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1. 发明申请

US20070179546A1 METHOD AND APPARATUS FOR OPTIMIZING STROKE VOLUME DURING DDD RESYNCHRONIZATION THERAPY USING ADJUSTABLE ATRIO-VENTRICULAR DELAYS 有权
标题翻译：在使用可调节ATRIO-VENTRICULAR延迟的DDD再生治疗中优化冲击体积的方法和装置
公开(公告)号：US20070179546A1
公开(公告)日：2007-08-02
申请号：US11567933
申请日：2006-12-07
申请人： Yinghong Yu , Jiang Ding , Julio Spinelli , Andrew Kramer
发明人： Yinghong Yu , Jiang Ding , Julio Spinelli , Andrew Kramer
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36564 , A61N1/3682
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：用于为诸如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）之间的参数提供最佳血液动力学心脏功能或行程体积（主动脉脉压）的起搏系统，用于计算心室间期延迟心室起搏脉冲的最佳时机。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

2. 发明申请

US20060116727A1 AUTOMATIC SELECTION OF STIMULATION CHAMBER FOR VENTRICULAR RESYNCHRONIZATION THERAPY 有权
标题翻译：自体选择刺激室进行心脏再生治疗
公开(公告)号：US20060116727A1
公开(公告)日：2006-06-01
申请号：US11276007
申请日：2006-02-09
申请人： Jiang Ding , Julio Spinelli , Yinghong Yu , Andrew Kramer
发明人： Jiang Ding , Julio Spinelli , Yinghong Yu , Andrew Kramer
IPC分类号： A61N1/36
CPC分类号： A61N1/36592 , A61B5/0472 , A61N1/3627 , A61N1/3684
摘要： A method and apparatus for selection of one or more ventricular chambers to stimulate for ventricular resynchronization therapy. Intrinsic intracardia electrograms that include QRS complexes, are recorded from a left and right ventricle. A timing relationship between the intrinsic intracardia electrograms recorded from the left and right ventricle is then determined. In one embodiment, the timing relationship is determined using a delay between a left ventricular and a right ventricular sensed intrinsic ventricular depolarizations and a duration interval of one or more QRS complexes. In one embodiment, the duration of QRS complexes is determined from either intracardiac electrograms or from surface ECG recordings. One or more ventricular chambers in which to provide pacing pulses are then selected based on the timing relationship between intrinsic intracardia electrograms recorded from the right and left ventricle, and the duration of one or more QRS complexes.
摘要翻译：用于选择一个或多个心室以刺激心室再同步治疗的方法和装置。包括QRS复合物在内的心内电图从左心室和右心室记录。然后确定从左心室和右心室记录的内在心内电描记图之间的时间关系。在一个实施例中，使用左心室和右心室感测的内心室去极化之间的延迟和一个或多个QRS复合物的持续时间间隔来确定时间关系。在一个实施方案中，QRS复合物的持续时间由心脏内电刺激图或从表面心电图记录确定。然后基于从右心室和左心室记录的内在心内电描记图与一个或多个QRS复合物的持续时间之间的时间关系来选择其中提供起搏脉冲的一个或多个心室。

3. 发明申请

US20050131472A1 Cardiac pacing using adjustable atrio-ventricular delays 有权
标题翻译：心脏起搏使用可调节的心房延迟
公开(公告)号：US20050131472A1
公开(公告)日：2005-06-16
申请号：US11049181
申请日：2005-02-02
申请人： Jiang Ding , Yinghong Yu , Andrew Kramer , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Andrew Kramer , Julio Spinelli
IPC分类号： A61N1/362 , A61N1/368 , A61N1/365
CPC分类号： E21B17/01 , A61N1/3627 , A61N1/3682 , E21B43/36
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机心室起搏脉搏。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

4. 发明申请

US20050131480A1 Method and apparatus for adjustable AVD programming using a table 有权
标题翻译：使用表格调整AVD编程的方法和装置
公开(公告)号：US20050131480A1
公开(公告)日：2005-06-16
申请号：US10735267
申请日：2003-12-12
申请人： Andrew Kramer , Jiang Ding , Yinghong Yu , Julio Spinelli
发明人： Andrew Kramer , Jiang Ding , Yinghong Yu , Julio Spinelli
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/365 , A61N1/3682
摘要： A pacing system provides for optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal. A look-up table relating the timing of such electrical or mechanical events to atrioventricular delay time intervals is provided for programming the pacing system.
摘要翻译：起搏系统提供用于参数的最佳血液动力学心脏功能，例如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）或行程体积（主动脉脉压），用于计算房室延迟的系统心室起搏脉冲的最佳时机。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。提供了将这种电气或机械事件的时间与房室延迟时间间隔相关联的查找表用于对起搏系统进行编程。

5. 发明申请

US20070135854A1 METHOD AND APPARATUS FOR ADJUSTABLE AVD PROGRAMMING USING A TABLE 审中-公开
标题翻译：使用表可调节AVD编程的方法和装置
公开(公告)号：US20070135854A1
公开(公告)日：2007-06-14
申请号：US11674773
申请日：2007-02-14
申请人： Andrew Kramer , Jiang Ding , Yinghong Yu , Julio Spinelli
发明人： Andrew Kramer , Jiang Ding , Yinghong Yu , Julio Spinelli
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/365 , A61N1/3682
摘要： A pacing system provides for optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal. A look-up table relating the timing of such electrical or mechanical events to atrio-ventricular delay time intervals is provided for programming the pacing system.
摘要翻译：起搏系统提供用于参数的最佳血液动力学心脏功能，例如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）或行程体积（主动脉脉压），用于计算房室延迟的系统心室起搏脉冲的最佳时机。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。提供了将这种电气或机械事件的时间与心房延迟时间间隔相关联的查找表，用于对起搏系统进行编程。

6. 发明申请

US20060276847A1 METHOD AND APPARATUS FOR OPTIMIZING VENTRICULAR SYNCHRONY DURING DDD RESYNCHRONIZATION THERAPY USING ADJUSTABLE ATRIO-VENTRICULAR DELAYS 有权
标题翻译：使用可调节ATRIO-VENTRICULAR延迟在DDD再生治疗中优化心脏同步的方法和装置
公开(公告)号：US20060276847A1
公开(公告)日：2006-12-07
申请号：US11463176
申请日：2006-08-08
申请人： Yinghong Yu , Jiang Ding , Julio Spinelli , Andrew Kramer
发明人： Yinghong Yu , Jiang Ding , Julio Spinelli , Andrew Kramer
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/36564 , A61N1/368 , A61N1/3682
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchorny or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：用于为诸如室性同步或收缩性（心脏收缩期左心室压力变化峰值或LV + dp / dt）之间的参数提供最佳血液动力学心脏功能的起搏系统或用于计算心室延迟的系统的行程体积（主动脉脉压）心室起搏脉冲的最佳时机。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

7. 发明申请

US20110071588A1 CARDIAC PACING USING ADJUSTABLE ATRIO-VENTRICULAR DELAYS 有权
标题翻译：使用可调节ATRIO-VENTRICULAR延迟的心脏瓣膜
公开(公告)号：US20110071588A1
公开(公告)日：2011-03-24
申请号：US12955218
申请日：2010-11-29
申请人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
IPC分类号： A61N1/365
CPC分类号： E21B17/01 , A61N1/3627 , A61N1/3682 , E21B43/36
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机心室起搏脉搏。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

8. 发明申请

US20080114410A1 CLOSED LOOP IMPEDANCE-BASED CARDIAC RESYNCHRONIZATION THERAPY SYSTEMS, DEVICES, AND METHODS 有权
标题翻译：基于闭环阻塞的心脏再生治疗系统，装置和方法
公开(公告)号：US20080114410A1
公开(公告)日：2008-05-15
申请号：US12016830
申请日：2008-01-18
申请人： Jiang Ding , Julio Spinelli , Yinghong Yu , Jeffrey Stahmann
发明人： Jiang Ding , Julio Spinelli , Yinghong Yu , Jeffrey Stahmann
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/053 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.
摘要翻译：本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。第三个例子测量心室容积的峰 - 峰体积或最大变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

9. 发明授权

US07346393B2 Implantable cardiac rhythm management system having multiple therapy modalities 有权
标题翻译：具有多种治疗方式的植入式心律管理系统
公开(公告)号：US07346393B2
公开(公告)日：2008-03-18
申请号：US10460975
申请日：2003-06-12
申请人： Julio Spinelli , Qingsheng Zhu , Bruce H. Kenknight , Yinghong Yu , Jiang Ding
发明人： Julio Spinelli , Qingsheng Zhu , Bruce H. Kenknight , Yinghong Yu , Jiang Ding
IPC分类号： A61N1/36
CPC分类号： A61N1/3627
摘要： A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.
摘要翻译：一种用于提供多种治疗方式的心律管理系统。例如，该系统可以包括用于提供心脏再同步治疗的心脏再同步治疗模块和用于提供心动过缓治疗的起搏器模块，以及耦合到心脏再同步治疗模块和心动过缓模块的选择器模块。选择器模块可以从包括心脏再同步治疗模块和起搏器模块的多个操作模式中选择操作模式。可以使用各种手动和自动方法来选择操作模式。此外，还可以包括回归管理系统以帮助心律管理系统在系统中断的情况下恢复。

10. 发明授权

US06766189B2 Method and apparatus for predicting acute response to cardiac resynchronization therapy 有权
公开(公告)号：US06766189B2
公开(公告)日：2004-07-20
申请号：US09822790
申请日：2001-03-30
申请人： Yinghong Yu , Jiang Ding , Julio Spinelli , Angelo Auricchio
发明人： Yinghong Yu , Jiang Ding , Julio Spinelli , Angelo Auricchio
IPC分类号： A61B106
CPC分类号： A61N1/3627 , A61N1/3682
摘要： A method and apparatus for predicting acute response to cardiac resynchronization therapy is disclosed. The method can comprise measuring a first interval during an intrinsic systolic cycle and measuring a second interval during a stimulated systolic cycle. The acute response can be predicted by comparing the percent change in duration between the first interval and the second interval against a pre-determined threshold value. The first and second time intervals can be measured using, for example, a surface ECG or, alternatively, an intracardiac electrogram. In one embodiment, the first interval can be the duration of an intrinsic QRS complex measured during a non-stimulated systolic cycle. Similarly, the second interval can be the duration of a stimulated QRS complex measured during a stimulated systolic cycle.

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