with nucleophilic compounds, or agents that trap nucleophilic compounds may be incorporated into the filter element of tobacco smoking device such as a cigarette, cigar, pipe, or in a separate filter through which tobacco smoke passes before entering the mouth. The agents may also be incorporated into air filters for removing tobacco combustion product toxins from room air. The agents may also be incorporated into smoking or smokeless tobacco to remove toxins.
摘要翻译：本发明提供了除去烟草和烟草烟雾中存在的亲核毒素的方法，装置和试剂，而不除去尼古丁。与烟草吸烟装置一起使用的烟草吸烟装置或空气过滤装置的过滤元件可以包括与亲核化合物反应的化学部分，或者捕获亲核化合物的试剂可以并入烟草吸烟装置的过滤元件中，例如香烟，雪茄，烟斗，或烟草烟雾在进入口腔之前通过的单独过滤器。还可以将这些试剂并入空气过滤器中，以从室内空气中除去烟草燃烧产物毒素。这些药剂也可以并入吸烟或无烟烟草中以去除毒素。

2. 发明授权

US06615842B1 Methods for removing nucleophilic toxins from tobacco smoke 失效
标题翻译：从烟草烟雾中去除亲核毒素的方法
公开(公告)号：US06615842B1
公开(公告)日：2003-09-09
申请号：US09603633
申请日：2000-06-26
申请人： Anthony Cerami , Carla Cerami , Peter Ulrich
发明人： Anthony Cerami , Carla Cerami , Peter Ulrich
IPC分类号： A24D306
CPC分类号： A24D3/10 , A24D3/14
摘要： This invention provides methods, devices and agents for the removal of nucleophilic toxins present in tobacco and tobacco smoke. The filter element of a tobacco smoking device or an air filtration device used in conjunction with a tobacco smoking device may comprise chemical moieties reactive with nucleophilic compounds, or agents that trap nucleophilic compounds may be incorporated into the filter element of tobacco smoking device such as a cigarette, cigar, pipe, or in a separate filter through which tobacco smoke passes before entering the mouth. The agents may also be incorporated into air filters for removing tobacco combustion product toxins from room air. The agents may also be incorporated into smoking or smokeless tobacco to remove toxins.
摘要翻译：本发明提供了用于去除烟草和烟草烟雾中存在的亲核毒素的方法，装置和试剂。与烟草吸烟装置一起使用的烟草吸烟装置或空气过滤装置的过滤元件可以包括与亲核化合物反应的化学部分，或者捕获亲核化合物的试剂可以并入烟草吸烟装置的过滤元件中，例如香烟，雪茄，烟斗，或烟草烟雾在进入口腔之前通过的单独过滤器。还可以将这些试剂并入空气过滤器中，以从室内空气中除去烟草燃烧产物毒素。这些药剂也可以并入吸烟或无烟烟草中以去除毒素。

3. 发明申请

US20110245169A1 PROTECTION, RESTORATION AND ENHANCEMENT OF ERYTHROPOIETIN RESPONSIVE CELLS, TISSUES AND ORGANS 审中-公开
标题翻译：保护，恢复和增强ERYTHROPOIETIN反应细胞，组织和器官
公开(公告)号：US20110245169A1
公开(公告)日：2011-10-06
申请号：US13036638
申请日：2011-02-28
申请人： Michael Brines , Anthony Cerami , Carla Cerami
发明人： Michael Brines , Anthony Cerami , Carla Cerami
IPC分类号： A61K38/18 , A61P25/00 , A61P27/02 , A61P9/00 , A61P13/12
CPC分类号： C07K14/505 , A61K38/1816
摘要： Methods and compositions are provided for protecting or enhancing an erythropoietin-responsive cell, tissue, organ or body part function or viability in vivo, in situ or ex vivo in mammals, including human beings, by systemic or local administration of an erythropoietin receptor activity modulator, such as an erythropoietin or a modified erythropoietin.
摘要翻译：提供了通过全身或局部施用促红细胞生成素受体活性调节剂，在哺乳动物（包括人）中原位或离体保护或增强促红细胞生成素反应性细胞，组织，器官或身体部位功能或活体活性的方法和组合物，例如促红细胞生成素或修饰的红细胞生成素。

4. 发明申请

US20120142589A1 TISSUE-PROTECTIVE CYTOKINES FOR THE PROTECTION, RESTORATION AND ENHANCEMENT OF RESPONSIVE CELLS, TISSUES AND ORGANS 审中-公开
标题翻译：用于保护，恢复和增强反应性细胞，组织和器官的组织保护性细胞因子
公开(公告)号：US20120142589A1
公开(公告)日：2012-06-07
申请号：US13195757
申请日：2011-08-01
申请人： Michael Brines , Anthony Cerami , Carla Cerami
发明人： Michael Brines , Anthony Cerami , Carla Cerami
IPC分类号： A61K38/19 , A61P39/00
CPC分类号： A61K31/00 , A61K31/5377 , A61K31/573 , A61K31/65 , A61K31/66 , A61K38/00 , A61K45/06 , C07K14/505 , A61K2300/00
摘要： Methods and compositions are provided for protecting or enhancing a responsive cell, tissue, organ or body part function or viability in vivo, in situ or ex vivo in mammals, including human beings, by systemic or local administration of a tissue protective cytokine.
摘要翻译：提供了通过全身或局部施用组织保护性细胞因子，在哺乳动物（包括人）中原位或离体保护或增强体内反应性细胞，组织，器官或身体部位功能或活力的方法和组合物。

5. 发明申请

US20070298031A1 Methods for preventing or treating neuromuscular or muscular conditions by peripherally administered erythropoietin 审中-公开
标题翻译：通过外周给予的促红细胞生成素预防或治疗神经肌肉或肌肉状况的方法
公开(公告)号：US20070298031A1
公开(公告)日：2007-12-27
申请号：US11881759
申请日：2007-07-26
申请人： Michael Brines , Anthony Cerami , Carla Cerami Hand
发明人： Michael Brines , Anthony Cerami , Carla Cerami Hand
IPC分类号： A61K38/19 , A61K35/00 , A61K39/395 , A61P21/00 , A61P29/00 , A61P9/10
CPC分类号： A61K38/1816
摘要： Methods and compositions are provided for protecting or enhancing excitable tissue function in mammals by systemic administration of an erythropoietin receptor activity modulator, such as erythropoietin, which signals via an EPO-activated receptor to modulate the function of excitable tissue. Excitable tissues include central neuronal tissues, such as the brain, peripheral neuronal tissues, retina, and heart tissue. Protection of excitable tissues provides treatment of hypoxia, seizure disorders, neurodegenerative diseases, hypoglycemia, and neurotoxin poisoning. Enhancement of function is useful in learning and memory. The invention is also directed to compositions and methods for facilitating the transport of molecules across endothelial cell tight junction barriers, such as the blood-brain barrier, by association of molecules with an erythropoietin receptor activity modulator, such as an erythropoietin.
摘要翻译：通过全身给予促红细胞生成素受体活性调节剂如红细胞生成素，通过EPO激活的受体信号调节可兴奋组织的功能，提供了用于保护或增强哺乳动物可激发组织功能的方法和组合物。可兴奋组织包括中枢神经元组织，如脑，周围神经元组织，视网膜和心脏组织。保护可兴奋组织提供治疗缺氧，癫痫发作，神经退行性疾病，低血糖症和神经毒素中毒。功能的增强在学习和记忆中是有用的。本发明还涉及通过分子与促红细胞生成素受体活性调节剂如红细胞生成素的缔合促进分子穿过内皮细胞紧密连接屏障（例如血脑屏障）的转运的组合物和方法。

6. 发明授权

US07309687B1 Methods for treatment and prevention of neuromuscular and muscular conditions by peripherally administered erythropoietin 失效
标题翻译：通过外周给予的促红细胞生成素治疗和预防神经肌肉和肌肉状况的方法
公开(公告)号：US07309687B1
公开(公告)日：2007-12-18
申请号：US09717053
申请日：2000-11-21
申请人： Michael Brines , Anthony Cerami , Carla Cerami
发明人： Michael Brines , Anthony Cerami , Carla Cerami
IPC分类号： A61K38/18
CPC分类号： A61K38/1816
摘要： Methods and compositions are provided for protecting or enhancing excitable tissue function in mammals by systemic administration of an erythropoietin receptor activity modulator, such as erythropoietin, which signals via an EPO-activated receptor to modulate the function of excitable tissue. Excitable tissues include central neuronal tissues, such as the brain, peripheral neuronal tissues, retina, and heart tissue. Protection of excitable tissues provides treatment of hypoxia, seizure disorders, neurodegenerative diseases, hypoglycemia, and neurotoxin poisoning. Enhancement of function is useful in learning and memory. The invention is also directed to compositions and methods for facilitating the transport of molecules across endothelial cell tight junction barriers, such as the blood-brain barrier, by association of molecules with an erythropoietin receptor activity modulator, such as an erythropoietin.
摘要翻译：通过全身给予促红细胞生成素受体活性调节剂如红细胞生成素，通过EPO激活的受体信号调节可兴奋组织的功能，提供了用于保护或增强哺乳动物可激发组织功能的方法和组合物。可兴奋组织包括中枢神经元组织，如脑，周围神经元组织，视网膜和心脏组织。保护可兴奋组织提供治疗缺氧，癫痫发作，神经退行性疾病，低血糖症和神经毒素中毒。功能的增强在学习和记忆中是有用的。本发明还涉及通过分子与促红细胞生成素受体活性调节剂如红细胞生成素的缔合促进分子穿过内皮细胞紧密连接屏障（例如血脑屏障）的转运的组合物和方法。

7. 发明授权

US08404226B2 Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs 有权
标题翻译：用于保护，恢复和增强响应性细胞，组织和器官的组织保护性细胞因子
公开(公告)号：US08404226B2
公开(公告)日：2013-03-26
申请号：US10520140
申请日：2003-07-03
申请人： Michael Brines , Anthony Cerami , Carla Cerami
发明人： Michael Brines , Anthony Cerami , Carla Cerami
IPC分类号： A61K45/00 , A61K38/18 , A61K38/16
CPC分类号： A61K31/00 , A61K31/5377 , A61K31/573 , A61K31/65 , A61K31/66 , A61K38/00 , A61K45/06 , C07K14/505 , A61K2300/00
摘要： Methods and compositions are provided for treating a mammal having inflammation by protecting or enhancing a responsive cell, tissue, organ or body part exhibiting or associated with the inflammation, by systemic or local administration of a composition comprising a tissue protective cytokine. The invention also encompasses combination treatments comprising administering a composition comprising a tissue protective cytokine of the invention and administering at least one anti-inflammatory or least one immunomodulatory agent.
摘要翻译：提供了通过全身或局部施用包含组织保护性细胞因子的组合物来治疗具有炎症的哺乳动物，通过保护或增强显示或与炎症相关的反应性细胞，组织，器官或身体部位来治疗炎症。本发明还包括组合治疗，其包括施用包含本发明的组织保护性细胞因子的组合物并施用至少一种抗炎或至少一种免疫调节剂。

8. 发明授权

US07767643B2 Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs 有权
标题翻译：红细胞生成素反应性细胞，组织和器官的保护，恢复和增强
公开(公告)号：US07767643B2
公开(公告)日：2010-08-03
申请号：US10185841
申请日：2002-06-26
申请人： Michael Brines , Anthony Cerami , Carla Cerami
发明人： Michael Brines , Anthony Cerami , Carla Cerami
IPC分类号： A61K38/18 , C07K14/505
CPC分类号： C07K14/505 , A61K38/1816
摘要： Methods and compositions are provided for protecting or enhancing an erythropoietin-responsive cell, tissue, organ or body part function or viability in vivo, in situ or ex vivo in mammals, including human beings, by systemic or local administration of an erythropoietin receptor activity modulator, such as an erythropoietin or a modified erythropoietin.
摘要翻译：提供了通过全身或局部施用促红细胞生成素受体活性调节剂，在哺乳动物（包括人）中原位或离体保护或增强促红细胞生成素反应性细胞，组织，器官或身体部位功能或活体活性的方法和组合物，例如促红细胞生成素或修饰的红细胞生成素。

9. 发明申请

US20080014193A1 Modulation of excitable tissue function by peripherally administered erythropoietin 审中-公开
公开(公告)号：US20080014193A1
公开(公告)日：2008-01-17
申请号：US11893294
申请日：2007-08-14
申请人： Michael Brines , Anthony Cerami , Carla Cerami
发明人： Michael Brines , Anthony Cerami , Carla Cerami
IPC分类号： A61K38/22 , A61P25/00
CPC分类号： A61K38/1816
摘要： Methods and compositions are provided for protecting or enhancing excitable tissue function in mammals by systemic administration of an erythropoietin receptor activity modulator, such as erythropoietin, which signals via an EPO-activated receptor to modulate the function of excitable tissue. Excitable tissues include central neuronal tissues, such as the brain, peripheral neuronal tissues, retina, and heart tissue. Protection of excitable tissues provides treatment of hypoxia, seizure disorders, neurodegenerative diseases, hypoglycemia, and neurotoxin poisoning. Enhancement of function is useful in learning and memory. The invention is also directed to compositions and methods for facilitating the transport of molecules across endothelial cell tight junction barriers, such as the blood-brain barrier, by association of molecules with an erythropoietin receptor activity modulator, such as an erythropoietin.

10. 发明申请

US20060034799A1 Tissue protective cytokines for the protection, restoration, and enhancement fo responsive cells, tissues and organs 有权
标题翻译：组织保护性细胞因子，用于保护，恢复和增强反应性细胞，组织和器官
公开(公告)号：US20060034799A1
公开(公告)日：2006-02-16
申请号：US10520140
申请日：2003-07-03
申请人： Michael Brines , Anthony Cerami , Carla Cerami
发明人： Michael Brines , Anthony Cerami , Carla Cerami
IPC分类号： A61K38/19 , A61K38/18 , A61K38/13 , A61K31/573 , A61K31/66 , A61K31/65 , A61K31/5377
CPC分类号： A61K31/00 , A61K31/5377 , A61K31/573 , A61K31/65 , A61K31/66 , A61K38/00 , A61K45/06 , C07K14/505 , A61K2300/00
摘要： Methods and compositions are provided for treating a mammal having inflammation by protecting or enhancing a responsive cell, tissue, organ or body part exhibiting or associated with the inflammation, by systemic or local administration of a composition comprising a tissue protective cytokine. The invention also encompasses combination treatments comprising administering a composition comprising a tissue protective cytokine of the invention and administering at least one anti-inflammatory or least one immunomodulatory agent.
摘要翻译：提供了通过全身或局部施用包含组织保护性细胞因子的组合物来治疗具有炎症的哺乳动物，通过保护或增强显示或与炎症相关的反应性细胞，组织，器官或身体部位来治疗炎症。本发明还包括组合治疗，其包括施用包含本发明的组织保护性细胞因子的组合物并施用至少一种抗炎或至少一种免疫调节剂。

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