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1. 发明申请

US20070014730A1 Compositions containing magnetic iron oxide particles, and use of said compositions in imaging methods 审中-公开
标题翻译：含有磁性氧化铁颗粒的组合物，以及所述组合物在成像方法中的用途
公开(公告)号：US20070014730A1
公开(公告)日：2007-01-18
申请号：US11476913
申请日：2006-06-29
申请人： Andreas Briel , Bernhard Gleich , Juergen Weizenecker , Martin Rohrer , Hanns- Weinmann , Hubertus Pietsch , Rudiger Lawaczeck , Matthias Rothe , Jens Thomsen
发明人： Andreas Briel , Bernhard Gleich , Juergen Weizenecker , Martin Rohrer , Hanns- Weinmann , Hubertus Pietsch , Rudiger Lawaczeck , Matthias Rothe , Jens Thomsen
IPC分类号： A61K49/10
CPC分类号： A61B5/418 , A61B5/0515 , A61B5/411 , A61B5/415 , A61B5/416 , A61K49/1836 , A61K49/1863 , A61K49/1866 , A61K49/1875 , B82Y5/00
摘要： The present invention relates to complexes which contain polycrystalline magnetic iron oxide particles in a pharmaceutically acceptable shell, and to the use of these compositions in magnetic particle imaging (MPI). Particular preference is given to the use of these compositions in examining the gastrointestinal tract, the vascular system of the heart and cranial components, in the diagnosis of arteriosclerosis, infarctions, and tumors and metastases, for example of the lymphatic system.
摘要翻译：本发明涉及在药学上可接受的壳中含有多晶磁性氧化铁颗粒的复合物，以及这些组合物在磁性颗粒成像（MPI）中的用途。特别优选使用这些组合物来检查胃肠道，心脏和颅脑部分的血管系统，诊断动脉硬化，梗死以及肿瘤和转移灶，例如淋巴系统。

2. 发明申请

US20070036729A1 Compositions containing magnetic iron oxide particles, and use of said compositions in imaging methods 审中-公开
标题翻译：含有磁性氧化铁颗粒的组合物，以及所述组合物在成像方法中的用途
公开(公告)号：US20070036729A1
公开(公告)日：2007-02-15
申请号：US11476934
申请日：2006-06-29
申请人： Andreas Briel , Bernhard Gleich , Juergen Weizenecker , Martin Rohrer , Hanns-Joachim Weinmann , Hubertus Pietsch , Rudiger LaWaczeck , Matthias Rothe , Jens Thomsen
发明人： Andreas Briel , Bernhard Gleich , Juergen Weizenecker , Martin Rohrer , Hanns-Joachim Weinmann , Hubertus Pietsch , Rudiger LaWaczeck , Matthias Rothe , Jens Thomsen
IPC分类号： A61K49/10
CPC分类号： A61B5/418 , A61B5/0515 , A61B5/411 , A61B5/415 , A61B5/416 , A61K49/1836 , A61K49/1863 , A61K49/1866 , A61K49/1875 , B82Y5/00
摘要： The present invention relates to complexes which contain magnetic iron oxide particles in a pharmaceutically acceptable shell, said particles having a diameter of 20 nm to 1 μm with an overall particle diameter/core diameter ratio of less than 6, and to the use of these complexes in magnetic particle imaging (MPI). Particular preference is given to the use of these compositions in examining the gastrointestinal tract, the vascular system of the heart and cranial components, in the diagnosis of arteriosclerosis, infarctions, and tumors and metastases, for example of the lymphatic system.
摘要翻译：本发明涉及在药学上可接受的壳中含有磁性氧化铁颗粒的复合物，所述颗粒的直径为20nm至1μm，总体颗粒直径/芯直径比小于6，并且使用这些配合物在磁粉成像（MPI）中。特别优选使用这些组合物来检查胃肠道，心脏和颅脑部分的血管系统，诊断动脉硬化，梗死以及肿瘤和转移灶，例如淋巴系统。

3. 发明授权

US06652782B1 Multi-stage method for producing gas-filled microcapsules 失效
标题翻译：用于生产充气微胶囊的多阶段方法
公开(公告)号：US06652782B1
公开(公告)日：2003-11-25
申请号：US09979554
申请日：2002-03-27
申请人： Uwe Budde , Andreas Briel , Georg Rossling , Kai Lovis , Wolfgang Schmidt , Hans-Ulrich Moritz , Michael Gottfried , Jan-Peter Ingwersen
发明人： Uwe Budde , Andreas Briel , Georg Rossling , Kai Lovis , Wolfgang Schmidt , Hans-Ulrich Moritz , Michael Gottfried , Jan-Peter Ingwersen
IPC分类号： B01J1302
CPC分类号： B01J13/02 , A61K49/223 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987
摘要： The invention relates to a multi-stage method for producing gas-filled microcapsules. In one stage of the method, the substance that forms the coat is polymerized. The microcapsules are formed in a physically and/or temporally separate stage, by means of a structuring process. The polymerization is carried out with moderate stirring, while the microcapsules are structured in dispersing conditions.
摘要翻译：本发明涉及一种用于生产充气微胶囊的多级方法。在该方法的一个阶段中，形成涂层的物质被聚合。通过结构化方法在物理和/或时间上分离的阶段形成微胶囊。在适度搅拌下进行聚合，而微胶囊在分散条件下进行结构化。

4. 发明授权

US06872180B2 Device and process for quantifying bodies by means of ultrasound 失效
标题翻译：通过超声波量化体的装置和过程
公开(公告)号：US06872180B2
公开(公告)日：2005-03-29
申请号：US10400928
申请日：2003-03-28
申请人： Michael Reinhardt , Peter Hauff , Andreas Briel
发明人： Michael Reinhardt , Peter Hauff , Andreas Briel
IPC分类号： A61B8/00 , A61K47/48 , A61K49/22 , A61B8/14
CPC分类号： B82Y5/00 , A61B8/481 , A61K47/6898 , A61K49/223 , G01S7/52041
摘要： In the quantification of bodies, especially bubbles, in ultrasonic diagnosis, the problem exists that the concentration of bodies, especially bubbles, is often so high that the image data that is obtained relative to the visualization becomes saturated, such that a quantification is impossible. To solve this problem, it is proposed that the bodies that are contained in the sectional layers of an object under examination first be excited by means of ultrasound to produce characteristic signals and to pick up these signals, to form data sets from the signals, to convert the data sets into an image of the body arrangement in the object under examination and to determine the number of bodies therefrom, whereby at least two ultrasonic signal sets from overlapping sectional layers in the object under examination are picked up.
摘要翻译：在超声波诊断中的体内，特别是气泡的量化中，存在物体的浓度，特别是气泡的浓度常常高到使得相对于可视化获得的图像数据变得饱和的问题，使得不可能进行定量。为了解决这个问题，提出了包含在被检查物体的截面层中的物体首先通过超声波来激发以产生特征信号并拾取这些信号，从信号形成数据集，将数据集转换为被检查物体中的身体排列的图像，并确定其身体的数量，由此拾取来自检查对象中的重叠部分层的至少两个超声波信号组。

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