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1. 发明申请

US20050142146A1 Chlamydia antigens and corresponding DNA fragments and uses thereof 审中-公开
标题翻译：衣原体抗原和相应的DNA片段及其用途
公开(公告)号：US20050142146A1
公开(公告)日：2005-06-30
申请号：US11070478
申请日：2005-03-03
申请人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
发明人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
IPC分类号： G01N33/50 , A61K38/00 , A61K38/16 , A61K39/00 , A61K39/118 , A61K48/00 , C07K14/295 , C07K16/12 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , A61K39/02
CPC分类号： C07K14/295 , A61K38/164 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/53 , C07K2319/00 , C07K2319/02 , Y02A50/476
摘要： The present invention provides a vaccine for immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The vaccine contains a polypeptide comprising an omp P6 precursor sequence of a strain of C. pneumoniae and variants of the sequence. Modifications are possible within the scope of this invention.
摘要翻译：本发明提供了用于免疫宿主（包括人）免疫衣原体特异性肺炎衣原体感染引起的疾病的疫苗。疫苗含有包含肺炎支原体菌株的omp P6前体序列和序列变体的多肽。在本发明的范围内可以进行修改。

2. 发明申请

US20050002960A1 Chlamydia antigens and corresponding DNA fragments and uses thereof 有权
标题翻译：衣原体抗原和相应的DNA片段及其用途
公开(公告)号：US20050002960A1
公开(公告)日：2005-01-06
申请号：US10897019
申请日：2004-07-23
申请人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
发明人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
IPC分类号： A61K38/00 , A61K39/00 , C07K14/295 , G01N33/569 , C07H21/04 , C07K14/47
CPC分类号： G01N33/56927 , A61K38/00 , A61K39/00 , A61K2039/53 , C07K14/295 , Y10S530/811 , Y10S530/814 , Y10S530/82
摘要： The present invention provides a method of immunizing a host against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The method involves nucleic acid immunization, including DNA immunization, and employs a vector containing a nucleotide sequence which encodes an ATP/ADP translocase of a strain of Chlamydia pneumoniae. The nucleotide sequence is operably linked to a promoter to effect expression of the ATP/ADP translocase in the host. The host may be a human host. Modifications are possible within the scope of this invention.
摘要翻译：本发明提供了免疫宿主免受衣原体特异性肺炎衣原体感染引起的疾病的方法。该方法包括核酸免疫，包括DNA免疫，并使用含有编码肺炎衣原体菌株的ATP / ADP转位酶的核苷酸序列的载体。核苷酸序列与启动子可操作地连接以在宿主中实现ATP / ADP转位酶的表达。主人可能是一个人的主人。在本发明的范围内可以进行修改。

3. 发明申请

US20050220805A1 Chlamydia antigens and corresponding DNA fragments and uses thereof 失效
标题翻译：衣原体抗原和相应的DNA片段及其用途
公开(公告)号：US20050220805A1
公开(公告)日：2005-10-06
申请号：US11142306
申请日：2005-06-02
申请人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
发明人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
IPC分类号： G01N33/50 , A61K9/127 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/118 , A61K39/395 , A61K48/00 , A61P11/00 , A61P31/00 , C07K14/295 , C07K16/12 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/68 , C12R1/01 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/569
CPC分类号： A61K9/127 , A61K39/00 , A61K39/118 , A61K2039/53 , C07K14/295 , C07K2319/00 , Y02A50/396 , Y02A50/472 , Y02A50/476 , Y10S435/975
摘要： The present invention provides vaccines and methods for immunizing a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The vaccine and method employ an OMP (outer membrane protein) of a strain of Chlamydia pneumoniae. Modifications are possible within the scope of this invention.
摘要翻译：本发明提供用于免疫宿主（包括人）免疫衣原体特异性肺炎衣原体感染引起的疾病的疫苗和方法。疫苗和方法采用肺炎衣原体菌株的OMP（外膜蛋白）。在本发明的范围内可以进行修改。

4. 发明申请

US20050202048A1 Chlamydia antigens and vaccine uses of the protein 失效
标题翻译：衣原体抗原和疫苗用途的蛋白质
公开(公告)号：US20050202048A1
公开(公告)日：2005-09-15
申请号：US11118381
申请日：2005-05-02
申请人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
发明人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
IPC分类号： G01N33/53 , A61K39/00 , A61K39/118 , A61K39/39 , A61K39/395 , A61K48/00 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P31/04 , C07K14/295 , C07K16/12 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12N15/85 , C12P21/02 , C12Q1/68 , G01N33/566 , G01N33/569 , A61K9/127 , A61K31/7052 , A61K31/65
CPC分类号： C12N15/85 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/295 , C07K2319/00 , C12N2830/42 , Y02A50/472 , Y02A50/476 , Y10S435/975
摘要： The present invention provides vaccines and methods for immunizing a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The vaccine and method employ a full-length, 5′-truncated or 3′-truncated 76kDa protein of a strain of Chlamydia pneumoniae. Modifications are possible within the scope of this invention.
摘要翻译：本发明提供用于免疫宿主（包括人）免疫衣原体特异性肺炎衣原体感染引起的疾病的疫苗和方法。疫苗和方法使用肺炎衣原体菌株的全长5'截短或3'截短的76kDa蛋白。在本发明的范围内可以进行修改。

5. 发明申请

US20050069942A1 Chlamydia antigens and corresponding DNA fragments and uses thereof 失效
标题翻译：衣原体抗原和相应的DNA片段及其用途
公开(公告)号：US20050069942A1
公开(公告)日：2005-03-31
申请号：US10976917
申请日：2004-11-01
申请人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
发明人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
IPC分类号： G01N33/569 , A61K31/711 , A61K38/00 , A61K39/118 , A61K39/395 , A61K48/00 , A61P11/00 , A61P31/04 , C07K14/295 , C07K16/12 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/68 , C07H21/04 , C12N15/74
CPC分类号： A61K31/711 , A61K39/118 , A61K2039/53 , C07K14/295 , Y10S435/975
摘要： The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector containing a nucleotide sequence encoding a 60 kDa cysteine-rich membrane protein of a strain of Chlamydia pneumoniae and a promoter to effect expression of the 60 kDa cysteine-rich membrane protein gene in the host. Modifications are possible within the scope of this invention.
摘要翻译：本发明提供了包含DNA，宿主（包括人）在内的免疫针对由衣原体特异性肺炎衣原体感染引起的疾病的核酸的方法，其使用含有编码60kDa半胱氨酸 - 肺炎衣原体菌株的富含膜蛋白和在宿主中有效表达60kDa富含半胱氨酸的膜蛋白基因的启动子。在本发明的范围内可以进行修改。

6. 发明申请

US20050002944A1 Chlamydia antigens and corresponding DNA fragments and uses thereof 失效
标题翻译：衣原体抗原和相应的DNA片段及其用途
公开(公告)号：US20050002944A1
公开(公告)日：2005-01-06
申请号：US10746251
申请日：2003-12-29
申请人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
发明人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
IPC分类号： G01N33/50 , A61K9/127 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/118 , A61K39/395 , A61K48/00 , A61P11/00 , A61P31/00 , C07K14/295 , C07K16/12 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/68 , C12R1/01 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/569 , A61K39/38
CPC分类号： A61K9/127 , A61K39/00 , A61K39/118 , A61K2039/53 , C07K14/295 , C07K2319/00 , Y02A50/396 , Y02A50/472 , Y02A50/476 , Y10S435/975
摘要： The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector containing a nucleotide sequence encoding OMP (outer membrane protein) of a strain of Chlamydia pneumoniae and a promoter to effect expression of the OMP (outer membrane protein) gene in the host. Modifications are possible within the scope of this invention.
摘要翻译：本发明提供了一种核酸的方法，包括DNA，宿主（包括人）免疫针对由衣原体特异性肺炎衣原体感染引起的疾病，使用含有编码OMP的核苷酸序列的载体（外膜蛋白）肺炎衣原体的菌株和在宿主中影响OMP（外膜蛋白）基因表达的启动子。在本发明的范围内可以进行修改。

7. 发明申请

US20050186266A1 Chlamydia antigens and corresponding DNA fragments and uses thereof 失效
标题翻译：衣原体抗原和相应的DNA片段及其用途
公开(公告)号：US20050186266A1
公开(公告)日：2005-08-25
申请号：US11107823
申请日：2005-04-18
申请人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
发明人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
IPC分类号： G01N33/569 , A61K31/711 , A61K38/00 , A61K39/118 , A61K39/395 , A61K48/00 , A61P11/00 , A61P31/04 , C07K14/295 , C07K16/12 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/68 , A61K9/127 , A61K39/00
CPC分类号： A61K31/711 , A61K39/118 , A61K2039/53 , C07K14/295 , Y10S435/975
摘要： The present invention provides vaccines and methods for immunizing a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The vaccine and method employ a 60 kDa cysteine-rich membrane protein of a strain of Chlamydia pneumoniae. Modifications are possible within the scope of this invention.
摘要翻译：本发明提供用于免疫宿主（包括人）免疫衣原体特异性肺炎衣原体感染引起的疾病的疫苗和方法。疫苗和方法使用肺炎衣原体菌株的60kDa富含半胱氨酸的膜蛋白。在本发明的范围内可以进行修改。

8. 发明申请

US20080112965A1 Chlamydia OMP antigen 审中-公开
标题翻译：衣原体OMP抗原
公开(公告)号：US20080112965A1
公开(公告)日：2008-05-15
申请号：US11907155
申请日：2007-10-10
申请人： Andrew Murdin , Raymond Oomen , Joe Wang
发明人： Andrew Murdin , Raymond Oomen , Joe Wang
IPC分类号： A61K39/00 , A61P43/00 , C07K14/00 , C12P21/04
CPC分类号： A61K39/118 , C07K14/295
摘要： The present invention provides purified and isolated polynucleotide molecules that encode Chlamydia polypeptides which can be used in methods to prevent, treat, and diagnose Chlamydia infection. In one form of the invention, the polypeptides relate to the 98 KDa OMP antigen designated CPN100686 RY 54 (SEQ ID No:14, encoded in one form by SEQ ID NO:1).
摘要翻译：本发明提供了编码衣原体多肽的纯化和分离的多核苷酸分子，其可用于预防，治疗和诊断衣原体感染的方法。在本发明的一种形式中，多肽涉及称为CPN100686 RY 54的98KDa OMP抗原（SEQ ID No：14，以SEQ ID NO：1以一种形式编码）。

9. 发明申请

US20080095793A1 Chlamydia flagellar protein antigen 有权
标题翻译：衣原体鞭毛蛋白抗原
公开(公告)号：US20080095793A1
公开(公告)日：2008-04-24
申请号：US11905430
申请日：2007-10-01
申请人： Andrew Murdin , Raymond Oomen , Joe Wang
发明人： Andrew Murdin , Raymond Oomen , Joe Wang
IPC分类号： A61K31/70 , A61K39/00 , A61P43/00 , C07K14/00 , C12N1/20 , C12N15/00 , C12N15/11
CPC分类号： G01N33/56927 , A61K39/00 , C07K14/295 , C07K2319/00 , Y02A50/472 , Y02A50/476
摘要： The present invention provides purified and isolated polynucleotide molecules that encode Chlamydia polypeptides which can be used in methods to prevent, treat, and diagnose Chlamydia infection. In one form of the invention, the polynucleotide molecules encode polypeptides CPN100988 RY-68 (SEQ ID Nos:13 and 26).
摘要翻译：本发明提供了编码衣原体多肽的纯化和分离的多核苷酸分子，其可用于预防，治疗和诊断衣原体感染的方法。在本发明的一种形式中，多核苷酸分子编码多肽CPN100988 RY-68（SEQ ID NO：13和26）。

10. 发明申请

US20050065106A1 Immunogenic compositions for protection against Chlamydial infection 审中-公开
标题翻译：用于防止衣原体感染的免疫原性组合物
公开(公告)号：US20050065106A1
公开(公告)日：2005-03-24
申请号：US10937372
申请日：2004-09-10
申请人： Andrew Murdin , Pamela Dunn
发明人： Andrew Murdin , Pamela Dunn
IPC分类号： A61K39/118 , C07H21/04 , A61K48/00
CPC分类号： A61K39/118 , A61K2039/53 , A61K2039/543 , C07H21/04
摘要： A protective immune response against Chlamydial infection is achieved by in vivo administration of an immunogenic composition comprising two vectors and a pharmaceutically-acceptable carrier therefor. One of the vectors comprises a first nucleotide sequence encoding a major outer membrane protein (MOMP) of a strain of Chlamydia, preferably C. pneumoniae, and a promoter sequence operatively coupled to the first nucleotide sequence for expression of the MOMP in the host. The other of the vectors comprises a second nucleotide sequence encoding a 76 kDa protein of a strain of Chlamydia, preferably C. pneumoniae, and a promoter sequence operatively coupled to the second nucleotide sequence for expression of the 76 kDa protein in the host. The protection efficiency which is achieved by the immunization procedure is enhanced over that attained with the individual vectors alone.
摘要翻译：针对衣原体感染的保护性免疫应答通过体内施用包含两种载体和其药学上可接受的载体的免疫原性组合物来实现。载体之一包含编码衣原体菌株（优选肺炎衣原体）的主要外膜蛋白（MOMP）的第一核苷酸序列和与第一核苷酸序列可操作偶联以在宿主中表达MOMP的启动子序列。载体中的另一个包含编码衣原体菌株76KDa蛋白质的第二核苷酸序列，优选肺炎衣原体，以及与第二核苷酸序列可操作偶联以在宿主中表达76kDa蛋白质的启动子序列。通过免疫程序实现的保护效率比单独的载体获得的保护效率增强。

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