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1. 发明申请

US20060173406A1 Algorithm sensor augmented bolus estimator for semi-closed loop infusion system 有权
公开(公告)号：US20060173406A1
公开(公告)日：2006-08-03
申请号：US11322489
申请日：2005-12-30
申请人： Andrew Hayes , John Mastrototaro , Sheldon Moberg , John Mueller , H. Clark , Mike Charles Tolle , Gary Williams , Bihong Wu , Garry Steil
发明人： Andrew Hayes , John Mastrototaro , Sheldon Moberg , John Mueller , H. Clark , Mike Charles Tolle , Gary Williams , Bihong Wu , Garry Steil
IPC分类号： A61M31/00 , A61B5/00
CPC分类号： A61B5/7239 , A61B5/14532 , A61M5/1723 , A61M2005/14208 , A61M2205/18 , A61M2205/35 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H40/63 , G16H50/50 , A61M2230/005
摘要： An infusion system is for infusing a fluid into the body of a patient. The infusion system includes at least one sensor for monitoring blood glucose concentration of the patient and an infusion device for delivering fluid to the patient. The sensor produces at least one sensor signal input. The infusion device uses the at least one sensor signal input and a derivative predicted algorithm to determine future blood glucose levels. The infusion device delivers fluid to the patient when future blood glucose levels are in a patient's target range. The infusion device is capable of suspending and resuming fluid delivery based on future blood glucose levels and a patient's low shutoff threshold. The infusion device suspends fluid delivery when future blood glucose levels falls below the low shutoff threshold. The infusion device resumes fluid delivery when a future blood glucose level is above the low shutoff threshold.

2. 发明申请

US20060272652A1 Virtual patient software system for educating and treating individuals with diabetes 审中-公开
标题翻译：用于教育和治疗糖尿病患者的虚拟病人软件系统
公开(公告)号：US20060272652A1
公开(公告)日：2006-12-07
申请号：US11145485
申请日：2005-06-03
申请人： David Stocker , Sami Kanderian , Gabriel Cortina , Tamir Nitzan , Jon Plummer , Garry Steil , John Mastrototaro
发明人： David Stocker , Sami Kanderian , Gabriel Cortina , Tamir Nitzan , Jon Plummer , Garry Steil , John Mastrototaro
IPC分类号： A61B19/00
CPC分类号： G16H50/50
摘要： A system to assist an individual in developing a therapy in diabetes treatment of a patient includes a user interface control module, a simulation engine, a charting and display module. The user interface control module receives an input related to the patient and captures a current time of the simulation. The simulation engine receives the input, generates a plurality of blood glucose readings for the patient up to the current time of the simulation based on the input, and to transfers the plurality of blood glucose readings. The charting and display module receives the plurality of blood glucose readings and display the plurality of blood glucose readings. The simulation engine receives patient parameters from a patient parameter library based on a selected patient model.
摘要翻译：帮助个体开发患者糖尿病治疗的治疗系统包括用户界面控制模块，模拟引擎，图表和显示模块。用户界面控制模块接收与患者相关的输入并捕获模拟的当前时间。模拟引擎接收输入，基于输入，生成直到模拟的当前时间的患者的多个血糖读数，并传送多个血糖读数。制图和显示模块接收多个血糖读数并显示多个血糖读数。模拟引擎基于所选择的患者模型从患者参数库接收患者参数。

3. 发明申请

US20070173761A1 Apparatus and method for controlling insulin infusion with state variable feedback 有权
标题翻译：用状态变量反馈控制胰岛素输注的装置和方法
公开(公告)号：US20070173761A1
公开(公告)日：2007-07-26
申请号：US11644526
申请日：2006-12-22
申请人： Sami Kanderian , Garry Steil
发明人： Sami Kanderian , Garry Steil
IPC分类号： A61M37/00
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14539 , A61B5/14865 , A61B5/6849 , A61M5/14244 , A61M5/158 , A61M5/1582 , A61M2005/14296 , A61M2005/1581 , A61M2005/1726 , A61M2230/201 , G06F19/00
摘要： An infusion system, which may be a closed loop infusion system or “semi-closed-loop” system, uses state variable feedback to controls the rate that fluid is infused into the body of a user. The closed loop infusion system includes a sensor system, a controller, and a delivery system. The “semi-closed-loop” system further includes prompts that are displayed or sounded or otherwise provide indications to the user prior to insulin delivery. The sensor system includes a sensor for monitoring a condition of the user. The sensor produces a sensor signal, which is representative of the condition of the user. The delivery system infuses a liquid into the user at a rate dictated by the commands from the controller. The system may use three state variables, subcutaneous insulin concentration, plasma insulin concentration, and insulin effect, and corresponding gains, to calculate an addition amount of liquid to be infused as a bolus and to be removed from the basal delivery of the liquid.
摘要翻译：可以是闭环输注系统或“半闭环”系统的输注系统使用状态变量反馈来控制流体输入到使用者体内的速率。闭环输注系统包括传感器系统，控制器和输送系统。 “半闭环”系统还包括显示或听到的提示，或者在胰岛素递送之前向用户提供指示。传感器系统包括用于监测用户状况的传感器。传感器产生一个传感器信号，代表用户的状态。输送系统以由控制器的命令指示的速率将液体注入用户。该系统可以使用三种状态变量，皮下胰岛素浓度，血浆胰岛素浓度和胰岛素效应以及相应的增益，以计算作为大剂量输注并从液体的基本输送中移出的液体的添加量。

4. 发明申请

US20060224109A1 Closed loop system for controlling insulin infusion 有权
公开(公告)号：US20060224109A1
公开(公告)日：2006-10-05
申请号：US11417426
申请日：2006-05-03
申请人： Garry Steil , Kerstin Rebrin
发明人： Garry Steil , Kerstin Rebrin
IPC分类号： A61M31/00 , A61B5/05
CPC分类号： A61B5/14532 , A61B5/14539 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6849 , A61M5/14244 , A61M5/158 , A61M5/1582 , A61M5/1723 , A61M2005/1581 , A61M2005/1726 , A61M2230/201
摘要： A closed loop infusion system controls the rate that fluid is infused into the body of a user. The closed loop infusion system includes a sensor system, a controller, and a delivery system. The sensor system includes a sensor for monitoring a condition of the user. The sensor produces a sensor signal, which is representative of the condition of the user. The sensor signal is used to generate a controller input. The controller uses the controller input to generate commands to operate the delivery system. The delivery system infuses a liquid into the user at a rate dictated by the commands from the controller. Preferably, the sensor system monitors the glucose concentration in the body of the user, and the liquid infused by the delivery system into the body of the user includes insulin.

5. 发明申请

US20050096511A1 System for monitoring physiological characteristics 审中-公开
标题翻译：监测生理特征的系统
公开(公告)号：US20050096511A1
公开(公告)日：2005-05-05
申请号：US10999658
申请日：2004-11-30
申请人： James Fox , Garry Steil , Kerstin Rebrin , Mark Estes , Frank Saidara
发明人： James Fox , Garry Steil , Kerstin Rebrin , Mark Estes , Frank Saidara
IPC分类号： A61B5/00 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： A61B5/7275 , A61B5/0002 , A61B5/14532 , A61B5/1468 , A61B5/1486 , A61B5/746 , A61B2560/0223 , A61B2560/0252 , A61B2560/045 , G16H15/00 , G16H40/63
摘要： Apparatuses and methods for medical monitoring physiological characteristics values such as blood glucose levels for the treatment of diabetes, are presented. The apparatuses and methods provide dynamic glucose monitoring functions that perform predictive analysis to anticipate harmful conditions, such as glucose crash and hyperglycemic incidents for a patient. The dynamic functions can also be used to maximize athletic performance and warn of inadequate nocturnal basal rate. Other aspects include advanced alarm and reminder functions, as well as advanced data presentation tools to further facilitate convenient and efficient management of various physiological conditions.
摘要翻译：提出了用于医学监测用于治疗糖尿病的生理特征值例如血糖水平的装置和方法。所述装置和方法提供动态葡萄糖监测功能，其执行预测分析以预测有害状况，例如患者的葡萄糖崩溃和高血糖事件。动态功能也可用于最大限度地提高运动成绩，并提醒夜间基础速度不足。其他方面包括先进的报警和提醒功能，以及先进的数据呈现工具，可进一步促进各种生理条件的便捷高效管理。

6. 发明申请

US20050113653A1 System for monitoring physiological characteristics 有权
公开(公告)号：US20050113653A1
公开(公告)日：2005-05-26
申请号：US10999491
申请日：2004-11-30
申请人： James Fox , Garry Steil , Kerstin Rebrin , Mark Estes , Frank Saidara
发明人： James Fox , Garry Steil , Kerstin Rebrin , Mark Estes , Frank Saidara
IPC分类号： A61B5/00 , G06F19/00 , A61B5/05
CPC分类号： A61B5/7275 , A61B5/0002 , A61B5/14532 , A61B5/1468 , A61B5/1486 , A61B5/746 , A61B2560/0223 , A61B2560/0252 , A61B2560/045 , G06F19/00 , G16H15/00 , G16H40/63
摘要： Apparatuses and methods for medical monitoring physiological characteristics values such as blood glucose levels for the treatment of diabetes, are presented. The apparatuses and methods provide dynamic glucose monitoring functions that perform predictive analysis to anticipate harmful conditions, such as glucose crash and hyperglycemic incidents for a patient. The dynamic functions can also be used to maximize athletic performance and warn of inadequate nocturnal basal rate. Other aspects include advanced alarm and reminder functions, as well as advanced data presentation tools to further facilitate convenient and efficient management of various physiological conditions.

7. 发明申请

US20050096512A1 System for monitoring physiological characteristics 审中-公开
公开(公告)号：US20050096512A1
公开(公告)日：2005-05-05
申请号：US10999671
申请日：2004-11-30
申请人： James Fox , Garry Steil , Kerstin Rebrin , Mark Estes , Frank Saidara
发明人： James Fox , Garry Steil , Kerstin Rebrin , Mark Estes , Frank Saidara
IPC分类号： A61B5/00 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： A61B5/7275 , A61B5/0002 , A61B5/14532 , A61B5/1468 , A61B5/1486 , A61B5/746 , A61B2560/0223 , A61B2560/0252 , A61B2560/045 , G16H15/00 , G16H40/63
摘要： Apparatuses and methods for medical monitoring physiological characteristics values such as blood glucose levels for the treatment of diabetes, are presented. The apparatuses and methods provide dynamic glucose monitoring functions that perform predictive analysis to anticipate harmful conditions, such as glucose crash and hyperglycemic incidents for a patient. The dynamic functions can also be used to maximize athletic performance and warn of inadequate nocturnal basal rate. Other aspects include advanced alarm and reminder functions, as well as advanced data presentation tools to further facilitate convenient and efficient management of various physiological conditions.

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