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1. 发明申请

US20110166068A1 Therapeutic Dosing of a Neuregulin or a Subsequence Thereof for Treatment or Pro-phylaxis of Heart Failure 审中-公开
标题翻译：神经调节素的治疗剂量或其后续治疗或心力衰竭的前期疗法
公开(公告)号：US20110166068A1
公开(公告)日：2011-07-07
申请号：US13055397
申请日：2009-07-17
申请人： Anthony Caggiano , Anindita Ganguly , Jennifer Iaci , Tom Parry
发明人： Anthony Caggiano , Anindita Ganguly , Jennifer Iaci , Tom Parry
IPC分类号： A61K38/18 , A61P9/00
摘要： The invention relates to treatment of heart failure in a mammal. Accordingly, the invention is directed to establishing a dosing regimen whereby the therapeutic benefits conferred by administration of a neuregulin such as glial growth factor 2 (GGF2) or a subsequence thereof are maintained and/or enhanced, while concomitantly minimizing any potential side effects.
摘要翻译：本发明涉及哺乳动物心脏衰竭的治疗。因此，本发明涉及建立一种给药方案，其中通过施用神经胶质细胞如神经胶质细胞生长因子2（GGF2）或其子序列来维持和/或增强神经调节蛋白所赋予的治疗益处，同时最小化任何潜在的副作用。

2. 发明申请

US20060019691A1 Method and system for evaluating the efficacy of locally-applied anti-proliferative or other agents on neointimal hyperplasia, immunohistochemical and vascular cell cycle changes in injured or atherosclerotic rabbit central ear arteries 审中-公开
标题翻译：用于评估局部应用抗增殖剂或其他药物对受损或动脉粥样硬化兔中枢动脉内膜增生，免疫组织化学和血管细胞周期变化的功效的方法和系统
公开(公告)号：US20060019691A1
公开(公告)日：2006-01-26
申请号：US10895548
申请日：2004-07-21
申请人： Robert Falotico , Tom Parry , Jonathon Zhao
发明人： Robert Falotico , Tom Parry , Jonathon Zhao
IPC分类号： H04Q7/20
CPC分类号： A61D1/00
摘要： A methodology for percutaneously accessing the central ear artery of a rabbit may be utilized for inducing, treating and evaluating injuries therein to determine the pathology of the injuries and the safety and efficacy of the treatment. The central ear artery of a rabbit is similar to morphology to human coronary arteries. Accordingly, the study of the central ear artery of a rabbit will provide valuable information in the biology and identification of new treatments for restenosis, atherosclerosis and vulnerable plaque.
摘要翻译：用于经皮进入兔中枢动脉的方法可用于诱导，治疗和评估其中的损伤，以确定损伤的病理以及治疗的安全性和功效。兔的中枢动脉与人冠状动脉的形态相似。因此，兔子中耳动脉的研究将为生物学提供有价值的信息，并为再狭窄，动脉粥样硬化和易损斑块的新治疗提供依据。

3. 发明申请

US20050202059A1 Local vascular delivery of topotecan in combination with rapamycin to prevent restenosis following vascular injury 有权
标题翻译：拓扑替康与雷帕霉素组合的局部血管输送，以防止血管损伤后的再狭窄
公开(公告)号：US20050202059A1
公开(公告)日：2005-09-15
申请号：US10796397
申请日：2004-03-09
申请人： Robert Falotico , Tom Parry , Jonathon Zhao
发明人： Robert Falotico , Tom Parry , Jonathon Zhao
IPC分类号： A61L31/00 , A61F2/84 , A61L27/44 , A61L27/54 , A61L31/12 , A61L31/16 , A61L33/00 , A61F2/00
CPC分类号： A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/434 , A61L2420/08 , C08L27/12 , C08L33/02
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

4. 发明申请

US20050209688A1 Local vascular delivery of Panzem in combination with rapamycin to prevent restenosis following vascular injury 有权
标题翻译：局部血管输送Panzem与雷帕霉素组合，以防止血管损伤后的再狭窄
公开(公告)号：US20050209688A1
公开(公告)日：2005-09-22
申请号：US10805736
申请日：2004-03-22
申请人： Robert Falotico , Tom Parry , Jonathon Zhao
发明人： Robert Falotico , Tom Parry , Jonathon Zhao
IPC分类号： A61L31/00 , A61F2/82 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61F2/06
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/416 , A61L2300/43 , A61L2300/45 , A61L2300/608 , A61L2420/08
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

5. 发明申请

US20050208092A1 Local vascular delivery of etoposide in combination with rapamycin to prevent restenosis following vascular injury 有权
标题翻译：局部血管输送依托泊苷与雷帕霉素联合，以防止血管损伤后的再狭窄
公开(公告)号：US20050208092A1
公开(公告)日：2005-09-22
申请号：US10805722
申请日：2004-03-22
申请人： Robert Falotico , Tom Parry , Jonathan Zhao
发明人： Robert Falotico , Tom Parry , Jonathan Zhao
IPC分类号： A61K9/00 , A61F2/84 , A61K31/436 , A61K31/7048 , A61K47/30 , A61K47/32 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61M35/00 , A61M37/00 , A61P9/10 , A61F2/00
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/416 , A61L2300/43 , A61L2300/45 , A61L2300/608 , A61L2420/08
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

6. 外观设计

USD383385S Combined package and dice game 失效
公开(公告)号：USD383385S
公开(公告)日：1997-09-09
申请号：US035872
申请日：1995-03-08
申请人： Scott Hayduk , Tom Parry
设计人： Scott Hayduk , Tom Parry

7. 发明申请

US20070116736A1 Local vascular delivery of PI3 kinase inhibitors alone or in combination with sirolimus to prevent restinosis following vascular injury 审中-公开
标题翻译：单独或与西罗莫司联合治疗PI3激酶抑制剂的局部血管输送，以防止血管损伤后的再狭窄
公开(公告)号：US20070116736A1
公开(公告)日：2007-05-24
申请号：US11285866
申请日：2005-11-23
申请人： Dennis Argentieri , Robert Falotico , Tom Parry , Jonathon Zhao
发明人： Dennis Argentieri , Robert Falotico , Tom Parry , Jonathon Zhao
IPC分类号： A61F2/02 , A61F2/82
CPC分类号： A61L27/54 , A61B2017/0641 , A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/432
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including vulnerable plaque. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括预防血栓形成。药物，药剂和/或化合物也可用于治疗特定疾病，包括易损斑块。治疗剂也可以递送到疾病部位的区域。在区域递送中，液体制剂可能是期望的，以增加特定药物的功效和递送能力。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药剂或化合物维持在医疗装置上，直到被输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

8. 发明申请

US20060104903A1 Model for evaluating the efficacy of locally applied antiproliferatives or other agents on neointimal hyperplasia, immunohistochemical and vascular cell cycle changes in balloon-injured rat carotid arteries 审中-公开
标题翻译：用于评估局部应用抗增生剂或其他药物对球囊损伤的大鼠颈动脉内膜增生，免疫组织化学和血管细胞周期变化的功效的模型
公开(公告)号：US20060104903A1
公开(公告)日：2006-05-18
申请号：US10991188
申请日：2004-11-17
申请人： Dennis Argentieri , Robert Falotico , Tom Parry , Jonathon Zhao
发明人： Dennis Argentieri , Robert Falotico , Tom Parry , Jonathon Zhao
IPC分类号： A61K49/00 , C12Q1/00
CPC分类号： A61K49/0008
摘要： A methodology for evaluating the efficacy of locally applied antiproliferatives and/or other therapeutic agents on neointimal hyperplasia, as well as immunohistochemical and vascular cell cycle changes, in balloon-injured rat carotid arteries may be utilized for determining the efficacy of treatments in humans.
摘要翻译：用于评估局部施用的抗增殖剂和/或其它治疗剂对新生内膜增生以及球囊损伤的大鼠颈动脉中的免疫组织化学和血管细胞周期变化的功效的方法可用于确定治疗在人中的功效。

9. 发明申请

US20050158360A1 Local vascular delivery of mycophenolic acid in combination with rapamycin to prevent restenosis following vascular injury 有权
标题翻译：局部血管输送霉酚酸与雷帕霉素联合，以防止血管损伤后的再狭窄
公开(公告)号：US20050158360A1
公开(公告)日：2005-07-21
申请号：US10761032
申请日：2004-01-20
申请人： Robert Falotico , Tom Parry , Jonathon Zhao
发明人： Robert Falotico , Tom Parry , Jonathon Zhao
IPC分类号： A61B17/00 , A61B17/11 , A61B17/115 , A61F2/06 , A61F2/82 , A61K31/343 , A61K31/436 , A61L31/00 , A61L31/10 , A61L31/16 , A61P7/02 , A61P9/10 , A61P9/14 , A61P41/00 , A61P43/00 , A61F2/02
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/21 , A61L2300/416 , A61L2420/08 , C08L27/16 , C08L27/20
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

10. 发明申请

US20050182485A1 Local vascular delivery of cladribine in combination with rapamycin to prevent restenosis following vascular injury 有权
标题翻译：局部血管输送克拉屈滨与雷帕霉素组合，以防止血管损伤后的再狭窄
公开(公告)号：US20050182485A1
公开(公告)日：2005-08-18
申请号：US10780596
申请日：2004-02-18
申请人： Robert Falotico , Tom Parry , Jonathon Zhao
发明人： Robert Falotico , Tom Parry , Jonathon Zhao
IPC分类号： A61B17/00 , A61B17/11 , A61B17/12 , A61F2/06 , A61F2/82 , A61K31/436 , A61K31/7076 , A61L17/00 , A61L31/00 , A61L31/10 , A61L31/16 , A61L33/00 , A61L33/10 , A61P7/02 , A61P9/10 , A61F2/02
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/45 , A61L2420/08 , C08L33/02 , C08L27/12
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

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