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1. 发明授权

US08506497B2 Continuous positioning apparatus and methods 有权
公开(公告)号：US08506497B2
公开(公告)日：2013-08-13
申请号：US11803559
申请日：2007-05-14
申请人： Andrew S. Katayama , Todd A. Keitel , Manouchehr Goharlaee , Stuart L. Gallant , Warren B. Craycroft
发明人： Andrew S. Katayama , Todd A. Keitel , Manouchehr Goharlaee , Stuart L. Gallant , Warren B. Craycroft
IPC分类号： A61B5/02
CPC分类号： A61B5/0225 , A61B5/021 , A61B5/02233 , A61B5/6843 , A61B5/72
摘要： Improved apparatus and methods for non-invasively assessing one or more parameters associated with systems such as fluidic circulating systems (e.g., the circulatory system of a living organism). In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using dynamically applied dither perturbations (e.g., modulation) on the various axes associated with the vessel. In a second aspect, an improved apparatus and method are provided for monitoring hemodynamic parameters, such as blood pressure, in a continuous and non-invasive manner while operating under a single unifying scheme. One variant of this scheme using a simulated annealing (SA) type approach to determining and maintaining an optimal operating state.

2. 发明申请

US20110263991A1 METHOD AND APPARATUS FOR CONTROL OF NON-INVASIVE PARAMETER MEASUREMENTS 有权
标题翻译：用于控制非入侵参数测量的方法和装置
公开(公告)号：US20110263991A1
公开(公告)日：2011-10-27
申请号：US13180315
申请日：2011-07-11
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
IPC分类号： A61B5/021 , A61B5/026 , A61B5/02
CPC分类号： A61B5/721 , A61B5/0048 , A61B5/02007 , A61B5/021 , A61B5/0225 , A61B5/7207 , A61B5/7264 , A61B5/7282 , A61B5/7285
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译：改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。

3. 发明授权

US07291112B2 Method and apparatus for control of non-invasive parameter measurements 有权
标题翻译：用于控制非侵入性参数测量的方法和装置
公开(公告)号：US07291112B2
公开(公告)日：2007-11-06
申请号：US10393660
申请日：2003-03-20
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译：改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。

4. 发明授权

US08961426B2 Method and apparatus for control of non-invasive parameter measurements 有权
标题翻译：用于控制非侵入性参数测量的方法和装置
公开(公告)号：US08961426B2
公开(公告)日：2015-02-24
申请号：US13180315
申请日：2011-07-11
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
IPC分类号： A61B5/02 , A61B5/00 , A61B5/021
CPC分类号： A61B5/721 , A61B5/0048 , A61B5/02007 , A61B5/021 , A61B5/0225 , A61B5/7207 , A61B5/7264 , A61B5/7282 , A61B5/7285
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译：改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。

5. 发明授权

US07976471B2 Method and apparatus for control of non-invasive parameter measurements 有权
标题翻译：用于控制非侵入性参数测量的方法和装置
公开(公告)号：US07976471B2
公开(公告)日：2011-07-12
申请号：US11982975
申请日：2007-11-05
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
IPC分类号： A61B5/02
CPC分类号： A61B5/721 , A61B5/0048 , A61B5/02007 , A61B5/021 , A61B5/0225 , A61B5/7207 , A61B5/7264 , A61B5/7282 , A61B5/7285
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译：改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。

6. 发明授权

US06730038B2 Method and apparatus for non-invasively measuring hemodynamic parameters using parametrics 有权
标题翻译：使用参数非侵入性测量血液动力学参数的方法和装置
公开(公告)号：US06730038B2
公开(公告)日：2004-05-04
申请号：US10072508
申请日：2002-02-05
申请人： Stuart L. Gallant , Gregory L. Voss
发明人： Stuart L. Gallant , Gregory L. Voss
IPC分类号： A01B502
CPC分类号： A61B5/021 , A61B5/6843 , A61B2562/02 , A61B2562/0247 , G06F19/00
摘要： An improved method and apparatus for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises a method of measuring a hemodynamic parameter (e.g., arterial blood pressure) by applanating or compressing portions of tissue proximate to the blood vessel of concern until a desired condition is achieved, and then measuring the hemodynamic parameter. Such applanation effectively mitigates transfer and other losses created by the tissue proximate to the blood vessel, thereby facilitating accurate and robust tonometric measurement. An algorithm adapted to maintain optimal levels of applanation is also described. Methods and apparatus for scaling such hemodynamic parameter measurements based on subject physiology, and providing treatment to the subject based on the measured parameters, are also disclosed.
摘要翻译：一种用于非侵入性评估与生物体的循环系统相关联的一个或多个血液动力学参数的改进的方法和装置。在一个方面，本发明包括通过压缩或压缩靠近所关注的血管的组织的部分直到达到所需条件，然后测量血液动力学参数来测量血液动力学参数（例如，动脉血压）的方法。这种扁平化有效地减轻了靠近血管的组织产生的转移和其它损失，从而有助于准确和稳健的测量计量。还描述了适于维持最佳压平水平的算法。还公开了基于受试者生理学来缩放这种血液动力学参数测量以及基于测量参数向对象提供治疗的方法和装置。

7. 发明授权

US3980944A Portable conductivity meter for artificial kidney machines 失效
标题翻译：人造肾机便携式电导率仪
公开(公告)号：US3980944A
公开(公告)日：1976-09-14
申请号：US522102
申请日：1974-11-08
申请人： Stuart L. Gallant , Louis C. Cosentino
发明人： Stuart L. Gallant , Louis C. Cosentino
IPC分类号： G01N27/04 , G01N27/06 , G01N27/30
CPC分类号： G01N27/046 , G01N27/06
摘要： An improved portable conductivity meter for automatically and rapidly drawing an electrolyte sample and for measuring and providing an accurate output indication of its electrical conductivity, which is independent of temperature variations of the electrolyte. A pen-like dip probe, housing an electrode pair and a thermistor in unique configuration, is designed to rapidly draw an electrolytic dialysate sample whenever the probe is immersed within the electrolyte. A high frequency AC source drives a balanced active measurement circuit, having a reference leg and a measurement leg which contains the electrode pair and the temperature compensating thermistor. The balanced circuit provides measurement and reference output signals of opposite polarity to a summing amplifier which drives a visual conductivity indicator.
摘要翻译：一种改进的便携式电导率仪，用于自动和快速地拉伸电解质样品，并用于测量和提供其电导率的精确输出指示，其独立于电解质的温度变化。设计有独特结构的电极对和热敏电阻的笔状浸探探针，用于在探针浸入电解液中时快速拉伸电解透析液样品。高频交流电源驱动平衡有源测量电路，具有参考支路和测量支路，该支路包含电极对和温度补偿热敏电阻。平衡电路提供与驱动视觉电导率指示器的求和放大器相反极性的测量和参考输出信号。

8. 发明授权

US08597195B2 Method and apparatus for non-invasively measuring hemodynamic parameters using parametrics 失效
公开(公告)号：US08597195B2
公开(公告)日：2013-12-03
申请号：US12987928
申请日：2011-01-10
申请人： Stuart L. Gallant , Gregory I. Voss , William H. Markle
发明人： Stuart L. Gallant , Gregory I. Voss , William H. Markle
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61B5/6843 , A61B2562/02 , A61B2562/0247 , G06F19/00
摘要： An improved method and apparatus for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises a method of measuring a hemodynamic parameter (e.g., arterial blood pressure) by applanating or compressing portions of tissue proximate to the blood vessel of concern until a desired condition is achieved, and then measuring the hemodynamic parameter. Such applanation effectively mitigates transfer and other losses created by the tissue proximate to the blood vessel, thereby facilitating accurate and robust tonometric measurement. An algorithm adapted to maintain optimal levels of applanation is also described. Methods and apparatus for scaling such hemodynamic parameter measurements based on subject physiology, and providing treatment to the subject based on the measured parameters, are also disclosed.

9. 发明授权

US5343870A Recorder unit for ambulatory ECG monitoring system 失效
标题翻译：记录仪用于动态心电图监测系统
公开(公告)号：US5343870A
公开(公告)日：1994-09-06
申请号：US790035
申请日：1991-11-12
申请人： Stuart L. Gallant , Paul R. Caron , Walter E. Palmer , David J. Lubocki
发明人： Stuart L. Gallant , Paul R. Caron , Walter E. Palmer , David J. Lubocki
IPC分类号： A61B5/0424 , A61B5/0436 , G06F17/00 , A66B5/04
CPC分类号： A61B5/0436 , A61B5/0424
摘要： A Holter-type recorder unit for use with an ambulatory ECG recording system is described. The recorder features real-time beat differentiation, including ST analysis and paced beat analysis of two or three channel sampled electrocardiogram data. The recorder also features real-time coding of beat morphology and summary information on cassette tape. Further, summary information for an entire analysis can be compiled and reverse recorded onto the cassette tape at the end of the analysis to allow downloading thereof into an ECG scanner while the cassette is being rewound.
摘要翻译：描述了一种与动态ECG记录系统一起使用的动态记录器单元。记录仪具有实时拍子差异化，包括ST分析和两路或三路采样心电图数据的起搏分析。录音机还具有节拍形态的实时编码和盒式磁带的摘要信息。此外，整个分析的概要信息可以在分析结束时被编译并反向记录到盒式磁带上，以便在磁带被倒带时将其下载到ECG扫描仪中。

10. 发明授权

US07048691B2 Method and apparatus for assessing hemodynamic parameters within the circulatory system of a living subject 有权
公开(公告)号：US07048691B2
公开(公告)日：2006-05-23
申请号：US09815080
申请日：2001-03-22
申请人： Frank R. Miele , Ronald Mucci , Stuart L. Gallant
发明人： Frank R. Miele , Ronald Mucci , Stuart L. Gallant
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61B5/0053 , A61B5/02028 , A61B5/02116 , A61B8/06 , A61B8/0858 , A61B2562/0247
摘要： An improved method and apparatus for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises a method of measuring a hemodynamic parameter by measuring a non-calibrated value of the parameter non-invasively, and inducing a stress of the circulatory system while measuring a second parameter. The response of the circulatory system to the stress is determined directly from the subject, and a calibration function is derived from the response and applied to the non-calibrated measured value to produce a calibrated measure of the actual value of the hemodynamic parameter. Methods of using backscattered acoustic energy for determination of hemodynamic markers are also disclosed.

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