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1. 发明申请

US20090318627A1 SOLID PHASE SYNTHESIS OF ACRIDINIUM DERIVATIVES 审中-公开
标题翻译：茜素衍生物的固相合成
公开(公告)号：US20090318627A1
公开(公告)日：2009-12-24
申请号：US12278621
申请日：2007-02-06
申请人： Anand Natrajan , David Sharpe , Jim Costello , Qingping Jiang
发明人： Anand Natrajan , David Sharpe , Jim Costello , Qingping Jiang
IPC分类号： C08G63/91 , C07D219/00 , C07J43/00 , C07K2/00 , C07H21/00
CPC分类号： C07D219/04
摘要： Acridinium-functionalized solid-phase supports and methods for making acridinium-functionalized solid-phase supports are disclosed. The acridinium-functionalized solid-phase supports comprise a solid phase support linked to a chemiluminescent substituted acridinium compound through a linker group covalently attached to the nitrogen atom of the acridinium nucleus and the solid phase support as exemplified in FIG. 1.
摘要翻译：公开了吖啶鎓官能化固相载体和制备吖啶酮官能化固相载体的方法。吖啶酮官能化的固相载体包括通过共价连接到吖啶核的氮原子的连接基团和固相载体连接到化学发光的取代的吖啶鎓化合物的固相载体，如图1所示。 1。

2. 发明申请

US20100099077A1 STABLE ACRIDINIUM ESTERS WITH FAST LIGHT EMISSION 有权
标题翻译：具有快速发光的稳定的阿司匹林
公开(公告)号：US20100099077A1
公开(公告)日：2010-04-22
申请号：US12445304
申请日：2007-10-15
申请人： Anand Natrajan , Qingping Jiang , David Sharpe
发明人： Anand Natrajan , Qingping Jiang , David Sharpe
IPC分类号： C12Q1/70 , C07D219/00 , C07D401/02 , G01N21/76 , G01N33/00 , G01N33/543 , G01N33/53
CPC分类号： C07D219/04 , Y10T436/13 , Y10T436/143333 , Y10T436/21
摘要： Chemiluminescent acridinium esters are provided which are fast light emitting and hydrolytically stable. The chemiluminescent acridinium esters are useful labels in assays for detecting or quantifying analytes.
摘要翻译：提供化学发光的吖啶酯，其具有快速发光和水解稳定性。化学发光吖啶酯是用于检测或定量分析物的测定中的有用标签。

3. 发明授权

US07611909B1 Near infrared chemiluminescent acridinium compounds and uses thereof 有权
标题翻译：近红外化学发光吖啶化合物及其用途
公开(公告)号：US07611909B1
公开(公告)日：2009-11-03
申请号：US11266902
申请日：2005-11-04
申请人： Anand Natrajan , Qingping Jiang , David Sharpe , Say-Jong Law
发明人： Anand Natrajan , Qingping Jiang , David Sharpe , Say-Jong Law
IPC分类号： G01N33/533 , G01N21/76 , G01N33/53
CPC分类号： G01N33/582 , C07D219/04 , Y10S436/80 , Y10S436/815 , Y10S436/817 , Y10S530/812 , Y10T436/13
摘要： A method for the detection or quantitation of unlabeled target analyte in a biological sample, the method comprising labeling a target analyte for a biological sample suspected of containing unlabeled target analyte with an acridinium compound to form a labeled target analyte and providing the labeled target analyte to the biological sample, or providing the labeled target analyte to the biological sample, wherein the acridinium compound comprises an acridinium nucleus having an electron-donating substituent directly attached to the acridinium nucleus, with the electron-donating substituent attached at the C2 position. Chemiluminescent acridinium compounds useful in the method have emission maxima close to or in the near infrared (NIR) region (>590 nm). These chemiluminescent acridinium compounds when used in conjunction with short wavelength-emitting acridinium esters (with emission maxima below 450 nm) can be highly useful labels for the simultaneous detection of multiple target analytes in a single assay.
摘要翻译：一种用于检测或定量生物样品中未标记的靶分析物的方法，所述方法包括用怀疑含有未标记的靶分析物的生物样品用吖啶鎓化合物标记目标分析物以形成标记的目标分析物，并将标记的目标分析物生物样品或将标记的靶分析物提供给生物样品，其中吖啶鎓化合物包含具有直接连接到吖啶核的给电子取代基的吖啶核，其中给电子取代基连接在C2位置。可用于该方法的化学发光吖啶鎓化合物具有接近或在近红外（NIR）区域（> 590nm）中的发射最大值。当与短波长发射的吖啶酯（发射最大值低于450nm）结合使用时，这些化学发光吖啶鎓化合物可以是在单次测定中同时检测多种靶分析物的非常有用的标记。

4. 发明申请

US20060202179A1 Chemiluminescent Acridinium Compounds and Analogues thereof as Substrates of Hydrolytic Enzymes 有权
标题翻译：化学发光吖啶鎓化合物及其类似物作为水解酶的底物
公开(公告)号：US20060202179A1
公开(公告)日：2006-09-14
申请号：US11422095
申请日：2006-06-05
申请人： Qingping Jiang , Anand Natrajan , David Sharpe , Wen-Jee Wong , Say-Jong Law
发明人： Qingping Jiang , Anand Natrajan , David Sharpe , Wen-Jee Wong , Say-Jong Law
IPC分类号： C09K3/00
CPC分类号： C07D491/10 , C07D219/04 , C07F9/64 , C12Q1/42 , C12Q2334/00 , G01N33/533 , G01N33/582
摘要： A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows: Lumi-M-P Formula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached and (c) with M attached. Examples of Lumi include chemiluminescent acridinium compounds, benzacridinium compounds, quinolinium compounds, isoquinolinium compounds, phenanthridinium compounds, and lucigenin compounds, spiroacridan compounds, luminol compounds and isoluminol compounds. M is a multivalent heteroatom having at least one lone pair of electrons selected from oxygen, nitrogen and sulfur, directly attached to the light emitting moiety of Lumi at one end and to P at the other end. P is a group that can be readily removed by hydrolytic enzymes. An enzymatic reaction utilizing the above compound is the following: where HE is a hydrolytic enzyme. Lumi-M is a chemiluminescent product having physical and/or chemical properties different from those of Lumi-M-P.
摘要翻译：公开了具有以下通式I的水解酶的化学发光底物，如下所示：<？in-line-formula description =“In-line Formulas”end =“lead”？> Lumi-MP Formula I < line-formula description =“In-line Formulas”end =“tail”？>其中“Lumi”是能够自身产生光的化学发光部分（a），（b）MP附着和（c）附着M的化学发光部分。 Lumi的实例包括化学发光吖啶鎓化合物，苯并吖啶鎓化合物，喹啉鎓化合物，异喹啉鎓化合物，菲啶鎓化合物和光合精化合物，螺吡啶化合物，鲁米诺化合物和异鲁米诺化合物。 M是具有至少一个选自氧，氮和硫的孤对电子的多价杂原子，其一端直接连接到Lumi的发光部分，另一端直接附着于P。 P是可以通过水解酶容易地除去的基团。使用上述化合物的酶反应如下：其中HE是水解酶。 Lumi-M是具有与Lumi-M-P不同的物理和/或化学性质的化学发光产物。

5. 发明授权

US07083986B2 Near infrared chemiluminescent acridinium compounds and uses thereof 有权
标题翻译：近红外化学发光吖啶化合物及其用途
公开(公告)号：US07083986B2
公开(公告)日：2006-08-01
申请号：US10006421
申请日：2001-12-06
申请人： Anand Natrajan , Qingping Jiang , David Sharpe , Say-Jong Law
发明人： Anand Natrajan , Qingping Jiang , David Sharpe , Say-Jong Law
IPC分类号： G01N33/533 , G01N33/78 , G01N33/554 , G01N33/569 , C12Q1/68
CPC分类号： G01N33/582 , C07D219/04 , Y10S436/80 , Y10S436/815 , Y10S436/817 , Y10S530/812 , Y10T436/13
摘要： A method for the detection or quantitation of an analyte in a biological sample is disclosed. The method comprises the steps of selecting a biological sample suspected of containing a target analyte and binding the target analyte in the sample to a binding partner conjugated to an acridinium compound, wherein the acridinium compound comprises an acridinium nucleus having an electron-donating substituent directly attached to the acridinium nucleus at the C2 position. Chemiluminescent acridinium compounds useful in the method have emission maxima close to or in the near infrared (NIR) region (>590 nm). These chemiluminescent acridinium compounds when used in conjunction with short wavelength-emitting acridinium esters (with emission maxima below 450 nm) can be highly useful labels for the simultaneous detection of multiple target analytes in a single assay.
摘要翻译：公开了用于检测或定量生物样品中的分析物的方法。该方法包括以下步骤：选择怀疑含有目标分析物并将样品中的目标分析物结合到与吖啶鎓化合物结合的结合对象的生物样品，其中所述吖啶鎓化合物包含具有直接连接的给电子取代基的吖啶核到C> 2位上的吖啶核。可用于该方法的化学发光吖啶鎓化合物具有接近或在近红外（NIR）区域（> 590nm）中的发射最大值。当与短波长发射的吖啶酯（发射最大值低于450nm）结合使用时，这些化学发光吖啶鎓化合物可以是在单次测定中同时检测多种靶分析物的非常有用的标记。

6. 发明申请

US20120225497A1 ZWITTERION-CONTAINING ACRIDINIUM COMPOUNDS 有权
标题翻译：含ZWITTERION的含有化合物
公开(公告)号：US20120225497A1
公开(公告)日：2012-09-06
申请号：US13510158
申请日：2010-11-12
申请人： Anand Natrajan , David Sharpe , Qingping Jiang
发明人： Anand Natrajan , David Sharpe , Qingping Jiang
IPC分类号： G01N33/543 , C07D401/12
CPC分类号： G01N33/54393 , C07D219/04 , C07D219/14 , C07D401/12 , C09B15/00 , Y10T436/13
摘要： Hydrophilic, chemiluminescent acridinium compounds containing zwitterions are disclosed. These acridinium compounds, when used as chemiluminescent labels in immunochemistry assays and the like, exhibit decreased non-specific binding to solid phases and provide increased assay sensitivity.
摘要翻译：公开了含有两性离子的亲水的，化学发光的吖啶鎓化合物。当这些吖啶鎓化合物在免疫化学测定等中用作化学发光标记时，表现出与固相的非特异性结合降低并提供增加的测定灵敏度。

7. 发明授权

US07785904B2 High quantum yield acridinium compounds and their uses in improving assay sensitivity 有权
标题翻译：高量子产率吖啶鎓化合物及其在提高测定灵敏度方面的应用
公开(公告)号：US07785904B2
公开(公告)日：2010-08-31
申请号：US11764924
申请日：2007-06-19
申请人： Anand Natrajan , Qingping Jiang , David Sharpe , James Costello
发明人： Anand Natrajan , Qingping Jiang , David Sharpe , James Costello
IPC分类号： G01N33/533 , G01N21/76 , G01N33/53 , C07D219/00
CPC分类号： G01N33/533 , B82Y15/00 , C07D219/04 , C07D219/06 , G01N33/542 , G01N33/582 , G01N33/588 , Y10S435/968 , Y10S436/80 , Y10S436/805
摘要： The present invention relates to hydrophilic, high quantum yield acridinium compounds. It has been discovered that the placement of electron-donating groups in the acridinium ring system increases the amount of light that is emitted by the corresponding acridinium compound when its chemiluminescence is triggered by alkaline peroxide. More specifically, it has been found that the placement of one or two hydrophilic, alkoxy groups at the C-2 and/or C-7 position of the acridinium ring system of acridinium compounds increases their quantum yield and enhances the aqueous solubility of these compounds. The present hydrophilic, high quantum yield, acridinium compounds are useful chemiluminescent labels for improving the sensitivity of immunoassays.
摘要翻译：本发明涉及亲水性高量子产率吖啶鎓化合物。已经发现，当其化学发光由碱性过氧化物触发时，电子给体基团在吖啶环体系中的放置增加了相应的吖啶鎓化合物发射的光的量。更具体地，已经发现，在吖啶鎓化合物的吖啶环体系的C-2和/或C-7位置上放置一个或两个亲水性烷氧基增加其量子产率并增强这些化合物的水溶性。本发明的亲水性，高量子产率的吖啶化合物是有用的化学发光标记，用于提高免疫测定的灵敏度。

8. 发明授权

US07459284B2 Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes 有权
标题翻译：化学发光吖啶鎓化合物及其类似物作为水解酶的底物
公开(公告)号：US07459284B2
公开(公告)日：2008-12-02
申请号：US11422095
申请日：2006-06-05
申请人： Qingping Jiang , Anand Natrajan , David Sharpe , Wen-Jee Wong , Say-Jong Law
发明人： Qingping Jiang , Anand Natrajan , David Sharpe , Wen-Jee Wong , Say-Jong Law
IPC分类号： C12Q1/34 , C07D219/02
CPC分类号： C07D491/10 , C07D219/04 , C07F9/64 , C12Q1/42 , C12Q2334/00 , G01N33/533 , G01N33/582
摘要： A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows: Lumi-M-P Formula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached and (c) with M attached. Examples of Lumi include chemiluminescent acridinium compounds, benzacridinium compounds, quinolinium compounds, isoquinolinium compounds, phenanthridinium compounds, and lucigenin compounds, spiroacridan compounds, luminol compounds and isoluminol compounds. M is a multivalent heteroatom having at least one lone pair of electrons selected from oxygen, nitrogen and sulfur, directly attached to the light emitting moiety of Lumi at one end and to P at the other end. P is a group that can be readily removed by hydrolytic enzymes. An enzymatic reaction utilizing the above compound is the following: where HE is a hydrolytic enzyme. Lumi-M is a chemiluminescent product having physical and/or chemical properties different from those of Lumi-M-P.
摘要翻译：公开了具有以下通式I的水解酶的化学发光底物，如下所示：<？in-line-formula description =“In-line Formulas”end =“lead”？> Lumi-MP Formula I < line-formula description =“In-line Formulas”end =“tail”？>其中“Lumi”是能够自身产生光的化学发光部分（a），（b）MP附着和（c）附着M的化学发光部分。 Lumi的实例包括化学发光吖啶鎓化合物，苯并吖啶鎓化合物，喹啉鎓化合物，异喹啉鎓化合物，菲啶鎓化合物和光合精化合物，螺吡啶化合物，鲁米诺化合物和异鲁米诺化合物。 M是具有至少一个选自氧，氮和硫的孤对电子的多价杂原子，其一端直接连接到Lumi的发光部分，另一端直接附着于P。 P是可以通过水解酶容易地除去的基团。使用上述化合物的酶反应如下：其中HE是水解酶。 Lumi-M是具有与Lumi-M-P不同的物理和/或化学性质的化学发光产物。

9. 发明申请

US20080014660A1 High Quantum Yield Acridinium Compounds and Their Uses in Improving Assay Sensitivity 有权
标题翻译：高量子产率吖啶鎓化合物及其用途提高了测定灵敏度
公开(公告)号：US20080014660A1
公开(公告)日：2008-01-17
申请号：US11764924
申请日：2007-06-19
申请人： Anand Natrajan , Qingping Jiang , David Sharpe , James Costello
发明人： Anand Natrajan , Qingping Jiang , David Sharpe , James Costello
IPC分类号： G01N33/543
CPC分类号： G01N33/533 , B82Y15/00 , C07D219/04 , C07D219/06 , G01N33/542 , G01N33/582 , G01N33/588 , Y10S435/968 , Y10S436/80 , Y10S436/805
摘要： The present invention relates to hydrophilic, high quantum yield acridinium compounds. It has been discovered that the placement of electron-donating groups in the acridinium ring system increases the amount of light that is emitted by the corresponding acridinium compound when its chemiluminescence is triggered by alkaline peroxide. More specifically, it has been found that the placement of one or two hydrophilic, alkoxy groups at the C-2 and/or C-7 position of the acridinium ring system of acridinium compounds increases their quantum yield and enhances the aqueous solubility of these compounds. The present hydrophilic, high quantum yield, acridinium compounds are useful chemiluminescent labels for improving the sensitivity of immunoassays.
摘要翻译：本发明涉及亲水性高量子产率吖啶鎓化合物。已经发现，当其化学发光由碱性过氧化物触发时，电子给体基团在吖啶环体系中的放置增加了相应的吖啶鎓化合物发射的光的量。更具体地，已经发现，在吖啶鎓化合物的吖啶环体系的C-2和/或C-7位置上放置一个或两个亲水性烷氧基增加其量子产率并增强这些化合物的水溶性。本发明的亲水性，高量子产率的吖啶化合物是有用的化学发光标记，用于提高免疫测定的灵敏度。

10. 发明申请

US20050032147A1 Chemiluminescent acridinum compounds and analogues thereof as substrates of hydrolytic enzymes 有权
标题翻译：化学发光的吖啶化合物及其类似物作为水解酶的底物
公开(公告)号：US20050032147A1
公开(公告)日：2005-02-10
申请号：US10928300
申请日：2004-08-27
申请人： Qingping Jiang , Anand Natrajan , David Sharpe , Wen-Jee Wong , Say-Jong Law
发明人： Qingping Jiang , Anand Natrajan , David Sharpe , Wen-Jee Wong , Say-Jong Law
IPC分类号： C07D219/04 , C07D491/10 , C07F9/64 , C12Q1/42 , C12Q1/34 , C07H17/02
CPC分类号： C07D491/10 , C07D219/04 , C07F9/64 , C12Q1/42 , C12Q2334/00 , G01N33/533 , G01N33/582
摘要： A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows: Lumi-M-P Formula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached and (c) with M attached. Examples of Lumi include chemiluminescent acridinium compounds, benzacridinium compounds, quinolinium compounds, isoquinolinium compounds, phenanthridinium compounds, and lucigenin compounds, spiroacridan compounds, luminol compounds and isoluminol compounds. M is a multivalent heteroatom having at least one lone pair of electrons selected from oxygen, nitrogen and sulfur, directly attached to the light emitting moiety of Lumi at one end and to P at the other end. P is a group that can be readily removed by hydrolytic enzymes. An enzymatic reaction utilizing the above compound is the following: where HE is a hydrolytic enzyme. Lumi-M is a chemiluminescent product having physical and/or chemical properties different from those of Lumi-M-P.
摘要翻译：具有以下通式I的水解酶的化学发光底物公开如下：Lumi-MP式I其中“Lumi”是能够自身产生光的化学发光部分（a），（b）MP附着和（ c）与M连接。 Lumi的实例包括化学发光吖啶鎓化合物，苯并吖啶鎓化合物，喹啉鎓化合物，异喹啉鎓化合物，菲啶鎓化合物和光合精化合物，螺吡啶化合物，鲁米诺化合物和异鲁米诺化合物。 M是具有至少一个选自氧，氮和硫的孤对电子的多价杂原子，其一端直接连接到Lumi的发光部分，另一端直接附着于P。 P是可以通过水解酶容易地除去的基团。使用上述化合物的酶反应如下：其中HE是水解酶。 Lumi-M是具有与Lumi-M-P不同的物理和/或化学性质的化学发光产物。

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