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1. 发明申请

US20100267823A1 AURONES AS SELECTIVE PDE INHIBITORS AND THEIR USE IN NEUROLOGICAL CONDITIONS AND DISORDERS 审中-公开
标题翻译：作为选择性PDE抑制剂的神经元及其在神经病学和病症中的使用
公开(公告)号：US20100267823A1
公开(公告)日：2010-10-21
申请号：US12749060
申请日：2010-03-29
申请人： Annie George D/O V.K. George , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Joerg Gruenwald , Matthias Gehling , Philipp Wabnitz , Tengku Shahrir bin Tengku Adnan , Torsten Grothe
发明人： Annie George D/O V.K. George , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Joerg Gruenwald , Matthias Gehling , Philipp Wabnitz , Tengku Shahrir bin Tengku Adnan , Torsten Grothe
IPC分类号： A61K31/343 , C07D307/83 , A61P25/00 , A61P25/24 , A61P25/22 , A61P25/18
CPC分类号： C07D307/83 , C07D407/04
摘要： The invention relates to aurones and extracts comprising them useful in the prophylactic and/or therapeutic treatment of an animal (including a human) with a phosphodiesterase (PDE) dependent disease or condition of the central nervous system, as well as methods, uses and other inventions related thereto.
摘要翻译：本发明涉及包含它们可用于预防和/或治疗具有磷酸二酯酶（PDE）依赖性疾病或中枢神经系统病症的动物（包括人）以及方法，用途和其它与此相关的发明。

2. 发明申请

US20100267822A1 AURONES AS ESTROGEN RECEPTOR MODULATORS AND THEIR USE IN SEX HORMONE DEPENDENT DISEASES 审中-公开
标题翻译：作为雌激素受体调节剂的神经元及其在性别依赖性疾病中的应用
公开(公告)号：US20100267822A1
公开(公告)日：2010-10-21
申请号：US12749024
申请日：2010-03-29
申请人： Annie George D/O V.K. George , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Joachim Hans , Joerg Gruenwald , Matthias Gehling , Philipp Wabnitz , Tengku Shahrir bin Tengku Adnan , Torsten Grothe
发明人： Annie George D/O V.K. George , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Joachim Hans , Joerg Gruenwald , Matthias Gehling , Philipp Wabnitz , Tengku Shahrir bin Tengku Adnan , Torsten Grothe
IPC分类号： A61K31/343 , C07D307/83 , A61P25/00 , A61P25/24 , A61P25/28 , A61P27/02 , A61P9/12 , A61P19/08 , A61P35/00 , A61P9/00 , A61P15/00 , A61P5/30
CPC分类号： C07D307/83 , C07D407/04
摘要： The invention relates to aurones and extracts comprising them useful in the prophylactic and/or therapeutic treatment of an animal (including a human) with an estrogen receptor (ER) related disease or condition of the animal or human body, as well as methods, uses and other inventions related thereto.
摘要翻译：本发明涉及包含它们可用于预防和/或治疗具有雌激素受体（ER）相关疾病或动物或人体的病症的动物（包括人））的赭色和提取物以及方法，用途和其他有关的发明。

3. 发明授权

US09453016B2 Terpenoid spiro ketal compounds with LXR agonists activity, their use and formulations with them 有权
标题翻译：具有LXR激动剂活性的萜类螺旋酮缩酮化合物，它们的用途和配方
公开(公告)号：US09453016B2
公开(公告)日：2016-09-27
申请号：US13994447
申请日：2011-12-08
申请人： Torsten Grothe , Marc Stadler , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Philipp Wabnitz , Thomas Küper
发明人： Torsten Grothe , Marc Stadler , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Philipp Wabnitz , Thomas Küper
IPC分类号： A61K31/35 , C07D493/00 , C07D471/10 , A61K31/56 , A61K31/58 , A61K36/07
CPC分类号： C07D471/10 , A61K31/56 , A61K31/58 , A61K36/07
摘要： The invention relates to compositions and methods (with regard to animals and humans) for utilizing an extract and/or one or more natural spiro triterpenoids and derivatives thereof alone or as a supplement. Certain materials utilized are from the blazeispirol family, obtainable from Agaricus species. Treatments include the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, as well as corresponding methods of treatment, the manufacture of a pharmaceutical and nutraceutical formulation for said treatment. The invention also relates to the use of the extract and compound(s) in the treatment or in the preparation of a medicament (e.g. a nutraceutical) for the prophylactic and/or therapeutic treatments, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations described herein which are useful in prophylactic and therapeutic treatments. They can also be used for non-therapeutic, e.g. cosmetic, purposes.
摘要翻译：本发明涉及用于单独使用提取物和/或一种或多种天然螺三萜类化合物及其衍生物或作为补充剂的组合物和方法（关于动物和人）。使用的某些材料来自于可从姬松茸（Agaricus）物种获得的烟草系列。治疗包括对对肝X受体的调节作出响应的疾病，病症或病状的预防和/或治疗性治疗，以及相应的治疗方法，制备用于所述治疗的药物和营养制剂。本发明还涉及提取物和化合物在治疗或制备用于预防和/或治疗性治疗的药物（例如营养药物）以及其制备中的用途。它还涉及可用于预防和治疗性治疗的本文所述的药物或营养制剂。它们也可以用于非治疗性的，例如，化妆品，用途。

4. 发明申请

US20130338219A1 Terpenoid Spiro Ketal Compounds with LXR Agonists Activity, Their Use and Formulations with Them 有权
标题翻译：萜类螺旋酮化合物与LXR激动剂的活性，它们的用途和配方
公开(公告)号：US20130338219A1
公开(公告)日：2013-12-19
申请号：US13994447
申请日：2011-12-08
申请人： Torsten Grothe , Marc Stadler , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Philipp Wabnitz , Thomas Küper
发明人： Torsten Grothe , Marc Stadler , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Philipp Wabnitz , Thomas Küper
IPC分类号： C07D471/10
CPC分类号： C07D471/10 , A61K31/56 , A61K31/58 , A61K36/07
摘要： The invention relates to compositions and methods (with regard to animals and humans) for utilizing an extract and/or one or more natural spiro triterpenoids and derivatives thereof alone or as a supplement. Certain materials utilized are from the blazeispirol family, obtainable from Agaricus species. Treatments include the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, as well as corresponding methods of treatment, the manufacture of a pharmaceutical and nutraceutical formulation for said treatment. The invention also relates to the use of the extract and compound(s) in the treatment or in the preparation of a medicament (e.g. a nutraceutical) for the prophylactic and/or therapeutic treatments, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations described herein which are useful in prophylactic and therapeutic treatments. They can also be used for non-therapeutic, e.g. cosmetic, purposes.
摘要翻译：本发明涉及用于单独使用提取物和/或一种或多种天然螺三萜类化合物及其衍生物或作为补充剂的组合物和方法（关于动物和人）。使用的某些材料来自于可从姬松茸（Agaricus）物种获得的烟草系列。治疗包括对对肝X受体的调节作出响应的疾病，病症或病状的预防和/或治疗性治疗，以及相应的治疗方法，制备用于所述治疗的药物和营养制剂。本发明还涉及提取物和化合物在治疗或制备用于预防和/或治疗性治疗的药物（例如营养药物）以及其制备中的用途。它还涉及可用于预防和治疗性治疗的本文所述的药物或营养制剂。它们也可以用于非治疗性的，例如，化妆品，用途。

5. 发明申请

US20130023586A1 USE OF TRICYCLIC SESQUITERPENE LACTONES IN THE TREATMENT OF OBESITY AND RELATED DISEASES AND NON-THERAPEUTIC TREATABLE CONDITIONS 审中-公开
标题翻译：在治疗肥胖和相关疾病和非治疗可治疗条件下使用三酯酸酯酶
公开(公告)号：US20130023586A1
公开(公告)日：2013-01-24
申请号：US13522110
申请日：2011-01-13
申请人： Torsten Grothe , Ernst Roemer , Philipp Wabnitz
发明人： Torsten Grothe , Ernst Roemer , Philipp Wabnitz
IPC分类号： A61K31/365 , A61Q90/00 , A61P3/04 , C07D307/93 , A61K8/49
CPC分类号： C07D307/93 , A61K8/4973 , A61K8/97 , A61K31/365 , A61K36/28 , A61Q19/06
摘要： A compound of the formula I, wherein the symbols are as defined in the remaining specification, or a mixture of two or more compounds of the formula I, for use as active ingredient in the therapeutic—including prophylactic—treatment of a warm-blooded animal for the regulation of body weight (preferred) and/or fat loss (preferred) and/or for the management of obesity and/or for improving the total cholesterol HDL/LDL ratio; where the compound(s) of the formula I may be present in free form, in the form of a pharmaceutically and/or nutraceutically acceptable salt, in the form of tautomers, in the form of esters and/or in the form of solvates, as well as related invention embodiments.
摘要翻译：式I化合物，其中符号如剩余说明书中所定义，或两种或更多种式I化合物的混合物，用作治疗性包括预防性治疗温血动物的活性成分用于调节体重（优选）和/或脂肪减少（优选）和/或用于管理肥胖症和/或改善总胆固醇HDL / LDL比率; 其中式I的化合物可以以互变异构体的形式，以酯和/或溶剂合物的形式以游离形式存在，以药物和/或营养学上可接受的盐的形式存在，以及相关的发明实施例。

6. 发明授权

US08962575B2 Clerodane derivatives for modulation of leukotriene receptor activity and related diseases 有权
标题翻译：用于调节白三烯受体活性和相关疾病的氯癸烷衍生物
公开(公告)号：US08962575B2
公开(公告)日：2015-02-24
申请号：US13402675
申请日：2012-02-22
申请人： Matthias Gehling , Torsten Grothe , Ernst Roemer , Peter Reinemer , Kathrin Reinhardt , Annie George , Nur Hanisah Mohtar , Noorsyarida Mohd Sapiai
发明人： Matthias Gehling , Torsten Grothe , Ernst Roemer , Peter Reinemer , Kathrin Reinhardt , Annie George , Nur Hanisah Mohtar , Noorsyarida Mohd Sapiai
IPC分类号： A61K31/70 , A61K31/34 , C07D407/08 , C07D407/04 , C07H17/08
CPC分类号： C07D407/08 , C07D407/04 , C07H17/08
摘要： The use or methods of use of extracts comprising one or more special clerodane compounds against inflammatory (including allergic) diseases or conditions, as well as novel compounds of this type, said clerodane derivatives for use against inflammatory (including allergic) diseases or conditions, pharmaceutical formulations comprising them especially for use against inflammatory disease or conditions, and related embodiments; said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disease or condition, as well as their preparation; pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment, and related embodiments.
摘要翻译：使用或使用包含一种或多种抗炎症（特别是过敏性）疾病或病症的特殊克洛膦酸化合物的提取物以及这种新型化合物的用途，所述用于抗炎症（包括过敏性）疾病或病症的氯化丹烷衍生物，药物包含它们的制剂，特别是用于抗炎性疾病或病症，以及相关实施方案; 所述提取物和/或化合物用于治疗或制备用于预防和/或治疗所述疾病或病症的药物（包括营养药物）及其制备; 包含可用于所述预防和/或治疗性治疗的所述提取物和/或天然化合物的药物或营养制剂以及相关实施方案。

7. 发明申请

US20110213026A1 EXTRACTS WITH LIVER-X-RECEPTOR MODULATORS, COMPOUNDS AND THEIR USE ESPECIALLY IN WEIGHT CONTROL 审中-公开
标题翻译：与肝脏受体调节剂，化合物及其在体重控制中特别有用的提取物
公开(公告)号：US20110213026A1
公开(公告)日：2011-09-01
申请号：US12673655
申请日：2008-07-29
申请人： Torsten Grothe , Ernst Roemer , Thomas Henkel
发明人： Torsten Grothe , Ernst Roemer , Thomas Henkel
IPC分类号： A61K31/36 , A61K31/09 , C07C43/23 , C07D317/70 , C07D493/04 , A61P3/04
CPC分类号： A61K31/36 , A61K31/085 , A61K31/09 , A61K31/215 , A61K31/222 , A61K31/343 , A61K36/57 , A61K36/79
摘要： The invention relates to the use, or methods (especially with regard to animals, especially human, that are in need of such treatment) comprising the use, of an extract and/or one or more natural compounds from plants or parts of plants, respectively, from a genus selected from the group consisting of Schisandra, Illicium, Kadsura, Steganotaenia and Magnolia, alone or as supplement, as active ingredient in the regulation of body weight and/or fat loss and/or for the management of obesity, either in humans or in animals, to the use of said extract and/or natural compound(s) or mixtures in the manufacture of a pharmaceutical or nutraceutical formulation for the regulation of body weight and/or fat loss and/or for the management of obesity either in humans or in animals. The above extract and/or compound(s) can further be used to reduce one or more adverse metabolic parameters in a subject. The invention relates also to said extract and/or compound(s) for use in the treatment or in the preparation of a medicament for the treatment of obesity, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in the regulation of body weight and/or fat loss and/or for the management of obesity.
摘要翻译：本发明涉及分别使用来自植物或植物部分的提取物和/或一种或多种天然化合物的用途或方法（特别是关于动物，特别是人类），选自五味子，Illicium，Kadsura，Steganotaenia和Magnolia的属，单独或作为补充作为活性成分，用于调节体重和/或脂肪减少和/或用于肥胖的管理，人或动物使用所述提取物和/或天然化合物或混合物来制造用于调节体重和/或脂肪损失的药物或营养制剂，和/或用于肥胖的管理在人类或动物中。上述提取物和/或化合物还可用于减少受试者中的一种或多种不利代谢参数。本发明还涉及用于治疗或制备用于治疗肥胖症的药物及其制备的所述提取物和/或化合物。它还涉及包含可用于调节体重和/或脂肪减少和/或用于肥胖的管理的所述提取物和/或天然化合物的药物或营养制剂。

8. 发明申请

US20110021613A1 PLANTS EXTRACTS FOR USE IN BRAIN MODULATION 审中-公开
标题翻译：植物提取物用于脑调节
公开(公告)号：US20110021613A1
公开(公告)日：2011-01-27
申请号：US12446481
申请日：2007-12-11
申请人： Ernst Roemer , Torsten Grothe
发明人： Ernst Roemer , Torsten Grothe
IPC分类号： A61K31/11 , C07C47/57 , C07D311/94 , A61K31/352 , C07D311/82 , C07D311/96 , C07D313/06 , A61K31/335 , C07C49/757 , A61K31/122 , C07C45/80 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/22
CPC分类号： C07C47/57 , C07C47/575 , C07C49/757 , C07C49/83 , C07C49/84
摘要： Compounds obtainable from plants, e.g. of the genus Eucalyptus, or from microorganisms are shown to be useful as CNS activity modulators useful e.g. in the treatment of depression, for lifting mood and/or for increasing behavioural initiative and the like. This use and related aspects form embodiments of the invention. Also compounds as such are presented.The compounds useful are acylphloroglucine derivatives of the formula I, wherein the substituents are as defined in the description.
摘要翻译：可从植物获得的化合物。的桉树属或微生物被证明可用作CNS活性调节剂，例如有用的。用于治疗抑郁症，提高心情和/或增加行为主动性等。该用途和相关方面形成本发明的实施例。还提出了这样的化合物。可用的化合物是式I的酰基绿葡萄糖衍生物，其中取代基如说明书中所定义。

9. 发明申请

US20120058172A1 PLANT EXTRACTS FOR USE IN BRAIN MODULATION 审中-公开
标题翻译：植物提取物用于脑调制
公开(公告)号：US20120058172A1
公开(公告)日：2012-03-08
申请号：US13294725
申请日：2011-11-11
申请人： Ernst Roemer , Torsten Grothe
发明人： Ernst Roemer , Torsten Grothe
IPC分类号： A61K31/122 , A61K38/02 , A61K31/70 , A61P25/24 , A61P25/00 , A61P25/28 , A61P25/22 , A61K31/11 , A61K9/00
CPC分类号： C07C47/57 , C07C47/575 , C07C49/757 , C07C49/83 , C07C49/84
摘要： Compounds obtainable from plants, e.g. of the genus Eucalyptus, or from microorganisms are shown to be useful as CNS activity modulators useful e.g. in the treatment of depression, for lifting mood and/or for increasing behavioural initiative and the like. This use and related aspects form embodiments of the invention. Also compounds as such are presented.The compounds useful are acylphloroglucine derivatives of the formula I, wherein the substituents are as defined in the description.
摘要翻译：可从植物获得的化合物。的桉树属或微生物被证明可用作CNS活性调节剂，例如有用的。用于治疗抑郁症，提高心情和/或增加行为主动性等。该用途和相关方面形成本发明的实施例。还提出了这样的化合物。可用的化合物是式I的酰基绿葡萄糖衍生物，其中取代基如说明书中所定义。

10. 发明授权

US07767428B2 Salutaridinol 7-O-acetyltransferase and derivatives thereof 有权
标题翻译： salutaridinol 7-O-乙酰转移酶及其衍生物
公开(公告)号：US07767428B2
公开(公告)日：2010-08-03
申请号：US12121280
申请日：2008-05-15
申请人： Toni M. Kutchan , Meinhart H. Zenk , Torsten Grothe
发明人： Toni M. Kutchan , Meinhart H. Zenk , Torsten Grothe
IPC分类号： C12N9/10 , C12N1/20 , C12N1/00 , C12P21/06 , C07H21/04
CPC分类号： C12N9/1029 , C12N15/8243 , C12P17/188 , C12Y203/0115
摘要： This invention provides a salutaridinol 7-O-acetyltransferase protein, a salutaridinol 7-O-acetyltransferase gene, and a sequence which is complementary thereto. This invention further provides a method for the production of thebaine comprising the steps of (i) contacting in vitro a protein having salutaridinol 7-O-acetyltransferase activity with salutaridinol and acetyl coenzyme A at pH 8 to 9, and (ii) recovering the thebaine thus produced.
摘要翻译：本发明提供了salutaridinol 7-O-乙酰转移酶蛋白，salutaridinol 7-O-乙酰转移酶基因及其互补序列。本发明进一步提供了一种生产蒂巴因的方法，包括以下步骤：（i）在pH8至9下体外接触具有salutaridinol 7-O-乙酰基转移酶活性的蛋白质与salutaridinol和乙酰辅酶A，和（ii）回收蒂巴因从而产生。

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