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1. 发明申请

US20100014157A1 MULTISPECTRAL LIGHTING APPARATUS 有权
标题翻译：多功能照明设备
公开(公告)号：US20100014157A1
公开(公告)日：2010-01-21
申请号：US12445132
申请日：2007-10-06
申请人： Andress Nolte , Matthias Kramer , Michael Brehm , Christian Boeker
发明人： Andress Nolte , Matthias Kramer , Michael Brehm , Christian Boeker
IPC分类号： G02B21/06
CPC分类号： G02B27/1006 , G01J3/02 , G01J3/0208 , G01J3/10 , G01N21/6458 , G02B21/16 , G02B27/145
摘要： The invention is directed to a multispectral illumination device for a microscope or for a reader. According to the invention, the illumination device comprises at least three receptacle positions for lighting modules and at least one receptacle position for coupling modules, the mechanical devices for connecting the lighting modules or coupling modules at the receptacle positions to the illumination device being designed in such a way that the lighting modules or coupling modules can be easily changed. Further, the receptacle positions are arranged in such a way that, with suitable selection of the lighting modules and coupling modules, all individual spectra of the lighting modules in a total spectrum are available simultaneously at the output of the illumination device.
摘要翻译：本发明涉及用于显微镜或读取器的多光谱照明装置。根据本发明，照明装置包括用于照明模块的至少三个插座位置和用于耦合模块的至少一个插座位置，用于将插座位置处的照明模块或耦合模块连接到照明装置的机械装置被设计为照明模块或耦合模块可以方便地更换的方式。此外，插座位置被布置成使得通过适当地选择照明模块和耦合模块，总体光谱中的照明模块的所有单独光谱可在照明装置的输出处同时获得。

2. 发明授权

US08203784B2 Multispectral lighting apparatus 有权
标题翻译：多光照明装置
公开(公告)号：US08203784B2
公开(公告)日：2012-06-19
申请号：US12445132
申请日：2007-10-06
申请人： Andreas Nolte , Matthias Kramer , Michael Brehm , Christian Boeker
发明人： Andreas Nolte , Matthias Kramer , Michael Brehm , Christian Boeker
IPC分类号： G02B21/06 , F21V9/00
CPC分类号： G02B27/1006 , G01J3/02 , G01J3/0208 , G01J3/10 , G01N21/6458 , G02B21/16 , G02B27/145
摘要： The invention is directed to a multispectral illumination device for a microscope or for a reader. According to the invention, the illumination device comprises at least three receptacle positions for lighting modules and at least one receptacle position for coupling modules, the mechanical devices for connecting the lighting modules or coupling modules at the receptacle positions to the illumination device being designed in such a way that the lighting modules or coupling modules can be easily changed. Further, the receptacle positions are arranged in such a way that, with suitable selection of the lighting modules and coupling modules, all individual spectra of the lighting modules in a total spectrum are available simultaneously at the output of the illumination device.
摘要翻译：本发明涉及用于显微镜或读取器的多光谱照明装置。根据本发明，照明装置包括用于照明模块的至少三个插座位置和用于耦合模块的至少一个插座位置，用于将插座位置处的照明模块或耦合模块连接到照明装置的机械装置被设计为照明模块或耦合模块可以方便地更换的方式。此外，插座位置被布置成使得通过适当地选择照明模块和耦合模块，总体光谱中的照明模块的所有单独光谱可在照明装置的输出处同时获得。

3. 发明申请

US20090224174A1 Calibration device and laser scanning microscope with such a calibration device 有权
标题翻译：校准装置和激光扫描显微镜用这种校准装置
公开(公告)号：US20090224174A1
公开(公告)日：2009-09-10
申请号：US12320599
申请日：2009-01-29
申请人： Ralf Netz , Wolfgang Bathe , Joerg Steinert , Werner Kleinschmidt , Ingo Fahlbusch , Michael Brehm
发明人： Ralf Netz , Wolfgang Bathe , Joerg Steinert , Werner Kleinschmidt , Ingo Fahlbusch , Michael Brehm
IPC分类号： G01N21/64 , G02B21/06
CPC分类号： G02B21/34 , G01M11/0264 , G02B21/002 , G02B27/32
摘要： A calibration device for managing a variety of performance tests and/or calibration tasks in a laser scanning microscope. The calibration device, which has focusing optics and a test structure arranged in the focal plane of the focusing optics, with structural elements detectable in reflected and/or transmitted light aligned to each other in a common mounting, can be switched into the microscope beam path in a laser scanning microscope, so that the pupil of the focusing optics coincides with the objective pupil of the laser scanning microscope or lies in a plane conjugated to it.
摘要翻译：用于在激光扫描显微镜中管理各种性能测试和/或校准任务的校准装置。具有聚焦光学元件和布置在聚焦光学器件的焦平面中的测试结构的校准装置可以被转换成显微镜光束路径，该结构元件可在反射和/或透射的光中可检测到，在共同安装中彼此对准在激光扫描显微镜中，使得聚焦光学元件的瞳孔与激光扫描显微镜的客观瞳孔重合或位于与其共轭的平面中。

4. 发明授权

US07706076B2 Optical system 有权
标题翻译：光学系统
公开(公告)号：US07706076B2
公开(公告)日：2010-04-27
申请号：US11664734
申请日：2005-09-21
申请人： Michael Brehm , Rolf Wartmann
发明人： Michael Brehm , Rolf Wartmann
IPC分类号： G02B21/02 , G02B21/00
CPC分类号： G02B21/082
摘要： An optical system for arranging between a light source and a field diaphragm in an illumination beam path of a microscope comprises n imaging optical elements with focal lengths fi and Abbe numbers νi (i=1, . . . , n). The following relationship is met for the optical system: ∑ i = 1 n ⁢ h i f i · v i ≤ 0.07 , where hi is one half of the bundle diameter of a bundle of light rays proceeding from a point of the light source at the entrance to the imaging optical element i.
摘要翻译：用于在显微镜的照明光束路径中在光源和场光阑之间布置的光学系统包括具有焦距fi和阿贝数＆ngr; i（i = 1，...，n）的n个成像光学元件。对于光学系统，满足以下关系：Σi = 1 n hifi·vi≤0.07，其中hi是从入口处的光源的点开始的一束光线的束直径的一半成像光学元件

5. 发明授权

US07430075B2 Condenser arrangement for brightfield illumination and/or darkfield illumination for optical microscopes 有权
标题翻译：用于光场显微镜的明场照明和/或暗场照明的冷凝器布置
公开(公告)号：US07430075B2
公开(公告)日：2008-09-30
申请号：US11193845
申请日：2005-07-29
申请人： Peter Dietrich , Michael Brehm , Heino Heise
发明人： Peter Dietrich , Michael Brehm , Heino Heise
IPC分类号： G02B21/14
CPC分类号： G02B21/125
摘要： A condenser arrangement for brightfield illumination and/or darkfield illumination for optical microscopes comprises in a housing basic optics having at least one lens, at least one front optics which can be inserted into the illumination beam path in front of the basic optics, and means for inserting the front optics into the illumination beam path of the microscope. A first swiveling arm and a second swiveling arm are swivelably arranged at the housing of the condenser. The first swiveling arm carries first front optics with a high aperture for brightfield illumination and the second swiveling arm carries second front optics for darkfield illumination. The two swiveling arms are arranged at a defined distance from the shared basic optics of the condenser in direction of the optical axis of the illumination beam path. An aperture iris diaphragm is provided on the object side in front of the basic optics and is opened when the cardioid optics are inserted. Further, a darkfield slide with an annular mirror element is provided on the object side at the housing. Operator's controls serve to swivel the two swiveling arms for moving the darkfield slide and for adjusting the aperture iris diaphragm.
摘要翻译：用于光学显微镜的明场照明和/或暗场照明的冷凝器布置包括在具有至少一个透镜的壳体基本光学元件中，至少一个可以被插入到基本光学器件前面的照明光束路径中的前光学器件，以及用于将前光学元件插入显微镜的照明光束路径。第一旋转臂和第二旋转臂可旋转地布置在冷凝器的壳体处。第一个旋转臂承载第一个具有高光圈的前光学器件，用于明场照明，第二个旋转臂承载用于暗场照明的第二个前光学元件。两个旋转臂在照明光束路径的光轴方向上以与冷凝器的共用基本光学器件隔开的距离布置。光阑光阑设置在基本光学元件前方的物体侧，并且当插入心形光学元件时打开。此外，在壳体的物体侧设置具有环形镜元件的暗视野滑块。操作员的控制装置用于旋转两个旋转臂以移动暗场滑块并调节孔径光阑。

6. 发明授权

US08115164B2 Calibration device and laser scanning microscope with such a calibration device 有权
标题翻译：校准装置和激光扫描显微镜用这种校准装置
公开(公告)号：US08115164B2
公开(公告)日：2012-02-14
申请号：US12320599
申请日：2009-01-29
申请人： Ralf Netz , Wolfgang Bathe , Joerg Steinert , Werner Kleinschmidt , Ingo Fahlbusch , Michael Brehm
发明人： Ralf Netz , Wolfgang Bathe , Joerg Steinert , Werner Kleinschmidt , Ingo Fahlbusch , Michael Brehm
IPC分类号： G01D18/00
CPC分类号： G02B21/34 , G01M11/0264 , G02B21/002 , G02B27/32
摘要： A calibration device for managing a variety of performance tests and/or calibration tasks in a laser scanning microscope. The calibration device, which has focusing optics and a test structure arranged in the focal plane of the focusing optics, with structural elements detectable in reflected and/or transmitted light aligned to each other in a common mounting, can be switched into the microscope beam path in a laser scanning microscope, so that the pupil of the focusing optics coincides with the objective pupil of the laser scanning microscope or lies in a plane conjugated to it.
摘要翻译：用于在激光扫描显微镜中管理各种性能测试和/或校准任务的校准装置。具有聚焦光学元件和布置在聚焦光学器件的焦平面中的测试结构的校准装置可以被转换成显微镜光束路径，该结构元件可在反射和/或透射的光中可检测到，在共同安装中彼此对准在激光扫描显微镜中，使得聚焦光学元件的瞳孔与激光扫描显微镜的客观瞳孔重合或位于与其共轭的平面中。

7. 发明申请

US20090224694A1 Illumination Device, In Particular for Microscopes 失效
标题翻译：照明装置，特别是显微镜
公开(公告)号：US20090224694A1
公开(公告)日：2009-09-10
申请号：US11887462
申请日：2006-06-22
申请人： Lutz Höring , Andreas Nolte , Michael Brehm , Mario Sondermann
发明人： Lutz Höring , Andreas Nolte , Michael Brehm , Mario Sondermann
IPC分类号： H05B37/02 , H01J1/63
CPC分类号： G02B21/06
摘要： The present invention is directed to a controllable microscope illumination within a microscope system by which all essential contrasting methods in microscopy can be realized. The illumination device according to the invention comprises a plurality of individual light sources which can be regulated with respect to brightness, wherein these individual light sources are formed as unit cells and form a luminous surface by a periodic arrangement. In an advantageous arrangement, imaging optics are associated with each individual light source in order to magnify the image of the source surface of the individual light source so that the images of the source surfaces of adjacent individual light sources touch. Illumination variants for all of the essential contrasting methods in microscopy can be generated by means of the proposed solution. The proposed LED illumination is electronically switchable, can be regulated with respect to brightness, supplies all colors, is long-lasting and economical. LEDs have a long life and are very robust and insensitive to vibrations. The spatial light distribution and the color temperature are adjustable.
摘要翻译：本发明涉及在显微镜系统内的可控显微照明，通过该照明可以实现显微镜中的所有必要的对比方法。根据本发明的照明装置包括可以相对于亮度调节的多个单独的光源，其中这些单个光源被形成为单元电池并且通过周期性布置形成发光表面。在有利的布置中，成像光学器件与每个单独的光源相关联，以便放大单个光源的源表面的图像，使得相邻单独光源的源表面的图像接触。通过提出的解决方案可以产生显微镜中所有基本对比方法的照明变体。提出的LED照明是电子可切换的，可以根据亮度进行调节，供应所有颜色，是持久和经济的。 LED寿命长，非常坚固，对振动不敏感。空间光分布和色温可调。

8. 发明授权

US4132754A Rinsing multi component foam machines 失效
标题翻译：冲洗多组分泡沫机
公开(公告)号：US4132754A
公开(公告)日：1979-01-02
申请号：US767923
申请日：1977-02-11
申请人： Kurt Weber , Michael Brehm
发明人： Kurt Weber , Michael Brehm
IPC分类号： B01F17/38 , C11D3/43 , C11D7/50 , B08B3/08 , B08B9/08
CPC分类号： C11D3/43
摘要： In the production of a polyurethane foam by supplying two or more components to a machine, mixing said components, extruding the mixture to form a foaming mass, subsequently discontinuing supply and extrusion, rinsing the machine, and subsequently resuming supply and extrusion, the improvement which comprises effecting said rinsing with a rinsing agent having the approximate weight compositionWater: 70-80 partsSorbitol: 25-18 partsEmulsifier: 5-2 parts
摘要翻译：在通过向机器中供应两种或更多种组分的聚氨酯泡沫的生产中，混合所述组分，挤出混合物以形成发泡团块，随后中断供应和挤出，冲洗机器，随后恢复供应和挤出，改进包括用具有近似重量组成的漂洗剂进行所述冲洗水：70-80份山梨糖醇：25-18份乳化剂：

9. 发明授权

US08125709B2 Illumination device, in particular for microscopes 失效
标题翻译：照明装置，特别是显微镜
公开(公告)号：US08125709B2
公开(公告)日：2012-02-28
申请号：US11887462
申请日：2006-06-22
申请人： Lutz Hoering , Andreas Nolte , Michael Brehm , Mario Sondermann
发明人： Lutz Hoering , Andreas Nolte , Michael Brehm , Mario Sondermann
IPC分类号： G02B21/06
CPC分类号： G02B21/06
摘要： The present invention is directed to a controllable microscope illumination within a microscope system by which all essential contrasting methods in microscopy can be realized. The illumination device according to the invention comprises a plurality of individual light sources which can be regulated with respect to brightness, wherein these individual light sources are formed as unit cells and form a luminous surface by a periodic arrangement. In an advantageous arrangement, imaging optics are associated with each individual light source in order to magnify the image of the source surface of the individual light source so that the images of the source surfaces of adjacent individual light sources touch. Illumination variants for all of the essential contrasting methods in microscopy can be generated by way of the proposed solution. The proposed LED illumination is electronically switchable, can be regulated with respect to brightness, supplies all colors, is long-lasting and economical. LEDs have a long life and are very robust and insensitive to vibrations. The spatial light distribution and the color temperature are adjustable.
摘要翻译：本发明涉及在显微镜系统内的可控显微照明，通过该照明可以实现显微镜中的所有必要的对比方法。根据本发明的照明装置包括可以相对于亮度调节的多个单独的光源，其中这些单个光源被形成为单元电池并且通过周期性布置形成发光表面。在有利的布置中，成像光学器件与每个单独的光源相关联，以便放大单个光源的源表面的图像，使得相邻单独光源的源表面的图像接触。可以通过提出的解决方案来产生显微镜中所有基本对比方法的照明变体。提出的LED照明是电子可切换的，可以根据亮度进行调节，供应所有颜色，是持久和经济的。 LED寿命长，非常坚固，对振动不敏感。空间光分布和色温可调。

10. 发明申请

US20090225408A1 Optical system 有权
标题翻译：光学系统
公开(公告)号：US20090225408A1
公开(公告)日：2009-09-10
申请号：US11664734
申请日：2005-09-21
申请人： Michael Brehm , Rolf Wartmann
发明人： Michael Brehm , Rolf Wartmann
IPC分类号： G02B21/06
CPC分类号： G02B21/082
摘要： An optical system for arranging between a light source and a field diaphragm in an illumination beam path of a microscope comprises n imaging optical elements with focal lengths fi and Abbe numbers νi (i=1, . . . , n). The following relationship is met for the optical system: ∑ i = 1 n  h i f i · v i ≤ 0.07 , where hi is one half of the bundle diameter of a bundle of light rays proceeding from a point of the light source at the entrance to the imaging optical element i.
摘要翻译：用于在显微镜的照明光束路径中的光源和场隔膜之间布置的光学系统包括具有焦距fi和阿贝数nui（i = 1，...，n）的n个成像光学元件。光学系统满足以下关系： $Σ我=1n>h我f。vi<=0.07，从入射处的光源的点到成像光学元件i的一束光线的直径。$

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