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1. 发明授权

US06379515B1 Process for separating mixtures of substances using capillary affinity gel electrophoresis 有权
标题翻译：使用毛细管亲和凝胶电泳分离物质混合物的方法
公开(公告)号：US06379515B1
公开(公告)日：2002-04-30
申请号：US09180984
申请日：1998-11-19
申请人： Angelika Muscate-Magnussen , Aran Paulus , François Natt
发明人： Angelika Muscate-Magnussen , Aran Paulus , François Natt
IPC分类号： G01N2726
CPC分类号： G01N27/44747
摘要： Process for the selective separation of electrically charged target molecules in an analytical mixture by means of capillary affinity gel electrophoresis, using a capillary tube which is at least partly filled with a polymer gel, whereby receptors for target molecules are covalently bound to the polymer, and an electric field of at least 50 volts/cm is applied, characterized in that (a) the capillary tube is charged with the analytical mixture, (b) in a first separation stage the target molecules in the analytical mixture are bound to the receptors and the remaining components are eluted, optionally while splitting open, and (c) in a second stage of the process the elution conditions are changed, optionally in stages, so that the affinity of the target molecules for the receptor is eliminated and the target molecules are eluted and detected, optionally whilst splitting open.
摘要翻译：通过毛细管亲和性凝胶电泳，使用至少部分填充有聚合物凝胶的毛细管选择性分离分析混合物中的带电荷的靶分子的方法，由此靶分子的受体共价结合到聚合物上，以及施加至少50伏/厘米的电场，其特征在于（a）毛细管装有分析混合物，（b）在第一分离阶段，分析混合物中的靶分子与受体结合，洗脱剩余的组分，任选地分开开放，和（c）在该过程的第二阶段中，洗脱条件可任选地分阶段改变，从而消除靶分子对受体的亲和力，靶分子是洗脱和检测，任选地同时分开开放。

2. 发明申请

US20050217994A1 Use of a reversed-phase support material in capillary electrochromatography 审中-公开
标题翻译：在毛细管电色谱中使用反相支撑材料
公开(公告)号：US20050217994A1
公开(公告)日：2005-10-06
申请号：US11134282
申请日：2005-05-23
申请人： Klaus Unger , Karl-Siegfried Boos , Angelika Muscate-Magnussen , Dieter Lubda
发明人： Klaus Unger , Karl-Siegfried Boos , Angelika Muscate-Magnussen , Dieter Lubda
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/44747
摘要： The use of a support material for capillary electrochromatography is disclosed, wherein the support material, which is based on a base material containing hydroxy groups, has reversed phases which are limited to the inner surfaces of porous particles, said reversed phases consisting of fatty acid residues. Further, separating capillaries suitable for such a use are disclosed.
摘要翻译：公开了使用用于毛细管电色谱的支撑材料，其中基于含有羟基的基材的支撑材料具有限制于多孔颗粒的内表面的反相，所述反相由脂肪酸残基组成。此外，公开了适用于这种用途的分离毛细管。

3. 发明申请

US20090032400A1 Use of support materials in capillary electrochromatography 审中-公开
公开(公告)号：US20090032400A1
公开(公告)日：2009-02-05
申请号：US12078533
申请日：2008-04-01
申请人： Angelika Muscate-Magnussen
发明人： Angelika Muscate-Magnussen
IPC分类号： G01N27/26
CPC分类号： G01N27/44747
摘要： Use of a support material for capillary electrochromatography (CEC), characterized in that the support material has a porous design and a surface which consists of an outer surface and a pore surface, wherein the outer surface has regions of different derivatization and/or functionality from that of the pore surface.

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