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1. 发明授权

US4529589A Pharmaceutical composition for the treatment of diabetes mellitus 失效
标题翻译：用于治疗糖尿病的药物组合物
公开(公告)号：US4529589A
公开(公告)日：1985-07-16
申请号：US536578
申请日：1983-09-29
申请人： Anatoly B. Davydov , Eduard A. Babaian , Vladimir I. Metelitsa , Tamara P. Ostrovskaya , Rustam I. Utyamyshev , Gennady L. Khromov , Evgeny I. Chazov
发明人： Anatoly B. Davydov , Eduard A. Babaian , Vladimir I. Metelitsa , Tamara P. Ostrovskaya , Rustam I. Utyamyshev , Gennady L. Khromov , Evgeny I. Chazov
IPC分类号： C07D237/22 , A61K9/00 , A61K9/20 , A61K9/70 , A61K31/50 , A61K38/28 , A61K37/26 , A61K31/78 , A61K31/79
CPC分类号： A61K9/2027 , A61K38/28 , A61K9/006 , Y10S514/866
摘要： A pharmaceutical preparation for the treatment of diabetes mellitus comprising the following components, in percent by weight:______________________________________ crystalline insulin with a conventional 1 to 25.0 activity of 1 mg = 20 units additives inhibiting deactivation of insulin, 0.02 to 10.0 viz. 5-(para-[N--(3-methoxypyridazinyl-6)- sulphamido]-phenylazo)-salicylic acid, calcium gluconate or a mixture thereof preservatives 0.1 to 15.0 additives adjusting solubility of 0.01 to 10.0 insulin water-soluble polymeric base the balance. ______________________________________
摘要翻译：用于治疗糖尿病的药物制剂，其包含以重量百分比计的以下组分：具有常规1至25.0活性的1mg的结晶胰岛素=抑制胰岛素失活的20单位添加剂，0.02至10.0 5-（对 - [N-（3-甲氧基哒嗪基-6） - 磺酰氨基] - 苯偶氮） - 水杨酸，葡萄糖酸钙或其混合物防腐剂0.1至15.0添加剂调节溶解度为0.01至10.0胰岛素水溶性聚合物碱。

2. 发明授权

US4842854A Antianginal plate for treating ischemic heart disease 失效
标题翻译：用于治疗缺血性心脏病的抗骨质板
公开(公告)号：US4842854A
公开(公告)日：1989-06-27
申请号：US50526
申请日：1987-05-13
申请人： Eduard A. Babaian , Galina A. Gerasimova , Anatoly B. Davydov , Rustam I. Utyamyshev , Gennady L. Khromov , Vladimir I. Metelitsa , Anatoly M. Vikhert , Konstantin L. Savvateev , Vladimir K. Piotrovsky , Elizaveta B. Novikova
发明人： Eduard A. Babaian , Galina A. Gerasimova , Anatoly B. Davydov , Rustam I. Utyamyshev , Gennady L. Khromov , Vladimir I. Metelitsa , Anatoly M. Vikhert , Konstantin L. Savvateev , Vladimir K. Piotrovsky , Elizaveta B. Novikova
IPC分类号： A61K9/00 , A61K9/70
CPC分类号： A61K9/7007 , A61K9/006
摘要： An antianginal composition in the form of a plate is provided for treating ischemic heart disease and is comprised of a biologically soluble and resolvable film and an antianginal coronary vasodilating nitrate. This film is placed buccally on the gum or mouth mucosa for rapid arresting or prevention of angina pectoris attacks.The antianginal film is in the form of a plate, 0.1 to 1.5 mm thick, consisting of a biologically soluble and resolvable carrier. Preferably, the film is comprised of a homopolymer of acrylamide or vinylpyrrolidone, or a copolymer thereof with acrylate, containing from 99 to 70 percent by weight of acrylamide with vinylpyrrolidone and from 1 to 30 percent by weight of acrylate having a molecular mass from 50,000 to 1,000,000 and the active principle having antianginal action, the components being taken in the following proportions, in percent by weight:active substance having antianginal action: 3.0-30.0biologically soluble and resolvable carrier: 70.0-97.0
摘要翻译：提供板形式的抗心绞痛组合物用于治疗缺血性心脏病，并且由生物可溶性和可分辨的膜和抗心绞痛冠状动脉血管扩张硝酸盐组成。该胶片颊部放置在牙龈或口腔粘膜上，用于快速阻止或预防心绞痛发作。抗脊髓膜是由0.1至1.5mm厚的板，由生物可溶和可分辨的载体组成。优选地，该膜由丙烯酰胺或乙烯基吡咯烷酮的均聚物或其与丙烯酸酯的共聚物组成，其含有99至70重量％的丙烯酰胺与乙烯基吡咯烷酮和1至30重量％的分子量为50,000至 1,000,000，具有抗心绞痛作用的活性成分，按以下比例摄取组分，按重量％计：具有抗心绞痛作用的活性物质：3.0-30.0生物可溶性和可分辨载体：70.0-97。

3. 发明授权

US4921695A Antianginal plate for treating ischemic heart disease 失效
标题翻译：用于治疗缺血性心脏病的抗骨质板
公开(公告)号：US4921695A
公开(公告)日：1990-05-01
申请号：US320976
申请日：1989-03-09
申请人： Eduard A. Babaian , Galina A. Gerasimova , Anatoly B. Davydov , Rustam I. Utyamyshev , Gennady L. Khromov , Vladimir I. Metelitsa , Anatoly M. Vikhert , Konstantin L. Savvateev , Vladimir K. Piotrovsky , Elizaveta B. Novikova
发明人： Eduard A. Babaian , Galina A. Gerasimova , Anatoly B. Davydov , Rustam I. Utyamyshev , Gennady L. Khromov , Vladimir I. Metelitsa , Anatoly M. Vikhert , Konstantin L. Savvateev , Vladimir K. Piotrovsky , Elizaveta B. Novikova
IPC分类号： A61K9/00 , A61K9/22 , A61K9/70
CPC分类号： A61K9/006 , A61K9/7007
摘要： An antianginal composition in the form of a plate is provided for treating ischemic heart disease and is comprised of a biologically soluble and resolvable film and an antianginal coronary vasodilating nitrate. This film is placed buccally on the gum or mouth mucosa for rapid arresting or prevention of angina pectoris attacks.The antianginal film is in the form of a plate, 0.1 to 1.5 mm thick, consisting of a biologically soluble and resolvable carrier. Preferably, the film is comprised of a homoploymer of acrylamide or vinylpyrrolidone, or a copolymer thereof with acrylate, containing from 99 to 70 percent by weight of acrylamide with vinylpyrrolidone and from 1 to 30 percent by weight of acrylate having a molecular mass from 50,000 to 1,000,000, and the active principle having antianginal action, the components being taken in the following proportions, in percent by weight:______________________________________ active substance having 3.0-30.0 antianginal action biologically soluble and 70.0-97.0 resolvable carrier ______________________________________
摘要翻译：提供板形式的抗心绞痛组合物用于治疗缺血性心脏病，并且由生物可溶性和可分辨的膜和抗心绞痛冠状动脉血管扩张硝酸盐组成。该胶片颊部放置在牙龈或口腔粘膜上，用于快速阻止或预防心绞痛发作。抗脊髓膜是由0.1至1.5mm厚的板，由生物可溶和可分辨的载体组成。优选地，该膜由丙烯酰胺或乙烯基吡咯烷酮的共聚物或其与丙烯酸酯的共聚物组成，其含有99至70重量％的丙烯酰胺与乙烯基吡咯烷酮和1至30重量％的分子量为50,000至 1,000,000，并且具有抗心绞痛作用的活性成分，组分按以下比例以重量百分数表示： - 具有3.0-30.0-抗原作用 - 可溶性和70.0-97.0-可溶性载体的活性物质 -

4. 发明授权

US4713239A Antianginal film and method of treating ischemic heart disease 失效
标题翻译：抗骨质膜和治疗缺血性心脏病的方法
公开(公告)号：US4713239A
公开(公告)日：1987-12-15
申请号：US799210
申请日：1985-11-19
申请人： Eduard A. Babaian , Galina A. Gerasimova , Anatoly B. Davydov , Rustam I. Utyamyshev , Gennady L. Khromov , Vladimir I. Metelitsa , Anatoly M. Vikhert , Konstantin L. Savvateev , Vladimir K. Piotrovsky , Elizaveta B. Novikova
发明人： Eduard A. Babaian , Galina A. Gerasimova , Anatoly B. Davydov , Rustam I. Utyamyshev , Gennady L. Khromov , Vladimir I. Metelitsa , Anatoly M. Vikhert , Konstantin L. Savvateev , Vladimir K. Piotrovsky , Elizaveta B. Novikova
IPC分类号： A61K9/00 , A61K9/22 , A61K9/70 , A61K31/04
CPC分类号： A61K9/006 , A61K9/7007
摘要： The antianginal film is a plate, 0.1 to 1.5 thick, consisting of a biologically soluble and resolvable carrier, which is a hompolymer of acrylamide or vinylpyrrolidone, or a copolymer thereof with acrylate, containing from 99 to 70 percent by weight of acrylamide with vinylpyrrolidone and from 1 to 30 percent by weight of acrylate having a molecular mass from 50,000 to 1,000,000, and the active principle having antianginal action, the components being taken in the following proportions, in percent by weight:active substance having antianginal action 3.0-30.0biologically soluble and resolvable carrier 70.0-97.0The method of treating ischemic heart disease with the proposed antianginal film by individual doses, consists in that a biologically soluble and resolvable film without any active substance is first applied to a selected site of the mouth mucosa and the time during which this film is fully resolved is determined, this time being characteristic of the period during which the active substance is delivered into the patient's body. Next a medicinal film containing the active substance in the quantity which should be delivered into the patient's body during the time of the film resolution is selected. Finally the film containing the required quantity of the antianginal preparation is applied once or several times, to the selected site of the mouth mucosa to ensure continuous and optimal therapeutic effect during the entire period of the full resolution of the proposed film.
摘要翻译：抗心绞膜是0.1至1.5厚的平板，由生物可溶和可分辨的载体构成，其为丙烯酰胺或乙烯基吡咯烷酮的均聚物，或其与丙烯酸酯的共聚物，其含有99至70重量％的丙烯酰胺与乙烯基吡咯烷酮，以及 1至30重量％的分子量为50,000至1,000,000的丙烯酸酯，并且具有抗心绞痛作用的活性成分按以下比例以重量百分数表示：具有抗心绞痛作用的活性物质为3.0-30.0生物可溶性和可分辨载体70.0-97.0。通过单独剂量提出的抗心绞痛膜治疗缺血性心脏病的方法，在于首先将没有任何活性物质的生物可溶性和可分辨的膜应用于口腔粘膜的选定部位，这部电影完全解决了，这次是ac的时期的特征将有害物质输送到患者体内。接下来，选择含有活性物质的药膜，其量在胶片分解时应该输送到患者体内。最后，将含有所需量的抗心绞痛制剂的薄膜一次或数次施用于口腔粘膜的选定部位，以确保在所提出的膜的全部分辨率的整个期间内持续且最佳的治疗效果。

5. 发明授权

US5011493A Material for connecting members for inner soft tissues and organs 失效
标题翻译：用于内部软组织和器官的连接构件的材料
公开(公告)号：US5011493A
公开(公告)日：1991-04-30
申请号：US105460
申请日：1987-10-02
申请人： Sergei I. Belykh , Vladimir S. Gigauri , Anatoly B. Davydov , Viktor V. Keshelava , Vyacheslav E. Mlynchik , Rustam I. Utyamyshev , Elizaveta V. Firsova
发明人： Sergei I. Belykh , Vladimir S. Gigauri , Anatoly B. Davydov , Viktor V. Keshelava , Vyacheslav E. Mlynchik , Rustam I. Utyamyshev , Elizaveta V. Firsova
IPC分类号： A61L24/04 , A61B17/04 , A61L24/00 , A61L24/06 , A61L31/04 , A61L31/14
CPC分类号： A61L31/148 , A61L24/0042 , A61L24/06 , A61L31/048 , A61B17/04
摘要： A material for connecting members for soft tissues and inner organs which consists of a copolymer of N-vinylpyrrolidone and alkyl esters of acrylic and/or methacrylic acid containing in the alkyl group 2 to 8 carbon atoms at the following proportions of the components, molar percent:______________________________________ N-vinylpyrrolidone 40-90 alkyl esters of acrylic and/or methacrylic acid 10-60. ______________________________________
摘要翻译：用于连接软组织和内脏的构件的材料，其由N-乙烯基吡咯烷酮和丙烯酸和/或甲基丙烯酸的烷基酯的共聚物组成，所述丙烯酸和/或甲基丙烯酸的含量为2-8个碳原子的烷基，组分的摩尔百分数：N-乙烯基吡咯烷酮40-90-丙烯酸和/或 - 甲基丙烯酸10-60-烷基酯。 -

6. 发明授权

US4875479A Sutural material 失效
标题翻译：缝合材料
公开(公告)号：US4875479A
公开(公告)日：1989-10-24
申请号：US191149
申请日：1988-02-19
申请人： Sergei I. Belykh , Anatoly B. Davydov , Anatoly D. Moschensky , Nikolai N. Kanshin , Igor L. Kovalenko , Jury B. Kirillov , Gennady I. Osipov , Rustam I. Utyamyshev
发明人： Sergei I. Belykh , Anatoly B. Davydov , Anatoly D. Moschensky , Nikolai N. Kanshin , Igor L. Kovalenko , Jury B. Kirillov , Gennady I. Osipov , Rustam I. Utyamyshev
IPC分类号： A61L17/00 , A61L15/00 , A61L17/10
CPC分类号： A61L17/10 , Y10S525/937
摘要： The sutural material consists of a base from a bio-resolvable polymer and a layer of a copolymer of N-vinylpyrrolidone with an alkylacrylate and/or an alkylmethacrylate deposited onto the base and containing an antimicrobal preparation or a mixture of preparations and having the period of its biodestruction shorter than that of the base, the thickness of this layer being equal to 0.1 to 1.0 of the base thickness.
摘要翻译： PCT No.PCT / SU86 / 00072 Sec。 371日期1988年2月19日 102（e）日期1988年2月19日PCT提交1986年7月4日PCT公布。第WO88 / 00062号公报日期：1988年1月14日。缝合材料由生物可分解的聚合物的基底和N-乙烯基吡咯烷酮与丙烯酸烷基酯和/或甲基丙烯酸烷基酯的共聚物层沉积到基底上并含有抗微生物制剂或混合物的制剂，其生物破坏时间短于基底的周期，该层的厚度等于基底厚度的0.1至1.0。

7. 发明授权

US5075105A Composition for treatment of progressive myopia 失效
标题翻译：用于治疗进展性MYOPIA的组合物
公开(公告)号：US5075105A
公开(公告)日：1991-12-24
申请号：US678269
申请日：1991-04-23
申请人： Eduard S. Avetisov , Maya I. Vinetskaya , Elena N. Iomdina , Zulfia K. Boltaeva , Gennady L. Khromov , Antonina A. Dolgopyatova , Anatoly B. Davydov , Elena P. Tarutta , Ljudmila D. Andreeva
发明人： Eduard S. Avetisov , Maya I. Vinetskaya , Elena N. Iomdina , Zulfia K. Boltaeva , Gennady L. Khromov , Antonina A. Dolgopyatova , Anatoly B. Davydov , Elena P. Tarutta , Ljudmila D. Andreeva
IPC分类号： A61K31/44 , A61F9/00 , A61K9/00 , A61K9/107 , A61K31/30 , A61K31/78 , A61K31/79 , A61K33/22 , A61K33/26 , A61K33/40 , A61K33/44 , A61K47/24 , A61K47/30 , A61P27/02
CPC分类号： A61K31/79 , A61K33/40 , A61K9/0048
摘要： The invention relates to medicine.A composition for treatment of progressive myopia is composed of the following constituents, taken in mass percent:______________________________________ a mixture of polyvinylpyrrolidone, acrylamide- 18.8 to 29.5 hydrazide, and ethylacrylate (1;1;1) an aqueous solution, containing the follow- 69.5 to 80.1 ing ingredients, taken in mg/l: hydrochloric acid 940.0 boric acid 4.12 ferrous oxide 115.0 cupric citrate 16.0 3-percent aqueous hydrogen peroxide 0.79 to 0.89 dichlorodi-[ 2-methyl-3-hydroxy-4,5-di- 0.11 to 0.31. (hydroxymethyl)-pyridine] of copper (II) ______________________________________

8. 发明授权

US4263185A Biodestructive material for bone fixation elements 失效
标题翻译：用于骨固定元件的生物破坏性材料
公开(公告)号：US4263185A
公开(公告)日：1981-04-21
申请号：US80296
申请日：1979-10-01
申请人： Sergei I. Belykh , Anatoly B. Davydov , Gennady L. Khromov , Anatoly D. Moschensky , Ilya A. Movshovich , Gennady I. Roitberg , Gennady L. Voskresensky , Gely G. Pershin , Valery A. Moskvitin
发明人： Sergei I. Belykh , Anatoly B. Davydov , Gennady L. Khromov , Anatoly D. Moschensky , Ilya A. Movshovich , Gennady I. Roitberg , Gennady L. Voskresensky , Gely G. Pershin , Valery A. Moskvitin
IPC分类号： A61L31/12 , A61L31/14 , C08L77/06 , C08L1/04 , C08L33/10 , C08L33/26 , C08L39/06
CPC分类号： A61L31/148 , A61L31/129
摘要： This invention relates to medical technique and more particularly it relates to biodestructive materials used to manufacture elements for fixation of bone fragments.Said material contains a matrix of non-toxic polymer resolvable in the body consisting of hydrophilic and hydrophobic repeat units, and a reinforcing component of non-toxic fibres or threads resolvable in the body. The matrix polymer is preferably a copolymer of methyl methacrylate and N-vinyl pyrrolidone, and the reinforcing component is preferably fibre or threads of polyamide and oxycellulose.Said material can be used in medicine for fixation of bone fragments in fractures or injuries of bones.
摘要翻译：本发明涉及医疗技术，更具体地说，涉及用于制造用于固定骨碎片的元件的生物破坏性材料。所述材料包含在体内可分解的无毒聚合物的基质，其由亲水和疏水的重复单元组成，以及在体内可分解的无毒纤维或线的增强成分。基质聚合物优选为甲基丙烯酸甲酯和N-乙烯基吡咯烷酮的共聚物，增强成分优选为聚酰胺和氧化纤维素的纤维或线。所述材料可用于固定骨碎片骨折或骨骼损伤的药物。

9. 发明授权

US4999188A Methods for embolization of blood vessels 失效
标题翻译：血管栓塞方法
公开(公告)号：US4999188A
公开(公告)日：1991-03-12
申请号：US362503
申请日：1989-06-07
申请人： Valentin D. Solodovnik , Tatyana I. Solodkaya , Maria T. Litvinova , Taisa A. Meshkova , Alexandra V. Usova , Anatoly B. Davydov
发明人： Valentin D. Solodovnik , Tatyana I. Solodkaya , Maria T. Litvinova , Taisa A. Meshkova , Alexandra V. Usova , Anatoly B. Davydov
IPC分类号： A61K31/765 , A61K9/00 , A61K31/715 , A61K31/74 , A61K31/77 , A61K31/78 , A61K31/79 , A61K33/26 , A61K45/08 , A61K47/10 , A61K49/04 , A61L31/00 , A61P7/04
CPC分类号： A61K31/74 , A61K47/10 , A61K49/0414 , A61K9/0019 , A61L24/046 , A61L2430/36
摘要： A composition for embolization of blood vessels contains the following ingredients in weight percent:______________________________________ particles of an embolizing material from 0.01 to 15.0 polyalkyleneoxide from 0.02 to 0.2 fluid medium the balance. ______________________________________ The composition can be used in surgery for reducing blood supply of individual organs, preventing haemorrhage, producing ischemia of malignant tumors and many other cases.
摘要翻译：用于血管栓塞的组合物包含以重量百分比计的以下成分： - 0.02至0.2-流体介质中的0.01至15.0-聚环氧烷的栓塞材料 - 余量。 - 该组合物可用于手术中以减少单个器官的血液供应，预防出血，产生恶性肿瘤缺血和许多其他病例。

10. 发明授权

US4981483A Biocompatible material for treatment of tissular or organic defects 失效
标题翻译：用于治疗组织或有机缺陷的生物相容性材料
公开(公告)号：US4981483A
公开(公告)日：1991-01-01
申请号：US266633
申请日：1988-08-23
申请人： Alla Y. Akimova , Anatoly B. Davydov , Valery N. Egiev , Anna I. Iliina , Jury P. Kapustin , Anesty K. Orfanidi , Alexei N. Smirnov , Eduard A. Stepanov , Valeria I. Timokhina , Anatoly Nikolaevich Chigir , Kirill G. Schitkov
发明人： Alla Y. Akimova , Anatoly B. Davydov , Valery N. Egiev , Anna I. Iliina , Jury P. Kapustin , Anesty K. Orfanidi , Alexei N. Smirnov , Eduard A. Stepanov , Valeria I. Timokhina , Anatoly Nikolaevich Chigir , Kirill G. Schitkov
IPC分类号： A61K31/78 , A61L24/06 , A61L26/00 , A61L27/00 , A61P17/00 , A61P43/00
CPC分类号： A61L24/06 , A61L26/0014 , Y10S623/92
摘要： A biocompatible material for treatment of tissular or organic defects is composed of a graft copolymer of alpha-cyanacrylate and polyacrylic acid having a molecular weight of 200,000 to 600,000, obtained by interaction of alpha-cyanacrylate with polyacrylic acid in the presence of a cross-linking agent, the weight percentage ratio of the aforesaid components being as follows:______________________________________ alpha-cyanacrylate 14 to 34 polyacrylic acid having a molecular weight of 200,000 to 600,000 15 to 43 cross-linking agent 71 to 23 ______________________________________ .
摘要翻译： PCT No.PCT / SU87 / 00002 Sec。 371日期1988年8月23日 102（e）日期1988年8月23日PCT提交1987年1月14日PCT公布。出版物WO88 / 05311 PCT 日本1987年7月28日。用于治疗组织或有机缺陷的生物相容性材料由α-氰基丙烯酸酯和聚丙烯酸的接枝共聚物组成，分子量为200,000至600,000，通过α-氰基丙烯酸酯与聚丙烯酸的相互作用获得交联剂的存在，上述成分的重量百分比如下：α-氰基丙烯酸酯14〜34-聚丙烯酸，分子量为-200,000〜600,000 15〜43交联剂71〜 23 - 。

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