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1. 发明授权

US07700833B2 Process for the production of unsaturated fatty acids 失效
标题翻译：生产不饱和脂肪酸的方法
公开(公告)号：US07700833B2
公开(公告)日：2010-04-20
申请号：US10505590
申请日：2003-02-27
申请人： Andreas Renz , Martijn Gipmans , Ivo Feussner , Claire-Lise Rosenfield , Douglas C. Knipple
发明人： Andreas Renz , Martijn Gipmans , Ivo Feussner , Claire-Lise Rosenfield , Douglas C. Knipple
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12P7/6472 , C12N9/0083 , C12N15/8247
摘要： The invention relates to processes for the production of unsaturated fatty acids, preferably of conjugated polyunsaturated fatty acids such as conjugated linoleic acid (CLA), by the recombinant expression of desaturases from insects of the order Lepidoptera. Expression preferably takes place in an organism selected from the group of the plant organisms, yeasts, fungi and algae. Also, according to the invention are recombinant expression cassettes for the recombinant expression of desaturases from insects of the order Lepidoptera, and the transgenic organisms transformed with these.
摘要翻译：本发明涉及生产不饱和脂肪酸，优选共轭多不饱和脂肪酸如共轭亚油酸（CLA）的方法，重组表达来自鳞翅目鳞翅目昆虫的去饱和酶。表达优选在选自植物生物，酵母，真菌和藻类的生物体中进行。此外，根据本发明，用于从鳞翅目鳞翅目昆虫中重组表达去饱和酶的重组表达盒，以及用它们转化的转基因生物体。

2. 发明授权

US5876994A Pheromone desaturases 失效
标题翻译：信息素去饱和酶
公开(公告)号：US5876994A
公开(公告)日：1999-03-02
申请号：US558823
申请日：1995-11-16
申请人： Douglas C. Knipple , Wendell L. Roelofs , Stuart J. Miller
发明人： Douglas C. Knipple , Wendell L. Roelofs , Stuart J. Miller
IPC分类号： C12N9/02
CPC分类号： C12N9/0083
摘要： The present invention is directed to isolated membrane-associated acyl-CoA desaturases expressed in the pheromone gland of an insect and, in particular, the .DELTA.11 desaturase of Trichoplusia ni. The present invention further relates to an isolated DNA molecule encoding the T. ni .DELTA.11 desaturase, expression vectors comprising the DNA molecule, and host cells comprising the expression vectors. Methods for isolating DNA sequences of homologous acyl-CoA desaturases expressed in the pheromone glands of insects are provided. The use of these acyl-CoA desaturases, DNA molecules, expression vectors, and host cells to produce an unsaturated fatty acyl-CoA product from a saturated or unsaturated fatty acyl-CoA reactant is also disclosed. The unsaturated fatty acyl-CoA products are useful as pheromones or as pheromone precursors as well as in the preparation of organic molecules, such as drugs.
摘要翻译：本发明涉及在昆虫的信息素腺中表达的分离的膜相关酰基-CoA去饱和酶，特别是粉纹夜蛾的DELTA 11去饱和酶。本发明进一步涉及编码T.NITA DELTA 11去饱和酶的分离的DNA分子，包含DNA分子的表达载体和包含表达载体的宿主细胞。提供了在昆虫的信息素腺中表达的同源酰基-CoA去饱和酶的DNA序列的分离方法。还公开了使用这些酰基辅酶A去饱和酶，DNA分子，表达载体和宿主细胞从饱和或不饱和脂肪酰基-CoA反应物产生不饱和脂肪酰基辅酶A产物。不饱和脂肪酰辅酶A产物可用作信息素或信息素前体以及有机分子如药物的制备。

3. 发明授权

US6022705A Insect sodium channels gene from insecticide-susceptible and insecticide-resistant house flies 失效
标题翻译：昆虫钠通道基因从杀虫剂敏感和杀虫剂的房子苍蝇
公开(公告)号：US6022705A
公开(公告)日：2000-02-08
申请号：US772512
申请日：1996-12-24
申请人： David M. Soderlund , Douglas C. Knipple , Patricia J. Ingles
发明人： David M. Soderlund , Douglas C. Knipple , Patricia J. Ingles
IPC分类号： C07K14/435 , C07K14/705 , C12N15/12 , C07H21/04 , C12N15/85 , C12N15/86
CPC分类号： C07K14/43577 , C07K14/705
摘要： The present invention is directed to isolated nucleic acid molecules encoding a voltage-sensitive sodium channel (VSSC) of Musca domestica, the VSSC being capable of conferring insecticide susceptibility or insecticide resistance to Musca domestica, as well as to the isolated voltage-sensitive sodium channels of Musca domestica encoded thereby. Nucleic acid molecules encoding insecticide susceptible VSSCs and nucleic acid molecules encoding insecticide resistant VSSCs are provided. Methods for increasing or decreasing the expression of functional voltage-sensitive sodium channels in host cells are also provided, as well as methods using the sodium channels. Also provided is a method for isolating other voltage-sensitive sodium channels.
摘要翻译：本发明涉及编码家蝇的电压敏感钠通道（VSSC）的分离的核酸分子，VSSC能够赋予家蝇对杀虫剂敏感性或杀虫剂抗性以及分离的电压敏感性钠通道的家蝇由其编码。提供编码杀虫剂敏感VSSC的核酸分子和编码杀虫剂抗性VSSC的核酸分子。还提供了增加或降低宿主细胞中功能性电压敏感性钠通道表达的方法，以及使用钠通道的方法。还提供了隔离其它电压敏感钠通道的方法。

4. 发明授权

US06800435B2 Insect sodium channels from insecticide-susceptible and insecticide-resistant house flies 失效
标题翻译：昆虫钠通道从杀虫剂敏感和杀虫剂的房子苍蝇
公开(公告)号：US06800435B2
公开(公告)日：2004-10-05
申请号：US09428371
申请日：1999-10-28
申请人： David M. Soderlund , Douglas C. Knipple , Patricia J. Ingles
发明人： David M. Soderlund , Douglas C. Knipple , Patricia J. Ingles
IPC分类号： C12Q168
CPC分类号： C07K14/43577 , C07K14/705
摘要： The present invention is directed to isolated nucleic acid molecules encoding a voltage-sensitive sodium channel (VSSC) of Musca domestica, the VSSC being capable of conferring insecticide susceptibility or insecticide resistance to Musca domestica, as well as to the isolated voltage-sensitive sodium channels of Musca domestica encoded thereby. Nucleic acid molecules encoding insecticide susceptible VSSCs and nucleic acid molecules encoding insecticide resistant VSSCs are provided. Methods for increasing or decreasing the expression of functional voltage-sensitive sodium channels in host cells are also provided, as well as methods using the sodium channels. Also provided is a method for isolating other voltage-sensitive sodium channels.
摘要翻译：本发明涉及编码家蝇的电压敏感钠通道（VSSC）的分离的核酸分子，VSSC能够赋予家蝇对杀虫剂敏感性或杀虫剂抗性以及分离的电压敏感性钠通道的家蝇由其编码。提供编码杀虫剂敏感VSSC的核酸分子和编码杀虫剂抗性VSSC的核酸分子。还提供了增加或降低宿主细胞中功能性电压敏感性钠通道表达的方法，以及使用钠通道的方法。还提供了隔离其它电压敏感钠通道的方法。

5. 发明授权

US5487976A DNA encoding an insect gamma-aminobutyric acid (GABA) receptor subunit cells expressing it, and pesticide screening methods using such cells 失效
标题翻译：编码表达它的昆虫γ-氨基丁酸（GABA）受体亚基细胞的DNA和使用这种细胞的农药筛选方法
公开(公告)号：US5487976A
公开(公告)日：1996-01-30
申请号：US137614
申请日：1993-10-15
申请人： David M. Soderlund , Douglas C. Knipple , Joseph E. Henderson
发明人： David M. Soderlund , Douglas C. Knipple , Joseph E. Henderson
IPC分类号： C07K14/435 , C12N15/12 , G01N33/50 , G01N33/94 , C12N1/11 , C12N5/00 , G01N33/68
CPC分类号： G01N33/5014 , C07K14/435 , G01N33/9426 , G01N2430/10
摘要： The present invention provides for the isolation of genomic DNA fragments from Drosophila melanogaster encoding conserved amino acid sequence elements unique to the ligand-gated chloride channel gene family. A polymerase chain reaction (PCR)-based homology probing strategy was utilized to isolate the genomic DNA fragments. Using the PCR strategy, three discrete amplified sequence elements designated LCCH1, LCCH2 and LCCH3, were isolated, LCCH2 and LCCH3 being novel. In another aspect of the present invention, there is provided the cloning and characterization of a cDNA encoding a novel member of the ligand-gated chloride channel gene family of insects isolated from Drosophila melanogaster. The cDNA corresponds to the LCCH3 genomic sequence of the invention.
摘要翻译：本发明提供了从配体门控氯化物通道基因家族特有的编码保守氨基酸序列元件的黑腹果蝇分离基因组DNA片段。使用基于聚合酶链反应（PCR）的同源性探测策略来分离基因组DNA片段。使用PCR策略，分离出三个独立的扩增序列元件LCCH1，LCCH2和LCCH3，LCCH2和LCCH3是新的。在本发明的另一方面，提供了编码从果蝇分离的昆虫的配体门控氯化物通道基因家族的新成员的cDNA的克隆和表征。 cDNA对应于本发明的LCCH3基因组序列。

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