会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 5. 发明授权
    • Near infrared chemiluminescent acridinium compounds and uses thereof
    • 近红外化学发光吖啶化合物及其用途
    • US07611909B1
    • 2009-11-03
    • US11266902
    • 2005-11-04
    • Anand NatrajanQingping JiangDavid SharpeSay-Jong Law
    • Anand NatrajanQingping JiangDavid SharpeSay-Jong Law
    • G01N33/533G01N21/76G01N33/53
    • G01N33/582C07D219/04Y10S436/80Y10S436/815Y10S436/817Y10S530/812Y10T436/13
    • A method for the detection or quantitation of unlabeled target analyte in a biological sample, the method comprising labeling a target analyte for a biological sample suspected of containing unlabeled target analyte with an acridinium compound to form a labeled target analyte and providing the labeled target analyte to the biological sample, or providing the labeled target analyte to the biological sample, wherein the acridinium compound comprises an acridinium nucleus having an electron-donating substituent directly attached to the acridinium nucleus, with the electron-donating substituent attached at the C2 position. Chemiluminescent acridinium compounds useful in the method have emission maxima close to or in the near infrared (NIR) region (>590 nm). These chemiluminescent acridinium compounds when used in conjunction with short wavelength-emitting acridinium esters (with emission maxima below 450 nm) can be highly useful labels for the simultaneous detection of multiple target analytes in a single assay.
    • 一种用于检测或定量生物样品中未标记的靶分析物的方法,所述方法包括用怀疑含有未标记的靶分析物的生物样品用吖啶鎓化合物标记目标分析物以形成标记的目标分析物,并将标记的目标分析物 生物样品或将标记的靶分析物提供给生物样品,其中吖啶鎓化合物包含具有直接连接到吖啶核的给电子取代基的吖啶核,其中给电子取代基连接在C2位置。 可用于该方法的化学发光吖啶鎓化合物具有接近或在近红外(NIR)区域(> 590nm)中的发射最大值。 当与短波长发射的吖啶酯(发射最大值低于450nm)结合使用时,这些化学发光吖啶鎓化合物可以是在单次测定中同时检测多种靶分析物的非常有用的标记。
    • 6. 发明申请
    • Chemiluminescent Acridinium Compounds and Analogues thereof as Substrates of Hydrolytic Enzymes
    • 化学发光吖啶鎓化合物及其类似物作为水解酶的底物
    • US20060202179A1
    • 2006-09-14
    • US11422095
    • 2006-06-05
    • Qingping JiangAnand NatrajanDavid SharpeWen-Jee WongSay-Jong Law
    • Qingping JiangAnand NatrajanDavid SharpeWen-Jee WongSay-Jong Law
    • C09K3/00
    • C07D491/10C07D219/04C07F9/64C12Q1/42C12Q2334/00G01N33/533G01N33/582
    • A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows: Lumi-M-P   Formula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached and (c) with M attached. Examples of Lumi include chemiluminescent acridinium compounds, benzacridinium compounds, quinolinium compounds, isoquinolinium compounds, phenanthridinium compounds, and lucigenin compounds, spiroacridan compounds, luminol compounds and isoluminol compounds. M is a multivalent heteroatom having at least one lone pair of electrons selected from oxygen, nitrogen and sulfur, directly attached to the light emitting moiety of Lumi at one end and to P at the other end. P is a group that can be readily removed by hydrolytic enzymes. An enzymatic reaction utilizing the above compound is the following: where HE is a hydrolytic enzyme. Lumi-M is a chemiluminescent product having physical and/or chemical properties different from those of Lumi-M-P.
    • 公开了具有以下通式I的水解酶的化学发光底物,如下所示:<?in-line-formula description =“In-line Formulas”end =“lead”?> Lumi-MP Formula I < line-formula description =“In-line Formulas”end =“tail”?>其中“Lumi”是能够自身产生光的化学发光部分(a),(b)MP附着和(c)附着M的化学发光部分。 Lumi的实例包括化学发光吖啶鎓化合物,苯并吖啶鎓化合物,喹啉鎓化合物,异喹啉鎓化合物,菲啶鎓化合物和光合精化合物,螺吡啶化合物,鲁米诺化合物和异鲁米诺化合物。 M是具有至少一个选自氧,氮和硫的孤对电子的多价杂原子,其一端直接连接到Lumi的发光部分,另一端直接附着于P。 P是可以通过水解酶容易地除去的基团。 使用上述化合物的酶反应如下:其中HE是水解酶。 Lumi-M是具有与Lumi-M-P不同的物理和/或化学性质的化学发光产物。