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1. 发明授权

US06017871A Protease-containing cleaning compositions 失效
标题翻译：含蛋白酶的清洁组合物
公开(公告)号：US06017871A
公开(公告)日：2000-01-25
申请号：US898218
申请日：1997-07-22
申请人： Andre Baeck , Chanchal Kumar Ghosh , Thomas Paul Graycar , Richard Ray Bott , Lori Jean Wilson , Philip Frederick Brode , Bobby Lee Barnett , Donn Nelton Rubingh
发明人： Andre Baeck , Chanchal Kumar Ghosh , Thomas Paul Graycar , Richard Ray Bott , Lori Jean Wilson , Philip Frederick Brode , Bobby Lee Barnett , Donn Nelton Rubingh
IPC分类号： C12N15/09 , A61K8/22 , A61K8/23 , A61K8/24 , A61K8/41 , A61K8/42 , A61K8/46 , A61K8/49 , A61K8/66 , A61K31/44 , A61Q11/00 , A61Q11/02 , A61Q19/10 , C11D3/386 , C11D17/06 , C11D17/08 , C12N9/54 , C12N15/57 , C12Q1/37 , C12R1/125 , G06Q40/04
CPC分类号： A61K8/416 , A61K8/22 , A61K8/23 , A61K8/24 , A61K8/42 , A61K8/463 , A61K8/466 , A61K8/49 , A61K8/4906 , A61K8/66 , A61Q11/00 , A61Q11/02 , A61Q19/10 , C11D3/386 , C12N9/54 , G06Q40/04 , A61K2800/222 , A61K2800/86
摘要： The present invention relates to cleaning compositions comprising protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions corresponds to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as Bacillus lentus subtilisin).
摘要翻译：本发明涉及包含蛋白酶的清洗组合物，它是一种羰基水解酶变体，其具有自然界中没有发现的氨基酸序列，其通过用不同氨基酸替代前体羰基水解酶的多个氨基酸残基而得到，其中所述在前体酶中替换的多个氨基酸残基对应于与一个或多个以下残基组合的位置+76：+99，+ 101，+ 103，+ 104，+ 107，+ 123，+ 27，+ 105， +109，+126，+128，+135，+ 156，+166，+ 195，+ 197，+ 204，+ 206，+210，+216，+217，+218，+222，+260，+265 ，和/或+274，其中编号的位置对应于从解淀粉芽孢杆菌杆菌中天然存在的枯草杆菌蛋白酶或其它羰基水解酶或枯草杆菌蛋白酶（例如迟缓芽孢杆菌枯草杆菌蛋白酶）中的等同氨基酸残基。

2. 发明授权

US5679630A Protease-containing cleaning compositions 失效
标题翻译：含蛋白酶的清洁组合物
公开(公告)号：US5679630A
公开(公告)日：1997-10-21
申请号：US322676
申请日：1994-10-13
申请人： Andre Baeck , Chanchal Kumar Ghosh , Thomas Paul Graycar , Richard Ray Bott , Lori Jean Wilson , Philip Frederick Brode , Bobby Lee Barnett , Donn Nelton Rubingh
发明人： Andre Baeck , Chanchal Kumar Ghosh , Thomas Paul Graycar , Richard Ray Bott , Lori Jean Wilson , Philip Frederick Brode , Bobby Lee Barnett , Donn Nelton Rubingh
IPC分类号： C12N15/09 , A61K8/22 , A61K8/23 , A61K8/24 , A61K8/41 , A61K8/42 , A61K8/46 , A61K8/49 , A61K8/66 , A61K31/44 , A61Q11/00 , A61Q11/02 , A61Q19/10 , C11D3/386 , C11D17/06 , C11D17/08 , C12N9/54 , C12N15/57 , C12Q1/37 , C12R1/125 , G06Q40/04 , C11D7/42 , C11D9/40
CPC分类号： A61K8/416 , A61K8/22 , A61K8/23 , A61K8/24 , A61K8/42 , A61K8/463 , A61K8/466 , A61K8/49 , A61K8/4906 , A61K8/66 , A61Q11/00 , A61Q11/02 , A61Q19/10 , C11D3/386 , C12N9/54 , G06Q40/04 , A61K2800/222 , A61K2800/86
摘要： The present invention relates to cleaning compositions comprising subtilisin proteases from Bacillus lentus having the following alterations: N76D, S103A and V104I, where the numbering is based on the corresponding positions in the subtilisin from Bacillus amyloliquefaciens.
摘要翻译：本发明涉及包含枯叶杆菌素蛋白酶的清洁组合物，其具有以下改变：N76D，S103A和V104I，其中编号基于来自解淀粉芽孢杆菌的枯草杆菌蛋白酶中的相应位置。

3. 发明授权

US06436690B1 BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted 失效
标题翻译： BPN'变体具有降低的吸附和增加的水解，其中一个或多个环区被取代
公开(公告)号：US06436690B1
公开(公告)日：2002-08-20
申请号：US08394011
申请日：1995-03-03
申请人： Philip Frederick Brode, III , Bobby Lee Barnett , Donn Nelton Rubingh , Chanchal Kumar Ghosh
发明人： Philip Frederick Brode, III , Bobby Lee Barnett , Donn Nelton Rubingh , Chanchal Kumar Ghosh
IPC分类号： C12N956
CPC分类号： C11D3/38609 , A61K8/66 , A61Q11/00 , C11D3/386 , C12N9/54
摘要： The present invention relates to subtilisin BPN′ variants having a modified amino acid sequence of wild-type BPN′ amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region and a fifth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type subtilisin BPN′ (i.e., substitution) at specifically identified positions in one or more of the loop regions whereby the BPN′ variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild-type subtilisin BPN′. The present invention also relates to the genes encoding such subtilisin BPN′ variants. The present invention also relates to compositions comprising such subtilisin BPN′ variants for cleaning a variety of surfaces.
摘要翻译：本发明涉及具有野生型BPN'氨基酸序列的修饰氨基酸序列的枯草杆菌蛋白酶BPN'变体，野生型氨基酸序列包含第一环区，第二环区，第三环区，第四环环路区域和第五环路区域; 其中所述修饰的氨基酸序列包含不同于在一个或多个环区中特异性鉴定的位置处的野生型枯草杆菌蛋白酶BPN'（即取代）中发生的氨基酸，由此BPN变体具有减少的吸附和增加的水解的，与野生型枯草杆菌蛋白酶BPN'相比不溶性底物。本发明还涉及编码这种枯草杆菌蛋白酶BPN'变体的基因。本发明还涉及包含用于清洁各种表面的这种枯草杆菌蛋白酶BPN'变体的组合物。

4. 发明授权

US06440717B1 BPN′ variants having decreased adsorption and increased hydrolysis 失效
标题翻译： BPN'变体具有减少的吸附和增加的水解
公开(公告)号：US06440717B1
公开(公告)日：2002-08-27
申请号：US08397329
申请日：1995-03-02
申请人： Philip Frederick Brode, III , Bobby Lee Barnett , Donn Nelton Rubingh , Chanchal Kumar Ghosh
发明人： Philip Frederick Brode, III , Bobby Lee Barnett , Donn Nelton Rubingh , Chanchal Kumar Ghosh
IPC分类号： C12N956
CPC分类号： A61K8/66 , A61Q11/00 , C11D3/386 , C11D3/38609 , C12N9/54
摘要： The present invention relates to subtilisin BPN′ variants comprising at least one or more amino acid positions having a different amino acid than that occurring in wild-type subtilisin BPN′ (i.e., substitution) at specifically identified positions, whereby the BPN′ variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to wild-type subtilisin BPN′. The present invention further relates to various cleaning compositions comprising such BPN′ variants.
摘要翻译：本发明涉及包含至少一个或多个氨基酸位置的枯草杆菌蛋白酶BPN'变体，所述氨基酸位置具有与在特异性鉴定位置处的野生型枯草杆菌蛋白酶BPN'（即取代）中发生的氨基酸不同的氨基酸，由此BPN变体已降低与野生型枯草杆菌蛋白酶BPN'相比，不溶性底物的吸附和水解增加。本发明还涉及包含这种BPN变体的各种清洁组合物。

5. 发明申请

US20130048005A1 Skin Care Regimen Comprising At Least One Composition Comprising A Pyrithione Source 审中-公开
标题翻译：皮肤护理方案包含至少一种包含吡硫酮源的组合物
公开(公告)号：US20130048005A1
公开(公告)日：2013-02-28
申请号：US13589428
申请日：2012-08-20
申请人： Edward Dewey Smith, III , Jason Edward Cook , Brian Joseph Limberg , Chanchal Kumar Ghosh
发明人： Edward Dewey Smith, III , Jason Edward Cook , Brian Joseph Limberg , Chanchal Kumar Ghosh
IPC分类号： A45D27/00
CPC分类号： A45D27/00 , A45D34/04
摘要： A method of treating skin comprising: applying a first composition to a portion of skin to form a prepared surface; and contacting said prepared surface with a hair removal device to form a contacted surface, wherein said hair removal device comprises at least one of: a skin engaging member, a molded shaving aid, and a combination thereof; applying a second composition to said contacted surface to form a treated surface, wherein at least one of said first composition, said hair removal device, said second composition, or a combination thereof comprises a pyrithione source, such as zinc pyrithione.
摘要翻译：一种治疗皮肤的方法，包括：将第一组合物施用到皮肤的一部分以形成制备的表面; 并使所述制备的表面与脱毛装置接触以形成接触表面，其中所述脱毛装置包括以下至少一种：皮肤接合构件，模制剃须助剂及其组合中的至少一种; 将第二组合物施加到所述接触表面以形成经处理的表面，其中所述第一组合物，所述脱毛装置，所述第二组合物或其组合中的至少一种包含吡啶硫酮源，例如吡啶硫酮锌。

6. 发明申请

US20080301890A1 Electric Toothbrush Comprising An Electrically Powered Element 有权
标题翻译：电动牙刷包括电动元件
公开(公告)号：US20080301890A1
公开(公告)日：2008-12-11
申请号：US12191370
申请日：2008-08-14
申请人： John Geoffrey Chan , Chanchal Kumar Ghosh , Stephen Andras Kovacs , Lowen Robert Morrision, JR. , Ping Wang , Aleksey Mikhailovich Pinyayev
发明人： John Geoffrey Chan , Chanchal Kumar Ghosh , Stephen Andras Kovacs , Lowen Robert Morrision, JR. , Ping Wang , Aleksey Mikhailovich Pinyayev
IPC分类号： A46B13/02
CPC分类号： A61C17/222 , A46B15/0002 , A46B15/0036 , A46B2200/1066 , A61C1/088 , A61C17/22 , A61C17/3436 , A61C17/349 , A61C19/063 , A61C19/066 , A61N5/0601 , A61N5/062 , A61N2005/0606 , A61N2005/0651 , H01L2224/48091 , H01L2224/48247 , H01L2224/49113 , H01L2924/00014
摘要： An electric toothbrush having a handle, a head, and a neck extending between the handle and the head is disclosed. The handle has a hollow interior region having a motor and an electrical power source. The head includes an ultrasonic transducer and a bristle field. The ultrasonic transducer is in electrical communication with the electrical power source, and a shaft is operatively connected to the motor for moving the bristle field.
摘要翻译：公开了一种电动牙刷，其具有在把手和头部之间延伸的手柄，头部和颈部。手柄具有中空的内部区域，其具有马达和电源。头包括超声换能器和刷毛场。超声波换能器与电源电连通，并且轴可操作地连接到马达以移动刷毛场。

7. 发明授权

US06472359B1 Laundry detergent compositions comprising zwitterionic polyamines and xyloglucanase 失效
标题翻译：包含两性离子多胺和木葡聚糖酶的洗衣洗涤剂组合物
公开(公告)号：US06472359B1
公开(公告)日：2002-10-29
申请号：US09790044
申请日：2001-02-21
申请人： Chanchal Kumar Ghosh
发明人： Chanchal Kumar Ghosh
IPC分类号： C11D183
CPC分类号： C11D3/3796 , C11D1/22 , C11D1/29 , C11D1/662 , C11D1/72 , C11D3/3723 , C11D3/38636 , C11D3/38645
摘要： The present invention solves the problem of soil and dirt becoming entrained in cellulosic material loosened and removed from fabric during washing wherein said dirt and soil is entrapped by the cellulosic material and re-deposited onto the fabric surface. The compositions of the present invention comprise: a) from about 0.01% by weight, of a zwitterionic polyamine which comprises a polyamine backbone, said backbone comprising two or more amino units wherein at least one of said amino units is quaternized and wherein at least one amino unit is substituted by one or more moieties capable of having an anionic charge wherein further the number of amino unit substitutions which comprise said anionic moiety is less than or equal to the number of quaternized backbone amino units; b) from about 0.00005% by weight, of a xyloglucanase enzyme; c) from about 0.5% to about 50% by weight, of a surfactant system comprising: i) from about 10% to about 99% by weight, of said surfactant system, of a nonionic surfactant; ii) from about 1% to about 90% by weight, of said surfactant system, of an anionic surfactant; iii) optionally, from 1% to about 50% by weight, of said surfactant system, of a detersive surfactant selected from the group consisting of cationic surfactants, zwitterionic surfactants, ampholytic surfactants, and mixtures thereof; and d) the balance carriers and adjunct ingredients.
摘要翻译：本发明解决了在洗涤期间从织物松开和去除的纤维素材料中夹带污垢和污垢的问题，其中所述污垢和污物被纤维素材料包裹并重新沉积在织物表面上。本发明的组合物包含：a）约0.01重量％的包含多胺主链的两性离子多胺，所述骨架包含两个或更多个氨基单元，其中至少一个所述氨基单元是季铵化的，并且其中至少一个氨基单元被一个或多个能够具有阴离子电荷的部分取代，其中进一步包含所述阴离子部分的氨基单元取代数小于或等于季铵化主链氨基单元的数量; b）约0.00005重量％的木葡聚糖酶; c）约0.5重量％至约50重量％的表面活性剂体系，其包含：i）约10重量％至约99重量％的所述表面活性剂体系的非离子表面活性剂; ii）约1重量％至约90重量％的所述表面活性剂体系;阴离子表面活性剂; iii）任选地，所述表面活性剂体系的1重量％至约50重量％的选自下组的去污表面活性剂：阳离子表面活性剂，两性离子表面活性剂，两性表面活性剂及其混合物; andd）平衡载体和辅助成分。

8. 发明授权

US08214958B2 Sensor responsive electric toothbrushes and methods of use 有权
标题翻译：传感器电动牙刷及使用方法
公开(公告)号：US08214958B2
公开(公告)日：2012-07-10
申请号：US11899657
申请日：2007-09-07
申请人： Aleksey Mikhailovich Pinyayev , Eric Altman Goulbourne, Jr. , Stephen Andras Kovacs , Chanchal Kumar Ghosh
发明人： Aleksey Mikhailovich Pinyayev , Eric Altman Goulbourne, Jr. , Stephen Andras Kovacs , Chanchal Kumar Ghosh
IPC分类号： A61C3/00
CPC分类号： A61N5/0603 , A61B5/0088 , A61B5/415 , A61B5/418 , A61B5/4547 , A61B5/6898 , A61C17/221 , A61C19/066 , A61N2005/0606 , A61N2005/0652
摘要： A sensor-responsive toothbrush that can adjust its output or operation depending upon information received by one or more sensors incorporated in the toothbrush or as selected by a user. The information typically relates to certain conditions or the presence of particular substances or agents within or outside of the oral cavity. The sensor-responsive toothbrush also includes one or more responsive output components that provide a responsive output in response to the sensed information. A method of providing an oral care benefit, comprising steps of: activating a toothbrush comprising a sensor; detecting a sensor input with the sensor; and initiating a responsive output from the toothbrush in response to the sensor input.
摘要翻译：一种传感器响应牙刷，其可以根据结合在牙刷中或由用户选择的一个或多个传感器接收的信息调节其输出或操作。这些信息通常涉及某些条件或口腔内或外部特定物质或药剂的存在。传感器响应牙刷还包括响应于感测到的信息提供响应输出的一个或多个响应输出部件。一种提供口腔护理益处的方法，包括以下步骤：激活包括传感器的牙刷; 用传感器检测传感器输入; 以及响应于传感器输入启动来自牙刷的响应输出。

9. 发明授权

US6121226A Compositions comprising cotton soil release polymers and protease enzymes 有权
标题翻译：包含棉花去污聚合物和蛋白酶的组合物
公开(公告)号：US6121226A
公开(公告)日：2000-09-19
申请号：US354972
申请日：1999-07-16
申请人： Eugene Paul Gosselink , Kenneth Nathan Price , Chanchal Kumar Ghosh
发明人： Eugene Paul Gosselink , Kenneth Nathan Price , Chanchal Kumar Ghosh
IPC分类号： C08G73/02 , C11D3/00 , C11D3/37 , C11D3/386 , C11D3/30
CPC分类号： C11D3/0036 , C08G73/02 , C08G73/0213 , C08G73/024 , C11D3/3723 , C11D3/3792 , C11D3/38609 , C11D3/38618
摘要： Cotton soil release polymers comprising water soluble and/or dispersible, modified polyamines having functionalized backbone moieties and improved stability toward bleach. Also, laundry detergent compositions comprising these cotton soil release polymers having enhanced hydrophilic soil removal benefits in combination with a protease enzyme system are provided.
摘要翻译：棉花污垢释放聚合物，其包含具有官能化主链部分的水溶性和/或可分散的改性多胺，并且改进了对漂白剂的稳定性。此外，提供了包含与蛋白酶系统组合的具有增强的亲水污物去除益处的这些棉污渍释放聚合物的衣物洗涤剂组合物。

10. 发明授权

US5932532A Bleach compositions comprising protease enzyme 失效
标题翻译：包含蛋白酶的漂白组合物
公开(公告)号：US5932532A
公开(公告)日：1999-08-03
申请号：US931684
申请日：1997-09-16
申请人： Chanchal Kumar Ghosh , Gayle Marie Frankenbach , Catherine Michelle Quinn
发明人： Chanchal Kumar Ghosh , Gayle Marie Frankenbach , Catherine Michelle Quinn
IPC分类号： A61K8/22 , A61K8/23 , A61K8/24 , A61K8/41 , A61K8/42 , A61K8/46 , A61K8/49 , A61Q11/00 , A61Q11/02 , A61Q19/10 , C11D3/386 , C11D3/39 , G06Q40/04 , C11D3/395
CPC分类号： C11D3/386 , C11D3/3905 , C11D3/3945 , G06Q40/04 , C11D3/3915 , C11D3/3917 , C11D3/392
摘要： Bleaching and cleaning compositions comprising a bleaching compound, one or more bleach activators, and protease enzymes are provided. Thus, laundry detergent compositions which comprise protease, perborate or percarbonate and activators such as benzoyl caprolactain exhibit improved dingy clean-up performance.
摘要翻译：提供了包含漂白化合物，一种或多种漂白活化剂和蛋白酶的漂白和清洁组合物。因此，包含蛋白酶，过硼酸盐或过碳酸盐和活化剂如苯甲酰基己内酰胺的衣物洗涤剂组合物表现出改进的肮脏清洁性能。

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