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1. 发明授权

US06551618B2 Compositions and methods for delivery of agents for neuronal regeneration and survival 失效
标题翻译：用于神经元再生和存活的药物递送的组合物和方法
公开(公告)号：US06551618B2
公开(公告)日：2003-04-22
申请号：US09178286
申请日：1998-10-23
申请人： Andrew Baird , Ana Maria Gonzalez , Ann Logan , Martin Berry
发明人： Andrew Baird , Ana Maria Gonzalez , Ann Logan , Martin Berry
IPC分类号： A61K914
CPC分类号： A61K38/179 , A61K9/0024 , A61K35/15 , A61K35/30 , A61K38/00 , A61K38/1709 , A61K38/1841 , A61K38/185 , A61K41/0042 , A61K47/42 , A61K47/642 , A61K47/6425 , A61K48/00 , A61K48/0008 , A61K48/0058 , A61K48/0075 , C07K14/415 , C07K14/475 , C07K14/503 , C07K14/52 , C07K2319/00 , C07K2319/03 , C07K2319/04 , C07K2319/09 , C07K2319/21 , C07K2319/50 , C07K2319/55 , C07K2319/75 , C07K2319/80 , C12N15/62 , C12N15/85 , C12N15/87 , C12N2799/026 , C12N2800/107 , C12N2810/851 , C12N2830/008 , Y10S977/912 , Y10S977/927
摘要： Devices useful in the delivery of DNA encoding neurotrophic agents, anti-fibrotic agents, and related compositions are disclosed herein for use in the treatment of central and/or peripheral nervous system injury. Methods of making and using the disclosed devices and DNA are also described. In various embodiments, the invention also discloses compositions and devices that may further include a targeting agent, such as a polypeptide that is reactive with an FGF receptor (e.g., bFGF), or another ligand that binds to cell surface receptors on neuronal cells, or a support cell. The invention also discloses methods of promoting neuronal survival and regeneration via transfection of an axon as it grows through a device or composition of the present invention, or via transfection of a repair cell.
摘要翻译：用于递送编码神经营养剂，抗纤维化剂和相关组合物的DNA的装置在本文中公开用于治疗中枢和/或周围神经系统损伤。还描述了制造和使用所公开的装置和DNA的方法。在各种实施方案中，本发明还公开了可以进一步包括靶向剂，例如与FGF受体（例如bFGF）反应的多肽或与神经元细胞上的细胞表面受体结合的另一种配体的组合物和装置，或支撑细胞本发明还公开了当轴突通过本发明的装置或组合物生长或通过转染修复细胞时转染轴突促进神经元存活和再生的方法。

2. 发明申请

US20080152689A1 DEVICES CONTAINING DNA ENCODING NEUROTROPHIC AGENTS AND RELATED COMPOSITIONS AND METHODS 审中-公开
标题翻译：含有编码神经营养因子的DNA的装置及相关组合物和方法
公开(公告)号：US20080152689A1
公开(公告)日：2008-06-26
申请号：US11951970
申请日：2007-12-06
申请人： Andrew Baird , Ana Maria Gonzalez , Martin Berry , Ann Logan
发明人： Andrew Baird , Ana Maria Gonzalez , Martin Berry , Ann Logan
IPC分类号： A61K9/00 , A61K35/12 , A61P25/00
CPC分类号： A61K38/179 , A61K9/0024 , A61K35/15 , A61K35/30 , A61K38/00 , A61K38/1709 , A61K38/1841 , A61K38/185 , A61K41/0042 , A61K47/42 , A61K47/642 , A61K47/6425 , A61K48/00 , A61K48/0008 , A61K48/0058 , A61K48/0075 , C07K14/415 , C07K14/475 , C07K14/503 , C07K14/52 , C07K2319/00 , C07K2319/03 , C07K2319/04 , C07K2319/09 , C07K2319/21 , C07K2319/50 , C07K2319/55 , C07K2319/75 , C07K2319/80 , C12N15/62 , C12N15/85 , C12N15/87 , C12N2799/026 , C12N2800/107 , C12N2810/851 , C12N2830/008 , Y10S977/912 , Y10S977/927
摘要： Devices useful in the delivery of DNA encoding neurotrophic agents, anti-fibrotic agents, and related compositions are disclosed herein for use in the treatment of central and/or peripheral nervous system injury. Methods of making and using the disclosed devices and DNA are also described. In various embodiments, the invention also discloses compositions and devices that may further include a targeting agent, such as a polypeptide that is reactive with an FGF receptor (e.g., bFGF), or another ligand that binds to cell surface receptors on neuronal cells, or a support cell. The invention also discloses methods of promoting neuronal survival and regeneration via transfection of an axon as it grows through a device or composition of the present invention, or via transfection of a repair cell.
摘要翻译：用于递送编码神经营养剂，抗纤维化剂和相关组合物的DNA的装置在本文中公开用于治疗中枢和/或周围神经系统损伤。还描述了制造和使用所公开的装置和DNA的方法。在各种实施方案中，本发明还公开了可以进一步包括靶向剂，例如与FGF受体（例如bFGF）反应的多肽或与神经元细胞上的细胞表面受体结合的另一种配体的组合物和装置，或支撑细胞本发明还公开了当轴突通过本发明的装置或组合物生长或通过转染修复细胞时转染轴突促进神经元存活和再生的方法。

3. 发明授权

US5958411A Methods of inhibiting ECM accumulation in the CNS by inhibition of TGF-.beta. 失效
标题翻译：通过抑制TGF-β抑制CNS中ECM积累的方法
公开(公告)号：US5958411A
公开(公告)日：1999-09-28
申请号：US410573
申请日：1995-03-24
申请人： Ann Logan , Andrew Baird
发明人： Ann Logan , Andrew Baird
IPC分类号： A61K38/00 , A61K38/04 , A61K38/17 , A61K38/18 , C07K16/22 , A61K38/16 , A61K39/395
CPC分类号： C07K16/22 , A61K38/04 , A61K38/1709 , A61K38/1841
摘要： The present invention relates to methods for preventing, suppressing or treating a CNS pathology characterized by a deleterious accumulation of extracellular matrix in a tissue by contacting the tissue with an agent that inhibits the extracellular matrix producing activity of TGF-.beta.. The methods can be used to prevent, suppress or treat scar formation in the CNS. Agents that are useful in the present methods include neutralizing anti-TGF-.beta. antibodies, Arg-Gly-Asp-containing peptides, decorin and its functional equivalents such as biglycan, and TGF-.beta. antagonists. The present invention further provides methods for preventing, suppressing or treating a CNS pathology characterized by the insufficient accumulation of extracellular matrix. Agents that enhance the production of extracellular matrix, such as TGF-.beta., can be used in such methods. Finally, the present invention provides pharmaceutical compositions containing these agents, which can be administered to patients to inhibit or enhance the production of extracellular matrix in the CNS.
摘要翻译：本发明涉及用于预防，抑制或治疗CNS病理学的方法，其特征在于通过使组织与抑制TGF-β的细胞外基质产生活性的试剂接触将组织中的细胞外基质有害积累。该方法可用于预防，抑制或治疗CNS中的瘢痕形成。在本方法中有用的试剂包括中和抗TGF-β抗体，含Arg-Gly-Asp的肽，核心蛋白聚糖及其功能等同物如双糖链聚糖和TGF-β拮抗剂。本发明还提供了预防，抑制或治疗以细胞外基质积累不足为特征的CNS病理学的方法。可以使用增强细胞外基质如TGF-β产生的药剂。最后，本发明提供含有这些试剂的药物组合物，其可以施用于患者以抑制或增强CNS中细胞外基质的产生。

4. 发明授权

US07943755B2 Neuron regeneration 失效
标题翻译：神经元再生
公开(公告)号：US07943755B2
公开(公告)日：2011-05-17
申请号：US11577663
申请日：2004-10-22
申请人： Zubair Ahmed , Martin Berry , Ann Logan
发明人： Zubair Ahmed , Martin Berry , Ann Logan
IPC分类号： C07H21/04
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/14
摘要： The invention provides a gene silencing molecule, which is adapted to down-regulate expression of a gene encoding a peptide involved with the Rho-A inhibitory pathway. The gene silencing molecule is used to promote neuron survival and axon regeneration in the central nervous system (CNS). The invention also provides compositions and methods of using same to improve neural survival and promote axonal growth.
摘要翻译：本发明提供了一种基因沉默分子，其适于下调编码涉及Rho-A抑制途径的肽的基因的表达。基因沉默分子用于促进中枢神经系统（CNS）中的神经元存活和轴突再生。本发明还提供了使用其组合物和方法来改善神经存活并促进轴突生长。

5. 发明申请

US20080253989A1 Neuron Regeneration 失效
标题翻译：神经元再生
公开(公告)号：US20080253989A1
公开(公告)日：2008-10-16
申请号：US11577663
申请日：2004-10-22
申请人： Zubair Ahmed , Martin Berry , Ann Logan
发明人： Zubair Ahmed , Martin Berry , Ann Logan
IPC分类号： A61K38/20 , C07H21/04 , C12N9/24 , A61P25/28 , A61K38/28 , A61K31/7052
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/14
摘要： The invention provides a gene silencing molecule, which is adapted to down-regulate expression of a gene encoding a peptide involved with the Rho-A inhibitory pathway. The gene silencing molecule is used to promote neuron survival and axon regeneration in the central nervous system (CNS). The invention also provides compositions and methods of using same to improve neural survival and promote axonal growth.
摘要翻译：本发明提供了一种基因沉默分子，其适于下调编码涉及Rho-A抑制途径的肽的基因的表达。基因沉默分子用于促进中枢神经系统（CNS）中的神经元存活和轴突再生。本发明还提供了使用其组合物和方法来改善神经存活并促进轴突生长。

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