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1. 发明授权

US08232061B2 Method and device for examining the attachment or detachment of living or dead cells or cell-like particles or other surface accumulations on surfaces by means of plasmon resonance and use of said method and said device 失效
标题翻译：用于通过等离子体共振和使用所述方法和所述装置检查生物或死细胞或细胞样颗粒或表面上的其它表面积聚物附着或分离的方法和装置
公开(公告)号：US08232061B2
公开(公告)日：2012-07-31
申请号：US12525418
申请日：2008-02-01
申请人： Andreas Hofmann , Norbert Danz , Silke Hofmann , Michael Keusgen , Ulla Magdolen
发明人： Andreas Hofmann , Norbert Danz , Silke Hofmann , Michael Keusgen , Ulla Magdolen
IPC分类号： G01N33/53
CPC分类号： G01N21/553
摘要： A method for examining an attachment or detachment of living cells, dead cells or cell-like particles on a surface using plasmon resonance includes irradiating a measurement region with beams over the entire angle of incidence spectrum and capturing, combining and evaluating beams with identical angles of incidence reflected from different points of the measurement region with a determination of the angle of light incidence with a lowest reflected light intensity and measuring an angle of incidence shift of an intensity minimum that occurs. The evaluating includes registering different angles of incidence of two or more intensity minima occurring simultaneously to reflect a respective level of the surface accumulations.
摘要翻译：使用等离子体共振检查表面上的活细胞，死细胞或细胞样颗粒的附着或分离的方法包括：在整个入射光谱上照射具有光束的测量区域，并且捕获，组合和评估具有相同角度通过确定具有最低反射光强度的光入射角度并测量出现的强度最小值的入射偏移角，测量区域的不同点反射的入射。评估包括记录同时发生的两个或更多个强度最小值的不同入射角，以反映表面积累的相应水平。

2. 发明申请

US20100028903A1 METHOD AND DEVICE FOR EXAMINING THE ATTACHMENT OR DETACHMENT OF LIVING OR DEAD CELLS OR CELL-LIKE PARTICLES OR OTHER SURFACE ACCUMULATIONS ON SURFACES BY MEANS OF PLASMON RESONANCE AND USE OF SAID METHOD AND SAID DEVICE 失效
标题翻译：方法和装置，用于通过平均共振方法检测生活或死亡细胞或细胞样颗粒或其他表面积累表面积的附着或分离，以及使用方法和设备的使用
公开(公告)号：US20100028903A1
公开(公告)日：2010-02-04
申请号：US12525418
申请日：2008-02-01
申请人： Silke Hofmann , Andreas Hofmann , Norbert Danz , Michael Keusgen , Ulla Magdolen
发明人： Silke Hofmann , Andreas Hofmann , Norbert Danz , Michael Keusgen , Ulla Magdolen
IPC分类号： G01N33/53 , G01N21/55 , C12Q1/02
CPC分类号： G01N21/553
摘要： The invention relates to the examination of the attachment or detachment of living or dead cells, or cell-like particles, or other surface accumulations on surfaces, by means of plasmon resonance. The reflected light is evaluated such that two or more intensity minima of the reflected light occurring within a time frame are registered in a time dependant manner for different incident angles. The registered measurement signals reflect the respective amount of the surface accumulation. In case two intensity minima have occurred at the same time, valuable information about particular processes regarding the surface accumulation, for example regarding the adhesion of cells, can be obtained. Said information is of particular importance in the field of medicine/biology.
摘要翻译：本发明涉及通过等离子共振来检查活体或死细胞，细胞样颗粒或表面上的其它表面积聚物的附着或分离。评估反射光，使得在时间范围内发生的反射光的两个或更多个强度最小值以时间依赖的方式登记到不同的入射角。注册的测量信号反映表面积累的相应量。在同时发生两个强度最小值的情况下，可以获得关于表面积累的具体过程的有价值的信息，例如关于细胞的粘附。所述信息在医学/生物学领域尤其重要。

3. 发明授权

US07973934B2 Plasmon resonance sensor 有权
标题翻译：等离子体共振传感器
公开(公告)号：US07973934B2
公开(公告)日：2011-07-05
申请号：US12438911
申请日：2007-08-24
申请人： Andreas Hofmann , Norbert Danz
发明人： Andreas Hofmann , Norbert Danz
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N33/54373 , G01N2021/0321
摘要： The plasmon resonance sensor (1) comprises a chip (2) of transparent plastic with a gold layer (3) made up of narrow part surfaces (4), arranged in a row, on the inner side of which light from a planar light source (12) is convergently guided. A Fourier lens (24) integrated in the chip (2) forms the reflected angular spectrum on the detector (23), arranged at a focal separation (F) from the integrated Fourier lens (24) for temporal determination of the incident angle with a resonant intensity minimum of reflected light. An incident lens (13) brings about imaging of the planar light source (12) in the form of lines of light on the part surfaces (4), which are further imaged in the form of lines of light on the detector (23).
摘要翻译：所述等离子体共振传感器（1）包括透明塑料芯片（2），所述芯片（2）具有由窄层部分表面（4）构成的金层（3），所述金属层（3）在其内侧排列成平行的光源（12）被收敛地引导。集成在芯片（2）中的傅里叶透镜（24）在检测器（23）上形成反射角谱，其布置在与积分付里叶透镜（24）的聚焦分离（F）处，用于时间确定与共振强度最小的反射光。入射透镜（13）以部分表面（4）上的光线形式引起平面光源（12）的成像，其进一步以检测器（23）上的光线形式成像。

4. 发明授权

US07919673B2 Transgenic pig with altered incretin function 有权
标题翻译：转基因猪具有改变的肠降血糖素功能
公开(公告)号：US07919673B2
公开(公告)日：2011-04-05
申请号：US12348294
申请日：2009-01-04
申请人： Eckhard Wolf , Simone Renner , Barbara Kessler , Rüdiger Wanke , Nadja Herbach , Alexander Pfeifer , Andreas Hofmann
发明人： Eckhard Wolf , Simone Renner , Barbara Kessler , Rüdiger Wanke , Nadja Herbach , Alexander Pfeifer , Andreas Hofmann
IPC分类号： A01K67/027 , A01K67/00 , A01K67/033
CPC分类号： C07K14/723 , A01K67/0276 , A01K2217/056 , A01K2227/108 , A01K2267/0362 , C12N2799/027 , G01N33/507 , G01N2500/10 , G01N2800/042
摘要： The present invention relates to transgenic pigs containing a dominant-negative incretin hormone receptor, namely the dominant-negative human glucose-dependent insulinotropic polypeptide receptor. The present invention furthermore relates to uses of these transgenic pigs as clinically relevant animal model systems for studying the pathogenesis and novel therapies for diabetes mellitus type 2, particularly for the maintenance and expansion of pancreatic β-cell mass.
摘要翻译：本发明涉及含有显性阴性的肠降血糖素激素受体的转基因猪，即显性阴性人葡萄糖依赖性促胰岛素多肽受体。本发明还涉及这些转基因猪作为临床相关动物模型系统的用途，用于研究2型糖尿病的发病机理和新疗法，特别是用于胰腺和细胞质量的维持和扩增。

5. 发明授权

US06384789B2 Apparatus for testing mobile telephones 有权
标题翻译：移动电话测试装置
公开(公告)号：US06384789B2
公开(公告)日：2002-05-07
申请号：US09843840
申请日：2001-04-30
申请人： Andreas Hofmann
发明人： Andreas Hofmann
IPC分类号： H01Q124
CPC分类号： H04B1/3877 , H01Q1/242 , H01Q9/16 , H01Q13/08 , H01Q13/10 , H01Q21/30
摘要： A testing apparatus for testing mobile telephones includes an antenna coupler, a holder and a testing device. The antenna coupler includes a printed circuit board upon one side of which is formed a slot antenna operative in a first frequency range and a dipole antenna operative in a second frequency range. The holder secures a mobile telephone under test in proximity to the antenna coupler. A coupler formed on a second side of the printed circuit board selectively supplies signals received by one of the antenna elements to the testing device. The testing device measures transmission and reception characteristics of the mobile telephone under test, including transmission phase error, frequency error, power and spectrum, and bit error rate.
摘要翻译：用于测试移动电话的测试装置包括天线耦合器，保持器和测试装置。天线耦合器包括印刷电路板，其一侧形成有在第一频率范围内操作的缝隙天线和在第二频率范围内工作的偶极天线。支架将待测的移动电话固定在天线耦合器附近。形成在印刷电路板的第二侧上的耦合器选择性地将由天线元件之一接收的信号提供给测试装置。测试装置测量被测移动电话的传输和接收特性，包括传输相位误差，频率误差，功率和频谱以及误码率。

6. 外观设计

USD325854S Combined cake decorating nozzle and receptacle 失效
公开(公告)号：USD325854S
公开(公告)日：1992-05-05
申请号：US410791
申请日：1989-09-21
申请人： Andreas Hofmann
设计人： Andreas Hofmann

7. 发明申请

US20110208284A1 PROTECTIVE SLEEVE FOR A MEDICAL DEVICE, SYSTEM COMPRISING A PROTECTIVE SLEEVE AND A MEDICAL DEVICE, AND A METHOD FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：用于医疗装置的保护套管，包括保护套管和医疗装置的系统及其生产方法
公开(公告)号：US20110208284A1
公开(公告)日：2011-08-25
申请号：US13029461
申请日：2011-02-17
申请人： Andreas Hofmann , Michael Filippi , Raimund Moehl , Helen Strub
发明人： Andreas Hofmann , Michael Filippi , Raimund Moehl , Helen Strub
IPC分类号： A61M25/00 , A61F2/84 , A61M25/10 , B23P17/04 , B23P25/00
CPC分类号： A61M25/0111 , A61F2/0095 , A61F2/95 , A61M25/002 , A61M25/013 , A61M25/0668 , Y10T29/49826 , Y10T29/49885
摘要： A protective sleeve for a medical device including a main body which has a distal end and a proximal end and on the lateral surface of which at least one stop element is disposed, which during insertion of the protective sleeve into an introducer limits the insertion depth of the protective sleeve into the introducer and which preferably is disposed at the distal end of the main body.
摘要翻译：一种用于医疗装置的保护套管，其包括具有远端和近端的主体，并且在其侧表面上设置有至少一个止动元件，在将保护套插入导引器期间，该保护套管限制了插入深度保护套管插入导引器中，并且优选地设置在主体的远端。

8. 发明申请

US20110152766A1 IMPLANT WITH COATING 审中-公开
标题翻译：植入涂层
公开(公告)号：US20110152766A1
公开(公告)日：2011-06-23
申请号：US12961931
申请日：2010-12-07
申请人： Andreas Hofmann , Alexander Borck , Michael Tittelbach
发明人： Andreas Hofmann , Alexander Borck , Michael Tittelbach
IPC分类号： A61K31/337 , A61F2/00 , A61P29/00 , A61P35/00 , A61P21/02 , A61M25/10 , B05D3/10
CPC分类号： A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606
摘要： One embodiment of the invention relates to an implant with a coating containing at least one active pharmaceutical substance. The inventive implant is characterized in that the coating is covered by a protective layer comprising or containing one or more materials from the group including shellac, vinylpyrrolidone-vinyl acetate copolymer, vinyl acetate-crotonic acid copolymer, vinyl acetate-vinyl propionate-crotonic acid terpolymer, methylvinyl ether-maleic anhydride copolymer, vinylpyrrolidone-dimethylaminoethyl acrylate copolymer, polyvinylpyrrolidone, polyvinyl acetate, polycrotonic acid, polyvinyl propionate, polymethylvinyl ether, polymaleic anhydride and polydimethylaminoethyl acrylate.
摘要翻译：本发明的一个实施方案涉及具有包含至少一种活性药物物质的涂层的植入物。本发明的植入物的特征在于，涂层被包含或含有一种或多种包括虫胶，乙烯基吡咯烷酮 - 乙酸乙烯酯共聚物，乙酸乙烯酯 - 巴豆酸共聚物，乙酸乙烯酯 - 丙酸乙烯酯 - 巴豆酸三元共聚物甲基乙烯基醚 - 马来酸酐共聚物，乙烯基吡咯烷酮 - 二甲基氨基乙基丙烯酸酯共聚物，聚乙烯吡咯烷酮，聚乙酸乙烯酯，聚巴豆酸，聚乙酸丙烯酯，聚甲基乙烯基醚，聚马来酸酐和聚二甲基氨基乙基丙烯酸酯。

9. 发明申请

US20100286992A1 Integration of Third-Party Business Applications with Hosted Multi-Tenant Business Software System 审中-公开
标题翻译：将第三方业务应用与托管多租户业务软件系统集成
公开(公告)号：US20100286992A1
公开(公告)日：2010-11-11
申请号：US12463269
申请日：2009-05-08
申请人： Alexander Tkatch , Amit Kumar , Manisha Powar , Preethi Ramarathinam , Andreas Hofmann
发明人： Alexander Tkatch , Amit Kumar , Manisha Powar , Preethi Ramarathinam , Andreas Hofmann
IPC分类号： G06Q99/00 , G06F15/16 , G06F7/04 , G06Q30/00
CPC分类号： G06Q30/00
摘要： A computing device includes a processing unit and a memory with instructions that, when executed by the processing unit, cause the processing unit to create: a business software processing module that manages business application software for a plurality of businesses. The business processing software module comprises a customization module, a registration module and an activation module. The customization module stores and processes definitions for business solutions that permit a business application external to the computing device to be integrated with business application software included on the computing device. The registration module makes the business solutions available to users of the computing device. The activation module generates an activation token and a web page for each request to activate a business solution. For each activation request, the activation module redirects the web page to a URL specified in the business solution definition corresponding to the activation request.
摘要翻译：计算设备包括处理单元和具有指令的存储器，所述指令在由所述处理单元执行时使得所述处理单元创建：管理多个业务的业务应用软件的商业软件处理模块。业务处理软件模块包括定制模块，注册模块和激活模块。定制模块存储和处理允许计算设备外部的业务应用程序与计算设备上包括的业务应用软件集成的业务解决方案的定义。注册模块使业务解决方案可用于计算设备的用户。激活模块为激活业务解决方案的每个请求生成激活令牌和网页。对于每个激活请求，激活模块将网页重定向到与激活请求对应的业务解决方案定义中指定的URL。

10. 发明授权

US09422947B1 High efficiency actuator method, system and apparatus 有权
公开(公告)号：US09422947B1
公开(公告)日：2016-08-23
申请号：US14036075
申请日：2013-09-25
申请人： Daniel Theobald , Andreas Hofmann
发明人： Daniel Theobald , Andreas Hofmann
IPC分类号： F15B11/16 , F15B13/04
CPC分类号： F15B11/162 , B25J9/144 , F15B13/0417 , F15B15/202 , F15B15/204 , F15B2201/21 , F15B2211/20515 , F15B2211/20538 , F15B2211/212 , F15B2211/25 , F15B2211/30575 , F15B2211/625 , F15B2211/6313 , F15B2211/6651 , F15B2211/6653 , F15B2211/7053 , F15B2211/761 , F15B2211/88 , Y02P80/13
摘要： A method, system and apparatus including a mechanism capable of performing a variety of operations, each operation having a respective power requirement and a power source capable of providing power to the mechanism at a variety of different levels corresponding to the operations being undertaken by the mechanism where the power source is regulated to at least provide a first lower power level sufficient for one or more operations requiring a lower power level and is increased to provide a higher power level as needed for one or more alternative operations requiring a higher power level.

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