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    • 7. 发明申请
    • REGULATORS OF NFAT
    • NFAT调节器
    • US20110269174A1
    • 2011-11-03
    • US13161307
    • 2011-06-15
    • Anjana RAOStefan FeskePatrick HoganYousang Gwack
    • Anjana RAOStefan FeskePatrick HoganYousang Gwack
    • C12Q1/02C12N5/10
    • C07K14/4702A61K35/12C07H21/04C07K16/18C12N5/16C12N15/63C12N15/907C12N2510/00C12Q1/00G01N33/5041
    • Disclosed are methods of identifying an agent that modulates an NFAT regulator protein. One such method comprises contacting at least one test agent with a recombinant cell comprising at least one NFAT regulator protein or fragment or derivative thereof, assessing the effect of the test agent on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, and identifying the test agent that has an effect on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, whereby the identified test agent is characterized as an agent that modulates an NFAT regulator protein. Methods of identifying an agent that modulates intracellular calcium, methods to screen for an agent that modulates NFAT regulator function, methods to diagnose unexplained immunodeficiency in a subject, and methods for identifying an agent for treating or preventing a disease or disorder associated with a NFAT regulator protein or calcium signaling are also disclosed.
    • 公开了鉴定调节NFAT调节蛋白的试剂的方法。 一种这样的方法包括使至少一种测试试剂与包含至少一种NFAT调节蛋白或其片段或衍生物的重组细胞接触,评估测试试剂对NFAT调节蛋白的活性,相互作用,表达或结合的影响,或 片段或衍生物,并鉴定对NFAT调节蛋白或其片段或衍生物的活性,相互作用,表达或结合具有影响的测试剂,其中所鉴定的测试剂的特征在于调节NFAT调节剂 蛋白。 识别调节细胞内钙的试剂的方法,筛选调节NFAT调节功能的试剂的方法,诊断受试者中不明原因的免疫缺陷的方法,以及用于鉴定用于治疗或预防与NFAT调节相关的疾病或病症的药剂的方法 蛋白质或钙信号传导也被公开。