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1. 发明申请

US20070105852A1 Thiophene and furan compounds 失效
标题翻译：噻吩和呋喃化合物
公开(公告)号：US20070105852A1
公开(公告)日：2007-05-10
申请号：US10596419
申请日：2005-01-05
申请人： Ana Castano Mansanet , Esteban Dominguez-Manzanares , Ana Escribano , Maria Fernandez , William Hornback , Alma Jimenez-Aguado , Eric Tromiczak , Zhipei Wu , Hamideh Zarrinmayeh , Dennis Zimmerman
发明人： Ana Castano Mansanet , Esteban Dominguez-Manzanares , Ana Escribano , Maria Fernandez , William Hornback , Alma Jimenez-Aguado , Eric Tromiczak , Zhipei Wu , Hamideh Zarrinmayeh , Dennis Zimmerman
IPC分类号： A61K31/5377 , A61K31/665 , A61K31/497 , A61K31/506 , A61K31/433 , A61K31/4433 , A61K31/4436 , A61K31/425 , A61K31/453
CPC分类号： C07D307/68 , C07D333/38 , C07D409/10 , C07D417/10
摘要： The present invention relates to thiophene and furan compounds and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression.
摘要翻译：本发明涉及噻吩和呋喃化合物及其药学上可接受的盐，并且还涉及它们在治疗精神分裂症，与精神分裂症相关的认知缺陷，阿尔茨海默病，阿尔茨海默氏型痴呆，轻度认知障碍或抑郁症中的用途。

2. 发明申请

US20070066573A1 Pyrrole and pyrazole derivatives as potentiators of glutamate receptors 失效
标题翻译：吡咯和吡唑衍生物作为谷氨酸受体的增效剂
公开(公告)号：US20070066573A1
公开(公告)日：2007-03-22
申请号：US10570985
申请日：2004-09-27
申请人： Pamela Albaugh , Esteban Dominguez-Manzanares , Jian Hong , William Hornback , Delu Jiang , Paul Ornstein , Michelle Thompson , Eric Tromiczak , Zhipei Wu , Hamideh Zarrinmayeh , Dennis Zimmerman , Ana Castano Mansanet , Larry Huffman , William Miller
发明人： Pamela Albaugh , Esteban Dominguez-Manzanares , Jian Hong , William Hornback , Delu Jiang , Paul Ornstein , Michelle Thompson , Eric Tromiczak , Zhipei Wu , Hamideh Zarrinmayeh , Dennis Zimmerman , Ana Castano Mansanet , Larry Huffman , William Miller
IPC分类号： A61K31/675 , A61K31/433 , A61K31/4196 , A61K31/42 , A61K31/425 , A61K31/415 , A61K31/416 , A61K31/4025 , A61K31/401 , C07D417/02 , C07D413/02 , C07D405/02 , C07D403/02
CPC分类号： C07D207/34 , C07D207/36 , C07D231/14 , C07D401/10 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/10 , C07D409/10 , C07D409/12 , C07D413/10 , C07D417/10
摘要： The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.
摘要翻译：本发明涉及式（I）的吡咯和吡唑化合物及其药学上可接受的盐，并且还涉及它们在治疗精神分裂症，与精神分裂症相关的认知缺陷，阿尔茨海默病，阿尔茨海默氏型痴呆，轻度认知障碍或萧条。这些化合物作为谷氨酸受体，特别是AMPA和GluR家族的增效剂。

3. 发明申请

US20060030599A1 SULPHONAMIDE DERIVATIVES 失效
标题翻译：磺酰胺衍生物
公开(公告)号：US20060030599A1
公开(公告)日：2006-02-09
申请号：US10447619
申请日：2003-05-29
申请人： Macklin Arnold , Stephen Baker , Thomas Bleisch , Buddy Cantrell , Ana Escribano , Ken Matsumoto , Tracey Mckennon , Paul Ornstein , Richard Simon , Edward Smith , Hamideh Zarrinmayeh , Dennis Zimmerman
发明人： Macklin Arnold , Stephen Baker , Thomas Bleisch , Buddy Cantrell , Ana Escribano , Ken Matsumoto , Tracey Mckennon , Paul Ornstein , Richard Simon , Edward Smith , Hamideh Zarrinmayeh , Dennis Zimmerman
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4439 , A61K31/426 , A61K31/421
CPC分类号： A61K31/18 , A61K31/381 , A61K31/41 , A61K31/42 , A61K31/4245 , A61K31/4418 , A61K31/451 , A61K31/455 , C07C307/08 , C07C311/03 , C07C311/04 , C07C311/05 , C07C311/06 , C07C311/09 , C07C311/14 , C07C311/16 , C07C311/24 , C07C311/29 , C07C311/39 , C07C311/53 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D207/277 , C07D211/18 , C07D211/28 , C07D213/42 , C07D213/81 , C07D213/82 , C07D239/26 , C07D257/04 , C07D261/08 , C07D261/10 , C07D261/18 , C07D271/06 , C07D277/24 , C07D277/28 , C07D277/56 , C07D277/66 , C07D279/02 , C07D307/12 , C07D307/52 , C07D307/68 , C07D307/71 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/28 , C07D333/34 , C07D333/38 , C07D333/58 , C07D333/68 , C07D409/04
摘要： Glutamate receptor function in a mammal may be potentiated using an effective amount of a compound of formula R1-L-NHSO2R2 I in which R1 represents an unsubstituted or substituted aromatic or heteroaromatic group; R2 represents (1-6C)alkyl, (3-6C)cycloalkyl, (1-6C)fluoroalkyl, (1-6C) chloroalkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, or a group, of formula R3R4N in which R3 and R4 each independently represents (1-4C)alkyl or, together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and L represents a (2-4C)alkylene chain which is unsubstituted or substituted by one or two substituents selected independently from (1-6C)alkyl, aryl(1-6C)alkyl, (2-6C)alkenyl, aryl(2-6C)alkenyl and aryl, or by two substituents which, together with the carbon atom or carbon atoms to which they are attached form a (3-8C)carbocyclic ring; and pharmaceutically acceptable salts thereof. Also disclosed are novel compounds of formula I, processes for preparing them and pharmaceutical compositions containing them.
摘要翻译：哺乳动物中的谷氨酸受体功能可以使用有效量的式α化合物进行增强化学式描述=“在线公式”末端=“引物”→R 1 - L-NHSO 2 2 在线公式描述=“在线公式”end =“tail”→>其中R 1 代表未取代或取代的芳族或杂芳族基团; （1-6C）烷基，（3-6C）环烷基，（1-6C）氟烷基，（1-6C）氯烷基，（2-6C）烯基，（1-4C）烷氧基（1-4C）烷基，未被取代或被卤素取代的苯基，（1-4C）烷基或（1-4C）烷氧基或式R 3的基团，其中R 3和R 4各自独立地表示（1-4C）烷基，或者与它们相连的氮原子一起形成一个氮杂环丁烷基，吡咯烷基，哌啶基，吗啉代，哌嗪基，六氢氮杂基或八氢az嗪基; （1-6C）烷基，（2-6C）烷基，（2-6C）烯基，芳基（2-甲基苯基）丙烯基， 6C）烯基和芳基，或两个与它们所连接的碳原子或碳原子一起形成（3-8C）碳环的取代基; 及其药学上可接受的盐。还公开了式I的新化合物，其制备方法和含有它们的药物组合物。

4. 发明申请

US20050023848A1 Fifth wheel release lever 失效
标题翻译：第五轮释放杆
公开(公告)号：US20050023848A1
公开(公告)日：2005-02-03
申请号：US10629752
申请日：2003-07-30
申请人： Dennis Zimmerman
发明人： Dennis Zimmerman
IPC分类号： B62D53/08 , B65G7/12 , B66F3/00
CPC分类号： B62D53/0857
摘要： A second class lever device provides additional mechanical advantage to pull the release handle in the fifth wheel hitch of a truck tractor and semi trailer combination. Such release handles can bind and become difficult to release due to misalignment between tractor and trailer, corrosion or lack of lubrication, etc. The present release lever includes an elongate fulcrum bar to bridge the gap between the tractor tires and the overlying side of the trailer, with a lever arm extending therefrom. A tension member extends from the lever arm, between the handle end and fulcrum end thereof. The lever arm telescopes for storage, with the fulcrum bar pivoting and sliding in its lever arm attachment to further facilitate compact storage. The tension member preferably comprises a chain, with a release handle engaging hook adjustably installed on the chain to adjust the effective length thereof as required.
摘要翻译：第二级杠杆装置提供额外的机械优点来拉动卡车拖拉机和半拖车组合的第五轮牵引中的释放手柄。这种释放手柄可能由于拖拉机和拖车之间的不对准而结合并变得难以释放，腐蚀或缺乏润滑等。本释放杆包括细长的支点杆，以跨越拖拉机轮胎和拖车的上侧之间的间隙具有从其延伸的杠杆臂。张力构件从杠杆臂延伸在手柄端和支点之间。杠杆臂望远镜用于存储，支点杆在其杠杆臂附件中枢转和滑动，以进一步促进紧凑的存储。张紧构件优选地包括链条，其具有可调节地安装在链条上的释放手柄接合钩，以根据需要调整其有效长度。

5. 发明授权

US06445175B1 Remote, wireless electrical signal measurement device 有权
公开(公告)号：US06445175B1
公开(公告)日：2002-09-03
申请号：US09940745
申请日：2001-08-28
申请人： Randy Estep , Dennis Zimmerman
发明人： Randy Estep , Dennis Zimmerman
IPC分类号： G01P1500
CPC分类号： G01R1/025 , G01R1/02 , G10L13/00 , G10L15/26
摘要： A remote, wireless electrical signal measurement device for measuring and adjusting a component in a communications system. The device includes a source device, a remote system and a base system. The device permits a technician wearing the remote system to control through verbal commands the measurement and adjustment of a source device operably attached to the base system.

6. 发明授权

US06353313B1 Remote, wireless electrical signal measurement device 有权
公开(公告)号：US06353313B1
公开(公告)日：2002-03-05
申请号：US09266318
申请日：1999-03-11
申请人： Randy Estep , Dennis Zimmerman
发明人： Randy Estep , Dennis Zimmerman
IPC分类号： G01P1500
CPC分类号： G01R1/025 , G01R1/02 , G10L13/00 , G10L15/26
摘要： A remote, wireless electrical signal measurement device for measuring and adjusting a component in a communications system. The device includes a source device, a remote system and a base system. The device permits a technician wearing the remote system to control through verbal commands the measurement and adjustment of a source device operably attached to the base system.

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