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    • 1. 发明授权
    • Corner padding attachment device
    • 角填料附件装置
    • US06682037B1
    • 2004-01-27
    • US10321753
    • 2002-12-18
    • Andre Ouellette
    • Andre Ouellette
    • A47B9500
    • A47B95/043
    • A corner padding attachment device for padding corners which otherwise could cause serious injuries to the occupants including children, in particular. The corner padding attachment device includes an elongate cushion member having a groove being disposed in a longitudinal side thereof and extending a length of the elongate cushion member to pad a corner structure; and also includes suction cup members being spacedly disposed in the groove for fastening the elongate cushion member about the corner structure.
    • 特别是用于填充角落的角落式附着装置,否则可能对包括儿童在内的乘客造成严重伤害。 拐角填充附接装置包括细长的缓冲构件,其具有设置在其纵向侧的凹槽,并且延伸长度的细长缓冲构件以衬垫拐角结构; 并且还包括间隔设置在凹槽中的吸盘构件,用于将细长的缓冲构件围绕拐角结构紧固。
    • 2. 发明申请
    • Antimicrobial theta defensins and methods of using same
    • 抗微生物θ防御素及其使用方法
    • US20050261193A1
    • 2005-11-24
    • US11126468
    • 2005-05-10
    • Michael SelstedYi-Quan TangJun YuanAndre Ouellette
    • Michael SelstedYi-Quan TangJun YuanAndre Ouellette
    • A61K38/00A61K38/10A61K38/12C07K7/08C07K14/47C12N15/12C12P21/00
    • C07K7/08A61K38/12C07K14/4723C12P21/00Y02A50/473Y02A50/481
    • The present invention relates to an isolated cyclic peptide, theta defensin, having antimicrobial activity, and to theta defensin analogs. A theta defensin can have the amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-Xaa5-Xaa1-Xaa3-Xaa7-Xaa5, wherein Xaa1 to Xaa8 are defined; wherein Xaa1 can be linked through a peptide bond to Xaa8; and wherein crosslinks can be formed between Xaa3 and Xaa3, between Xaa5 and Xaa5, and between Xaa7 and Xaa7. For example, the invention provides a theta defensin having the amino acid sequence Gly-Phe-Cy-Arg-Cys-Leu-Cys-Arg-Arg-Gly-Val-Cys-Arg-Cys-Ile-Cys-Thr-Arg (SEQ ID NO:1), wherein the Gly at position 1 (Gly-1) is linked through a peptide bond to Arg-18, and wherein disulfide bonds are present between Cys-3 and Cys-16, between Cys-5 and Cys-14, and between Cys-7 and Cys-12. The invention also relates to antibodies that specifically bind a theta defensin and to isolated nucleic acid molecules encoding a theta defensin. In addition, the invention relates to methods of using theta defensin or a theta defensin analog to reduce or inhibit microbial growth or survival in an environment capable of sustaining microbial growth or survival by contacting the environment with the theta defensin.
    • 本发明涉及具有抗微生物活性的分离的环肽,θ防御素,以及θ防御素类似物。 θ防御素可以具有氨基酸序列Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-Xaa5-Xaa1-Xaa3-Xaa7-Xaa5,其中Xaa1至Xaa8是 定义 其中Xaa1可通过肽键与Xaa8连接; 并且其中可以在Xaa3和Xaa3之间,Xaa5和Xaa5之间以及Xaa7和Xaa7之间形成交联。 例如,本发明提供具有氨基酸序列Gly-Phe-Cy-Arg-Cys-Leu-Cys-Arg-Arg-Gly-Val-Cys-Arg-Cys-Ile-Cys-Thr-Arg的θ防御素 SEQ ID NO:1),其中位置1处的Gly(Gly-1)通过肽键与Arg-18连接,并且其中二硫键存在于Cys-3和Cys-16之间,Cys-5和Cys之间 -14,以及Cys-7和Cys-12之间。 本发明还涉及特异性结合θ防御素和编码θ防御素的分离的核酸分子的抗体。 此外,本发明涉及使用θ防御素或θ防御素类似物以通过使环境与θ防御素接触来在能够维持微生物生长或存活的环境中减少或抑制微生物生长或存活的方法。
    • 3. 发明授权
    • Ditch digger
    • 沟渠挖掘机
    • US09027264B2
    • 2015-05-12
    • US13650741
    • 2012-10-12
    • Andre Ouellette
    • Andre Ouellette
    • E02D17/06E02F5/02E02F5/14E02F7/02
    • E02F5/022E02F5/025E02F5/027E02F5/14E02F5/145E02F7/02
    • A ditch digger for removing earth from the ground to dig a ditch, the ditch digger comprising: a body; a substantially elongated blade mounted to the body, the blade defining a blade front end and a substantially longitudinally opposed blade rear end, the blade defining a blade bottom section and a pair of laterally opposed blade side sections extending generally upwardly therefrom. When the ditch digger is in an operational configuration, the blade bottom section is lower adjacent the blade front end than adjacent the blade rear end. Moving the ditch digger along the ground with the blade front end inserted in the ground and the blade rear end provided above the ground removes the earth from the ground to dig the ditch.
    • 一个挖沟机,用于将地面从地面上挖出一条沟,挖沟机包括:一个身体; 安装到主体上的基本上细长的叶片,叶片限定叶片前端和基本上纵向相对的叶片后端,所述叶片限定叶片底部部分和从其大致向上延伸的一对横向相对的叶片侧部分。 当挖沟机处于操作配置时,叶片底部部分在叶片前端附近比靠近叶片后端低。 将挖沟机沿地面移动,将刀片前端插入地面,并将地面上的刀片后端从地面上移除,以挖掘沟渠。
    • 4. 发明申请
    • Ditch Digger
    • 沟渠挖掘机
    • US20130091744A1
    • 2013-04-18
    • US13650741
    • 2012-10-12
    • Andre Ouellette
    • Andre Ouellette
    • E02F5/02
    • E02F5/022E02F5/025E02F5/027E02F5/14E02F5/145E02F7/02
    • A ditch digger for removing earth from the ground to dig a ditch, the ditch digger comprising: a body; a substantially elongated blade mounted to the body, the blade defining a blade front end and a substantially longitudinally opposed blade rear end, the blade defining a blade bottom section and a pair of laterally opposed blade side sections extending generally upwardly therefrom. When the ditch digger is in an operational configuration, the blade bottom section is lower adjacent the blade front end than adjacent the blade rear end. Moving the ditch digger along the ground with the blade front end inserted in the ground and the blade rear end provided above the ground removes the earth from the ground to dig the ditch.
    • 一个挖沟机,用于将地面从地面上挖出一条沟,挖沟机包括:一个身体; 安装到主体上的基本上细长的叶片,叶片限定叶片前端和基本上纵向相对的叶片后端,所述叶片限定叶片底部部分和从其大致向上延伸的一对横向相对的叶片侧部分。 当挖沟机处于操作配置时,叶片底部部分在叶片前端附近比靠近叶片后端低。 将挖沟机沿地面移动,将刀片前端插入地面,并将地面上的刀片后端从地面上移除,以挖掘沟渠。