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1. 发明申请

US20060264913A1 Implantable flow regulator with failsafe mode and reserve drug supply 审中-公开
标题翻译：具有故障安全模式和储备药物供应的植入式流量调节器
公开(公告)号：US20060264913A1
公开(公告)日：2006-11-23
申请号：US11476372
申请日：2006-06-27
申请人： Andrew Poutiatine , Edward Gillis , Pierre-Alain Mausli , Volker Gass
发明人： Andrew Poutiatine , Edward Gillis , Pierre-Alain Mausli , Volker Gass
IPC分类号： A61K9/22
CPC分类号： A61M5/16881 , A61M2205/04
摘要： An implantable flow regulator (22) for regulating flow of a drug along a drug delivery pathway (14) from a drug source to a treatment site within a subject includes a movable diversion member (24) and an actuator. The movable diversion member (24) is operably coupled to a delivery pathway (14). The actuator is actuatable to move the diversion member (24) between at least a first mode position where the diversion member (24) restricts flow through the delivery pathway (14) (i.e., delivery pathway is “closed”), and a second mode position where the diversion member (24) is position to allow flow through the delivery pathway (14) (i.e., delivery pathway is “open”). Supplying power to actuate the actuator moves the diversion member (24) from its normally biased first mode or “closed” position, which is also a failsafe position, toward its second mode or “open” position. In the “open” position, drug is supplied to target sites, typically from a drug supply reserve within the regulator.
摘要翻译：用于调节药物沿着药物输送路径（14）从药物源到受治疗者内的治疗部位的流动的可植入流量调节器（22）包括可移动分支构件（24）和致动器。可移动分支构件（24）可操作地联接到输送路径（14）。所述致动器可致动以在所述转向构件（24）限制流经所述输送通道（14）（即，输送路径为“闭合”）的至少第一模式位置和第二模式之间移动所述转向构件（24）分流构件（24）位于允许流过输送路径（14）（即，输送路径“打开”）的位置。用于致动致动器的供电使得转向构件（24）从其正常偏置的第一模式或“关闭”位置（其也是故障安全位置）朝向其第二模式或“打开”位置移动。在“开放”的位置，药物通常由监管机构内的药物储备供应给目标地点。

2. 发明申请

US20060009739A1 Implantable flow regulator with failsafe mode and reserve drug supply 审中-公开
标题翻译：具有故障安全模式和储备药物供应的植入式流量调节器
公开(公告)号：US20060009739A1
公开(公告)日：2006-01-12
申请号：US10525882
申请日：2002-09-06
申请人： Andrew Poutiatine , Edward Gillis , Pierre-Alain Mausli , Volker Gass
发明人： Andrew Poutiatine , Edward Gillis , Pierre-Alain Mausli , Volker Gass
IPC分类号： A61M5/00
CPC分类号： A61M5/16881 , A61M2205/04
摘要： An implantable flow regulator (22) for regulating flow of a drug along drug delivery pathway (14) form a drug source to a treatment site within a subject includes a movable diversion member (24) and an actuator. The movable diversion member (24) is operably coupled to a delivery pathway (14). The actuator is actuatable to move the diversion member (24) between at least a first mode position where the diversion member (24) restricts flow through the delivery pathway (14) (i.e., delivery pathway is “closed”), and a second mode position where the diversion member (24) is positioned to allow flow through the delivery pathway (14) (i.e., delivery pathway is “open”). Supplying power to actuate the actuator moves the diversion member (24) from its normally biased first mode or “closed” position, which is also a failsafe position, toward its second mode or “open” position. In the “open” position, drug is supplied to target sites, typically from a drug supply reserve within the regulator.
摘要翻译：用于调节药物沿着药物递送通道（14）的流动的可植入流量调节器（22）形成药物源到受试者内的治疗部位，包括可移动分支构件（24）和致动器。可移动分支构件（24）可操作地联接到输送路径（14）。所述致动器可致动以在所述转向构件（24）限制流经所述输送通道（14）（即，输送路径为“闭合”）的至少第一模式位置和第二模式之间移动所述转向构件（24）分流构件（24）被定位成允许流过输送路径（14）（即，输送路径“打开”）的位置。用于致动致动器的供电使得转向构件（24）从其正常偏置的第一模式或“关闭”位置（其也是故障安全位置）朝向其第二模式或“打开”位置移动。在“开放”的位置，药物通常由监管机构内的药物储备供应给目标地点。

3. 发明申请

US20060047248A1 Catheter loop manager 审中-公开
标题翻译：导管回路经理
公开(公告)号：US20060047248A1
公开(公告)日：2006-03-02
申请号：US10537196
申请日：2003-12-04
申请人： Andrew Poutiatine , Edward Gillis , Riten Parikh , James Filice
发明人： Andrew Poutiatine , Edward Gillis , Riten Parikh , James Filice
IPC分类号： A61M5/32
CPC分类号： A61M5/14276 , A61M25/0097 , A61M25/0113 , A61M39/12
摘要： A catheter loop manager apparatus which controls the slack portion of a catheter located adjacent to an implanted pump and prevents fibrotic encapsulation of the slack catheter portion. The catheter loop manager comprises a retainer element configured to associate with an implantable pump and to releasibly hold or retain a loop or section of catheter adjacent to the pump. A pull tool is used to releasibly engage a catheter section and pull the catheter section into a loop within a retention channel in retainer element.
摘要翻译：导管回路管理器装置，其控制位于邻近植入泵的导管的松弛部分，并防止松弛导管部分的纤维化封装。导管回路管理器包括被配置为与可植入泵相关联并且可释放地保持或保持邻近于泵的导管的环或部分的保持器元件。拉动工具用于可释放地接合导管部分并将导管部分拉入保持器元件内的保持通道内的环中。

4. 发明申请

US20060224145A1 Device and method for accurate delivery of an active agent 失效
标题翻译：准确递送活性剂的装置和方法
公开(公告)号：US20060224145A1
公开(公告)日：2006-10-05
申请号：US11444934
申请日：2006-05-31
申请人： Edward Gillis , Andrew Poutiatine , James Filice , Peter Wickman , John Culwell , John Dinka
发明人： Edward Gillis , Andrew Poutiatine , James Filice , Peter Wickman , John Culwell , John Dinka
IPC分类号： A61K9/22
CPC分类号： A61K9/0024 , A61F2/02 , A61F2250/0067 , A61K9/0004 , A61M5/141 , A61M5/14276 , A61M5/1452 , A61M5/16881 , A61M2005/14264
摘要： Implantable delivery devices (1) for accurately controlling release of an agent therefrom and for preventing release of the agent during storage, prior to use. The devices include a reservoir (3) for storing the agent, a driving means for driving the agent from the reservoir (3) and a valving and control mechanism (10) which is positively actuatable between a closed configuration and an open configuration.
摘要翻译：植入式输送装置（1），用于从使用前准确控制试剂的释放并防止储存期间试剂的释放。这些装置包括用于储存试剂的储存器（3），用于从储存器（3）驱动试剂的驱动装置和在关闭构型和打开构型之间可靠地致动的阀门和控制机构（10）。

5. 发明申请

US20050106205A1 Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners 审中-公开
标题翻译：通过输送芬太尼和芬太尼同系物治疗疼痛的植入式装置和方法
公开(公告)号：US20050106205A1
公开(公告)日：2005-05-19
申请号：US10922239
申请日：2004-08-18
申请人： Edward Gillis , Barbara Laidlaw , John Culwell , James Filice , Peter Wickman , Andrew Poutiatine , John Dinka
发明人： Edward Gillis , Barbara Laidlaw , John Culwell , James Filice , Peter Wickman , Andrew Poutiatine , John Dinka
IPC分类号： A61J1/10 , A61F2/00 , A61F2/02 , A61K9/00 , A61K9/22 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61M5/14 , A61M5/142 , A61M5/145 , A61M5/148 , A61M5/168 , A61M31/00 , A61P25/04 , A61K31/445
CPC分类号： A61F2/02 , A61F2250/0067 , A61K9/0004 , A61K9/0024 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61M5/141 , A61M5/14276 , A61M5/1452 , A61M5/168 , A61M5/16804 , A61M5/16881 , A61M31/002 , A61M2005/14264 , Y02A50/401
摘要： The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.
摘要翻译：本发明的特征在于用于治疗疼痛的装置和方法。药物递送装置是适于整个植入受试者的药物递送系统，并通过在持续的时间段内输送芬太尼或芬太尼（例如舒芬太尼）来提供疼痛缓解（例如，至少3天或更多 3天）。该装置包括限定容纳药物制剂的储存器的壳体，可操作地连接到壳体的泵，以促进药物从储存器移出并离开装置;以及热膨胀元件，其限定流动通路，该热膨胀元件包括热膨胀通道，以适应储层中配方的热膨胀。该装置还可以包括位于流动通道内的阀，以便在使用之前防止药物从储存器中移动。

6. 发明申请

US20050101942A1 Device and method for accurate delivery of an active agent 审中-公开
标题翻译：准确递送活性剂的装置和方法
公开(公告)号：US20050101942A1
公开(公告)日：2005-05-12
申请号：US10490331
申请日：2002-08-29
申请人： Edward Gillis , Andrew Poutiatine , James Filice , Peter Wickman , John Culwell
发明人： Edward Gillis , Andrew Poutiatine , James Filice , Peter Wickman , John Culwell
IPC分类号： A61F2/00 , A61F2/02 , A61K9/00 , A61K9/22 , A61M5/14 , A61M5/142 , A61M5/145 , A61M5/168
CPC分类号： A61K9/0024 , A61F2/02 , A61F2250/0067 , A61K9/0004 , A61M5/141 , A61M5/14276 , A61M5/1452 , A61M5/16881 , A61M2005/14264
摘要： Implantable delivery devices (1) for accurately controlling release of an agent therefrom and for preventing release of the agent during storage, prior to use. The devices include a reservoir (3) for storing the agent, a driving means for driving the agent from the reservoir (3) and a valving and control mechanism (10) which is positively actuatable between a closed configuration and an open configuration.
摘要翻译：植入式输送装置（1），用于从使用前准确控制试剂的释放并防止储存期间试剂的释放。这些装置包括用于储存试剂的储存器（3），用于从储存器（3）驱动试剂的驱动装置和在关闭构型和打开构型之间可靠地致动的阀门和控制机构（10）。

7. 发明申请

US20050070883A1 Devices and methods for controlled delivery from a drug delivery device 审中-公开
标题翻译：用于从药物递送装置控制递送的装置和方法
公开(公告)号：US20050070883A1
公开(公告)日：2005-03-31
申请号：US10433196
申请日：2001-11-21
申请人： James Brown , John Culwell , James Filice , Edward Gillis , Felix Theeuwes , Peter Wickman , Su Il Yum
发明人： James Brown , John Culwell , James Filice , Edward Gillis , Felix Theeuwes , Peter Wickman , Su Il Yum
IPC分类号： A61M37/00 , A61K9/00 , A61K9/22 , A61M5/142 , A61M5/168 , A61M5/36 , A61M31/00
CPC分类号： A61M5/14276 , A61K9/0004 , A61M5/168 , A61M5/16804 , A61M5/36 , A61M31/002 , A61M2205/0294
摘要： The invention features a plug for use with a drug delivery device, wherein the plug defines an expansion control channel, which accommodates thermal expansion of a formulation in a reservoir of a drug delivery device, and an exit channel. In one embodiment, the plug comprises an inner plug member and an outer plug member, which members define an expansion control channel to facilitate release of entrapped air and to accommodate thermal expansion of formulation from the sealed drug reservoir. The plug further defines an exit channel, and may optionally further comprise a frit positioned within the flow pathway just prior to the delivery outlet, or both.
摘要翻译：本发明的特征在于一种用于药物递送装置的塞子，其中塞子限定扩张控制通道，其适应制剂在药物递送装置的储存器中的热膨胀和出口通道。在一个实施例中，塞子包括内塞构件和外塞构件，这些构件限定了膨胀控制通道，以便于捕获的空气的释放和适应制剂从密封的药物储存器的热膨胀。插头进一步限定出口通道，并且可以任选地进一步包括刚刚在输送出口之前或两者位于流动通道内的玻璃料。

8. 外观设计

USD316845S Boat 失效
公开(公告)号：USD316845S
公开(公告)日：1991-05-14
申请号：US203030
申请日：1988-06-06
申请人： Douglas G. Slanker , Edward Gillis
设计人： Douglas G. Slanker , Edward Gillis

9. 发明申请

US20070000497A1 Devices, systems, and methods using magnetic force systems in or on tissue 有权
标题翻译：在组织中或组织上使用磁力系统的装置，系统和方法
公开(公告)号：US20070000497A1
公开(公告)日：2007-01-04
申请号：US11397744
申请日：2006-04-04
申请人： Ryan Boucher , Edward Gillis , Joe Paraschac , Scott McGill , Charles Rampersaud , Craig Purdy
发明人： Ryan Boucher , Edward Gillis , Joe Paraschac , Scott McGill , Charles Rampersaud , Craig Purdy
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F5/56 , Y10S602/902
摘要： Systems and methods include magnetic structures for placement in or on tissues in an airway. The magnetic structures carry sources of magnetism, which generate magnetic fields having directions. The magnetic fields interact to provide magnetic forces that provide a desired therapeutic effect, e.g., maintaining separation between the soft palate and/or tongue and the posterior pharyngeal wall. The systems and methods size and configure the directions of the magnetic fields to provide stability, which makes possible the achievement of the desired therapeutic effect in a straightforward and elegant manner.
摘要翻译：系统和方法包括用于放置在气道中或组织中的磁性结构。磁结构带有磁场，其产生具有方向的磁场。磁场相互作用以提供提供所需治疗效果的磁力，例如维持软腭和/或舌与咽后壁之间的分离。系统和方法规定和配置磁场的方向以提供稳定性，这使得可以以直观和优雅的方式实现期望的治疗效果。

10. 发明申请

US20060289015A1 Magnetic devices, systems, and methods placed in or on a tongue 有权
标题翻译：放置在舌头中或舌上的磁性装置，系统和方法
公开(公告)号：US20060289015A1
公开(公告)日：2006-12-28
申请号：US11404631
申请日：2006-04-14
申请人： Ryan Boucher , Joe Paraschac , Edward Gillis , Eric Doelling , Craig Purdy
发明人： Ryan Boucher , Joe Paraschac , Edward Gillis , Eric Doelling , Craig Purdy
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F5/56 , Y10S602/902
摘要： Magnetic structures develop a magnetic force between a tongue and a posterior pharyngeal wall to stabilize an orientation of the tongue. The magnetic structures include magnetic materials that are sized, configured, and arranged on at least one of the first and second magnetic structures, to maintain a substantially mutually repelling orientation between the first and second magnetic structures during a native range of movement of the tongue relative to the pharyngeal wall, i.e., during swallowing and/or drinking/and or speech.
摘要翻译：磁性结构在舌头和后咽壁之间产生磁力，以稳定舌头的取向。磁性结构包括磁性材料，其尺寸，构造和布置在第一和第二磁性结构中的至少一个上，以在舌形相对的自然运动范围内在第一和第二磁性结构之间保持基本相互排斥的取向到咽壁，即在吞咽和/或饮酒和/或言语期间。

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