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1. 发明申请

US20070010568A1 Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists 审中-公开
标题翻译：取代的氮杂双环己烷衍生物作为毒蕈碱受体拮抗剂
公开(公告)号：US20070010568A1
公开(公告)日：2007-01-11
申请号：US10544520
申请日：2003-02-07
申请人： Anita Mehta , Bruhaspathy Miriyala , Naresh Kumar , Jang Gupta
发明人： Anita Mehta , Bruhaspathy Miriyala , Naresh Kumar , Jang Gupta
IPC分类号： A61K31/403 , C07D209/02
CPC分类号： C07D471/08
摘要： This invention relates to derivatives of substituted azabicyclo hexanes. The compound of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.
摘要翻译：本发明涉及取代的氮杂双环己烷的衍生物。本发明化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸道，尿路和胃肠道系统的各种疾病。本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物以及通过毒蕈碱受体介导的疾病的治疗方法。

2. 发明申请

US20060247225A1 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists 失效
公开(公告)号：US20060247225A1
公开(公告)日：2006-11-02
申请号：US10543585
申请日：2003-01-23
申请人： Anita Mehta , Arundutt Silamkoti , Naresh Kumar , Jang Gupta
发明人： Anita Mehta , Arundutt Silamkoti , Naresh Kumar , Jang Gupta
IPC分类号： A61K31/55 , A61K31/46
CPC分类号： C07D401/04 , C07D209/52 , C07D401/06 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/04
摘要： This invention generally relates to derivatives of 3,6 disubstituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

3. 发明申请

US20060122253A1 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists 失效
标题翻译：用作毒蕈碱受体拮抗剂的3,6-二取代的氮杂双环[3.1.0]己烷衍生物
公开(公告)号：US20060122253A1
公开(公告)日：2006-06-08
申请号：US10523208
申请日：2002-07-31
申请人： Anita Mehta , Arundutt Silamkoti , Kirandeep Kaur , Jang Gupta
发明人： Anita Mehta , Arundutt Silamkoti , Kirandeep Kaur , Jang Gupta
IPC分类号： A61K31/403 , C07D209/52
CPC分类号： C07D209/52
摘要： This invention generally relates to the derivatives of 3,6 disubstituted azabicyclo[3.1.0]hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.
摘要翻译：本发明一般涉及3,6-二取代的氮杂双环[3.1.0]己烷的衍生物。本发明的化合物是毒蕈碱受体拮抗剂，其特别用于治疗通过毒蕈碱受体介导的呼吸，尿和胃肠道系统的各种疾病。本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

4. 发明申请

US20060004083A1 Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists 失效
标题翻译：含有3,6-二取代的氮杂二环（3.1.0）己烷衍生物的氟磺酰氨基作为毒蕈碱受体拮抗剂
公开(公告)号：US20060004083A1
公开(公告)日：2006-01-05
申请号：US10525439
申请日：2002-08-23
申请人： Anita Mehta , Jang Gupta
发明人： Anita Mehta , Jang Gupta
IPC分类号： A61K31/403 , C07D209/02
CPC分类号： C07D209/94 , C07D209/52
摘要： This invention generally relates to the derivatives of novel 3,6 disubstituted azabicyclo[3.1.0] hexane's. The compounds of this invention are MUSCARINIC receptor antagonists which are useful, inter-ail for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through MUSCARINIC receptors. The invention also relates to processes for the preparation of the compounds of the invention, pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through MUSCARINIC receptors.
摘要翻译：本发明一般涉及新的3,6-二取代的氮杂双环[3.1.0]己烷的衍生物。本发明的化合物是MUSCARINIC受体拮抗剂，其可用于治疗通过MUSCARINIC受体介导的呼吸，尿和胃肠道系统的各种疾病。本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和通过MUSCARINIC受体介导的疾病的治疗方法。

5. 发明申请

US20070135508A1 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists 失效
标题翻译： 3,6-二取代的氮杂双环己烷衍生物作为毒蕈碱受体拮抗剂
公开(公告)号：US20070135508A1
公开(公告)日：2007-06-14
申请号：US10552502
申请日：2003-04-10
申请人： Anita Mehta , Bruhaspathy Miriyala , Arundutt Silamkoti , Jang Gupta
发明人： Anita Mehta , Bruhaspathy Miriyala , Arundutt Silamkoti , Jang Gupta
IPC分类号： A61K31/403 , C07D405/02
CPC分类号： C07D209/52
摘要： The present invention relates to a radio telephony network (1) supporting at least one link of a radio channel (6) for a packet data transmission service. The radio telephony network (1) comprises a plurality of network controllers (RNC). Each network controller (RNC) is connected, via an interface Iub, to at least one base radio station (B-node) supervising at least one macrocell (5a). The radio telephony network (1) additionally comprises at least one base radio microstation (B1-micronode) connected to the network controller (RNC) via an interface Iub of the same type as that connecting the base radio station (B-node) to said controller. The base radio microstation (B1 micronode) supervises at least one microcell (5b) incorporated in at least one macrocell (5a). The base radio microstation (B1-micronode) provides the packet data transmission service in the microcell (5b) on the link of the radio channel (6).
摘要翻译：本发明涉及支持用于分组数据传输服务的无线电信道（6）的至少一个链路的无线电电话网络（1）。无线电电话网络（1）包括多个网络控制器（RNC）。每个网络控制器（RNC）经由接口Iub连接到监督至少一个宏小区（5a）的至少一个基站无线电台（B节点）。无线电电话网络（1）还包括经由与将基站无线电台（B节点）连接到所述网络控制器（RNC）的相同类型的接口Iub连接到网络控制器（RNC）的至少一个基站无线电微站（B1微米）控制器。基站无线电微型站（B1微处理器）监督并入至少一个宏小区（5a）中的至少一个微小区（5b）。基站无线电微站（B1-micronode）在无线电信道（6）的链路上的微小区（5b）中提供分组数据传输服务。

6. 发明申请

US20060281805A1 Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists 失效
公开(公告)号：US20060281805A1
公开(公告)日：2006-12-14
申请号：US10552456
申请日：2003-04-09
申请人： Anita Mehta , Bruhaspathy Miriyala , Sudershan Arora , Jang Gupta
发明人： Anita Mehta , Bruhaspathy Miriyala , Sudershan Arora , Jang Gupta
IPC分类号： A61K31/403 , C07D209/02
CPC分类号： C07D209/52
摘要： This invention relates to the derivatives of substituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

7. 发明申请

US20060217432A1 3,6-Disubstituted azabicyclo [3.1.0] hexane derivatives as muscarinic receptor antagonists 失效
标题翻译： 3,6-二取代的氮杂双环[3.1.0]己烷衍生物作为毒蕈碱受体拮抗剂
公开(公告)号：US20060217432A1
公开(公告)日：2006-09-28
申请号：US10537851
申请日：2002-12-10
申请人： Anita Mehta , Arundutt Silamkoti , Bruhaspathy Miriyala , Sudershan Arora , Boju Srinivasulu , Bireshwar Mukherjee , Jang Gupta
发明人： Anita Mehta , Arundutt Silamkoti , Bruhaspathy Miriyala , Sudershan Arora , Boju Srinivasulu , Bireshwar Mukherjee , Jang Gupta
IPC分类号： A61K31/403 , C07D209/02
CPC分类号： C07D401/06 , C07D209/52 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/14
摘要： The invention relates to derivatives of 3,6-disubstituted azabicyclo[3.1.0]hexanes of structure (I). The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.
摘要翻译：本发明涉及结构（I）的3,6-二取代的氮杂双环[3.1.0]己烷的衍生物。本发明化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸道，尿路和胃肠道系统的各种疾病。本发明还涉及含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

8. 发明申请

US20060194862A1 1-Substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists 失效
标题翻译： 1-取代的3-吡咯烷衍生物作为毒蕈碱受体拮抗剂
公开(公告)号：US20060194862A1
公开(公告)日：2006-08-31
申请号：US10540245
申请日：2002-12-23
申请人： Anita Mehta , Jang Gupta , Pakala Sarma
发明人： Anita Mehta , Jang Gupta , Pakala Sarma
IPC分类号： A61K31/4025 , A61K31/40 , C07D405/02 , C07D207/04
CPC分类号： C07D405/12 , C07D207/12 , C07D207/14
摘要： This invention generally relates to the derivatives of 1-substituted-3-pyrroli dines having the structure of Formula (I): The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention. pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.
摘要翻译：本发明一般涉及具有式（I）结构的1-取代-3-吡咯烷二醇衍生物：本发明化合物可用作毒蕈碱受体拮抗剂，可用于治疗各种呼吸疾病，通过毒蕈碱受体介导的尿路和胃肠道系统。本发明还涉及制备本发明化合物的方法。含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

9. 发明申请

US20060142371A1 3,6-Disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor 失效
标题翻译：用作毒蕈碱受体的3,6-二取代的氮杂双环[3.1.0]己烷衍生物
公开(公告)号：US20060142371A1
公开(公告)日：2006-06-29
申请号：US10524081
申请日：2002-08-09
申请人： Anita Mehta , Arundutt Silamkoti , Miriyala Bruhaspathy , Jang Gupta
发明人： Anita Mehta , Arundutt Silamkoti , Miriyala Bruhaspathy , Jang Gupta
IPC分类号： A61K31/403 , C07D209/02
CPC分类号： C07D209/02 , C07D209/52
摘要： This invention generally relates to the derivatives of 3,6 disubstituted azabicyclo[3.1.0]hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.
摘要翻译：本发明一般涉及3,6-二取代的氮杂双环[3.1.0]己烷的衍生物。本发明的化合物是毒蕈碱受体拮抗剂，其特别用于治疗通过毒蕈碱受体介导的呼吸，尿和胃肠道系统的各种疾病。本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

10. 发明申请

US20060128781A1 Flavaxate derivatives as muscarinic receptor antagonists 失效
标题翻译：泛黄酸衍生物作为毒蕈碱受体拮抗剂
公开(公告)号：US20060128781A1
公开(公告)日：2006-06-15
申请号：US10540062
申请日：2002-12-23
申请人： Anita Mehta , Sanjay Srivastava , Jang Gupta
发明人： Anita Mehta , Sanjay Srivastava , Jang Gupta
IPC分类号： A61K31/403 , C07D405/02
CPC分类号： C07D209/52 , A61K31/352 , C07D405/12
摘要： This invention generally relates the derivatives of 3.6-disubstituted azabicyclo[3.1.0]hexanes of the following formula [IA]. The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the :h1ethods for treating the diseases mediated through muscarinic receptors.
摘要翻译：本发明通常涉及下式[IA]的3.6-二取代的氮杂双环[3.1.0]己烷的衍生物。本发明化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸道，尿路和胃肠道系统的各种疾病。本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和：用于治疗通过毒蕈碱受体介导的疾病的方法。

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