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1. 发明授权

US09738863B2 Bioreactor including a rocking device 有权
公开(公告)号：US09738863B2
公开(公告)日：2017-08-22
申请号：US13984887
申请日：2012-02-21
申请人： Andreas Andersson , Johan L. Carlsson , Christian Elnegard , Henrik K. Eriksson , Thomas Falkman , Patric Fricking , Linnea Pauler , Claes Petterson
发明人： Andreas Andersson , Johan L. Carlsson , Christian Elnegard , Henrik K. Eriksson , Thomas Falkman , Patric Fricking , Linnea Pauler , Claes Petterson
IPC分类号： C12M3/06 , C12M1/00 , B01F15/00 , B01F11/00
CPC分类号： C12M27/16 , B01F11/0017 , B01F15/0085 , C12M23/14 , C12M23/50
摘要： The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray (4) for holding said at least one bag, a rocking device for limited rocking motions of the tray (4) around a rocking axis (2). According to the invention the bioreactor comprises a device (6,7,8,9) for enabling swinging of the tray (4) around a second axis (7) parallel to and distanced from the rocking axis (2).

2. 发明申请

US20130316446A1 BIOREACTOR INCLUDING A ROCKING DEVICE 有权
标题翻译：包括摇摆装置的生物反应器
公开(公告)号：US20130316446A1
公开(公告)日：2013-11-28
申请号：US13984887
申请日：2012-02-21
申请人： Andreas Andersson , Johan L. Carlsson , Christian Elnegard , Henrik K. Eriksson , Thomas Falkman , Patric Fricking , Linnea Pauler , Claes Petterson
发明人： Andreas Andersson , Johan L. Carlsson , Christian Elnegard , Henrik K. Eriksson , Thomas Falkman , Patric Fricking , Linnea Pauler , Claes Petterson
IPC分类号： C12M3/06
CPC分类号： C12M27/16 , B01F11/0017 , B01F15/0085 , C12M23/14 , C12M23/50
摘要： The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray (4) for holding said at least one bag, a rocking device for limited rocking motions of the tray (4) around a rocking axis (2). According to the invention the bioreactor comprises a device (6,7,8,9) for enabling swinging of the tray (4) around a second axis (7) parallel to and distanced from the rocking axis (2).
摘要翻译：本发明涉及一种生物反应器，其包括至少一个塑料袋形式的反应器容器，用于保持所述至少一个袋子的托盘（4），用于托盘（4）围绕摇摆轴线的有限摇摆运动的摆动装置（2）。根据本发明，生物反应器包括一个装置（6,7,8,9），用于使托盘绕着与摆动轴线（2）平行并远离的第二轴线（7）摆动。

3. 发明申请

US20140193883A1 GAS EXHAUST FILTER DEVICE FOR A BIOREACTOR 有权
标题翻译：用于生物反应器的气体排气过滤装置
公开(公告)号：US20140193883A1
公开(公告)日：2014-07-10
申请号：US14241550
申请日：2012-08-29
申请人： Henrik K. Eriksson , Patric Fricking , L. Johan Carlsson
发明人： Henrik K. Eriksson , Patric Fricking , L. Johan Carlsson
IPC分类号： B01D46/00 , C12M1/00
CPC分类号： B01D46/0039 , B01D46/521 , C12M29/04 , C12M37/02
摘要： A gas exhaust filter device for a bioreactor with reduced blockage by condensed liquid is disclosed, which comprises a housing with a filter medium, a gas inlet and a gas outlet and also further comprises a plurality of ribs extending from at least one inner wall of the housing in a region between the gas inlet and the filter medium.
摘要翻译：公开了一种用于通过冷凝液体阻塞减少的生物反应器的排气过滤器装置，其包括具有过滤介质的壳体，气体入口和气体出口，并且还包括从至少一个内壁延伸的多个肋容纳在气体入口和过滤介质之间的区域中。

4. 发明授权

US09795909B2 Gas exhaust filter device for a bioreactor 有权
公开(公告)号：US09795909B2
公开(公告)日：2017-10-24
申请号：US14241550
申请日：2012-08-29
申请人： Henrik K. Eriksson , Patric Fricking , L. Johan Carlsson
发明人： Henrik K. Eriksson , Patric Fricking , L. Johan Carlsson
IPC分类号： B01D46/00 , B01D46/52 , C12M1/12 , C12M1/00
CPC分类号： B01D46/0039 , B01D46/521 , C12M29/04 , C12M37/02
摘要： A gas exhaust filter device for a bioreactor with reduced blockage by condensed liquid is disclosed, which comprises a housing with a filter medium, a gas inlet and a gas outlet and also further comprises a plurality of ribs extending from at least one inner wall of the housing in a region between the gas inlet and the filter medium.

5. 发明申请

US20130316396A1 BIOREACTOR WITH FEED AND HARVEST FLOW THROUGH FILTER ASSEMBLY 有权
标题翻译：通过过滤器装配的进料和收集流的生物反应器
公开(公告)号：US20130316396A1
公开(公告)日：2013-11-28
申请号：US13984937
申请日：2012-02-22
申请人： Patric Fricking
发明人： Patric Fricking
IPC分类号： C12M1/26
CPC分类号： C12M33/14 , C12M1/12 , C12M3/06 , C12M3/067 , C12M21/00 , C12M27/16 , C12M29/04 , C12M29/10
摘要： The present invention relates to a bioreactor and a method for operating a bioreactor which comprises a chamber (100) capable of receiving a liquid media, and a filter assembly (200) comprising a perfusion filter (210; 212; 214). The filter assembly (200) is disposed in the chamber (100) and the filter assembly (200) is free to move within the chamber (100). The filter assembly (200) comprises means for coupling a harvesting flow through said filter (210; 212; 214) and means for coupling a feed flow through said filter in an opposite direction compared to the harvesting flow. Through this arrangement, the clogging prevention of the perfusion filter can be improved.
摘要翻译：本发明涉及一种生物反应器和一种用于操作生物反应器的方法，该生物反应器包括能够接收液体介质的室（100）和包括灌注过滤器（210; 212; 214）的过滤器组件（200）。过滤器组件（200）设置在室（100）中，并且过滤器组件（200）在室（100）内自由移动。过滤器组件（200）包括用于将通过所述过滤器（210; 212; 214）的收集流耦合的装置和用于将进料流与收获流相反的方向与相反方向耦合通过所述过滤器的装置。通过这种布置，可以提高灌注过滤器的堵塞防止。

6. 发明授权

US10589239B2 Fluid mixing in a disposable fluid processing system 有权
公开(公告)号：US10589239B2
公开(公告)日：2020-03-17
申请号：US13808606
申请日：2011-06-27
申请人： Klaus Gebauer , Patric Fricking , Bjorn Jaderlund
发明人： Klaus Gebauer , Patric Fricking , Bjorn Jaderlund
IPC分类号： B01F15/02 , G05D11/13 , G01N30/34 , B01D15/16 , B01D15/12 , G01N30/86
摘要： High accuracy mixing of fluids in a disposable fluid processing system with at least two pumps is provided by a method where a calibration fluid volume is pumped through each pump via a flow meter at at least one calibration pump speed while registering the flow rate using data output from the flow meter, a pump calibration function is calculated from the calibration pump speed and flow rate data and two or more operation fluids are mixed to a predetermined mixture ratio and predetermined flow rate by controlling the pump speed of the respective pumps in accordance with the pump calibration functions.

7. 发明授权

US09428724B2 Bioreactor with feed and harvest flow through filter assembly 有权
标题翻译：具有进料和收获的生物反应器流过过滤器组件
公开(公告)号：US09428724B2
公开(公告)日：2016-08-30
申请号：US13984937
申请日：2012-02-22
申请人： Patric Fricking
发明人： Patric Fricking
IPC分类号： C12M1/12 , C12M1/00 , C12M3/06 , C12M1/26
CPC分类号： C12M33/14 , C12M1/12 , C12M3/06 , C12M3/067 , C12M21/00 , C12M27/16 , C12M29/04 , C12M29/10
摘要： The present invention relates to a bioreactor and a method for operating a bioreactor which comprises a chamber (100) capable of receiving a liquid media, and a filter assembly (200) comprising a perfusion filter (210; 212; 214). The filter assembly (200) is disposed in the chamber (100) and the filter assembly (200) is free to move within the chamber (100). The filter assembly (200) comprises means for coupling a harvesting flow through said filter (210; 212; 214) and means for coupling a feed flow through said filter in an opposite direction compared to the harvesting flow. Through this arrangement, the clogging prevention of the perfusion filter can be improved.
摘要翻译：本发明涉及一种生物反应器和一种用于操作生物反应器的方法，该生物反应器包括能够接收液体介质的室（100）和包括灌注过滤器（210; 212; 214）的过滤器组件（200）。过滤器组件（200）设置在室（100）中，并且过滤器组件（200）在室（100）内自由移动。过滤器组件（200）包括用于将通过所述过滤器（210; 212; 214）的收集流耦合的装置和用于将进料流与收获流相反的方向与相反方向耦合通过所述过滤器的装置。通过这种布置，可以提高灌注过滤器的堵塞防止。

8. 发明申请

US20120256641A1 CONDUCTIVITY SENSOR ASSEMBLY 有权
标题翻译：电导率传感器总成
公开(公告)号：US20120256641A1
公开(公告)日：2012-10-11
申请号：US13518501
申请日：2010-12-20
申请人： Lars Andersson , Stefan D'Argy , Patric Fricking , Joachim Tollstoy
发明人： Lars Andersson , Stefan D'Argy , Patric Fricking , Joachim Tollstoy
IPC分类号： G01R27/28
CPC分类号： G01R27/22 , G01N27/07 , G01N27/08 , G01N2030/645
摘要： A flow-through conductivity sensor assembly comprises a housing (4) having a flow passage with an inlet end and an outlet end. The cross section of at least a section of the flow passage extension between the inlet and outlet ends is divided into a conductivity measuring channel (2) and a parallel by-pass channel (3) of larger cross-sectional area than the measuring channel (2).
摘要翻译：流通电导率传感器组件包括具有入口端和出口端的流动通道的壳体（4）。入口端和出口端之间的流路延伸部分的至少一部分的横截面被分成比测量通道更大的横截面积的电导率测量通道（2）和平行旁通通道（3） 2）。

9. 发明授权

US09035661B2 Conductivity sensor assembly 有权
标题翻译：电导率传感器组件
公开(公告)号：US09035661B2
公开(公告)日：2015-05-19
申请号：US13518501
申请日：2010-12-20
申请人： Lars Andersson , Stefan D'Argy , Patric Fricking , Joachim Tollstoy
发明人： Lars Andersson , Stefan D'Argy , Patric Fricking , Joachim Tollstoy
IPC分类号： G01R27/28 , G01R27/22 , G01N27/07 , G01N27/08 , G01N30/64
CPC分类号： G01R27/22 , G01N27/07 , G01N27/08 , G01N2030/645
摘要： A flow-through conductivity sensor assembly comprises a housing (4) having a flow passage with an inlet end and an outlet end. The cross section of at least a section of the flow passage extension between the inlet and outlet ends is divided into a conductivity measuring channel (2) and a parallel by-pass channel (3) of larger cross-sectional area than the measuring channel (2).
摘要翻译：流通电导率传感器组件包括具有入口端和出口端的流动通道的壳体（4）。入口端和出口端之间的流路延伸部分的至少一部分的横截面被分成比测量通道更大的横截面面积的电导率测量通道（2）和平行旁通通道（3） 2）。

10. 发明申请

US20130112624A1 FLUID MIXING IN A DISPOSABLE FLUID PROCESSING SYSTEM 审中-公开
标题翻译：流体混合流体处理系统
公开(公告)号：US20130112624A1
公开(公告)日：2013-05-09
申请号：US13808606
申请日：2011-06-27
申请人： Klaus Gebauer , Patric Fricking , Bjorn Jaderlund
发明人： Klaus Gebauer , Patric Fricking , Bjorn Jaderlund
IPC分类号： B01F15/02 , B01D15/12
摘要： High accuracy mixing of fluids in a disposable fluid processing system with at least two pumps is provided by a method where a calibration fluid volume is pumped through each pump via a flow meter at at least one calibration pump speed while registering the flow rate using data output from the flow meter, a pump calibration function is calculated from the calibration pump speed and flow rate data and two or more operation fluids are mixed to a predetermined mixture ratio and predetermined flow rate by controlling the pump speed of the respective pumps in accordance with the pump calibration functions.
摘要翻译：通过一种方法提供一次性流体处理系统中具有至少两个泵的流体的高精度混合，其中校准流体体积以至少一个校准泵速度通过流量计泵送通过每个泵，同时使用数据输出根据流量计，根据校准泵速度和流量数据计算泵校准功能，并且通过根据相应的泵控制各泵的泵速来将两个或多个操作流体混合到预定混合比和预定流量泵校准功能。

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