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1. 发明授权

US06919373B1 Methods and devices for providing prolonged drug therapy 有权
公开(公告)号：US06919373B1
公开(公告)日：2005-07-19
申请号：US09253317
申请日：1999-02-19
申请人： Andrew C. Lam , Padmaja Shivanand , Atul D. Ayer , Richard G. Weyers , Suneel K. Gupta , Diane R. Guinta , Carol A. Christopher , Samuel R. Saks , Lawrence G. Hamel , Jeri D. Wright , Zahedeh Hatamkhany
发明人： Andrew C. Lam , Padmaja Shivanand , Atul D. Ayer , Richard G. Weyers , Suneel K. Gupta , Diane R. Guinta , Carol A. Christopher , Samuel R. Saks , Lawrence G. Hamel , Jeri D. Wright , Zahedeh Hatamkhany
IPC分类号： A61K9/00 , A61K9/20 , A61K9/24 , A61K9/50 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458 , A61K31/235
CPC分类号： A61K9/2086 , A61K9/0002 , A61K9/0004 , A61K9/2072 , A61K9/209 , A61K9/5084 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458
摘要： Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.

2. 发明授权

US09029416B2 Methods and devices for providing prolonged drug therapy 有权
公开(公告)号：US09029416B2
公开(公告)日：2015-05-12
申请号：US10638977
申请日：2003-08-12
申请人： Andrew C. Lam , Padmaja Shivanand , Atul D. Ayer , Zahedeh Hatamkhany , Suneel K. Gupta , Diane R. Guinta , Carol A. Christopher , Samuel R. Saks , Lawrence G. Hamel , Jeri D. Wright , Richard G. Weyers
发明人： Andrew C. Lam , Padmaja Shivanand , Atul D. Ayer , Zahedeh Hatamkhany , Suneel K. Gupta , Diane R. Guinta , Carol A. Christopher , Samuel R. Saks , Lawrence G. Hamel , Jeri D. Wright , Richard G. Weyers
IPC分类号： A61K9/20 , A61K9/00 , A61K9/24 , A61K9/50 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458
CPC分类号： A61K9/2086 , A61K9/0002 , A61K9/0004 , A61K9/2072 , A61K9/209 , A61K9/5084 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458
摘要： Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.

3. 发明授权

US06930129B2 Methods and devices for providing prolonged drug therapy 有权
标题翻译：提供延长药物治疗的方法和装置
公开(公告)号：US06930129B2
公开(公告)日：2005-08-16
申请号：US09802709
申请日：2001-03-08
申请人： Andrew C. Lam , Padmaja Shivanand , Atul D. Ayer , Zahedeh Hatamkhany , Suneel K. Gupta , Diane R. Guinta , Carol A. Christopher , Samuel R. Saks , Lawrence G. Hamel , Jeri D. Wright , Richard G. Weyers
发明人： Andrew C. Lam , Padmaja Shivanand , Atul D. Ayer , Zahedeh Hatamkhany , Suneel K. Gupta , Diane R. Guinta , Carol A. Christopher , Samuel R. Saks , Lawrence G. Hamel , Jeri D. Wright , Richard G. Weyers
IPC分类号： A61K9/00 , A61K9/20 , A61K9/24 , A61K9/50 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458 , A61K31/235
CPC分类号： A61K9/2086 , A61K9/0002 , A61K9/0004 , A61K9/2072 , A61K9/209 , A61K9/5084 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458
摘要： Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.
摘要翻译：提供了用于在延长的治疗期间维持期望的治疗药物作用的方法和装置。特别地，提供了在延长的时间段内以升高释放速率在胃肠道内释放药物的口服剂型。剂型还可包含立即释放剂量的药物。

4. 发明授权

US4902514A Dosage form for administering nilvadipine for treating cardiovascular symptoms 失效
标题翻译：尼伐地平治疗心血管症状的剂型
公开(公告)号：US4902514A
公开(公告)日：1990-02-20
申请号：US222476
申请日：1988-07-21
申请人： Brian L. Barclay , Patrick S. L. Wong , Jeri D. Wright , Jerry D. Childers
发明人： Brian L. Barclay , Patrick S. L. Wong , Jeri D. Wright , Jerry D. Childers
IPC分类号： A61K9/00 , A61K31/44
CPC分类号： A61K9/0004 , A61K31/44
摘要： A dosage form is disclosed comprising nilvadipine for administering to a patient in need of cardiovascular therapy.
摘要翻译：公开了一种剂型，其包含用于对需要心血管治疗的患者施用的尼伐地平。

5. 发明授权

US5595759A Process for providing therapeutic composition 失效
标题翻译：提供治疗组合物的方法
公开(公告)号：US5595759A
公开(公告)日：1997-01-21
申请号：US337701
申请日：1994-11-10
申请人： Jeri D. Wright , Brian L. Barclay , Linda E. Atkinson
发明人： Jeri D. Wright , Brian L. Barclay , Linda E. Atkinson
IPC分类号： A61K9/00 , A61K9/20 , A61K31/565 , A61K31/567 , A61K31/57
CPC分类号： A61K31/565 , A61K31/567 , A61K31/57 , A61K9/0004 , A61K9/2031 , A61K9/2054
摘要： A process is disclosed and claimed for preparing a therapeutic composition comprising asteroid or a dosage form comprising the composition, which therapeutic composition or dosage form is indicated for human administration.
摘要翻译：一种方法被公开并要求用于制备包含小行星的治疗组合物或包含该组合物的剂型，该治疗组合物或剂型用于人给药。

6. 发明授权

US4948593A Osmotic dosage form comprising an estrogen and a progestogen 失效
标题翻译：包含雌激素和孕激素的渗透剂型
公开(公告)号：US4948593A
公开(公告)日：1990-08-14
申请号：US351365
申请日：1989-05-15
申请人： Jeri D. Wright , Jerry D. Childers , Brian L. Barcley , Patrick S. L. Wong , Linda E. Atkinson
发明人： Jeri D. Wright , Jerry D. Childers , Brian L. Barcley , Patrick S. L. Wong , Linda E. Atkinson
IPC分类号： A61K9/00 , A61K9/22 , A61K31/565 , A61K31/57
CPC分类号： A61K9/0004 , A61K31/565
摘要： An osmotic device is disclosed comprising an estrogenic and a progestogenic steroid that are delivered as a contraceptive pair for fertility regulation in a female.
摘要翻译：公开了一种渗透装置，其包含雌激素和孕激素类固醇，其作为孕妇的生殖调节的避孕对递送。

7. 发明授权

US5817335A Osmotic device with high drug loading and delayed activation of drug delivery 失效
标题翻译：渗透装置具有高药物负荷和药物递送延迟激活
公开(公告)号：US5817335A
公开(公告)日：1998-10-06
申请号：US451647
申请日：1995-05-26
申请人： Patrick S.-L. Wong , Liang C. Dong , Vincent J. Ferrari , Jeri D. Wright , Steven D. Larsen
发明人： Patrick S.-L. Wong , Liang C. Dong , Vincent J. Ferrari , Jeri D. Wright , Steven D. Larsen
IPC分类号： A61K9/00 , A61K9/52 , A61K9/48
CPC分类号： A61K9/0004 , Y10S514/962
摘要： The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation being of a predetermined length of time. The dispensing device is formed of a first and second housing that are in reversibly sliding telescoping arrangement with each other. The first housing contains the active agent formulation and has an aspect ratio less than 1. The housings are preferably. ovoloid in shape.
摘要翻译：本发明涉及一种流体吸收药物递送装置，其用于将活性剂制剂初始延迟递送至使用的流体环境，起始或启动的初始延迟时间为预定时间长度。分配装置由彼此可逆地滑动伸缩布置的第一和第二壳体形成。第一壳体包含活性剂制剂并且具有小于1的纵横比。该外壳是优选的。 ovoloid形状。

8. 发明授权

US5573776A Oral osmotic device with hydrogel driving member 失效
标题翻译：具有水凝胶驱动构件的口腔渗透装置
公开(公告)号：US5573776A
公开(公告)日：1996-11-12
申请号：US303288
申请日：1994-09-08
申请人： Juan M. E. Harrison , Brian L. Barclay , Jerry D. Childers , Jeri D. Wright , Virgil A. Place , Patrick S. Wong
发明人： Juan M. E. Harrison , Brian L. Barclay , Jerry D. Childers , Jeri D. Wright , Virgil A. Place , Patrick S. Wong
IPC分类号： A61K9/00 , A61K31/48 , A61K9/24
CPC分类号： A61K31/48 , A61K9/0004
摘要： An osmotic device (10) for delivering an ergot alkaloid into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a wall (12) surrounding a compartment (13) housing a layer of an ergot alkaloid (14) and a layer (16) of a fluid swellable, hydrophilic polymer. A passageway (17) in the wall (12) connects the ergot alkaloid (14) with the exterior of the device (10). The wall (12) is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer (16). In one embodiment the ergot alkaloid (14) has a different color than the hydrophilic polymer (16). The wall (12) is sufficiently translucent to permit the patient to see the amount of ergot alkaloid (14) remaining to be delivered. Marking lines (19) may be provided on the wall (12) indicating the amount of ergot alkaloid (14) which has been delivered and/or the amount remaining to be delivered.
摘要翻译：公开了一种用于将麦角生物碱输送到人类患者的口中的渗透装置（10）。装置（10）具有适应其舒适地保持在口中长时间的尺寸和形状。装置（10）包括围绕容纳一角麦角生物碱（14）层和流体可溶胀的亲水性聚合物层（16）的隔室（13）的壁（12）。壁（12）中的通道（17）将麦角生物碱（14）与装置（10）的外部连接。所述壁（12）对于水性生物流体的通道是可渗透的，但是对于亲水性聚合物（16）的通过基本上是不透水的。在一个实施方案中，麦角生物碱（14）具有与亲水性聚合物（16）不同的颜色。壁（12）足够半透明以允许患者看到剩余的待转运麦角生物碱（14）的量。标记线（19）可以设置在壁（12）上，指示已经输送的麦角生物碱（14）的量和/或剩余的待传送量。

9. 发明授权

US5098714A Osmotic, oral dosage form for fertility control 失效
标题翻译： OSMOTIC，口服剂型用于肥胖控制
公开(公告)号：US5098714A
公开(公告)日：1992-03-24
申请号：US437480
申请日：1989-11-16
申请人： Jeri D. Wright , Jerry D. Childers , Brian L. Barclay , Patrick S. Wong , Linda E. Atkinson
发明人： Jeri D. Wright , Jerry D. Childers , Brian L. Barclay , Patrick S. Wong , Linda E. Atkinson
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22 , A61K31/565 , A61K31/57
CPC分类号： A61K31/565 , A61K9/0004
摘要： An osmotic device is disclosed comprising an exterior coat comprising an estrogenic and a progestogenic steroid that are delivered immediately as a contraceptive pair for fertility regulation in a female, and a compartment comprising an estrogenic steroid that is delivered at a controlled rate over a prolonged period of time for fertility regulation in a female.
摘要翻译：公开了一种渗透装置，其包含包含雌激素和孕激素类固醇的外涂层，其立即作为避孕对进行递送，用于雌性中的生殖调节，以及包含雌激素类固醇的隔室，所述雌激素类固醇以长期的受控率递送一个女性的生育调节时间。

10. 发明授权

US5326571A Dosage forms comprising polymers comprising different molecular weights 失效
标题翻译：包含不同分子量的聚合物的剂型
公开(公告)号：US5326571A
公开(公告)日：1994-07-05
申请号：US941332
申请日：1992-09-04
申请人： Jeri D. Wright , Brian L. Barclay , David R. Swanson
发明人： Jeri D. Wright , Brian L. Barclay , David R. Swanson
IPC分类号： A61K9/00 , A61K9/22 , A61K47/38 , A61K9/24
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising a wall surrounding a compartment, which comprises a first composition comprising a carboxymethylcellulose and a second composition comprising a higher molecular weight carboxymethylcellulose. The first composition comprises a dosage amount of drug that delivers from the dosage form at a controlled rate over time.
摘要翻译：公开了一种剂型，其包括围绕隔室的壁，其包含含有羧甲基纤维素的第一组合物和包含较高分子量羧甲基纤维素的第二组合物。第一组合物包含以受控速率随时间从剂型递送的剂量的药物。

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