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1. 发明申请

US20070048320A1 Method for indentifying modulators of PPIL2 useful for treating Alzheimer's disease 审中-公开
标题翻译：用于鉴定治疗阿尔茨海默病的PPIL2调节剂的方法
公开(公告)号：US20070048320A1
公开(公告)日：2007-03-01
申请号：US11514737
申请日：2006-08-31
申请人： Amy Espeseth , Daria Hazuda , Peter Linsley , Qian Huang
发明人： Amy Espeseth , Daria Hazuda , Peter Linsley , Qian Huang
IPC分类号： A61K39/395 , G01N33/567 , A61K39/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/40 , C12N9/90 , G01N33/6896 , G01N2333/4709 , G01N2500/10
摘要： Methods for identifying modulators of PPIL2 are described. The methods are particularly useful for identifying analytes that antagonize PPIL2's effect on processing of amyloid precursor protein to Aβ peptide and thus useful for identifying analytes that can be used for treating Alzheimer disease.
摘要翻译：描述了用于鉴定PPIL2调节剂的方法。该方法特别适用于鉴定拮抗PPIL2对淀粉样蛋白前体蛋白加工成Abeta肽的影响的分析物，因此可用于鉴定可用于治疗阿尔茨海默病的分析物。

2. 发明申请

US20100113577A1 ISOLATED NUCLEIC ACID MOLECULES CORRESPONDING TO MICRO RNA 145 (MIRNA-145) AND THEIR USE IN TREATING COLON CANCER 审中-公开
标题翻译：与MICRO RNA 145（MIRNA-145）相关的分离的核酸分子及其在治疗结肠癌中的应用
公开(公告)号：US20100113577A1
公开(公告)日：2010-05-06
申请号：US12594962
申请日：2008-04-07
申请人： Bin Shi , Laura Sepp-Lorenzino , Peter Linsley , Renato Baserga
发明人： Bin Shi , Laura Sepp-Lorenzino , Peter Linsley , Renato Baserga
IPC分类号： A61K31/7088 , C12Q1/68
CPC分类号： C07K14/47 , A61K48/00
摘要： Provided herein are isolated nucleic acid molecule corresponding to miR145 that are useful in treating colon cancer. The disclosed miR145 nucleic acids specifically bind the 3′ UTR within endogenous IRS-I such as to suppress or inhibit colon cell proliferation.
摘要翻译：本文提供了对应于可用于治疗结肠癌的miR145的分离的核酸分子。公开的miR145核酸特异性结合内源IRS-1内的3'UTR，以抑制或抑制结肠细胞增殖。

3. 发明申请

US20050169919A1 CTLA4 molecules and IL4-binding molecules and uses thereof 失效
标题翻译： CTLA4分子和IL4结合分子及其用途
公开(公告)号：US20050169919A1
公开(公告)日：2005-08-04
申请号：US10461000
申请日：2003-06-13
申请人： Peter Linsley , Jeffrey Ledbetter , Nitin Damle , William Brady
发明人： Peter Linsley , Jeffrey Ledbetter , Nitin Damle , William Brady
IPC分类号： A61K38/00 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , A61K39/395 , C07K14/74
CPC分类号： C07K16/247 , A61K38/00 , A61K2039/505 , C07K14/70521 , C07K14/7155 , C07K16/00 , C07K16/2818 , C07K16/2827 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C07K2319/30 , Y10S514/885
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
摘要翻译：本发明鉴定CTLA4受体作为B7抗原的配体。提供编码人CTLA4受体基因的完整氨基酸序列。提供用于表达CTLA4作为免疫球蛋白融合蛋白的方法，用于制备杂合CTLA4融合蛋白，并使用可溶性融合蛋白，其片段和衍生物，包括与B7和CTLA4反应的单克隆抗体调节T细胞相互作用和免疫应答介导通过这种互动。

4. 发明授权

US08713172B1 Identification of websites that break out of frames 有权
标题翻译：识别出框架的网站
公开(公告)号：US08713172B1
公开(公告)日：2014-04-29
申请号：US13468322
申请日：2012-05-10
申请人： Peter Linsley
发明人： Peter Linsley
IPC分类号： G06F15/16 , G06F12/00
CPC分类号： G06F17/30905
摘要： Websites or webpages that break frames may be automatically detected by determining a first value, based on a number of occurrences, that a child webpage and a container webpage are provided for presentation, the child webpage being presented within a frame of the container webpage. A second value may be determined, based on a number of occurrences, of user interaction data, indicating user interaction with the container webpage. The method may further include calculating a frame break score for the child webpage based on the first value and the second value and comparing the frame break score to a threshold. The method may further include identifying, based on the comparison to the threshold, the child webpage as a webpage that breaks frames.
摘要翻译：可以通过基于出现次数确定子网页和容器网页用于呈现来确定第一个值来自动检测出框架的网站或网页，该子网页被呈现在容器网页的框架内。可以基于多次出现的用户交互数据来确定第二个值，指示用户与容器网页的交互。该方法还可以包括基于第一值和第二值计算子网页的帧间分数，并将帧间分数与阈值进行比较。该方法还可以包括基于与阈值的比较来识别作为中断帧的网页的子网页。

5. 发明申请

US20130117258A1 Previewing Search Results 有权
标题翻译：预览搜索结果
公开(公告)号：US20130117258A1
公开(公告)日：2013-05-09
申请号：US13288859
申请日：2011-11-03
申请人： Peter Linsley , Kenneth W. Dauber
发明人： Peter Linsley , Kenneth W. Dauber
IPC分类号： G06F17/30
CPC分类号： G06F17/30277 , G06F17/30572 , G06F17/30864
摘要： Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for previewing search results. In one aspect, a method includes receiving a query from a client device. One or more image search results are provided to the client device, each of the one or more image search results identifying a corresponding image resource and each of the one or more image search results including an image representation of the corresponding image resource. One or more related queries are provided to the client device, the one or more related queries having been determined to be related to the query, wherein each of the one or more related queries includes a preview image to be displayed at the client device, the preview image representing an image search result responsive to the related query.
摘要翻译：方法，系统和装置，包括在计算机存储介质上编码的计算机程序，用于预览搜索结果。一方面，一种方法包括从客户端设备接收查询。将一个或多个图像搜索结果提供给客户端设备，所述一个或多个图像搜索结果中的每一个标识对应的图像资源，并且所述一个或多个图像搜索结果中的每一个包括对应的图像资源的图像表示。将一个或多个相关查询提供给客户端设备，所述一个或多个相关查询已被确定为与查询相关，其中所述一个或多个相关查询中的每一个包括要在客户端设备处显示的预览图像，响应于相关查询的表示图像搜索结果的预览图像。

6. 发明申请

US20050181385A1 Synthetic lethal screen using RNA interference 审中-公开
标题翻译：合成致死屏幕采用RNA干扰
公开(公告)号：US20050181385A1
公开(公告)日：2005-08-18
申请号：US10947637
申请日：2004-09-22
申请人： Peter Linsley , Mao Mao , Annette Kim , Stephen Friend , Steven Bartz , Michele Cleary
发明人： Peter Linsley , Mao Mao , Annette Kim , Stephen Friend , Steven Bartz , Michele Cleary
IPC分类号： C07H21/02 , C12N15/11 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/12
摘要： The invention provides a method for identifying one or more genes in a cell of a cell type which interact with, e.g., modulate the effect of, an agent, e.g., a drug. For example, an identified gene may confer resistance or sensitivity to a drug, i.e., reduces or enhances the effect of the drug. The invention also provides STK6 and TPX2 as a gene that exhibits synthetic lethal interactions with KSP encoding a kinesin-like motor protein, and methods and compositions for treatment of diseases, e.g., cancers, by modulating the expression of STK6 or TPX2 gene and/or the activity of STK6 or TPX2 gene product. The invention also provides genes involved in cellular response to DNA damage, and their therapeutic uses.
摘要翻译：本发明提供了一种用于鉴定与例如药物的作用相互作用的细胞类型的细胞中的一种或多种基因的方法。例如，鉴定的基因可赋予药物抗药性或敏感性，即降低或增强药物的作用。本发明还提供STK6和TPX2作为与编码驱动蛋白样运动蛋白的KSP呈现合成的致死相互作用的基因，以及通过调节STK6或TPX2基因的表达和/或治疗疾病例如癌症的方法和组合物 STK6或TPX2基因产物的活性。本发明还提供涉及对DNA损伤的细胞反应及其治疗用途的基因。

7. 发明授权

US4873188A Method, monoclonal antibody, and monoclonal antibody fragments for detecting human non-small cell lung carcinomas and cell line for producing such antibodies 失效
标题翻译：方法，单克隆抗体和用于检测人非小细胞肺癌的单克隆抗体片段和用于产生此类抗体的细胞系
公开(公告)号：US4873188A
公开(公告)日：1989-10-10
申请号：US738612
申请日：1985-05-28
申请人： Ingegerd Hellstrom , Joseph P. Brown , Karl E. Hellstrom , Diane Horn , Peter Linsley
发明人： Ingegerd Hellstrom , Joseph P. Brown , Karl E. Hellstrom , Diane Horn , Peter Linsley
IPC分类号： G01N33/574 , A61K39/395 , C07K14/005 , C07K14/195 , C07K14/705 , C07K16/00 , C07K16/30 , C07K19/00 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/577
CPC分类号： C07K16/3023 , Y10S436/804 , Y10S436/813 , Y10S530/808 , Y10S530/864 , Y10S530/866
摘要： The present invention is concerned with two novel monoclonal antibodies which define carbohydrate antigens associated with human non-small cell lung carcinomas ("NSCLC") and certain other human carcinomas. The antibodies bind to normal human cells to a much lesser degree than to tumor cells. The antibodies find use in diagnostic methods such as the detection of malignant cells associated with NSCLC and in therapeutic methods. The invention also comprises a method for determining the presence of a malignant condition in the lung of a subject. The method involves examining tissue from the subject for the presence of antigens which are Le.sup.x or Le.sup.y antigen or which have the characteristics of Le.sup.y and Le.sup.x.
摘要翻译：本发明涉及定义与人非小细胞肺癌（“NSCLC”）和某些其他人类癌症相关的碳水化合物抗原的两种新型单克隆抗体。抗体与正常人细胞结合的程度远低于肿瘤细胞。抗体可用于诊断方法，例如检测与NSCLC相关的恶性细胞和治疗方法。本发明还包括用于确定受试者肺中恶性状况的存在的方法。该方法包括检查来自受试者的组织是否存在Lex或Ley抗原或具有Ley和Lex特征的抗原。

8. 发明申请

US20150169739A1 Query Classification 有权
标题翻译：查询分类
公开(公告)号：US20150169739A1
公开(公告)日：2015-06-18
申请号：US13462126
申请日：2012-05-02
申请人： Peter Linsley
发明人： Peter Linsley
IPC分类号： G06F17/30
CPC分类号： G06F17/30675 , G06F17/30029 , G06F17/3071 , G06F17/30867 , G06F17/30935
摘要： Methods, apparatus and software for classifying queries. In an aspect, for each of a plurality of queries, determines a first value based on a first number of occurrences for which the query was received for unfiltered search operations, and a determines a second value based on a second number of occurrences for which the query was received for filtered search operations. The method determines a first content type value based on the first value and the second value, and for each of the plurality of queries having a first content type value that meets a first threshold, classifies the query as a first content type seeking query, the classification being indicative of likely user interest in content of the first type.
摘要翻译：用于分类查询的方法，设备和软件。在一方面，对于多个查询中的每一个，基于针对未过滤的搜索操作接收到查询的第一个出现次数来确定第一个值，并且a基于第二个数量的事件来确定第二个值，收到过滤搜索操作的查询。该方法基于第一值和第二值确定第一内容类型值，并且对于具有满足第一阈值的第一内容类型值的多个查询中的每一个，将该查询分类为第一内容类型查询查询，分类表示可能的用户对第一类内容的兴趣。

9. 发明授权

US08846631B2 MicroRNA compositions and methods 有权
标题翻译：微RNA组合物和方法
公开(公告)号：US08846631B2
公开(公告)日：2014-09-30
申请号：US13521597
申请日：2011-01-14
申请人： Eric G. Marcusson , Balkrishen Bhat , Peter Linsley , Akin Akinc
发明人： Eric G. Marcusson , Balkrishen Bhat , Peter Linsley , Akin Akinc
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C07H21/04
CPC分类号： C12N15/113 , A61K31/713 , A61K45/06 , A61K48/00 , C12N2310/141
摘要： Provided herein are compositions comprising oligomeric compounds. In certain embodiments, the oligomeric compounds are useful as miRNA mimics. The oligomeric compounds may mimic the activity of miR-34. Also provided herein are methods for the treatment of cancer.
摘要翻译：本文提供包含低聚化合物的组合物。在某些实施方案中，寡聚化合物可用作miRNA模拟物。寡聚化合物可以模拟miR-34的活性。本文还提供了治疗癌症的方法。

10. 发明申请

US20130123329A1 MICRORNA COMPOSITIONS AND METHODS 有权
公开(公告)号：US20130123329A1
公开(公告)日：2013-05-16
申请号：US13521597
申请日：2011-01-14
申请人： Eric G. Marcusson , Balkrishen Bhat , Peter Linsley , Akin Akinc
发明人： Eric G. Marcusson , Balkrishen Bhat , Peter Linsley , Akin Akinc
IPC分类号： A61K48/00 , A61K45/06 , C12N15/113
CPC分类号： C12N15/113 , A61K31/713 , A61K45/06 , A61K48/00 , C12N2310/141
摘要： Provided herein are compositions comprising oligomeric compounds. In certain embodiments, the oligomeric compounds are useful as miRNA mimics. The oligomeric compounds may mimic the activity of miR-34. Also provided herein are methods for the treatment of cancer.

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