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1. 发明授权

US09217026B2 Method of inactivating a glucocorticoid receptor gene in an isolated cell 有权
标题翻译：在分离的细胞中灭活糖皮质激素受体基因的方法
公开(公告)号：US09217026B2
公开(公告)日：2015-12-22
申请号：US11983888
申请日：2007-11-13
申请人： Andreas Reik , Michael Jensen , Michael C. Holmes , Philip D. Gregory , Dale Ando
发明人： Andreas Reik , Michael Jensen , Michael C. Holmes , Philip D. Gregory , Dale Ando
IPC分类号： C07K14/72 , C12N15/62
CPC分类号： C12N15/86 , C07K14/721 , C12N9/22 , C12N15/62 , C12N2710/10043 , C12N2740/15043 , G01N33/743 , G01N2333/723
摘要： Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.
摘要翻译：本文公开了通过靶向切割编码GR的基因组DNA来灭活人类糖皮质激素受体（GR）基因的方法和组合物。这些方法和组合物可用于例如在糖皮质激素治疗期间需要保留免疫功能的治疗应用中。

2. 发明申请

US20080188000A1 Methods and compositions for modification of the human glucocorticoid receptor locus 有权
标题翻译：用于修饰人类糖皮质激素受体位点的方法和组合物
公开(公告)号：US20080188000A1
公开(公告)日：2008-08-07
申请号：US11983888
申请日：2007-11-13
申请人： Andreas Reik , Michael Jensen , Michael C. Holmes , Philip D. Gregory , Dale Ando
发明人： Andreas Reik , Michael Jensen , Michael C. Holmes , Philip D. Gregory , Dale Ando
IPC分类号： C12N15/87 , C07K16/00 , C07H21/04
CPC分类号： C12N15/86 , C07K14/721 , C12N9/22 , C12N15/62 , C12N2710/10043 , C12N2740/15043 , G01N33/743 , G01N2333/723
摘要： Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.
摘要翻译：本文公开了通过靶向切割编码GR的基因组DNA来灭活人类糖皮质激素受体（GR）基因的方法和组合物。这些方法和组合物可用于例如在糖皮质激素治疗期间需要保留免疫功能的治疗应用中。

3. 发明授权

US09127507B2 Rotatable wireline tool of enhanced hydraulic drive consistency 有权
标题翻译：可旋转电缆工具，增强液压驱动一致性
公开(公告)号：US09127507B2
公开(公告)日：2015-09-08
申请号：US13316239
申请日：2011-12-09
申请人： Michael Jensen , Ruben Martinez
发明人： Michael Jensen , Ruben Martinez
IPC分类号： E21B4/02 , E21B4/00 , E21B4/18 , E21B23/14 , E21B29/00
CPC分类号： E21B4/02 , E21B3/00 , E21B4/00 , E21B4/006 , E21B4/18 , E21B23/14 , E21B29/00 , E21B29/002
摘要： A rotatable downhole cutting tool configured for enhanced drive consistency in low power circumstances. The tool is equipped with a hydraulic axial drive actuator suitable for use in wireline deployment. The actuator itself includes a reciprocating piston with a ball screw that threadably interfaces a ball nut for dampening the axial drive imparted by the piston. As such, even though hydraulically driven at generally well under about 10 horsepower, bounce in the axial drive is substantially eliminated.
摘要翻译：一种可旋转的井下切割工具，其配置为在低功率环境下提高驱动一致性。该工具配备有适用于有线部署的液压轴向驱动执行器。致动器本身包括具有滚珠丝杠的往复式活塞，该滚珠丝杠与滚珠螺母螺纹接合，以阻尼由活塞施加的轴向驱动。因此，即使液压驱动通常在大约10马力以下，基本上消除了轴向驱动中的反弹。

4. 发明申请

US20120210914A1 KEYBOARD AND MOUSE SUPPORT 有权
标题翻译：键盘和鼠标支持
公开(公告)号：US20120210914A1
公开(公告)日：2012-08-23
申请号：US13029727
申请日：2011-02-17
申请人： Larry HAMILTON , Taiwon Choi , Michael Jensen , ChunSheng Li , Douglas Carpiaux , Adam Shileny , Heidi Anna Dondlinger , Martin Behling, II
发明人： Larry HAMILTON , Taiwon Choi , Michael Jensen , ChunSheng Li , Douglas Carpiaux , Adam Shileny , Heidi Anna Dondlinger , Martin Behling, II
IPC分类号： A47B37/00 , A47B96/07
CPC分类号： A47B21/0314 , A47B2200/0085
摘要： A support device including a keyboard platform and a bracket for mounting the keyboard platform a work surface to elevate the keyboard platform above the work surface. The keyboard platform is mounted on the bracket for sliding movement relative to an edge of the work surface along a horizontal fore-aft axis. The keyboard platform is mounted on the bracket for tilting movement about a tilting axis perpendicular to the fore-aft axis. The support device includes a lock movable between a locked position wherein sliding/tilting movement of the keyboard platform is prevented and an unlocked position wherein sliding/tilting movement of the keyboard platform is permitted. One aspect includes a clamp provided on the bracket and engageable with the work surface to elevate the keyboard platform above the work surface. One aspect provides a mouse platform pivotally attached to the keyboard platform and configured to support the mouse at a tilted position.
摘要翻译：包括键盘平台和支架的支撑装置，用于将键盘平台安装在工作表面上，以将键盘平台提升到工作表面上方。键盘平台安装在支架上，用于沿着水平的前后轴线相对于工作表面的边缘滑动运动。键盘平台安装在支架上，用于围绕垂直于前后轴线的倾斜轴线倾斜运动。支撑装置包括可在锁定位置之间移动的锁，其中防止键盘平台的滑动/倾斜运动和允许键盘平台的滑动/倾斜运动的解锁位置。一个方面包括设置在支架上并可与工作表面接合以提升键盘平台在工作表面上方的夹具。一个方面提供了一种可枢转地附接到键盘平台并被配置为在倾斜位置支撑鼠标的鼠标平台。

5. 发明申请

US20120061082A1 SEALING OF THIEF ZONES 有权
标题翻译：密封区域
公开(公告)号：US20120061082A1
公开(公告)日：2012-03-15
申请号：US13129950
申请日：2009-11-18
申请人： Michael Jensen
发明人： Michael Jensen
IPC分类号： E21B43/16 , C09K8/58
CPC分类号： C04B28/14 , C04B28/16 , C09K8/46 , C09K8/5045
摘要： The present invention provides a method for selectively sealing a thief zone in a hydrocarbon reservoir located in a calcium-rich formation and penetrated by a borehole comprising injecting into the thief zone a sealing fluid comprising a mixture of and hydronium ions (H+) and a source of sulfate ions (SO42−) which mixture can provide precipitation of a designated calcium sulfate compound.
摘要翻译：本发明提供了一种用于选择性地密封位于富钙地层中并被钻孔穿透的烃储层中的小偷区的方法，包括将包含水合氢离子（H +）和源的混合物的密封流体的硫酸根离子（SO42-），该混合物可以提供指定的硫酸钙化合物的沉淀。

6. 发明申请

US20110097449A1 SEASONING AND METHOD FOR SEASONING A FOOD PRODUCT WHILE REDUCING DIETARY SODIUM INTAKE 审中-公开
标题翻译：在减少食物摄入钠时食用食物的季节和方法
公开(公告)号：US20110097449A1
公开(公告)日：2011-04-28
申请号：US12909586
申请日：2010-10-21
申请人： Michael Jensen , Gordon Smith , Shawn Fear , Lance Schilmoeller , Clint Johnson
发明人： Michael Jensen , Gordon Smith , Shawn Fear , Lance Schilmoeller , Clint Johnson
IPC分类号： A23L1/237 , A23L1/18
CPC分类号： A23L7/191 , A23L13/428 , A23L19/03 , A23L27/40 , A23L27/86 , A23V2002/00 , A23V2200/254 , A23V2250/1614
摘要： A seasoning for food that provides taste enhancement and flavor potentiation is disclosed. The seasoning can be used for reducing dietary sodium intake. The portion of seasoning has a mean particle size of less than or equal to 20 microns. In one embodiment, the invention is a seasoning comprising a first seasoning component including a salt and a second seasoning component selected for at least one of complementing and reducing the amount of the first seasoning component required for flavoring a food product.
摘要翻译：公开了提供味道增强和风味增强的食物调味料。调味料可用于减少膳食钠摄入。调料的部分平均粒度小于或等于20微米。在一个实施方案中，本发明是一种调味料，其包括第一调味成分，其包含盐和第二调味成分，所述第二调味成分选自补充和减少调味食品所需的第一调味成分的量中的至少一种。

7. 发明授权

US07446191B2 DNA construct encoding CE7-specific chimeric T cell receptor 有权
标题翻译：编码CE7特异性嵌合T细胞受体的DNA构建体
公开(公告)号：US07446191B2
公开(公告)日：2008-11-04
申请号：US12028442
申请日：2008-02-08
申请人： Michael Jensen
发明人： Michael Jensen
IPC分类号： C07H21/04 , C12N15/09 , A61K39/395 , C12P21/04 , C12P21/08 , C12N7/00 , C12N5/06 , C12N5/08
CPC分类号： C07K14/7051 , A61K48/00 , C07H21/04 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/30
摘要： Genetically engineered, CE7-specific redirected immune cells expressing a cell surface protein having an extracellular domain comprising a receptor which is specific for CE7, an intracellular signaling domain, and a transmembrane domain, and methods of use for such cells for cellular immunotherapy of CE7+ neuroblastoma are disclosed. In one embodiment, the immune cell is a T cell and the cell surface protein is a single chain FvFc: receptor where Fv designates the VH and VL chains of a single chain monoclonal antibody to CE7 linked by peptide, Fc represents a hinge-CH2-CH3 region of a human IgG1, and represents the intracellular signaling domain of the zeta chain of human CD3. DNA constructs encoding a chimeric T-cell receptor and a method of making a redirected T cell expressing a chimeric T cell receptor by electroporation using naked DNA encoding the receptor are also disclosed.
摘要翻译：基因工程化的CE7特异性重定向免疫细胞，其表达具有细胞外结构域的细胞表面蛋白，所述胞外结构域包含对CE7特异性的受体，细胞内信号转导结构域和跨膜结构域，以及用于这些细胞用于CE7细胞免疫治疗的方法，公开了SUP + +神经母细胞瘤。在一个实施方案中，免疫细胞是T细胞，细胞表面蛋白是单链FvFc： receptor，其中Fv表示V H H和V L，通过肽连接的对CE7的单链单克隆抗体的“SUB”链，Fc表示人IgG1的铰链C 2 H 2 -C 3 H 3区和表示人CD3的zeta链的细胞内信号结构域。还公开了编码嵌合T细胞受体的DNA构建体和通过使用编码受体的裸DNA通过电穿孔制备表达嵌合T细胞受体的重定向T细胞的方法。

8. 发明申请

US20080003339A1 Seasoning and method for seasoning a food product utilizing small particle sea salt 审中-公开
标题翻译：调味和利用小颗粒海盐调味食品的方法
公开(公告)号：US20080003339A1
公开(公告)日：2008-01-03
申请号：US11820530
申请日：2007-06-20
申请人： Clinton Johnson , Michael Jensen , Lance Schilmoeller , Gordon Smith
发明人： Clinton Johnson , Michael Jensen , Lance Schilmoeller , Gordon Smith
IPC分类号： A23L1/22
CPC分类号： A23L33/16 , A23L7/191 , A23L27/40 , A23L27/72 , A23L27/86 , A23P10/35
摘要： A method and seasoning including sea salt for flavoring food is disclosed. The sea salt has a mean particle size less than about 20 microns. In another embodiment, the present invention is directed to a seasoning comprising a first seasoning component, including a sea salt, and a second seasoning component selected for at least one of complementing the first seasoning component and reducing the amount of the first seasoning component required for flavoring a food product. The sea salt component has a mean particle size less than 20 microns.
摘要翻译：公开了一种包括海盐调味食品的方法和调味料。海盐的平均粒度小于约20微米。在另一个实施方案中，本发明涉及一种包含第一调味成分（包括海盐）和第二调味成分的调味料，所述第二调味成分选自补充第一调味成分和减少第一调味成分的量调味食品。海盐组分的平均粒度小于20微米。

9. 发明申请

US20070254073A1 Composition(s) for providing glaze on microwave popcorn, products, and methods 审中-公开
标题翻译：用于在微波爆米花，产品和方法上提供釉料的组合物
公开(公告)号：US20070254073A1
公开(公告)日：2007-11-01
申请号：US11788364
申请日：2007-04-19
申请人： Michael Jensen , Jody Shands , Jamie Halgerson
发明人： Michael Jensen , Jody Shands , Jamie Halgerson
IPC分类号： B65D81/34
CPC分类号： B65D81/3469 , A23L7/183 , A23L7/191 , A23P20/00 , B65D81/3453 , B65D2581/3421 , B65D2581/3494
摘要： Techniques for preparation of a glazed microwave popcorn product are disclosed. In one embodiment, a glazed microwave popcorn product includes a first package comprising unpopped popcorn for popping in a microwave oven, an oil/fat-based slurry, and a second addition package comprising a glazing blend for adding to the popcorn after popping are described. In another embodiment, a one-step process comprises a charge of microwavable popcorn with a particulate glazing blend included with a charge of unpopped popcorn and a charge of oil/fat-based slurry.
摘要翻译：公开了用于制备玻璃微波爆米花产品的技术。在一个实施例中，玻璃微波爆米花产品包括第一包装，其包含用于在微波炉中爆炸的未受欢迎的爆米花，基于油脂的浆料，以及包含用于在爆裂之后添加到爆米花的玻璃混合物的第二加料包装。在另一个实施方案中，一步法包括具有微粒玻璃混合物的微波加工炸药的装料，所述混合物包含未受挤的爆米花和电荷的基于油/脂肪的浆料。

10. 发明申请

US20070232483A1 Polymerization catalysts for producing polymers with low levels of long chain branching 有权
标题翻译：用于生产低水平长链支化聚合物的聚合催化剂
公开(公告)号：US20070232483A1
公开(公告)日：2007-10-04
申请号：US11395961
申请日：2006-03-31
申请人： Qing Yang , Max McDaniel , Michael Jensen , Matthew Thorn , Joel Martin , Youlu Yu , David Rohlfing
发明人： Qing Yang , Max McDaniel , Michael Jensen , Matthew Thorn , Joel Martin , Youlu Yu , David Rohlfing
IPC分类号： C08F4/44
CPC分类号： C08F10/00 , C08F4/65912 , C08F4/65916 , C08F210/16 , Y10S526/943 , C08F4/65927 , C08F210/14
摘要： This invention relates to catalyst compositions, methods, and polymers encompassing at least one Group 4 metallocene compound comprising bridging η5-cyclopentadienyl-type ligands, typically in combination with at least one cocatalyst, and at least one activator. The compositions and methods disclosed herein provide ethylene polymers with low levels of long chain branching.
摘要翻译：本发明涉及催化剂组合物，方法和聚合物，其包括至少一种包含桥连五元环戊二烯基型配体的至少一种第四族金属茂化合物，通常与至少一种助催化剂组合，以及至少一种活化剂。本文公开的组合物和方法提供具有低水平的长链支化的乙烯聚合物。

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