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1. 发明申请

US20120190685A1 NOVEL PHENYLIMIDAZOLE DERIVATIVE AS PDE10A ENZYME INHIBITOR 有权
标题翻译：新型苯乙烯胺衍生物作为PDE10A酶抑制剂
公开(公告)号：US20120190685A1
公开(公告)日：2012-07-26
申请号：US13378405
申请日：2010-06-17
申请人： Andreas Ritzén , Jan Kehler , Morten Langgård , Jacob Nielsen , John Paul Kilburn , Mohammed M. Farah
发明人： Andreas Ritzén , Jan Kehler , Morten Langgård , Jacob Nielsen , John Paul Kilburn , Mohammed M. Farah
IPC分类号： A61K31/4985 , A61P25/18 , A61P25/28
CPC分类号： C07D487/04 , C07D403/12 , C07D471/04
摘要： This invention provides the compound 5,8-Dimethyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]thazolo[1,5-a]pyrazine and pharmaceutically acceptable acid addition salts thereof.
摘要翻译：本发明提供化合物5,8-二甲基-2- [2-（1-甲基-4-苯基-1H-咪唑-2-基） - 乙基] - [1,2,4]噻唑并[1,5- a]吡嗪及其药学上可接受的酸加成盐。

2. 发明授权

US08841297B2 Phenylimidazole derivative as PDE10A enzyme inhibitor 有权
标题翻译：苯基咪唑衍生物作为PDE10A酶抑制剂
公开(公告)号：US08841297B2
公开(公告)日：2014-09-23
申请号：US13378405
申请日：2010-06-17
申请人： Andreas Ritzén , Jan Kehler , Morten Langgård , Jacob Nielsen , John Paul Kilburn , Mohammed M. Farah
发明人： Andreas Ritzén , Jan Kehler , Morten Langgård , Jacob Nielsen , John Paul Kilburn , Mohammed M. Farah
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495
CPC分类号： C07D487/04 , C07D403/12 , C07D471/04
摘要： This invention provides the compound 5,8-Dimethyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]thazolo[1,5-a]pyrazine and pharmaceutically acceptable acid addition salts thereof.
摘要翻译：本发明提供化合物5,8-二甲基-2- [2-（1-甲基-4-苯基-1H-咪唑-2-基） - 乙基] - [1,2,4]噻唑并[1,5- a]吡嗪及其药学上可接受的酸加成盐。

3. 发明申请

US20120135987A1 NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS 有权
标题翻译：新型苯并咪唑衍生物作为PDE10A酶抑制剂
公开(公告)号：US20120135987A1
公开(公告)日：2012-05-31
申请号：US13365504
申请日：2012-02-03
申请人： Andreas Ritzén , Jan Kehler , Morten Langgård , Jacob Nielsen , John Paul Kilburn , Mohamed M. Farah
发明人： Andreas Ritzén , Jan Kehler , Morten Langgård , Jacob Nielsen , John Paul Kilburn , Mohamed M. Farah
IPC分类号： A61K31/5377 , A61K31/4985 , C07D471/04 , A61K31/437 , A61K31/519 , A61P25/30 , A61K31/4184 , A61P25/28 , A61P25/18 , A61P25/16 , A61P25/00 , C07D487/04 , C07D403/12
CPC分类号： A61K31/4985 , A61K31/437 , A61K45/06 , C07D403/12 , C07D471/04 , C07D487/04
摘要： This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
摘要翻译：本发明涉及PDE10A酶抑制剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了制备式I化合物的方法。本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明本发明还提供了治疗患有药物成瘾症的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明还提供了治疗患有精神病障碍患者的方法，包括给予治疗有效量的式I化合物。

4. 发明申请

US20100016303A1 NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS 有权
标题翻译：新型苯并咪唑衍生物作为PDE10A酶抑制剂
公开(公告)号：US20100016303A1
公开(公告)日：2010-01-21
申请号：US12487694
申请日：2009-06-19
申请人： Andreas Ritzén , Jan Kehler , Morten Langgård , Jacob Nielsen , John Paul Kilburn , Mohamed M. Farah
发明人： Andreas Ritzén , Jan Kehler , Morten Langgård , Jacob Nielsen , John Paul Kilburn , Mohamed M. Farah
IPC分类号： A61K31/437 , C07D471/04 , C07D487/04 , C07D413/14 , A61K31/519 , A61K31/5377 , A61P25/30
CPC分类号： A61K31/4985 , A61K31/437 , A61K45/06 , C07D403/12 , C07D471/04 , C07D487/04
摘要： This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
摘要翻译：本发明涉及PDE10A酶抑制剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了制备式I化合物的方法。本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明本发明还提供了治疗患有药物成瘾症的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明还提供了治疗患有精神障碍的受试者的方法，其包括向治疗有效量的式I化合物。

5. 发明授权

US08865711B2 Phenylimidazole derivatives as PDE10A enzyme inhibitors 有权
标题翻译：苯基咪唑衍生物作为PDE10A酶抑制剂
公开(公告)号：US08865711B2
公开(公告)日：2014-10-21
申请号：US13365504
申请日：2012-02-03
申请人： Andreas Ritzén , Jan Kehler , Morten Langgård , Jacob Nielsen , John Paul Kilburn , Mohamed M. Farah
发明人： Andreas Ritzén , Jan Kehler , Morten Langgård , Jacob Nielsen , John Paul Kilburn , Mohamed M. Farah
IPC分类号： C07D487/04 , C07D471/04 , C07D403/12
CPC分类号： A61K31/4985 , A61K31/437 , A61K45/06 , C07D403/12 , C07D471/04 , C07D487/04
摘要： This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
摘要翻译：本发明涉及PDE10A酶抑制剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了制备式I化合物的方法。本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明本发明还提供了治疗患有药物成瘾症的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明还提供了治疗患有精神病障碍患者的方法，包括给予治疗有效量的式I化合物。

6. 发明授权

US08133897B2 Phenylimidazole derivatives as PDE10A enzyme inhibitors 有权
标题翻译：苯基咪唑衍生物作为PDE10A酶抑制剂
公开(公告)号：US08133897B2
公开(公告)日：2012-03-13
申请号：US12487694
申请日：2009-06-19
申请人： Andreas Ritzén , Jan Kehler , Morten Langgård , Jacob Nielsen , John Paul Kilburn
发明人： Andreas Ritzén , Jan Kehler , Morten Langgård , Jacob Nielsen , John Paul Kilburn
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： A61K31/4985 , A61K31/437 , A61K45/06 , C07D403/12 , C07D471/04 , C07D487/04
摘要： This invention is directed to phenylimidazole compounds, which are PDE10A enzyme inhibitors useful for the treatment of neurological and psychiatric disorders.
摘要翻译：本发明涉及苯基咪唑化合物，它们是可用于治疗神经和精神疾病的PDE10A酶抑制剂。

7. 发明申请

US20120302548A1 2-ARYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS 有权
标题翻译： 2-ARYLIMIDAZOLE DERIVATIVES PDE10A ENZYME INHIBITORS
公开(公告)号：US20120302548A1
公开(公告)日：2012-11-29
申请号：US13515325
申请日：2010-12-15
申请人： Ask Püschl , Jacob Nielsen , Jan Kehler , John Paul Kilburn , Mauro Marigo , Morten Langgård
发明人： Ask Püschl , Jacob Nielsen , Jan Kehler , John Paul Kilburn , Mauro Marigo , Morten Langgård
IPC分类号： A61K31/4985 , C07D471/04 , A61K31/437 , A61K31/551 , A61P25/30 , A61P25/28 , A61P25/18 , A61P25/32 , A61P25/36 , C07D487/04 , A61K31/554
CPC分类号： C07D487/04 , C07D471/04
摘要： This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
摘要翻译：本发明涉及PDE10A酶抑制剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了制备式I化合物的方法。本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明本发明还提供了治疗患有药物成瘾症的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明还提供了治疗患有精神病障碍患者的方法，包括给予治疗有效量的式I化合物。

8. 发明授权

US09096589B2 Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors 有权
标题翻译：杂芳基苯基咪唑衍生物作为PDE10A酶抑制剂
公开(公告)号：US09096589B2
公开(公告)日：2015-08-04
申请号：US13513867
申请日：2010-12-15
申请人： Ask Püschl , Jacob Nielsen , Jan Kehler , John Paul Kilburn , Mauro Marigo , Morten Langgård
发明人： Ask Püschl , Jacob Nielsen , Jan Kehler , John Paul Kilburn , Mauro Marigo , Morten Langgård
IPC分类号： C07D487/04 , C07D471/04 , A61P25/28 , A61P25/16 , A61P25/18 , A61P25/36 , A61P25/32 , A61P25/22 , A61P25/30 , A61P25/00
CPC分类号： A61K31/4985 , A61K45/06 , C07D471/04 , C07D487/04
摘要： This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
摘要翻译：本发明涉及PDE10A酶抑制剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了制备式I化合物的方法。本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明本发明还提供了治疗患有药物成瘾症的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明还提供了治疗患有精神病障碍患者的方法，包括给予治疗有效量的式I化合物。

9. 发明申请

US20120309764A1 Heteroaromatic aryl triazole derivatives as PDE10A enzyme inhibitors 有权
标题翻译：杂芳基三唑衍生物作为PDE10A酶抑制剂
公开(公告)号：US20120309764A1
公开(公告)日：2012-12-06
申请号：US13515351
申请日：2010-12-15
申请人： Ask Püschl , Jacob Nielsen , Jan Kehler , John Paul Kilburn , Mauro Marigo , Morten Langgård
发明人： Ask Püschl , Jacob Nielsen , Jan Kehler , John Paul Kilburn , Mauro Marigo , Morten Langgård
IPC分类号： A61K31/4985 , C07D487/04 , C07D471/04 , A61P25/16 , A61P25/18 , A61P25/28 , A61P25/32 , A61P25/30 , A61K31/437 , A61P25/00
CPC分类号： C07D487/04 , C07D471/04
摘要： This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
摘要翻译：本发明涉及PDE10A酶抑制剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了制备式I化合物的方法。本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明本发明还提供了治疗患有药物成瘾症的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明还提供了治疗患有精神病障碍患者的方法，包括给予治疗有效量的式I化合物。

10. 发明授权

US08552045B2 Tricyclic imidazole compounds as PDE10 inhibitors 有权
标题翻译：三环咪唑化合物作为PDE10抑制剂
公开(公告)号：US08552045B2
公开(公告)日：2013-10-08
申请号：US13299368
申请日：2011-11-18
申请人： Jan Kehler , Jacob Nielsen , Mauro Marigo , John Paul Kilburn , Morten Langgård
发明人： Jan Kehler , Jacob Nielsen , Mauro Marigo , John Paul Kilburn , Morten Langgård
IPC分类号： A61K31/415
CPC分类号： C07D487/04 , A61K31/437 , A61K31/4985 , A61K45/06 , C07D471/04 , C07D519/00
摘要： This invention is directed to compounds with the structure which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula 1. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula 1. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula 1. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula 1.
摘要翻译：本发明涉及具有PDE10A酶抑制剂结构的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了制备式1化合物的方法。本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括向受试者施用治疗有效量的式1的化合物。本发明本发明还提供了治疗患有药物成瘾的受试者的方法，包括向受试者施用治疗有效量的式1化合物。本发明还提供了治疗患有精神障碍的受试者的方法，包括给予服用治疗有效量的式1化合物。

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