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1. 发明申请

US20050283091A1 Method and apparatus for determining conditions of a biological tissue 有权
标题翻译：用于确定生物组织条件的方法和装置
公开(公告)号：US20050283091A1
公开(公告)日：2005-12-22
申请号：US11156757
申请日：2005-06-20
申请人： Andres Kink , Mart Min , Toomas Parve , Indrek Ratsep
发明人： Andres Kink , Mart Min , Toomas Parve , Indrek Ratsep
IPC分类号： A61B5/05 , A61B5/053
CPC分类号： A61B5/0537 , A61B5/413
摘要： In one method, one or more excitation signals with the same or different frequencies are applied to a biological object such as a tissue, simultaneously or consequently. Response signals are then cross-correlated with delayed excitation signals. Cross-correlation products are then auto-correlated. Cross-correlation products correspond to conditions of the tissue and auto-correlation product corresponds to changes in the conditions. Measuring electrical characteristics at low, intermediate and high frequency is also disclosed. At low frequency, the current flows mostly through the extracellular liquid of tissue. At high frequency, the current passes through the cell membranes freely enough to dominate the overall impedance. At both frequencies, the delay is less than 1/30 of the period of the respective signal. The intermediate frequency between the low frequency and the high frequency carries information about quick changes in the condition of the tissue. The delay in one example is from about 1/30 to ¼ of the period of the intermediate signal.
摘要翻译：在一种方法中，具有相同或不同频率的一个或多个激发信号同时或因此被施加到诸如组织的生物物体上。然后响应信号与延迟的激励信号互相关。互相关产品则自动相关。互相关产品对应于组织的条件和自相关产品对应于条件的变化。还公开了测量低，中，高频的电特性。在低频下，电流主要通过组织的细胞外液体。在高频下，电流自由流过细胞膜，以支配整体阻抗。在两个频率下，延迟小于相应信号周期的1/30。低频和高频之间的中频携带关于组织状况的快速变化的信息。一个示例中的延迟是中间信号的周期的大约1/30到1/4。

2. 发明授权

US07970461B2 Method and apparatus for determining conditions of a biological tissue 有权
标题翻译：用于确定生物组织条件的方法和装置
公开(公告)号：US07970461B2
公开(公告)日：2011-06-28
申请号：US11156757
申请日：2005-06-20
申请人： Andres Kink , Mart Min , Toomas Parve , Indrek Ratsep
发明人： Andres Kink , Mart Min , Toomas Parve , Indrek Ratsep
IPC分类号： A61B5/05
CPC分类号： A61B5/0537 , A61B5/413
摘要： In one method, one or more excitation signals with the same or different frequencies are applied to a biological object such as a tissue, simultaneously or consequently. Response signals are then cross-correlated with delayed excitation signals. Cross-correlation products are then auto-correlated. Cross-correlation products correspond to conditions of the tissue and auto-correlation product corresponds to changes in the conditions. Measuring electrical characteristics at low, intermediate and high frequency is also disclosed. At low frequency, the current flows mostly through the extracellular liquid of tissue. At high frequency, the current passes through the cell membranes freely enough to dominate the overall impedance. At both frequencies, the delay is less than 1/30 of the period of the respective signal. The intermediate frequency between the low frequency and the high frequency carries information about quick changes in the condition of the tissue. The delay in one example is from about 1/30 to ¼ of the period of the intermediate signal.
摘要翻译：在一种方法中，具有相同或不同频率的一个或多个激发信号同时或因此被施加到诸如组织的生物物体上。然后响应信号与延迟的激励信号互相关。互相关产品则自动相关。互相关产品对应于组织的条件和自相关产品对应于条件的变化。还公开了测量低，中，高频的电特性。在低频下，电流主要通过组织的细胞外液体。在高频下，电流自由流过细胞膜，以支配整体阻抗。在两个频率下，延迟小于相应信号周期的1/30。低频和高频之间的中频携带关于组织状况的快速变化的信息。一个示例中的延迟是中间信号的周期的大约1/30到1/4。

3. 发明申请

US20080058882A1 Device and Method for Monitoring Cardiac Pacing Rate 有权
标题翻译：监测心脏起搏率的装置及方法
公开(公告)号：US20080058882A1
公开(公告)日：2008-03-06
申请号：US11847430
申请日：2007-08-30
申请人： Andres Kink , Mart Min , Toomas Parve , Indrek Ratsep
发明人： Andres Kink , Mart Min , Toomas Parve , Indrek Ratsep
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61B5/029 , A61B5/0295 , A61B5/053 , A61N1/36521 , A61N1/36585
摘要： A device for monitoring cardiac pacing rate having a measuring unit for receiving an electrical signal representing the patient's cardiac demand, and a computing unit for determining the myocardial energy balance by calculating energy consumed by the myocardium for both an external dynamic work for pumping blood into a vascular system, and an internal static work of the myocardium. Volume and time based measurements are used, and in one embodiment, volumes are estimated and volume ratios are calculated from volume estimates. In another embodiment, volumes are estimated from bioimpedance measurements. A further aspect is a rate adaptive pacemaker, wherein the maximum pacing rate is determined from the myocardial energy balance such that the energy supplied to the myocardium approximately equals the energy consumed by the myocardium for both an external dynamic work for pumping blood into a vascular system and an internal static work of the myocardium.
摘要翻译：一种用于监测心脏起搏速率的装置，具有用于接收代表患者心脏需求的电信号的测量单元，以及计算单元，用于通过计算用于将血液抽入血液的外部动力学工作来计算心肌消耗的能量来确定心肌能量平衡血管系统和心肌的内部静态工作。使用基于体积和时间的测量，并且在一个实施例中，估计体积，并且根据体积估计计算体积比。在另一个实施例中，通过生物阻抗测量估计体积。另一方面是速率自适应起搏器，其中最大起搏速率是根据心肌能量平衡来确定的，使得提供给心肌的能量大致等于心肌消耗的能量，用于将血液泵入血管系统的外部动力学工作和心肌的内部静电作业。

4. 发明授权

US07706872B2 Method and device for measurement of electrical bioimpedance 失效
标题翻译：用于测量电生物阻抗的方法和装置
公开(公告)号：US07706872B2
公开(公告)日：2010-04-27
申请号：US10537643
申请日：2003-11-28
申请人： Mart Min , Andres Kink , Raul Land , Toomas Parve
发明人： Mart Min , Andres Kink , Raul Land , Toomas Parve
IPC分类号： A61B5/05
CPC分类号： A61B5/053
摘要： A method of measuring of an electrical bio-impedance, the method being characterized in that a symmetrical bipolar pulse-form periodical excitation signal (electrical current or voltage) is applied to the input (11) of the bio-object (1), a corresponding reaction of the bio-object to the mentioned excitation signal is measured from the output (12), which is connected to the input (201) of the synchronous detector (200). A symmetrical bipolar pulse-form periodical signal is also applied to the reference input (202) of the synchronous detector (200), whereby both pulse-form signals are shortened by the predetermined time interval in each half period of the signal, said time intervals being different for the excitation and reference signals. The proposed method ensures an increased accuracy of the impedance analysis by decreasing the influence of the higher harmonics in the spectra of the excitation and reference signals of the synchronous detectors to the measurement result. The use of the rectangular signals ensures that the device for implementing of the proposed method has a simple design and low power consumption.
摘要翻译：一种测量电生物阻抗的方法，所述方法的特征在于对称的双极脉冲周期激励信号（电流或电压）被施加到生物物体（1）的输入端（11），a 从连接到同步检测器（200）的输入（201）的输出（12）测量生物物体对所述激发信号的相应反应。对称双极脉冲周期信号也被施加到同步检测器（200）的参考输入（202），由此两个脉冲形式信号在信号的每个半周期中被缩短了预定的时间间隔，所述时间间隔对于激励和参考信号是不同的。所提出的方法通过减少同步检测器的激励和参考信号的频谱中的高次谐波对测量结果的影响来确保阻抗分析的精度提高。使用矩形信号确保用于实现所提出的方法的设备具有简单的设计和低功耗。

5. 发明申请

US20060100539A1 Method and device for measurement of electrical bioimpedance 失效
标题翻译：用于测量电生物阻抗的方法和装置
公开(公告)号：US20060100539A1
公开(公告)日：2006-05-11
申请号：US10537643
申请日：2003-11-28
申请人： Mart Min , Andres Kink , Raul Land , Toomas Parve
发明人： Mart Min , Andres Kink , Raul Land , Toomas Parve
IPC分类号： A61B5/05
CPC分类号： A61B5/053
摘要： A method of measuring of an electrical bio-impedance, the method being characterized in that a symmetrical bipolar pulse-form periodical excitation signal (electrical current or voltage) is applied to the input (11) of the bio-object (1), a corresponding reaction of the bio-object to the mentioned excitation signal is measured from the output (12), which is connected to the input (201) of the synchronous detector (200). A symmetrical bipolar pulse-form periodical signal is also applied to the reference input (202) of the synchronous detector (200), whereby both pulse-form signals are shortened by the predetermined time interval in each half period of the signal, said time intervals being different for the excitation and reference signals. The proposed method ensures an increased accuracy of the impedance analysis by decreasing the influence of the higher harmonics in the spectra of the excitation and reference signals of the synchronous detectors to the measurement result. The use of the rectangular signals ensures that the device for implementing of the proposed method has a simple design and low power consumption.
摘要翻译：一种测量电生物阻抗的方法，所述方法的特征在于对称的双极脉冲周期激励信号（电流或电压）被施加到生物物体（1）的输入端（11），a 从连接到同步检测器（200）的输入（201）的输出（12）测量生物物体对所述激发信号的相应反应。对称双极脉冲周期信号也被施加到同步检测器（200）的参考输入（202），由此两个脉冲形式信号在信号的每个半周期中被缩短了预定的时间间隔，所述时间间隔对于激励和参考信号是不同的。所提出的方法通过减少同步检测器的激励和参考信号的频谱中的高次谐波对测量结果的影响来确保阻抗分析的精度提高。使用矩形信号确保用于实现所提出的方法的设备具有简单的设计和低功耗。

6. 发明授权

US06975903B1 Rate adaptive pacemaker using impedance measurements and stroke volume calculations 失效
标题翻译：使用阻抗测量和笔画体积计算率自动起搏器
公开(公告)号：US06975903B1
公开(公告)日：2005-12-13
申请号：US09937875
申请日：2000-03-23
申请人： Mart Min , Andres Kink , Toomas Parve
发明人： Mart Min , Andres Kink , Toomas Parve
IPC分类号： A61N1/365
CPC分类号： A61N1/36585
摘要： A rate adaptive pacemaker comprises a means (2) for determining the demand of the patient's organism, a pacing rate controlling means (16) for controlling the pacing rate in response to the patient's demand, and a pacing rate limiting means (20) for preventing the pacing rate from becoming too low. The pacing rate limiting means is adapted to limit the pacing rate downwards such that a first predetermined relation is satisfied between actual cardiac output (CO) and cardiac output (COrest) for the patient in rest conditions and a second predetermined relation is satisfied between actual stroke volume (SV) and rest stroke volume (SVrest).
摘要翻译：速率自适应起搏器包括用于确定患者生物体的需求的装置（2），用于响应于患者需求来控制起搏速率的起搏速率控制装置（16），以及用于预防的起搏速率限制装置（20）起搏速度变得太低。起搏速率限制装置适于将起搏速率向下限制，使得在休息条件下患者的实际心输出量（CO）和心输出量（CO _{rest ）之间满足第一预定关系，并且在实际行程量（SV）和静止行程量（SV休息）之间满足第二预定关系。}

7. 发明授权

US06885892B1 Rate adaptive pacemaker 失效
标题翻译：评价自适应起搏器
公开(公告)号：US06885892B1
公开(公告)日：2005-04-26
申请号：US09937971
申请日：2000-03-23
申请人： Mart Min , Andres Kink , Toomas Parve
发明人： Mart Min , Andres Kink , Toomas Parve
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61N1/36564 , A61N1/36585
摘要： A rate adaptive pacemaker has a measuring unit which interacts with a patient to determine a demand, a pacing rate controller connected to the measuring unit for controlling the pacing rate in response to the demand, and a pacing rate limiter connected to the pacing rate controller which upwardly limits the pacing rate so as to always maintain the energy supplied to the myocardium at a level which exceeds the energy consumed by the myocardium.
摘要翻译：速率自适应起搏器具有与患者相互作用以确定需求的测量单元，连接到测量单元的起搏速率控制器，用于响应于需求控制起搏速率;以及起搏速率限制器，其与起搏速率控制器相连，向上限制起搏速率，以便始终将提供给心肌的能量保持在超过心肌消耗的能量的水平。

8. 发明授权

US08773151B2 Method and device for multichannel multifrequency analysis of an object 失效
标题翻译：对象多通道多频分析的方法和装置
公开(公告)号：US08773151B2
公开(公告)日：2014-07-08
申请号：US12298389
申请日：2007-04-24
申请人： Mart Min , Paul Annus , Alar Kuusik , Raul Land , Toomas Parve , Ants Ronk , Antti Haapalainen
发明人： Mart Min , Paul Annus , Alar Kuusik , Raul Land , Toomas Parve , Ants Ronk , Antti Haapalainen
IPC分类号： G01R27/08
CPC分类号： A61B5/053 , A61B5/7257 , G01R23/00
摘要： A method for multichannel multifrequency analysis of an object, applying a set of excitation signals to the object and sampling the response signal from the object, using uniform and non-uniform undersampling. Non-uniform sampling of the response signal is performed, i.e., the sampling is performed for two or more different frequencies in one observation time slot. Also, uniform sampling of the response signal is performed, i.e., the sampling of a signal, corresponding to one frequency, is performed for two or more channels within one observation time slot and then sampling the same signal for another frequency for two or more channels within the next observation time slot.
摘要翻译：一种用于对象的多通道多频分析的方法，将一组激励信号应用于对象，并使用均匀和不均匀的欠采样对来自对象的响应信号进行采样。执行响应信号的非均匀采样，即在一个观察时隙中针对两个或更多个不同的频率执行采样。此外，执行响应信号的均匀采样，即，在一个观察时隙内针对两个或更多个信道执行对应于一个频率的信号的采样，然后针对两个或更多个信道对另一个频率采样相同的信号在下一个观察时段内。

9. 发明申请

US20110095747A1 METHOD AND DEVICE FOR FAST MEASUREMENT OF FREQUENCY RESPONSE WITH SCALABLE SHORT CHIRP SIGNALS 有权
标题翻译：频率响应快速测量的方法和设备与可伸缩的短信号
公开(公告)号：US20110095747A1
公开(公告)日：2011-04-28
申请号：US12911432
申请日：2010-10-25
申请人： Mart Min , Toivo Paavle , Raul Land , Paul Annus , Toomas Parve
发明人： Mart Min , Toivo Paavle , Raul Land , Paul Annus , Toomas Parve
IPC分类号： G01R23/02
CPC分类号： G01N27/026 , B01L2300/0627 , G01N33/48735
摘要： A method and device are provided for fast impedance measurement of a biological object having dynamically varying in time parameters, wherein a titlet shaped pulse is introduced into the object and a voltage response signal is measured and analyzed by a processing unit for estimating the impedance of the object. The titlet pulse has a start frequency substantially in one end of the frequency range of interest and a stop frequency substantially in the other end of the frequency range of interest and a duration of the titlet pulse is one cycle or less.
摘要翻译：提供了一种方法和装置，用于对具有动态变化的时间参数的生物体进行快速阻抗测量，其中将tit形脉冲引入到物体中，并通过处理单元测量和分析电压响应信号，以估计目的。该小费脉冲具有基本上在感兴趣的频率范围的一端的起始频率和基本上在感兴趣的频率范围的另一端的停止频率，并且该小时脉冲的持续时间是一个周期以内。

10. 发明申请

US20100225303A1 METHOD AND DEVICE FOR MULTICHANNEL MULTIFREQUENCY ANALYSIS OF AN OBJECT 失效
标题翻译：用于多目标多目标分析的方法和装置
公开(公告)号：US20100225303A1
公开(公告)日：2010-09-09
申请号：US12298389
申请日：2007-04-24
申请人： Mart Min , Paul Annus , Alar Kuusik , Raul Land , Toomas Parve , Ants Ronk , Antti Haapalainen
发明人： Mart Min , Paul Annus , Alar Kuusik , Raul Land , Toomas Parve , Ants Ronk , Antti Haapalainen
IPC分类号： G01R23/00 , H03M1/00
CPC分类号： A61B5/053 , A61B5/7257 , G01R23/00
摘要： A method for multichannel multifrequency analysis of an object, applying a set of excitation signals to the object and sampling the response signal from the object, using uniform and non-uniform undersampling. Non-uniform sampling of the response signal is performed, i.e., the sampling is performed for two or more different frequencies in one observation time slot. Also, uniform sampling of the response signal is performed, i.e., the sampling of a signal, corresponding to one frequency, is performed for two or more channels within one observation time slot and then sampling the same signal for another frequency for two or more channels within the next observation time slot.
摘要翻译：一种用于对象的多通道多频分析的方法，将一组激励信号应用于对象，并使用均匀和不均匀的欠采样对来自对象的响应信号进行采样。执行响应信号的非均匀采样，即在一个观察时隙中针对两个或更多个不同的频率执行采样。此外，执行响应信号的均匀采样，即，在一个观察时隙内针对两个或更多个信道执行对应于一个频率的信号的采样，然后针对两个或更多个信道对另一个频率采样相同的信号在下一个观察时段内。

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