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1. 发明授权

US4780537A Pyrimidine derivatives and process preparing the same 失效
标题翻译：嘧啶衍生物及其制备方法
公开(公告)号：US4780537A
公开(公告)日：1988-10-25
申请号：US72010
申请日：1987-07-10
申请人： Andras Vedres , Csaba Szantay , Bela Stefko , Janos Kreidl , Andras Nemes , Gabor Blasko , Erik Bogsch , Denes Mathe , Istvan Hegedus , Adrien Szuchovszky nee Gergely , Tamas Mester
发明人： Andras Vedres , Csaba Szantay , Bela Stefko , Janos Kreidl , Andras Nemes , Gabor Blasko , Erik Bogsch , Denes Mathe , Istvan Hegedus , Adrien Szuchovszky nee Gergely , Tamas Mester
IPC分类号： C07D239/48 , C07D239/50 , C07D239/02
CPC分类号： C07D239/48 , C07D239/50
摘要： A pyrimidine derivative of the formulae (Ia), (Ib) and (Ic), ##STR1## wherein R stands for an alkyl group group with 1 to 6 carbon atoms or an aryl group optionally substituted by halogen atom; andX stands for chlorine or bromine atom or an arylsulfonyloxy group optionally substituted by 1 to 3 lower alkyl groups.The subject pyrimidine derivatives are intermediates for preparing 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine.
摘要翻译：（Ia），（Ib）和（Ic）的嘧啶衍生物，其中R代表具有1至6个碳原子的烷基基团或任选被卤素原子取代的芳基; X代表氯或溴原子或任选被1至3个低级烷基取代的芳基磺酰氧基。本发明的嘧啶衍生物是制备6-氨基-1,2-二氢-1-羟基-2-亚氨基-4-哌啶并嘧啶的中间体。

2. 发明授权

US4960888A Preparation of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine compounds 失效
标题翻译： 6-氨基-1,2-二氢-1-羟基-2-亚氨基-4-哌啶基嘧啶化合物的制备
公开(公告)号：US4960888A
公开(公告)日：1990-10-02
申请号：US320875
申请日：1989-03-09
申请人： Andras Vedres , Csaba Szantay , Bela Stefko , Janos Kreidl , Andras Nemes , Gabor Blasko , Erik Bogsch , Denes Mathe , Istvan Hegedus , Adrien Szuchovszky, nee Gergely , Tamas Mester
发明人： Andras Vedres , Csaba Szantay , Bela Stefko , Janos Kreidl , Andras Nemes , Gabor Blasko , Erik Bogsch , Denes Mathe , Istvan Hegedus , Adrien Szuchovszky, nee Gergely , Tamas Mester
IPC分类号： C07D401/04 , C07D239/50 , C07D295/12
CPC分类号： C07D239/50
摘要： The invention relates to a new process for preparing 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine of the formula (I), ##STR1## which comprises reacting a pyrimidine derivative of the general formula (II), ##STR2## wherein R.sub.1 stantds for hydrogen or a ##STR3## group, wherein R means a C.sub.1-6 alkyl group or an aryl group optionally substituted by halogen;R.sub.2 stands for a hydroxyl group or an ##STR4## group, wherein R is as defined above; andX represents chlorine or bromine or an optionally mono- or polysubstituted arenesulfonyloxy group,with the proviso that R.sub.2 is different from a hydroxyl group when R.sub.1 stands for hydrogen, with piperidine and hydrolyzing, optionally after isolation, the thus-obtained 4-piperidino derivative of the general formula (III), ##STR5## wherein R.sub.1 and R.sub.2 are as defined above.
摘要翻译：本发明涉及一种制备式（I），（I）的6-氨基-1,2-二氢-1-羟基-2-亚氨基-4-哌啶并嘧啶的新方法，其包括将其中R1代表氢或一个或者两个基团的通式（II），其中R表示任选被卤素取代的C 1-6烷基或芳基; R2代表羟基或基团，其中R如上定义; 并且X表示氯或溴或任选的单取代或多取代的芳烃磺酰氧基，条件是当R1代表氢时，R2不同于羟基，哌啶并水解，任选地在分离后，将由此得到的4-哌啶子基衍生物的通式（III），其中R 1和R 2如上所定义。

3. 发明授权

US5523303A Trisubstituted cycloalkane derivatives and process for the preparation thereof 失效
标题翻译：三取代环烷烃衍生物及其制备方法
公开(公告)号：US5523303A
公开(公告)日：1996-06-04
申请号：US226051
申请日：1994-04-11
申请人： Judit Bajnogel , Gabor Blasko , Zoltan Budai , Andras Egyed , Marton Fekete , Erika Karaffa , Tibor Mezei , Klara Reiter nee Esses , Gyula Simig , Katalin Szemeredi , Eniko Szirt nee Kiszelly
发明人： Judit Bajnogel , Gabor Blasko , Zoltan Budai , Andras Egyed , Marton Fekete , Erika Karaffa , Tibor Mezei , Klara Reiter nee Esses , Gyula Simig , Katalin Szemeredi , Eniko Szirt nee Kiszelly
IPC分类号： A61K31/15 , A61K31/357 , A61K31/36 , A61K31/395 , A61K31/40 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/55 , A61P1/04 , C07C249/12 , C07C251/58 , C07D295/08 , C07D295/088 , C07D317/58
CPC分类号： C07D295/088 , C07C251/58 , C07C2101/08 , C07C2101/14 , C07C2101/18 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/928
摘要： The invention relates to novel, pharmaceutically active trisubstituted cycloalkane derivatives, a process for the preparation thereof and pharmaceutical compositions comprising the same. The invention also encompasses the use of the said cycloalkane derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases.The compounds according to the invention are characterized by the general formula (I), ##STR1## wherein R represents hydrogen, C.sub.1-4 alkyl or hydroxyl,R.sup.1 stands for C.sub.1-12 alkyl,R.sup.2 and R.sup.3 each represents hydrogen, C.sub.1-12 alkyl or C.sub.2-12 alkenyl, orR.sup.2 and R.sup.3 together with the adjacent nitrogen atom form a 4- to 7-membered ring optionally comprising an oxygen, sulfur or a further nitrogen atom, which latter may carry a phenyl, benzyl or C.sub.1-4 alkyl substituent,R.sup.4 and R.sup.5 each stands for hydrogen, halogen or C.sub.1-4 alkoxy, or together represent a 3,4-methylenedioxy group,n is an integer from 2 to 5,A represents a valency bond or a --CH.sub.2 -- group.The compounds exert a valuable antiulcer effect, so they can be used to advantage in the therapy.
摘要翻译：本发明涉及新颖的药学活性三取代环烷烃衍生物，其制备方法和包含其的药物组合物。本发明还包括所述环烷烃衍生物用于治疗疾病和制备适于治疗疾病的药物组合物的用途。根据本发明的化合物的特征在于通式（I），其中R表示氢，C 1-4烷基或羟基，R 1表示C 1-12烷基，R 2和R 3各自表示氢，C 1 -12烷基或C2-12烯基，或R2和R3与相邻的氮原子一起形成任选地包含氧，硫或另外的氮原子的4-至7-元环，后者可以携带苯基，苄基或C1 -4-烷基取代基，R4和R5各自代表氢，卤素或C1-4烷氧基，或一起代表3,4-亚甲二氧基，n是2至5的整数，A表示价键或-CH 2 - 组。这些化合物具有有价值的抗溃疡作用，因此可用于治疗。

4. 发明授权

US07499002B2 Retractable string interface for stationary and portable devices 失效
标题翻译：固定和便携式设备的伸缩式串接口
公开(公告)号：US07499002B2
公开(公告)日：2009-03-03
申请号：US11053451
申请日：2005-02-08
申请人： Gabor Blasko , Chandrasekhar Naravanaswami
发明人： Gabor Blasko , Chandrasekhar Naravanaswami
IPC分类号： G09G5/00
CPC分类号： G01C1/00
摘要： An interface for a small form factor electronic device by enabling explicit measurement of extension or retraction of a retractable cord by monitoring the amount of string that passes by sensors, as the string exits the enclosure of the device. Input to such small form factor devices may be provided by sensors that measure the length of a string or wire that has been pulled out of an enclosure, in addition to an angle or direction (e.g., in 1-, 2- or 3-dimensions) at which the string was pulled out. Additionally, the rate of acceleration for the pulling and retracting motion may also be used as additional forms of input. In a further embodiment, a string interface is provided for a small form factor device that communicates information in the form of a pixel display provided integral with the string in response to string manipulation.
摘要翻译：一个小尺寸电子设备的接口，通过监视传感器通过的串的数量，通过显示测量伸缩线的延伸或缩回，当琴弦离开设备的外壳时。除了角度或方向（例如，在1或2或3维度之外），除了角度或方向之外，还可以通过传感器来提供对这种小尺寸装置的输入，所述传感器测量已经从外壳拉出的弦或线的长度），字符串被拉出。此外，牵引和缩回运动的加速度也可以用作输入的附加形式。在另一个实施例中，提供了一种小型形状因子装置的字符串接口，其响应于字符串操作以与该字符串一体化的像素显示器的形式传送信息。

5. 发明授权

US07053082B1 2,3-benzodiazepine derivatives 失效
公开(公告)号：US07053082B1
公开(公告)日：2006-05-30
申请号：US10030436
申请日：2000-07-04
申请人： Zoltan Greff , Geza Szabo , Jozsef Barkoczy , Zoltan Ratkai , Gabor Blasko , Gyula Simig , Gabor Gigler , Bernadett Martonné Marko , György Levay , Karoly Tihanyi , Andras Egyed , Annamaria Simo
发明人： Zoltan Greff , Geza Szabo , Jozsef Barkoczy , Zoltan Ratkai , Gabor Blasko , Gyula Simig , Gabor Gigler , Bernadett Martonné Marko , György Levay , Karoly Tihanyi , Andras Egyed , Annamaria Simo
IPC分类号： A61P25/00 , A61K31/551 , C07D491/04
CPC分类号： C07D491/04
摘要： The invention relates to new 2,3-benzodiazepine derivatives of general Formula (I), (wherein R1 stands for methyl, formyl, carboxy, cyano, —CH═NOH, —CH═NNHCONH2 or —NR5R6, wherein R5 and R6 independently from each other represent hydrogen or lower alkyl or together with the nitrogen atom, they are attached to, form a 5- or 6-membered, saturated or unsaturated heterocyclic ring optionally containing one or more further nitrogen, sulfur and/or oxygen atom(s); R2 is nitro or amino; R3 stands for hydrogen, lower alkanoyl or CO—NR7R8, wherein R7 and R8 independently from each other stand for hydrogen, lower alkoxy, lower alkyl or lower cycloalkyl or together with the nitrogen atom, they are attached to, form a 5- or 6-membered, saturated or unsaturated heterocyclic ring optionally containing one or more further nitrogen, sulfur and/or oxygen atom(s); R4 is hydrogen or lower alkyl; the dotted lines have the following meaning: if R3 and R4 are not present, the bond between positions C8 and C9 is a single bond and the bond between positions C8 and N7 is a double bond; if R3 and R4 are present, the bonds between positions C8 and C9 and between position C8 and N7 are single bonds; and if R3 is present and R4 is missing, the bond between positions C8 and C9 is a double bond and the bond between positions C8 and N7 is a single bond) and salts thereof. The invention compounds have neuroprotective effect.

6. 发明申请

US20090038004A1 ROLE CHANGE BASED ON COUPLING OR DOCKING OF INFORMATION HANDLING APPARATUS AND METHOD FOR SAME 审中-公开
标题翻译：基于信息处理装置的耦合或锁定的方法改变及其方法
公开(公告)号：US20090038004A1
公开(公告)日：2009-02-05
申请号：US11831842
申请日：2007-07-31
申请人： Gabor Blasko
发明人： Gabor Blasko
IPC分类号： H04L9/32
CPC分类号： G06F21/35 , G06F21/32
摘要： An information handling system, comprising an information handling device containing memory for information specific to a particular role or function to be performed by a user of the device, having a display for displaying a portion of the information and functional portions for manipulating the information; and apparatus for coupling to the device, the apparatus being associated with a user of the device and containing information concerning identity and preferences of the user of the device. The apparatus acts a dock for receiving the device. A method comprising loading information from the apparatus to which the device is coupled so as to customize operation of the device. Information can include at least one of preferences, settings, authorization rights, security codes and programs preferred by a user of the apparatus. Role of the device may change in response to communications hardware for receiving signals indicative of location of the device, which changes roles based on the signals.
摘要翻译：一种信息处理系统，包括信息处理装置，该信息处理装置包含存储器，用于特定于要由设备的用户执行的特定角色或功能的信息，具有用于显示信息的一部分的显示和用于操纵信息的功能部分; 以及用于耦合到所述设备的设备，所述设备与所述设备的用户相关联并且包含关于所述设备的用户的身份和偏好的信息。该设备用于接收设备的坞站。一种方法，包括从设备耦合的设备加载信息，以便定制设备的操作。信息可以包括设备的用户优选的偏好，设置，授权权限，安全代码和程序中的至少一个。设备的角色可以响应于用于接收指示设备位置的信号的通信硬件而改变，该设备基于信号改变角色。

7. 发明授权

US5942506A 1-�2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives 失效
标题翻译： 1- [2-（取代的乙烯基）] - 5H-2,3-苯并二氮杂衍生物
公开(公告)号：US5942506A
公开(公告)日：1999-08-24
申请号：US599236
申请日：1996-02-09
申请人： Pal Vago , Jozsef Reiter , Istvan Gyertyan , Istvan Gacsalyi , Andras Bilkei-Gorzo , Andras Egyed , Ferenc Andrasi , Anna Bakonyi , Pal Berzsenyi , Hilda Botka , Tamas Hamori , Cecilia Salamon Haskane , Edit Horvath , Katalin Horvath , Peter Korosi , Gyorgyne Mate , Imre Moravcsik , Eszter Szentkuti , Gabor Zolyomi , Gabor Blasko , Klara Daroczi Kazone , Gyula Simig , Karoly Tihanyi , Judit Bajnogel
发明人： Pal Vago , Jozsef Reiter , Istvan Gyertyan , Istvan Gacsalyi , Andras Bilkei-Gorzo , Andras Egyed , Ferenc Andrasi , Anna Bakonyi , Pal Berzsenyi , Hilda Botka , Tamas Hamori , Cecilia Salamon Haskane , Edit Horvath , Katalin Horvath , Peter Korosi , Gyorgyne Mate , Imre Moravcsik , Eszter Szentkuti , Gabor Zolyomi , Gabor Blasko , Klara Daroczi Kazone , Gyula Simig , Karoly Tihanyi , Judit Bajnogel
IPC分类号： A61K31/55 , A61K31/551 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/22 , C07D243/02 , C07D243/04 , C07D403/06 , C07D405/06 , C07D409/06 , C07D491/04 , C07D491/056 , C07D493/04
CPC分类号： C07D405/06 , C07D243/02 , C07D491/04 , C07D493/04
摘要： This invention relates to new 1-�2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said benzodiazepine derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The compounds according to the invention correspond to the general formula (I), ##STR1## wherein the variables are herein below defined, and the compounds possess central nervous activities.
摘要翻译：本发明涉及新的1- [2-（取代的乙烯基）] - 5H-2,3-苯并二氮杂衍生物，其制备方法，包含其的药物组合物，涉及使用所述苯并二氮杂衍生物治疗疾病和用于制备适于治疗疾病的药物组合物。根据本发明的化合物对应于通式（I），其中变量在本文下面定义，并且化合物具有中枢神经活性。

8. 发明授权

US5439940A Benz[e]indene derivatives 失效
标题翻译：苯并[e]茚衍生物
公开(公告)号：US5439940A
公开(公告)日：1995-08-08
申请号：US141954
申请日：1993-10-28
申请人： Klara Reiter nee Eszes , Zoltan Budai , Tibor Mezei , Gabor Blasko , Gyula Simig , Istvan Gyertyan , Luiza Petocz , Marton Fekete , Katalin Szemeredi , Istvan Gacsalyi , Gabor Gigler , Ludmilla Rohacas nee Zamkovaja , Maria Szecsey nee Hegedus , Eniko Szirt nee Kiszelly
发明人： Klara Reiter nee Eszes , Zoltan Budai , Tibor Mezei , Gabor Blasko , Gyula Simig , Istvan Gyertyan , Luiza Petocz , Marton Fekete , Katalin Szemeredi , Istvan Gacsalyi , Gabor Gigler , Ludmilla Rohacas nee Zamkovaja , Maria Szecsey nee Hegedus , Eniko Szirt nee Kiszelly
IPC分类号： A61K31/15 , A61K31/16 , A61K31/335 , A61K31/336 , A61K31/395 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/44 , A61K31/4402 , A61K31/4427 , A61K31/495 , A61P25/04 , A61P25/20 , A61P29/00 , C07C13/547 , C07C249/04 , C07C251/58 , C07C269/02 , C07C271/60 , C07D209/48 , C07D213/74 , C07D239/24 , C07D239/34 , C07D241/04 , C07D295/08 , C07D295/088 , C07D303/12 , C07D401/02 , C07D401/04 , C07C251/54
CPC分类号： C07D209/48 , C07C251/58 , C07C271/60 , C07D213/74 , C07D239/34 , C07D295/088 , C07D303/12 , C07C2101/02 , C07C2101/14 , C07C2103/16
摘要： The invention relates to novel, pharmaceutically active benz[e]indene derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, further to the use of the said benz[e]indene derivatives in the treatment of certain diseases and in the preparation of pharmaceutical compositions suitable for the treatment of said diseases.The new benz[e]indene derivatives according to the invention correspond to the general formula ##STR1## wherein A represents a group of the formula alk-NR.sup.1 R.sup.2, wherein alk represents a C.sub.2-7 alkylene group optionally carrying a hydroxy substituent,R.sup.1 and R.sup.2 are independently hydrogen, C.sub.1-7 alkyl, C.sub.2-7 alkenyl, C.sub.2-7 alkynyl, mono(C.sub.1-7)alkylamino(C.sub.1-7)alkyl, di(C.sub.1-7)alkylamino(C.sub.1-7)alkyl or C.sub.3-7 cycloalkyl; orR.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form a 4 to 7 membered ring, optionally comprising an oxygen atom or a further nitrogen atom, which latter may carry a phenyl, benzyl, pyridyl, pyrimidinyl or C.sub.1-3 alkyl substituent which substituents may, in turn, bear a hydroxy or methoxy group or a halogen atom or a halophenyl group; orR.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form a phthalimido group; orA represents pyrimidino, 2,3-epoxypropyl or a group of the formula --C(O)NHR.sup.3, whereinR.sup.3 stands for C.sub.1-7 alkyl, C.sub.2-7 alkenyl or C.sub.3-8 cycloalkyl; andR denotes hydrogen or C.sub.1-7 alkyl,stereoisomers and optically active isomers and the possible mixtures thereof, further acid addition salts and quaternary ammonium derivatives of these compounds.
摘要翻译：本发明涉及新的药学活性苯并[e]茚衍生物，其制备方法，包含其的药物组合物，进一步使用所述苯并[e]茚衍生物在某些疾病的治疗中以及在制备适于治疗所述疾病的药物组合物。根据本发明的新的苯并[e]茚衍生物对应于通式（I）其中A表示式alk-NR1R2的基团，其中alk表示任选携带羟基取代基的C 2-7亚烷基， R1和R2独立地是氢，C1-7烷基，C2-7烯基，C2-7炔基，单（C1-7）烷基氨基（C1-7）烷基，二（C1-7）烷基氨基（C1-7）烷基或 C3-7环烷基; 或R 1和R 2与它们所连接的氮原子一起形成4至7元环，任选地包含氧原子或另外的氮原子，后者可以携带苯基，苄基，吡啶基，嘧啶基或C 1-3烷基取代基，其取代基又可以具有羟基或甲氧基或卤素原子或卤代苯基; 或R 1和R 2与它们所连接的氮原子一起形成苯二甲酰亚氨基; 或A表示嘧啶基，2,3-环氧丙基或式-C（O）NHR 3的基团，其中R 3表示C 1-7烷基，C 2-7烯基或C 3-8环烷基; R表示氢或C 1-7烷基，立体异构体和旋光异构体及其可能的混合物，这些化合物的其它酸加成盐和季铵衍生物。

9. 发明授权

US5276207A Process for preparing 1-[/2S/-methyl -3-mercapto-propionyl]-pyrrolidine-/2S/-carboxylic acid 失效
标题翻译：制备1 - [/ 2S-甲基-3-巯基丙酰基] - 吡咯烷-2-磺酸的方法
公开(公告)号：US5276207A
公开(公告)日：1994-01-04
申请号：US25413
申请日：1993-03-01
申请人： Geza Schneider , Gabor Blasko , Agnes Kovacs nee Palotai , Gabriella rmos nee Lassu , Ilma Dinnyes nee Nagy , Ivan Beck , Elemer Jakfalvi , Andras Dietz
发明人： Geza Schneider , Gabor Blasko , Agnes Kovacs nee Palotai , Gabriella rmos nee Lassu , Ilma Dinnyes nee Nagy , Ivan Beck , Elemer Jakfalvi , Andras Dietz
IPC分类号： A61K31/40 , A61K31/401 , A61P9/12 , C07D207/16
CPC分类号： C07D207/16
摘要： The invention relates to a novel process for preparing 1-[/2S/-methyl-3-mercaptopropionyl]-pyrrolidine-/2S/-carboxylic acid of the formula I ##STR1## in which 1-[/2S/-methyl-3-thiocyanatopropionyl]-pyrrolidine-/2S/-carboxylic acid of the formula II ##STR2## is dissolved in an aqueous mineral acid, the solution obtained is diluted with water and the 1-[/2S/-methyl-3-carbamoylthiopropionyl]-pyrrolidine-/2S/-carboxylic acid of the formula III ##STR3## that forms is hydrolized with an aqueous solution of a base.
摘要翻译：本发明涉及一种制备式I（I）的1- [/ 2S-甲基-3-巯基丙酰基] - 吡咯烷/ 2S-羧酸的新方法，其中1 - [/ 2S / （II）的3-甲基-3-氰硫基丙酰基] - 吡咯烷/ 2S-羧酸溶解在无机酸水溶液中，将所得溶液用水稀释，并将1 - [（2S） - 甲基 -3-氨基甲酰基硫代丙酰基] - 吡咯烷/ 2S-羧酸与形成的式III的水溶液一起水解。

10. 发明申请

US20060177227A1 Retractable string interface for stationary and portable devices 失效
公开(公告)号：US20060177227A1
公开(公告)日：2006-08-10
申请号：US11053451
申请日：2005-02-08
申请人： Gabor Blasko , Chandrasekhar Naravanaswami
发明人： Gabor Blasko , Chandrasekhar Naravanaswami
IPC分类号： H04B10/00
CPC分类号： G01C1/00
摘要： An interface for a small form factor electronic device by enabling explicit measurement of extension or retraction of a retractable cord by monitoring the amount of string that passes by sensors, as the string exits the enclosure of the device. Input to such small form factor devices may be provided by sensors that measure the length of a string or wire that has been pulled out of an enclosure, in addition to an angle or direction (e.g., in 1-, 2- or 3-dimensions) at which the string was pulled out. Additionally, the rate of acceleration for the pulling and retracting motion may also be used as additional forms of input. In a further embodiment, a string interface is provided for a small form factor device that communicates information in the form of a pixel display provided integral with the string in response to string manipulation.

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